Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission

Malaria Journal

Volumn 11, Issue , 2012, Pages

  Huho, Bernadette J ^a,b,h   Killeen, Gerard F ^a,c   Ferguson, Heather M ^a,d   Tami, Adriana ^e,f   Lengeler, Christian ^b,h   Charlwood, J Derek ^c   Kihonda, Aniset ^a   Kihonda, Japhet ^a   Kachur, S Patrick ^a,g   Smith, Thomas A ^b,h   Abdulla, Salim M K ^a  

^a IFAKARA HEALTH INSTITUTE   (Tanzania)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f ROYAL TROPICAL INSTITUTE   (Netherlands)

^g CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^h UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Artemisinin based combination therapy; Malaria; Transmission reduction

Indexed keywords

ARTESUNATE; PYRIMETHAMINE PLUS SULFADOXINE; RAIN;

ANOPHELES FUNESTUS; ANOPHELES GAMBIAE; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL TEMPERATURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEALTH CARE POLICY; HUMAN; MALARIA; MONITORING; MONOTHERAPY; NONHUMAN; OOCYST; PARASITE TRANSMISSION; PARASITE VECTOR; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; PREVALENCE; SPOROZOITE; TANZANIA;

ANIMALS; ANTIGENS, PROTOZOAN; ANTIMALARIALS; ARTEMISININS; ASYMPTOMATIC DISEASES; CHILD, PRESCHOOL; CULICIDAE; DISEASE VECTORS; DRUG COMBINATIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PREGNANCY; PREVALENCE; PYRIMETHAMINE; SULFADOXINE; TANZANIA;

EID: 84862209304     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-11-118     Document Type: Article

References (55)

