Influence of ligand denticity on the properties of novel 99mTc(I)-carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 13, 2012, Pages 4040-4048

  Fernández, Soledad ^a   Giglio, Javier ^a   Rey, Ana M ^a   Cerecetto, Hugo ^b  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

Click reaction; Denticity; Huisgen reaction; Hypoxic tissue; Tc(I) carbonyl complexes

Indexed keywords

2 AMINE 3 [1 [2 (2 METHYL 5 NITRO 1H IMIDAZOLE 1 YL)ETHYL] 1H 1,2,3 TRIAZOLE 4 YL]PROPANOIC ACID COMPLEX TC 99M; 5 NITROIMIDAZOLE DERIVATIVE; METRONIDAZOLE; N METHYL 1 [1 [2 (2 METHYL 5 NITRO 1H IMIDAZOLE 1 YL)ETHYL] 1H 1,2,3 TRIAZOLE 4 YL]METHYLAMINE COMPLEX TC 99M; NTM 1; NTM 2; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL PARAMETERS; CLICK CHEMISTRY; COMPLEX FORMATION; DENTICITY; DRUG DECOMPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TUMOR LEVEL; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHILICITY; HYPOXEMIA; IMAGING; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; LIPOPHILICITY; LUNG CARCINOMA; MOUSE; NONHUMAN; NUCLEAR MEDICINE; PHARMACOPHORE; PHYSICAL CHEMISTRY; PLASMA;

ANIMALS; CELL LINE, TUMOR; CLICK CHEMISTRY; CONTRAST MEDIA; COORDINATION COMPLEXES; DIAGNOSTIC IMAGING; HUMANS; KETONES; LIGANDS; METRONIDAZOLE; MICE; MICE, INBRED C57BL; NEOPLASMS; NITROIMIDAZOLES; PROTEIN BINDING; PROTEINS; RADIOPHARMACEUTICALS; RHENIUM; TECHNETIUM; TISSUE DISTRIBUTION;

EID: 84862176159     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.010     Document Type: Article

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