Caffeine reduces 11β-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine a 2b receptor

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Sharmin, Saina ^a   Guan, Haiyan ^a   Williams, Andrew Scott ^a   Yang, Kaiping ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR; ADENYLATE CYCLASE; CAFFEINE; CYCLIC AMP; FORSKOLIN; PARAXANTHINE; RIBOSOME RNA; SMALL INTERFERING RNA; 1,7-DIMETHYLXANTHINE; PRIMER DNA; THEOPHYLLINE;

ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FETUS DEVELOPMENT; FETUS GROWTH; GENE FUNCTION; HUMAN; HUMAN CELL; INTRAUTERINE GROWTH RETARDATION; PLACENTA; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TROPHOBLAST; WESTERN BLOTTING; ANALYSIS OF VARIANCE; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; IN VITRO STUDY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CAFFEINE; CYCLIC AMP; DNA PRIMERS; FEMALE; FORSKOLIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, ADENOSINE A2B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; THEOPHYLLINE; TROPHOBLASTS;

EID: 84862210634     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038082     Document Type: Article

References (49)

1. Brodsky D, Christou H, (2004) Current concepts in intrauterine growth restriction. J Intensive Care Med 19: 307 319.
2. Mandruzzato G, Antsaklis A, Botet F, Chervenak FA, Figueras F, (2008) Intrauterine restriction (IUGR). J Perinat Med 36: 277 281.
3. Miller J, Turan S, Baschat AA, (2008) Fetal growth restriction. Semin Perinatol 32: 274 280.
4. Sankaran S, Kyle PM, (2009) Aetiology and pathogenesis of IUGR. Best Pract Res Clin Obstet Gynaecol 23: 765 777.
5. Joss-Moore LA, Lane RH, (2009) The developmental origins of adult disease. Curr Opin Pediatr 21: 230 234.
6. Langley-Evans SC, McMullen S, (2010) Developmental origins of adult disease. Med Princ Pract 19: 87 98.
7. Desai M, Ross MG, (2011) Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet. Semin Reprod Med 29: 237 245.
8. Neitzke U, Harder T, Plagemann A, (2011) Intrauterine growth restriction and developmental programming of the metabolic syndrome: a critical appraisal. Microcirculation 18: 304 311.
9. Neerhof MG, (1995) Causes of intrauterine growth restriction. Clin Perinatol 22: 375 385.
10. Ghidini A, (1996) Idiopathic fetal growth restriction: a pathophysiologic approach. Obstet Gynecol Surv 51: 376 382.
11. Vik T, Bakketeig LS, Trygg KU, Lund-Larsen K, Jacobsen G, (2003) High caffeine consumption in the third trimester of pregnancy: gender-specific effects on fetal growth. Paediatr Perinat Epidemiol 17: 324 331.
12. CARE Study Group (2008) Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study. BMJ 337: a2332.
13. Bakker R, Steegers EA, Obradov A, Raat H, Hofman A, (2010) Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study. Am J Clin Nutr 91: 1691 1698.
14. Peck JD, Leviton A, Cowan LD, (2010) A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: a 2000-2009 update. Food Chem Toxicol 48: 2549 2576.
15. Brent RL, Christian MS, Diener RM, (2011) Evaluation of the reproductive and developmental risks of caffeine. Birth Defects Res B Dev Reprod Toxicol 92: 152 187.
16. Infante-Rivard C, (2007) Caffeine intake and small-for-gestational-age birth: modifying effects of xenobiotic-metabolising genes and smoking. Paediatr Perinat Epidemiol 21: 300 309.
17. Bracken MB, Triche EW, Belanger K, Hellenbrand K, Leaderer BP, (2003) Association of maternal caffeine consumption with decrements in fetal growth. Am J Epidemiol 157: 456 466.
18. Klebanoff MA, Levine RJ, Clemens JD, Wilkins DG, (2002) Maternal serum caffeine metabolites and small-for-gestational age birth. Am J Epidemiol 155: 32 37.
19. Grosso LM, Triche EW, Belanger K, Benowitz NL, Holford TR, (2006) Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction. Am J Epidemiol 163: 1035 1041.
20. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE, (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51: 83 133.
21. Kuczkowski KM, (2009) Caffeine in pregnancy. Arch Gynecol Obstet 280: 695 698.
22. Knutti R, Rothweiler H, Schlatter C, (1982) The effect of pregnancy on the pharmacokinetics of caffeine. Arch Toxicol pp. 187 192.
23. Abdi F, Pollard I, Wilkinson J, (1993) Placental transfer and foetal disposition of caffeine and its immediate metabolites in the 20-day pregnant rat: function of dose. Xenobiotica 23: 449 456.
24. Kirkinen P, Jouppila P, Koivula A, Vuori J, Puukka M, (1983) The effect of caffeine on placental and fetal blood flow in human pregnancy. Am J Obstet Gynecol 147: 939 942.
