Core dysfunction in schizophrenia: Electrophysiology trait biomarkers

Acta Psychiatrica Scandinavica

Volumn 126, Issue 1, 2012, Pages 59-71

  Koychev, I ^a   El Deredy, W ^a   Mukherjee, T ^a   Haenschel, C ^b   Deakin, J F W ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CITY UNIVERSITY   (United Kingdom)

Author keywords

Information processing; Oscillations; P1; Schizophrenia; Top down

Indexed keywords

AMISULPRIDE; ARIPIPRAZOLE; BIOLOGICAL MARKER; CLOZAPINE; FLUPENTIXOL; QUETIAPINE; RISPERIDONE;

ADULT; ARTICLE; BETA RHYTHM; BRAIN DYSFUNCTION; BRAIN ELECTROPHYSIOLOGY; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; CORE DYSFUNCTION; ELECTRODE; ELECTROENCEPHALOGRAPHY; EVOKED VISUAL RESPONSE; FEMALE; GAMMA RHYTHM; HUMAN; INFORMATION PROCESSING; MALE; OSCILLATION; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; TASK PERFORMANCE; THETA RHYTHM; VISUAL INFORMATION; WORKING MEMORY;

ADULT; BIOLOGICAL MARKERS; EVOKED POTENTIALS, VISUAL; FEMALE; HUMANS; MALE; MEMORY, SHORT-TERM; NEUROPSYCHOLOGICAL TESTS; PSYCHOTIC DISORDERS; REACTION TIME; SCHIZOPHRENIA;

EID: 84862143654     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/j.1600-0447.2012.01849.x     Document Type: Article

References (91)

