Association Between PPAR-γ and RXR-α Gene Polymorphism and Metabolic Syndrome Risk: A Case-Control Study of a Chinese Han Population

Archives of Medical Research

Volumn 43, Issue 3, 2012, Pages 233-242

  Shi, Hui ^a   Yu, Xiaofang ^b   Li, Qian ^c   Ye, Xinhua ^d   Gao, Yanqin ^b   Ma, Jianhua ^c   Cheng, Jinluo ^d   Lu, Ying ^a   Du, Wencong ^a   Du, Juan ^a   Ye, Qing ^a   Zhao, Xu ^a   Zhou, Ling ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Department of Endocrinology   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^d The Second Affiliated Hospital of NJMU   (China)

Author keywords

Adiponectin; Metabolic syndrome; Peroxisome proliferator activated receptor gene; Retinoid X receptor ; Single nucleotide polymorphisms

Indexed keywords

ADIPONECTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR ALPHA;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CASE CONTROL STUDY; CHINESE; CIGARETTE SMOKING; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PHYSICAL ACTIVITY; POPULATION GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPONECTIN; AGED; CASE-CONTROL STUDIES; CHINA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR GAMMA; RETINOID X RECEPTOR ALPHA;

EID: 84862185657     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2012.03.006     Document Type: Article

References (51)

