Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes

Tropical Medicine and International Health

Volumn 9, Issue 1, 2004, Pages 53-61

  Drakeley, Christopher J ^a,b   Jawara, Musa ^c   Targett, Geoffrey A T ^b   Walraven, Gijs ^c   Obisike, Uche ^c   Coleman, Rosalind ^c   Pinder, Margaret ^c   Sutherland, Colin J ^b  

^a Joint Malaria Programme   (Tanzania)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

Artesunate; Chloroquine; Combination therapy; Gametocytes; Infectivity; Malaria; Plasmodium falciparum; The gambia

Indexed keywords

ARTESUNATE; CHLOROQUINE;

CHILD HEALTH; DISEASE TREATMENT; DRUG RESISTANCE; MALARIA; MOSQUITO;

ACUTE DISEASE; ANOPHELES GAMBIAE; ARTICLE; BLOOD SAMPLING; CHILD; CONTROLLED STUDY; DENSITY; DISEASE DURATION; DISEASE TRANSMISSION; DOSE RESPONSE; DRUG EFFECT; FEMALE; FOLLOW UP; GAMBIA; GAMETOCYTE; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MONOTHERAPY; MOSQUITO; NONHUMAN; OOCYST; PARASITEMIA; PATHOGENESIS; PLASMODIUM FALCIPARUM; PREVALENCE; STATISTICAL SIGNIFICANCE; TREATMENT FAILURE;

ACUTE DISEASE; AGE FACTORS; ANIMALS; ANOPHELES; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; FEMALE; GAMBIA; HUMANS; INFANT; MALARIA, FALCIPARUM; PARASITEMIA; PLASMODIUM FALCIPARUM; PREVALENCE; SESQUITERPENES; TREATMENT FAILURE;

AFRICA; GAMBIA; SUB-SAHARAN AFRICA; WEST AFRICA;

ANOPHELES GAMBIAE; ARTESUNATE; PLASMODIUM FALCIPARUM; PROTOZOA; TRIXIS;

EID: 0842287135     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3156.2003.01169.x     Document Type: Article

References (18)

1. Borrmann S, Adegnika AA, Missinou MA et al. (2003) Short course artesunate treatment of un-complicated Plasmodium falciparum malaria in Gabon. Antimicrobial Agents and Chemotherapy 47, 901-904.
2. Butcher GA, Mendoza J & Sinden RE (2000) Inhibition of the mosquito transmission of Plasmodium berghei by Malarone (atovoquone-proguanil). Annals of Tropical Medicine and Parasitology 94, 429-436.
3. Drakeley CJ, Flobbe K, Greenwood BM & Targett GAT (2000) Gametocyte carriage by Gambian adults. Annals of Tropical Medicine and Parasitology 94, 399-402.
4. Enosse S, Butcher GA, Margos G, Mendoza J, Sinden RE & Hogh B (2000) The mosquito transmission of malaria: the effects of atovaquone-proguanil (Malarone™) and chloroquine. Transactions of the Royal Society of Tropical Medicine and Hygiene 94, 77-82.
5. Greenwood BM & Armstrong JRM (1991) Comparison of two simple methods for determining malaria parasite density. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 186-188.
6. Hogh B, Gamage-Mendis A, Butcher GA et al. (1998) The differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector. American Journal of Tropical Medicine and Hygiene 58, 176-182.
7. Lensen A, van Druten J, Bolmer M, van Gemert G, Eling W & Sauerwein R (1996) Measurement by membrane feeding of reduction in Plasmodium falciparum transmission induced by endemic sera. Transactions of the Royal Society of Tropical Medicine and Hygiene 90, 20-22.
8. Muller O, Boele van Hensbroek M, Jaffar S et al. (1996) A randomised trial of chloroquine, amodiaquine and pyrimethamine-sulphadoxine in Gambian children with uncomplicated malaria. Tropical Medicine and International Health 1, 124-132.
9. Price R, Nosten F, Luxemburger C et al. (1996) Effects of artemisinin derivatives on malaria transmissibility. Lancet 347, 1654-1658.
10. Robert V, Awono-Ambene HP, Le Hesran J-Y & Trape J-F (2000) Gametocytaemia and infectivity to mosquitoes of patients with uncomplicated Plasmodium falciparum malaria attacks treated with chloroquine or sulfadoxine plus pyrimethamine. American Journal of Tropical Medicine and Hygiene 62, 210-216.
11. von Seidlein L, Milligan P, Pinder M et al. (2000) Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial. Lancet 355, 352-357.
12. von Seidlein L, Jawara M, Coleman R, Doherty T, Walraven G & Targett G (2001a) Parasitaemia and gametocytaemia after treatment with chloroquine, pyrimethamine/sulfadoxine, and pyrimethamine/sulfadoxine combined with artesunate in young Gambians with uncomplicated malaria. Tropical Medicine and International Health 6, 92-98.
13. von Seidlein L, Drakeley C, Greenwood B, Walraven G & Targett G (2001b) Risk factors for gametocyte carriage in Gambian children. American Journal of Tropical Medicine and Hygiene 65, 523-527.
14. Sutherland CJ, Alloueche A, Curtis J et al. (2002) Gambian children successfully treated with chloroquine can harbour and transmit Plasmodium falciparum gametocytes carrying resistance genes. American Journal of Tropical Medicine and Hygiene 67, 578-585.
15. Sutherland CJ, Drakeley CJ, Obisike U et al. (2003) Combination of chloroquine and artesunate for treatment of uncomplicated Plasmodium falciparum malaria in Gambian children prevents early, but not late, treatment failures. American Journal of Tropical Medicine and Hygiene 69, 19-25.
16. Targett G, Drakeley C, Jawara M et al. (2001) Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae. Journal of Infectious Diseases 183, 1254-1259.
17. Trape JF, Pison G, Preziosi MP et al. (1998) Impact of chloroquine resistance on malaria mortality. Comptes Rendus de l'Academie des Sciences, Paris, Life Sciences 321, 689-697.
18. White N, Nosten F, Looareesuwan S et al. (1999) Averting a malaria disaster. Lancet 353, 1965-1967.