1. Jansson LB, Parnas J. Competing definitions of schizophrenia: what can be learned from polydiagnostic studies? Schizophr Bull 2007;33:1178-1200.
2. Stober G, Ben-Shachar D, Cardon M et al. Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers. World J Biol Psychiatry 2009;10:127-155.
3. Allan CL, Cardno AG, Mcguffin P. Schizophrenia: from genes to phenes to disease. Curr Psychiatry Rep 2008;10:339-343.
4. American AP. Diagnostic and statistical manual of mental disorders, 4th edn. Washington, DC: American Psychiatric Press, 1994.
5. Tandon R, Nasrallah HA, Keshavan MS. Schizophrenia, "just the facts" 4. Clinical features and conceptualization. Schizophr Res 2009;110:1-23.
6. Davidson L, Mcglashan TH. The varied outcomes of schizophrenia. Can J Psychiatry 1997;42:34-43.
7. Dikeos DG, Wickham H, Mcdonald C et al. Distribution of symptom dimensions across Kraepelinian divisions. Br J Psychiatry 2006;189:346-353.
8. Harvey PD, Green MF, Bowie C, Loebel A. The dimensions of clinical and cognitive change in schizophrenia: evidence for independence of improvements. Psychopharmacology (Berl) 2006;187:356-363.
9. Braff DL, Greenwood TA, Swerdlow NR, Light GA, Schork NJ. Advances in endophenotyping schizophrenia. World Psychiatry 2008;7:11-18.
10. Owen MJ, Craddock N, Jablensky A. The genetic deconstruction of psychosis. Schizophr Bull 2007;33:905-911.
11. Preston GA, Weinberger DR. Intermediate phenotypes in schizophrenia: a selective review. Dialogues Clin Neurosci 2005;7:165-179.
12. Thaker GK. Schizophrenia endophenotypes as treatment targets. Expert Opin Ther Targets 2007;11:1189-1206.
13. Rund BR, Borg NE. Cognitive deficits and cognitive training in schizophrenic patients: a review. Acta Psychiatr Scand 1999;100:85-95.
14. Saykin AJ, Gur RC, Gur RE et al. Neuropsychological function in schizophrenia. Selective impairment in memory and learning. Arch Gen Psychiatry 1991;48:618-624.
15. Keefe RS, Eesley CE, Poe MP. Defining a cognitive function decrement in schizophrenia. Biol Psychiatry 2005;57:688-691.
16. Siever LJ, Davis KL. The pathophysiology of schizophrenia disorders: perspectives from the spectrum. Am J Psychiatry 2004;161:398-413.
17. Raine A. Schizotypal personality: neurodevelopmental and psychosocial trajectories. Annu Rev Clin Psychol 2006;2:291-326.
18. Woodberry KA, Giuliano AJ, Seidman LJ. Premorbid IQ in schizophrenia: a meta-analytic review. Am J Psychiatry 2008;165:579-587.
19. Rund BR. A review of longitudinal studies of cognitive functions in schizophrenia patients. Schizophr Bull 1998;24:425-435.
20. Hoff AL, Svetina C, Shields G, Stewart J, Delisi LE. Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia. Schizophr Res 2005;78:27-34.
21. Mcintosh AM, Moorhead TW, Mckirdy J et al. Prefrontal gyral folding and its cognitive correlates in bipolar disorder and schizophrenia. Acta Psychiatr Scand 2009;119:192-198.
22. Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 1996;153:321-330.
23. Lysaker PH, Shea AM, Buck KD et al. Metacognition as a mediator of the effects of impairments in neurocognition on social function in schizophrenia spectrum disorders. Acta Psychiatr Scand 2010;122:405-413.
24. Andreasen NC. A unitary model of schizophrenia: Bleuler's "fragmented phrene" as schizencephaly. Arch Gen Psychiatry 1999;56:781-787.
25. Friston K. Disconnection and cognitive dysmetria in schizophrenia. Am J Psychiatry 2005;162:429-432.
26. Silver H, Feldman P, Bilker W, Gur RC. Working memory deficit as a core neuropsychological dysfunction in schizophrenia. Am J Psychiatry 2003;160:1809-1816.
27. Gooding DC, Tallent KA. Nonverbal working memory deficits in schizophrenia patients: evidence of a supramodal executive processing deficit. Schizophr Res 2004;68:189-201.
28. Goldman-Rakic PS. Working memory dysfunction in schizophrenia. J Neuropsychiatry Clin Neurosci 1994;6(Fall):348-357.
29. Thermenos HW, Goldstein JM, Buka SL et al. The effect of working memory performance on functional MRI in schizophrenia. Schizophr Res 2005;74:179-194.
30. Barr MS, Farzan F, Tran LC, Chen R, Fitzgerald PB, Daskalakis ZJ. Evidence for excessive frontal evoked gamma oscillatory activity in schizophrenia during working memory. Schizophr Res 2010;121:146-152.
31. Parnas J, Vianin P, Saebye D, Jansson L, Volmer-Larsen A, Bovet P. Visual binding abilities in the initial and advanced stages of schizophrenia. Acta Psychiatr Scand 2001;103:171-180.
32. Haenschel C, Bittner RA, Haertling F et al. Contribution of impaired early-stage visual processing to working memory dysfunction in adolescents with schizophrenia: a study with event-related potentials and functional magnetic resonance imaging. Arch Gen Psychiatry 2007;64:1229-1240.