1. Jeremy R.W. Metabolic syndrome-is the whole really greater than the sum of the parts?. Heart Lung Cir 2011, 20:211-213.
2. Grundy S.M. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 2008, 28:629-636.
3. Cornier M.A., Dabelea D., Hernandez T.L., et al. The metabolic syndrome. Endocr Rev 2008, 29:777-822.
4. Gil-Campos M., Canete R., Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin Nutr 2004, 23:963-974.
5. Matsushita K., Yatsuya H., Tamakoshi K., et al. Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Arterioscler Thromb Vasc Biol 2006, 26:871-876.
6. Lim S., Lee H.K., Kimm K.C., et al. C-reactive protein level as an independent risk factor of metabolic syndrome in the Korean population. Diabetes Res Clin Pract 2005, 70:126-133.
7. Choi K.M., Ryu O.H., Lee K.W., et al. Serum adiponectin, interleukin-10 levels and inflammatory markers in the metabolic syndrome. Diabetes Res Clin Pract 2007, 75:235-240.
8. Matsuzawa Y., Funahashi T., Kihara S., et al. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 2004, 24:29-33.
9. Gotoda T. Genetic susceptibility to metabolic syndrome. Nippon Rinsho 2004, 62:1037-1044.
10. Steinle N.I., Kazlauskaite R., Imumorin I.G., et al. Variation in the lamin A/C gene: associations with metabolic syndrome. Arterioscler Thromb Vasc Biol 2004, 24:1708-1713.
11. Frederiksen L., Brodbaek K., Fenger M., et al. Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. J Clin Endocrinol Metab 2002, 87:3989-3992.
12. Lee Y.J., Tsai J.C. ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition of metabolic syndrome in Chinese type 2 diabetic patients. Diabetes Care 2002, 25:1002-1008.
13. Thomas G.N., Tomlinson B., Chan J.C., et al. Renin-angiotensin system gene polymorphisms, blood pressure, dyslipidemia, and diabetes in Hong Kong Chinese: a significant association of the ACE insertion/deletion polymorphism with type 2 diabetes. Diabetes Care 2001, 24:356-361.
14. McCarthy J.J., Meyer J., Moliterno D.J., et al. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. Hum Genet 2003, 114:87-98.
15. Dallongeville J., Helbecque N., Cottel D., et al. The Gly16->Arg16 and Gln27->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men. J Clin Endocrinol Metab 2003, 88:4862-4866.
16. Meirhaeghe A., Cottel D., Amouyel P., et al. Association between peroxisome proliferator-activated receptor γ haplotypes and the metabolic syndrome in French men and women. Brief Genetics Rep 2005, 54:3043-3048.
17. Bragt M.C., Popeijus H.E. Peroxisome proliferator-activated receptors and the metabolic syndrome. Physiol Behav 2008, 94:187-197.
18. Stumvoll M.H.H. The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism. Diabetes 2002, 51:2341-2347.
19. Iwaki M., Matsuda M., Maeda N., et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 2003, 52:1655-1663.
20. Neumeier M., Weigert J., Schaffler A., et al. Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. Biochem Biophys Res Commun 2005, 334:924-927.
21. Tregouet D.A., Barbaux S., Escolano S., et al. Specific haplotypes of the P-selectin gene are associated with myocardial infarction. Hum Mol Genet 2002, 11:2015-2023.
22. Tregouet D.A., Escolano S., Tiret L., et al. A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm. Ann Intern Med 2004, 68:165-177.
23. Rosen E.D., Spiecelman B.M. PPARγ: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 2001, 276:37731-37734.
24. Fajas L., Auboeuf D., Raspe E., et al. The organization, promoter analysis, and expression of the human PPARγ gene. J Biol Chem 1997, 272:18779-18789.
25. Gurnell M. PPARgamma and metabolism: insights from the study of human genetic variants. Clin Endocrinol 2003, 59:267-277.
26. Puddu P., Puddu G.M., Muscari A. Peroxisome proliferator-activated receptors: are they involved in atherosclerosis progression?. Int J Cardiol 2003, 90:133-140.
27. Hsueh W.A., Law R. The central role of fat and effect of peroxisome proliferator-activated receptor-gamma on progression of insulin resistance and cardiovascular disease. Am J Cardiol 2003, 92:3J-9J.
28. Jaziri R., Lobbens S., Aubert R., et al. The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism. Diabetes 2006, 55:1157-1162.
29. Altshuler D., Hirschhorn J.N., Klannemark M., et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000, 26:76-80.
30. Hara K., Okada T., Tobe K., et al. The Pro12Ala polymorphism in PPAR-γ2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun 2000, 271:212-216.
31. Mori H., Ikegami H., Kawaguchi Y., et al. The pro12ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. Diabetes 2001, 50:891-894.
32. Douglas J.A., Erdos M.R., Watanabe R.M., et al. The peroxisome proliferator-activated receptorγ2 Pro12Ala variant: association with type 2 diabetes and trait differences. Diabetes 2001, 50:886-890.
33. Ek J., Andersen G., Urhammer S.A., et al. Studies of the Pro12Ala polymorphism of the perioxisome proliferatoractivated receptor-γ2 PPAR-γ2 gene in relation to insulin sensitivity among glucose tolerant Caucasians. Diabetologia 2001, 44:1170-1176.
34. Poulsen P., Andersen G., Fenger M., et al. Impact of two common polymorphisms in the PPARγ gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?. Diabetes 2003, 52:194-198.
35. Oh E.Y., Min K.M., Chung J.H., et al. Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-gamma2 in Korean diabetic and obese subjects. J Clin Endocrinol Metab 2000, 85:1801-1814.
36. Lindi V.I., Uusitupa M.I.J., Lindstrom M.J., et al. Association of the Pro12Ala polymorphism in the PPAR-γ2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish diabetes prevention study. Diabetes 2002, 51:2581-2586.
37. Stefanski A., Majkowska L., Ciechanowicz A., et al. Lack of association between the Pro12Ala polymorphismin PPAR-γ2 gene and bodyweight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetes. Arch Med Res 2006, 37:736-743.
38. Meirhaeghe A., Cotte D., Amouye P., et al. Association between peroxisome proliferator-activated receptor g haplotypes and the metabolic syndrome in French men and women. Diabetes 2005, 54:3043-3048.
39. Dongxia L., Qi H., Lisong L., et al. Association of peroxisome proliferator-activated receptor g gene Pro12Ala and C161T polymorphisms with metabolic syndrome. Circ J 2008, 72:551-557.
40. Tai E.S., Corella D., Deurenberg-Yap M., et al. Differential effects of the C1431T and Pro12Ala PPARg gene variants on plasma lipids and diabetes risk in an Asian population. J Lipid Res 2004, 45:674-685.
41. Meirhaeghe A., Fajas L., Helbecque N., et al. A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans. Hum Mol Genet 1998, 7:435-440.
42. Li L.Y., Qi H., Rong K.L., et al. Association between two common polymorphisms of PPAR-γ gene and metabolic syndrome families in a Chinese population. Arch Med Res 2009, 40:89-96.
43. Yang W.S., Chuang L.M. Human genetics of adiponectin in the metabolic syndrome. J Mol Med Berl 2006, 84:112-121.
44. Won H., Kang S., Shin M., et al. Plasma adiponectin concentration and its association with metabolic syndrome in patients with heart failure. Yonsei Med J 2012, 53:91-98.
45. Chrzanowska J., Zubkiewicz-Kucharska A., Noczynska A. Adipocytokine concentration and metabolic parameters in obese children. Pediatr Endocrinol Diabetes Metab 2011, 17:145-151.
46. Zhuo Q., Wang Z.Q., Fu P., et al. Association between adiponectin and metabolic syndrome in older adults from major cities of China. Biomed Environ Sci 2010, 23:53-61.
47. Shi H., Lu Y., Du J., et al. Application of back propagation artificial neural network on genetic variants in adiponectin ADIPOQ, peroxisome proliferator-activated receptor-γ, and retinoid X receptor-α genes and type 2 diabetes risk in a Chinese Han population. Diabetes Technol Ther 2012, 14:293-300.
48. Lu Y., Ye X., Cao Y., et al. Genetic variants in peroxisome proliferator-activated receptor-γ and retinoid X receptor-α gene and type 2 diabetes risk: a case-control study of a Chinese Han population. Diabetes Technol Ther 2011, 13:157-164.
49. Mangelsdorf D.J., Borgmeyer U., Heyman R.A., et al. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 1992, 6:329-344.
50. Wan Y.J., An D., Cai Y., et al. Hepatocyte-specific mutation establishes retinoid X receptor α as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol 2000, 20:4436-4444.
51. Wan Y.J., Han G., Cai Y., et al. Hepatocyte retinoid X receptor-α-deficient mice have reduced food intake, increased body weight, and improved glucose tolerance. Endocrinology 2003, 144:605-611.