Preparation and characterization of technetium and rhenium tricarbonyl complexes bearing the 4-nitrobenzyl moiety as potential bioreductive diagnostic radiopharmaceuticals. In vitro and in vivo studies

European Journal of Medicinal Chemistry

Volumn 43, Issue 4, 2008, Pages 741-748

  Giglio, Javier ^a   Patsis, Georgios ^b   Pirmettis, Ioannis ^b   Papadopoulos, Minas ^a   Raptopoulou, Catherine ^b   Pelecanou, Maria ^b   León, Elsa ^a   González, Mercedes ^a   Cerecetto, Hugo ^a   Rey, Ana ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

Bioreductive compounds; Hypoxia imaging; Rhenium; Technetium; Tricarbonyl complexes

Indexed keywords

RHENIUM COMPLEX; TECHNETIUM 99M; TECHNETIUM COMPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMATOGRAPHY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LIPOPHILICITY; MOUSE; NONHUMAN; SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CELL HYPOXIA; CRYSTALLOGRAPHY, X-RAY; DIAGNOSTIC IMAGING; LIVER; LUNG; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RHENIUM; SARCOMA, EXPERIMENTAL; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 41249095240     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.05.015     Document Type: Article

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