Design of Ga-DOTA-based bifunctional radiopharmaceuticals: Two functional moieties can be conjugated to radiogallium-DOTA without reducing the complex stability

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4285-4289

  Mukai, Takahiro ^a   Suwada, Jun ^a   Sano, Kohei ^a   Okada, Mayumi ^a   Yamamoto, Fumihiko ^a   Maeda, Minoru ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Bifunctional radiopharmaceuticals; DOTA; Hypoxia; Metronidazole; Radiogallium

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 2,2' [4,10 BIS[2 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]AMINO] 2 OXOETHYL] 1,4,7,10 TETRAAZACYCLODODECANE 1,7 DIYL]DIACETIC ACID GA 67; FUNCTIONAL GROUP; GALLIUM CITRATE GA 67; METRONIDAZOLE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONJUGATION; CRYSTAL STRUCTURE; DECOMPOSITION; DEPROTECTION REACTION; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG TUMOR LEVEL; FEMALE; ISOTOPE LABELING; MALE; MOLECULAR STABILITY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; DRUG DESIGN; DRUG STABILITY; FEMALE; FIBROSARCOMA; GALLIUM RADIOISOTOPES; HETEROCYCLIC COMPOUNDS, 1-RING; IMIDAZOLES; METRONIDAZOLE; MICE; MICE, INBRED C3H; RADIOPHARMACEUTICALS;

MUS;

EID: 66449109838     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.041     Document Type: Article

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