33. Butler PD, Zemon V, Schechter I et al. Early-stage visual processing and cortical amplification deficits in schizophrenia. Arch Gen Psychiatry 2005;62:495-504.
34. Lalor EC, Yeap S, Reilly RB, Pearlmutter BA, Foxe JJ. Dissecting the cellular contributions to early visual sensory processing deficits in schizophrenia using the VESPA evoked response. Schizophr Res 2008;98:256-264.
35. Yeap S, Kelly SP, Sehatpour P et al. Visual sensory processing deficits in schizophrenia and their relationship to disease state. Eur Arch Psychiatry Clin Neurosci 2008;258:305-316.
36. Yeap S, Kelly SP, Sehatpour P et al. Early visual sensory deficits as endophenotypes for schizophrenia: high-density electrical mapping in clinically unaffected first-degree relatives. Arch Gen Psychiatry 2006;63:1180-1188.
37. Dias EC, Butler PD, Hoptman MJ, Javitt DC. Early sensory contributions to contextual encoding deficits in schizophrenia. Arch Gen Psychiatry 2011;68:654-664.
38. Butler PD, Abeles IY, Weiskopf NG et al. Sensory contributions to impaired emotion processing in schizophrenia. Schizophr Bull 2009;35:1095-1107.
39. Gruber WR, Klimesch W, Sauseng P, Doppelmayr M. Alpha phase synchronization predicts P1 and N1 latency and amplitude size. Cereb Cortex 2005;15:371-377.
40. Buzsaki G. Rhythms of the brain. NY: Oxford University Press, 2006.
41. Haenschel C, Bittner RA, Waltz J et al. Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophrenia. J Neurosci 2009;29:9481-9489.
42. Haenschel C, Linden DE, Bittner RA, Singer W, Hanslmayr S. Alpha phase locking predicts residual working memory performance in schizophrenia. Biol Psychiatry 2010;68:595-598.
43. Hong LE, Summerfelt A, Mcmahon R et al. Evoked gamma band synchronization and the liability for schizophrenia. Schizophr Res 2004;70:293-302.
44. Koh Y, Shin KS, Kim JS et al. An MEG study of alpha modulation in patients with schizophrenia and in subjects at high risk of developing psychosis. Schizophr Res 2010;126:36-42.
45. Uhlhaas PJ, Linden DE, Singer W et al. Dysfunctional long-range coordination of neural activity during Gestalt perception in schizophrenia. J Neurosci 2006;26:8168-8175.
46. Uhlhaas PJ, Haenschel C, Nikolic D, Singer W. The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia. Schizophr Bull 2008;34:927-943.
47. Yeap S, Kelly SP, Reilly RB, Thakore JH, Foxe JJ. Visual sensory processing deficits in patients with bipolar disorder revealed through high-density electrical mapping. J Psychiatry Neurosci 2009;34:459-464.
48. Ozerdem A, Guntekin B, Tunca Z, Basar E. Brain oscillatory responses in patients with bipolar disorder manic episode before and after valproate treatment. Brain Res 2008;1235:98-108.
49. Ozerdem A, Kocaaslan S, Tunca Z, Basar E. Event related oscillations in euthymic patients with bipolar disorder. Neurosci Lett 2008;444:5-10.
50. Barcelo F, Suwazono S, Knight RT. Prefrontal modulation of visual processing in humans. Nat Neurosci 2000;3:399-403.
51. Grice SJ, Spratling MW, Karmiloff-Smith A et al. Disordered visual processing and oscillatory brain activity in autism and Williams syndrome. Neuroreport 2001;12:2697-2700.
52. Weinstock-Guttman B, Baier M, Stockton R et al. Pattern reversal visual evoked potentials as a measure of visual pathway pathology in multiple sclerosis. Mult Scler 2003;9:529-534.
53. Grayson AS, Weiler EM, Sandman DE. Visual evoked potentials in early Alzheimer's dementia: an exploratory study. J Gen Psychol 1995;122:113-129.
54. Engel AK, Fries P, Singer W. Dynamic predictions: oscillations and synchrony in top-down processing. Nat Rev Neurosci 2001;2:704-716.
55. Dima D, Dietrich DE, Dillo W, Emrich HM. Impaired top-down processes in schizophrenia: a DCM study of ERPs. Neuroimage 2010;52:824-832.
56. Dima D, Roiser JP, Dietrich DE et al. Understanding why patients with schizophrenia do not perceive the hollow-mask illusion using dynamic causal modelling. Neuroimage 2009;46:1180-1186.
57. Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull 1991;17:555-564.
58. Koychev I, McMullen K, Lees J, Dadhiwala R, Grayson L, Perry C, Schmechtig A, Walters K, Craig J, Dawson GR, Dourish CT, Ettinger U, Wilkinson L, Williams S, Deakin JF, Barkus E. A validation of cognitive biomarkers for the early identification of cognitive enhancing agents in schizotypy: A three-center double-blind placebo-controlled study. Eur Neuropsychopharmacol 2011; DOI: [Epub ahead of print].
59. Luck SJ. An introduction to the event-related potential technique. Cambridge, MA: MIT Press, 2005.
60. Tallon-Baudry C, Bertrand O, Delpuech C, Permier J. Oscillatory gamma-band (30-70Hz) activity induced by a visual search task in humans. J Neurosci 1997;17:722-734.