1. Infectivity to mosquitoes of Plasmodium falciparum as related to gametocyte density and duration of infection. Jeffery GM, Eyles DE, AmJTrop Med Hyg 1955 4 781 789
2. Age- and species-specific duration of infection in asymptomatic malaria infections in Papua New Guinea. Bruce MC, Donnelly CA, Packer M, Lagog M, Gibson N, Narara A, Walliker D, Alpers MP, Day KP, Parasitology 2000 121 Pt 3 247 256 11085245
3. An immigration-death model to estimate the duration of malaria infection when detectability of the parasite is imperfect. Sama W, Owusu-Agyei S, Felger I, Vounatsou P, Smith T, Stat Med 2005 24 3269 3288 10.1002/sim.2189 16143990 (Pubitemid 41548980)
4. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Nosten F, van Vugt M, Price R, Luxemburger C, Thway KL, Brockman A, McGready R, ter Kuile F, Looareesuwan S, White NJ, Lancet 2000 356 297 302 10.1016/S0140-6736(00)02505-8 11071185 (Pubitemid 30459588)
5. Artemisinin-based combinations. Ashley EA, White NJ, Curr Opin Infect Dis 2005 18 531 536 10.1097/01.qco.0000186848.46417.6c 16258328 (Pubitemid 41634767)
6. Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. Okell LC, Drakeley CJ, Ghani AC, Bousema T, Sutherland CJ, Malar J 2008 7 125 10.1186/1475-2875-7-125 18613962
7. Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal. Barnes KI, Durrheim DN, Little F, Jackson A, Mehta U, Allen E, Dlamini SS, Tsoka J, Bredenkamp B, Mthembu DJ, White NJ, Sharp BL, South Africa. PLoS Med 2005 2 330
8. Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar. Bhattarai A, Ali AS, Kachur SP, Martensson A, Abbas AK, Khatib R, Al-Mafazy AW, Ramsan M, Rotllant G, Gerstenmaier JF, Molteni F, Abdulla S, Montgomery SM, Kaneko A, Bjorkman A, PLoS Med 2007 4 309 10.1371/journal.pmed.0040309 17988171 (Pubitemid 350220531)
9. Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes. Drakeley CJ, Jawara M, Targett GAT, Walraven G, Obisike U, Coleman R, Pinder M, Sutherland CJ, Trop Med Int Health 2004 9 53 61 10.1046/j.1365-3156.2003.01169.x 14728607 (Pubitemid 38178012)
10. Reduction of malaria transmission to Anopheles mosquitoes with a six-dose regimen of co-artemether. Sutherland CJ, Ord R, Dunyo S, Jawara M, Drakeley CJ, Alexander N, Coleman R, Pinder M, Walraven G, Targett GA, PLoS Med 2005 2 92 10.1371/journal.pmed.0020092 15839740 (Pubitemid 40721079)
11. Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia. Barnes KI, Chanda P, Ab Barnabas G, Malar J 2009 8 Suppl 1 8 10.1186/1475-2875-8-S1-S8 19917078
12. Measurement of malarial infectivity of human populations to mosquitoes in the Madang area, Papua, New Guinea. Graves PM, Burkot TR, Carter R, Cattani JA, Lagog M, Parker J, Brabin BJ, Gibson FD, Bradley DJ, Alpers MP, Parasitology 1988 96 Pt 2 251 263 3374964
13. Absence of relationships between selected human factors and natural infectivity of Plasmodium falciparum to mosquitoes in an area of high transmission. Haji H, Smith T, Charlwood JD, Meuwissen JH, Parasitology 1996 113 425 431 10.1017/S0031182000081488 8893528 (Pubitemid 26354536)
14. (Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate. Schneider P, Bousema T, Omar S, Gouagna L, Sawa P, Schallig H, Sauerwein R, Int J Parasitol 2006 36 403 408 10.1016/j.ijpara.2006.01.002 16500657 (Pubitemid 43744427)
15. Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya. Bousema JT, Gouagna LC, Drakeley CJ, Meutstege AM, Okech BA, Akim INJ, Beier JC, Githure JI, Sauerwein RW, Malar J 2004 3
16. Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum. Bousema JT, Schneider P, Gouagna LC, Drakeley CJ, Tostmann A, Houben R, Githure JI, Ord R, Sutherland CJ, Omar SA, Sauerwein RW, J Infect Dis 2006 193 1151 1159 10.1086/503051 16544256
17. The influence of malaria parasite genetic diversity and anaemia on mosquito feeding and fecundity. Ferguson HM, Rivero A, Read AF, Parasitology 2003 127 9 19 10.1017/S0031182003003287 12885184 (Pubitemid 36836573)
18. Virulence and competitive ability in genetically diverse malaria infections. de Roode JC, Pansini R, Cheesman SJ, Helinski ME, Huijben S, Wargo AR, Bell AS, Chan BH, Walliker D, Read AF, Proc Natl Acad Sci U S A 2005 102 7624 7628 10.1073/pnas.0500078102 15894623 (Pubitemid 40741021)
19. Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity. Okell LC, Drakeley CJ, Bousema T, Whitty CJ, Ghani AC, PLoS Med 2008 5 226 10.1371/journal.pmed.0050226 19067479
20. The effects of host immunity on virulence-transmissibility relationships in the rodent malaria parasite Plasmodium chabaudi. Mackinnon MJ, Read AF, Parasitology 2003 126 103 112 10.1017/S003118200200272X 12636347 (Pubitemid 36308245)
21. Malaria infection increases attractiveness of humans to mosquitoes. Lacroix R, Mukabana WR, Gouagna LC, Koella JC, PLoS Biol 2005 3 298 10.1371/journal.pbio.0030298 16076240 (Pubitemid 41306442)
22. Clinical malaria reduces human attractiveness to mosquitoes. Mukabana WR, Takken W, Killeen G, Knols BG, Proceedings of the Netherlands Entomological Society Meeting 2007 18 125 129
23. Relationships between host infectivity to mosquitoes and asexual parasite density in Plasmodium falciparum. Ross A, Killeen G, Smith T, AmJTrop Med Hyg 2006 75 32 37
24. Estimation of anopheline survival rate, vectorial capacity and mosquito infection probability from malaria vector infection rates in villages near Madang, Papua New Guinea. Graves PM, Burkot TR, Saul AJ, Hayes RJ, Carter R, J Appl Ecol 1990 27 134 146 10.2307/2403573
25. Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study. Khatib RA, Skarbinksi J, Njau JD, Goodman CA, Elling BF, Kahigwa E, Roberts JM, MacArthur JR, Gutman J, Kabanywanyi AM, Smith EE, Somi MF, Lyimo T, Mwita A, Genton B, Tanner M, Mills A, Mshinda H, Bloland PB, Abdulla S, Kachur SP, Malar J 2012 submitted
26. Socio-economic status and health inequities in rural Tanzania: evidence from the Rufiji Demographic Surveillance System. Mwageni E, Masanja H, Juma Z, Momburi D, Mkilindi Y, Mbuya C, Kasale H, Reid G, de Savigny D, Measuring Health Equity in Small Areas - Findings from Demographic Surveillance Systems International Development Research Centre, Ottawa, Network I, 2005 19 29
27. National Bureau of Statistics, The 2002 Population and Housing Census-General Report United Republic of Tanzania, Dar-es-Salaam 2003 22858813
28. Chapter 11: Ifakara DSS, Tanzani. Armstrong-Schellenberg J, Mukasa O, Abdulla S, Marchant T, Lengeler C, Kikumbih N, Mshinda H, Nathan R, Population and Health in Developing Countries. Volume 1 International Development Research Centre, Ottawa, Network I, 2002 159 164
29. Cost-sharing strategies combining targeted public subsidies with private-sector delivery achieve high bednet coverage and reduced malaria transmission in Kilombero Valley, southern Tanzania. Killeen GF, Tami A, Kihonda J, Okumu FO, Kotas ME, Grundmann H, Kasigudi N, Ngonyani H, Mayagaya V, Nathan R, Abdulla S, Charlwood JD, Smith TA, Lengeler C, BMC Infect Dis 2007 7 121 10.1186/1471-2334-7-121 17961211
30. Markets, voucher subsidies and free nets combine to achieve high bed net coverage in rural Tanzania. Khatib RA, Killeen GF, Abdulla SM, Kahigwa E, McElroy PD, Gerrets RP, Mshinda H, Mwita A, Kachur SP, Malar J 2008 7 98 10.1186/1475-2875-7-98 18518956 (Pubitemid 351826855)
31. Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa. Abdullah S, Adazu K, Masanja H, Diallo D, Hodgson A, Ilboudo-Sanogo E, Nhacolo A, Owusu-Agyei S, Thompson R, Smith T, Binka FN, AmJTrop Med Hyg 2007 77 99 105
32. Chapter 13: Rufiji DSS, Tanzania. Mwageni E, Momburi D, Juma Z, Irema M, Masanja H, Population and Health in Developing Countries. Volume 1 International Development Research Centre, Ottawa, Network I, 2002 173 181
33. The changing epidemiology of malaria in Ifakara Town, southern Tanzania. Schellenberg D, Menendez C, Aponte J, Guinovart C, Mshinda H, Tanner M, Alonso P, Trop Med Int Health 2004 9 68 76 10.1046/j.1365-3156.2003.01161.x 14728609 (Pubitemid 38178014)
34. How reliable are light traps in estimating biting rates of adult Anopheles gambiae s.l. (Diptera: Culicidae) in the presence of treated bed nets? Magbity EB, Lines JD, Marbiah MT, David K, Peterson E, Bull Entomol Res 2002 92 71 76 12020364 (Pubitemid 34253533)