25. Balat O, Balat A, Ugur MG, Pence S, (2003) The effect of smoking and caffeine on the fetus and placenta in pregnancy. Clin Exp Obstet Gynecol 30: 57 59.
26. Shams M, Kilby MD, Somerset DA, Howie AJ, Gupta A, (1998) 11Beta-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction. Hum Reprod 13: 799 804.
27. McTernan CL, Draper N, Nicholson H, Chalder SM, Driver P, (2001) Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms. J Clin Endocrinol Metab 86: 4979 4983.
28. Dy J, Guan H, Sampath-Kumar R, Richardson BS, Yang K, (2008) Placental 11beta-hydroxysteroid dehydrogenase type 2 is reduced in pregnancies complicated with idiopathic intrauterine growth Restriction: evidence that this is associated with an attenuated ratio of cortisone to cortisol in the umbilical artery. Placenta 29: 193 200.
29. Wyrwoll CS, Seckl JR, Holmes MC, (2009) Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice. Endocrinology 150: 1287 1293.
30. Fredholm BB, (2010) Adenosine receptors as drug targets. Exp Cell Res 316: 1284 1288.
31. Pasquarette MM, Stewart PM, Ricketts ML, Imaishi K, Mason JI, (1996) Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells. J Mol Endocrinol 16: 269 275.
32. Sun K, Yang K, Challis JR, (1998) Regulation of 11beta-hydroxysteroid dehydrogenase type 2 by progesterone, estrogen, and the cyclic adenosine 5'-monophosphate pathway in cultured human placental and chorionic trophoblasts. Biol Reprod 58: 1379 1384.
33. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF 3rd (1986) Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 118: 1567 1582.
34. Hardy DB, Yang K, (2002) The expression of 11 beta-hydroxysteroid dehydrogenase type 2 is induced during trophoblast differentiation: effects of hypoxia. J Clin Endocrinol Metab 87: 3696 3701.
35. Sharma A, Guan H, Yang K, (2009) The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger ribonucleic acid stability. Endocrinology 150: 4278 4286.
36. Krozowski Z, MaGuire JA, Stein-Oakley AN, Dowling J, Smith RE, (1995) Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta. J Clin Endocrinol Metab 80: 2203 2209.
37. van Beek JP, Guan H, Julan L, Yang K, (2004) Glucocorticoids stimulate the expression of 11beta-hydroxysteroid dehydrogenase type 2 in cultured human placental trophoblast cells. J Clin Endocrinol Metab 89: 5614 5621.
38. Guan H, Arany E, van Beek JP, Chamson-Reig A, Thyssen S, (2005) Adipose tissue gene expression profiling reveals distinct molecular pathways that define visceral adiposity in offspring of maternal protein-restricted rats. Am J Physiol Endocrinol Metab 288: E663 673.
39. Stewart A, Guan H, Yang K, (2010) BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway. J Cell Physiol 223: 658 666.
40. Grosso LM, Bracken MB, (2005) Caffeine metabolism, genetics, and perinatal outcomes: a review of exposure assessment considerations during pregnancy. Ann Epidemiol 15: 460 466.
41. Smith SE, McElhatton PR, Sullivan FM, (1987) Effects of administering caffeine to pregnant rats either as a single daily dose or as divided doses four times a day. Food Chem Toxicol 25: 125 133.
42. Momoi N, Tinney JP, Liu LJ, Elshershari H, Hoffmann PJ, (2008) Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growth. Am J Physiol Heart Circ Physiol 294: H2248 2256.
43. Gilbert SG, Rice DC, (1991) Somatic development of the infant monkey following in utero exposure to caffeine. Fundam Appl Toxicol 17: 454 465.
44. Cook DG, Peacock JL, Feyerabend C, Carey IM, Jarvis MJ, (1996) Relation of caffeine intake and blood caffeine concentrations during pregnancy to fetal growth: prospective population based study. BMJ 313: 1358 1362.
45. Biaggioni I, Davis SN, (2002) Caffeine: a cause of insulin resistance? Diabetes Care 25: 399 400.
46. Hentges CR, Guedes RR, Silveira RC, Procianoy RS, (2010) Serum levels of caffeine in umbilical cord and apnea of prematurity. J Pediatr (Rio J) 86: 137 142.
47. von Versen-Hoynck F, Rajakumar A, Bainbridge SA, Gallaher MJ, Roberts JM, (2009) Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor. Placenta 30: 434 442.
48. Puffinbarger NK, Hansen KR, Resta R, Laurent AB, Knudsen TB, (1995) Production and characterization of multiple antigenic peptide antibodies to the adenosine A2b receptor. Mol Pharmacol 47: 1126 1132.
49. Kim YH, Hwang HS, Kim YT, Kim HS, Park YW, (2008) Modulation of matrix metalloproteinase secretion by adenosine A3 receptor in preeclamptic villous explants. Reprod Sci 15: 939 949.