61. Roach BJ, Mathalon DH. Event-related EEG time-frequency analysis: an overview of measures and an analysis of early gamma band phase locking in schizophrenia. Schizophr Bull 2008;34:907-926.
62. Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol Rep 1962;10:799-812.
63. Nose M, Tansella M, Thornicroft G et al. Is the defined daily dose system a reliable tool for standardizing antipsychotic dosages? Int Clin Psychopharmacol 2008;23:287-290.
64. Rey MJ, Schulz P, Costa C, Dick P, Tissot R. Guidelines for the dosage of neuroleptics. I: Chlorpromazine equivalents of orally administered neuroleptics. Int Clin Psychopharmacol 1989;4:95-104.
65. Woods SW. Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry 2003;64:663-667.
66. Koychev I, Deakin JF, Haenschel C, El-Deredy W. Abnormal neural oscillations in schizotypy during a visual working memory task: support for a deficient top-down network? Neuropsychologia 2011;49:2866-2873.
67. Butler PD, Martinez A, Foxe JJ et al. Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments. Brain 2007;130:417-430.
68. Yeap S, Kelly SP, Thakore JH, Foxe JJ. Visual sensory processing deficits in first-episode patients with schizophrenia. Schizophr Res 2008;102:340-343.
69. Koychev I, El-Deredy W, Haenschel C, Deakin JF. Visual information processing deficits as biomarkers of vulnerability to schizophrenia: an event-related potential study in schizotypy. Neuropsychologia 2010;48:2205-2214.
70. Doniger GM, Foxe JJ, Murray MM, Higgins BA, Javitt DC. Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia. Arch Gen Psychiatry 2002;59:1011-1020.
71. Foxe JJ, Doniger GM, Javitt DC. Early visual processing deficits in schizophrenia: impaired P1 generation revealed by high-density electrical mapping. Neuroreport 2001;12:3815-3820.
72. Foxe JJ, Murray MM, Javitt DC. Filling-in in schizophrenia: a high-density electrical mapping and source-analysis investigation of illusory contour processing. Cereb Cortex 2005;15:1914-1927.
73. Vogel EK, Luck SJ. The visual N1 component as an index of a discrimination process. Psychophysiology 2000;37:190-203.
74. Cho RY, Ford JM, Krystal JH, Laruelle M, Cuthbert B, Carter CS. Functional neuroimaging and electrophysiology biomarkers for clinical trials for cognition in schizophrenia. Schizophr Bull 2005;31:865-869.
75. Javitt DC, Spencer KM, Thaker GK, Winterer G, Hajos M. Neurophysiological biomarkers for drug development in schizophrenia. Nat Rev Drug Discov 2008;7:68-83.
76. Winterer G, Coppola R, Goldberg TE et al. Prefrontal broadband noise, working memory, and genetic risk for schizophrenia. Am J Psychiatry 2004;161:490-500.
77. Singer W. Neuronal synchrony: a versatile code for the definition of relations? Neuron 1999;24:49-65.
78. Sharma A, Weisbrod M, Kaiser S, Markela-Lerenc J, Bender S. Deficits in fronto-posterior interactions point to inefficient resource allocation in schizophrenia. Acta Psychiatr Scand 2011;123:125-135.
79. Dakin S, Carlin P, Hemsley D. Weak suppression of visual context in chronic schizophrenia. Curr Biol 2005;15:R822-R824.
80. Green MF, Nuechterlein KH, Mintz J. Backward masking in schizophrenia and mania. I. Specifying a mechanism. Arch Gen Psychiatry 1994;51:939-944.
81. Green MF, Nuechterlein KH, Mintz J. Backward masking in schizophrenia and mania. II. Specifying the visual channels. Arch Gen Psychiatry 1994;51:945-951.
82. Bullier J. Integrated model of visual processing. Brain Res 2001;36:96-107.
83. Javitt DC. When doors of perception close: bottom-up models of disrupted cognition in schizophrenia. Annu Rev Clin Psychol 2009;5:249-275.
84. Butler PD, Javitt DC. Early-stage visual processing deficits in schizophrenia. Curr Opin Psychiatry 2005;18:151-157.
85. Skottun BC, Skoyles JR. Are masking abnormalities in schizophrenia limited to backward masking? Int J Neurosci 2009;119:88-104.
86. Skottun BC, Skoyles JR. Contrast sensitivity and magnocellular functioning in schizophrenia. Vision Res 2007;47:2923-2933.
87. Skottun BC, Skoyles JR. A few remarks on attention and magnocellular deficits in schizophrenia. Neurosci Biobehav Rev 2008;32:118-122.
88. Haenschel C. Abnormalities in task-related neural network formation in schizophrenia. Acta Psychiatr Scand 2011;123:96-97.
89. Nielsen J, Damkier P, Lublin H, Taylor D. Optimizing clozapine treatment. Acta Psychiatr Scand 2011;123:411-422.
90. Stip E, Sepehry AA, Prouteau A et al. Cognitive discernible factors between schizophrenia and schizoaffective disorder. Brain Cogn 2005;59:292-295.
91. Bora E, Yucel M, Pantelis C. Cognitive functioning in schizophrenia, schizoaffective disorder and affective psychoses: meta-analytic study. Br J Psychiatry 2009;195:475-482.