35. Estimation of the infectious reservoir of Plasmodium falciparum in natural vector populations based on oocyst size. Haji H, Smith T, Meuwissen JT, Sauerwein RW, Charlwood JD, T Roy Soc Trop Med H 1996 90 494 497 10.1016/S0035-9203(96)90292-8 (Pubitemid 26356622)
36. Identification of Plasmodium falciparum-infected mosquitoes by a double antibody enzyme-linked immunosorbent assay. Burkot TR, Williams JL, Schneider I, AmJTrop Med Hyg 1984 33 783 788 (Pubitemid 15201687)
37. Comparative evaluation of methods used for sampling malaria vectors in the Kilombero Valley, South Eastern Tanzania. Okumu FO, Kotas ME, Kihonda J, Mathenge E, Killeen GF, Moore SJ, Open Tropical Medicine Journal 2008 1 51 55 10.2174/1874315300801010051
38. Survival and infection probabilities of anthropophagic anophelines from an area of high prevalence of Plasmodium falciparum in humans. Charlwood JD, Smith T, Billingsley PF, Takken W, Lyimo EOL, Meuwissen JHET, Bull Entomol Res 1997 87 445 453 10.1017/S0007485300041304 (Pubitemid 128724090)
39. Infectiousness of malaria-endemic human populations to vectors. Killeen GF, Ross A, Smith T, AmJTrop Med Hyg 2006 75 38 45
40. Efficacy and safety of artemether-lumefantrine (Coartem) tablets (six-dose regimen) in African infants and children with acute, uncomplicated falciparum malaria. Falade C, Makanga M, Premji Z, Ortmann CE, Stockmeyer M, de Palacios PI, Trans R Soc Trop Med Hyg 2005 99 459 467 10.1016/j.trstmh.2004.09. 013 15837358 (Pubitemid 40521344)
41. Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G, PLoS Med 2005 2 190 10.1371/journal.pmed.0020190 16033307 (Pubitemid 46179276)
42. Plasmodium falciparum malaria disease manifestations in humans and transmission to Anopheles gambiae: a field study in Western Kenya. Gouagna LC, Ferguson HM, Okech BA, Killeen GF, Kabiru EW, Beier JC, Githure JI, Yan G, Parasitology 2004 128 235 243 10.1017/S003118200300444X 15074873 (Pubitemid 38437955)
43. The role of anti-malarial drugs in eliminating malaria. White NJ, Malar J 2008 7 Suppl 1 8 10.1186/1475-2875-7-S1-S8 19091042
44. The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania. Njau JD, Goodman CA, Kachur SP, Mulligan J, Munkondya JS, McHomvu N, Abdulla S, Bloland P, Mills A, Malar J 2008 7 4 10.1186/1475-2875-7-4 18179716 (Pubitemid 351313746)
45. Adherence to antimalarial combination therapy with sulfadoxine- pyrimethamine and artesunate in rural Tanzania. Kachur SP, Khatib RA, Kaizer E, Fox SS, Abdulla SM, Bloland PB, AmJTrop Med Hyg 2004 71 715 722 (Pubitemid 40075619)
46. Prevalence of malaria parasitemia among clients seeking treatment for fever or malaria at drug stores in rural Tanzania 2004. Kachur SP, Schulden J, Goodman CA, Kassala H, Elling BF, Khatib RA, Causer LM, Mkikima S, Abdulla S, Bloland PB, Trop Med Int Health 2006 11 441 451 10.1111/j.1365-3156.2006.01588.x 16553927
47. WHO, Guidelines for the Treatment of Malaria World Health Organization, Geneva Second 2010
48. The pros and cons of modelling malaria transmission. Molineaux L, Trans R Soc Trop Med Hyg 1985 79 743 747 10.1016/0035-9203(85)90107-5 3914114
49. Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania. Mugittu K, Genton B, Mshinda H, Beck HP, Malar J 2006 5 126 10.1186/1475-2875-5-126 17177997 (Pubitemid 46177993)
50. The multiplicity of malaria transmission: a review of entomological inoculation rate measurements and methods across sub-Saharan Africa. Kelly-Hope LA, McKenzie FE, Malar J 2009 8 19 10.1186/1475-2875-8-19 19166589
51. Comparative evaluation of the Ifakara tent trap-B, the standardized resting boxes and the human landing catch for sampling malaria vectors and other mosquitoes in urban Dar es Salaam. Sikulu M, Govella NJ, Ogoma SB, Mpangile J, Kambi SH, Kannady K, Chaki PC, Mukabana WR, Killeen GF, Tanzania. Malar J 2009 8 197
52. Roll Back Malaria Partnership, Progress and Impact Series Roll Back Malaria Partnership, Geneva 2011
53. Roll Back Malaria: A Decade of Progress and Results. Roll Back Malaria Partnership, Progress and Impact Series Roll Back Malaria Partnership, Geneva 2011
54. http://earlywarning.usgs.gov/fews/africa/
55. http://modis.gsfc.nasa.gov/