Hematotoxicity and genotoxicity of mercuric chloride following subchronic exposure through drinking water in male rats

Biological Trace Element Research

Volumn 148, Issue 1, 2012, Pages 76-82

  Boujbiha, Mohamed Ali ^a   Ben Salah, Ghada ^b   Ben Feleh, Abdelraouf ^c   Saoudi, Mongi ^a   Kamoun, Hassen ^b   Bousslema, Ali ^d   Ommezzine, Asma ^d   Said, Khaled ^c   Fakhfakh, Faiza ^b   El Feki, Abdelfattah ^a  

^a UNIVERSITY OF SFAX   (Tunisia)

^b UNIVERSITY OF SFAX   (Tunisia)

^c Research Unit of Genetic Biodiversity and Valorisation of Bioresources   (Tunisia)

^d SAHLOUL UNIVERSITY HOSPITAL   (Tunisia)

Author keywords

Erythrocytes; Genotoxicity; Mercuric chloride; Oxidative stress; Rat

Indexed keywords

CATALASE; DRINKING WATER; FOLIC ACID; FREE RADICAL; GLUTATHIONE PEROXIDASE; HEMOGLOBIN; MERCURIC CHLORIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD TOXICITY; BONE MARROW CELL; CHROMOSOME ABERRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DAMAGE; ENZYME ACTIVITY; ERYTHROCYTE COUNT; FOLIC ACID BLOOD LEVEL; GENOTOXICITY; HEMATOCRIT; HEMOGLOBIN DETERMINATION; LEUKOCYTE COUNT; LIPID PEROXIDATION; LONG TERM EXPOSURE; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; METAPHASE; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; ANTIOXIDANTS; BONE MARROW; CHROMOSOME ABERRATIONS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTE COUNT; FREE RADICALS; HEMOGLOBINS; HEMOLYTIC AGENTS; LIPID PEROXIDATION; MALE; MERCURIC CHLORIDE; OXIDATIVE STRESS; OXIDOREDUCTASES; RATS; RATS, WISTAR; TIME FACTORS;

RATTUS;

EID: 84862142347     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-012-9342-8     Document Type: Article

References (35)

1. C Betti T Davini R Barale 1992 Genotoxic activity of methyl mercury chloride and dimethyl mercury in human lymphocytes Mutat Res 281 255 260
2. JS Woods CA Calas LD Aicher BH Robinson C Maler 1990 Stimulation of phorfirinogen oxidation by mercuric ion 1. Evidence of free radical formation in the presence of thiols and hydrogen peroxide Mol Pharmacol 38 253 260 (Pubitemid 20255312)
3. R Patni MK Sharma M Kumar 2001 Modulation of certain hematological parameters in mercuric toxicity by Spirulina fusiformis in Swiss albino mice Indian J Environ Toxicol 11 32 34
4. L Su M Wang ST Yin HL Wang L Chen LG Sun DY Ruan 2008 The interaction of selenium and mercury in the accumulations and oxidative stress of rat tissues Ecotoxicol Environ Saf 70 438 489
5. EJ Park K Park 2007 Induction of reactive oxygen species and apoptosis in BEAS-2B cells by mercuric chloride Toxicol in Vitro 21 789 794 (Pubitemid 46603232)
6. C Emrah A Metin H Ihsan 2008 Antioxidant effects of methionine, α-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats Exp Toxicol Pathol 60 289 294
7. MY Cimen 2008 Free radical metabolism in human erythrocytes Clin Chim Acta 390 1 11
8. E Oztekin AK Baltaci AM Tiftik R Mogulkoc 2007 Lipid peroxidation in ovariectomized and pinealectomized rats: the effects of estradiol and progesterone supplementation Cell Biochem Funct 5 551 554 (Pubitemid 47436096)
9. R Mogulkoc AK Baltaci E Oztekin L Aydin A Sivrikaya 2006 Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism Life Sci 3 311 315 (Pubitemid 43782541)
10. CS Bediz AK Baltaci R Mogulkoc E Oztekin 2006 Zinc supplementation ameliorates electromagnetic field-induced lipid peroxidation in the rat brain Tohoku J Exp Med 2 133 140 (Pubitemid 43174165)
11. SH Jadhav SN Sarkar HC Tripathi 2006 Cytogenetic effects of mixture of selected metals following subchronic exposure through drinking water in male rats Indian J Exp Biol 44 997 1005 (Pubitemid 46797006)
12. F Schurz M Sabater-Vilar J Fink-Gremmels 2000 Mutagenicity of mercury chloride and mechanisms of cellular defence: the role of metal-binding proteins Mutagenesis 15 525 530
13. K Al-Sabti DC Lloyd AA Edwards P Stenar 1992 Survey of lymphocyte chromosomal damage in Slovenian workers exposed to occupational clastogens Mutat Res 280 215 223
14. A Loftenius J Ekstrand E Moller 1997 In vitro effects of mercuric chloride (HgCl2) on human mononuclear cells Clin Exp Immunol 110 418 422 (Pubitemid 27525273)
15. M Topashka-Ancheva R Metcheva S Teodorova 2003 A comparative analysis of the heavy metal loading of small mammals in different regions of Bulgaria II: chromosomal aberrations and blood pathology Ecotoxicol Environ Saf 54 188 193 (Pubitemid 36269006)
16. I Falnoga I Kregar M Skreblin M Tusek-Znidaric P Stegnar 1993 Interactions of mercury in rat brain Biol Trace Elem Res 37 71 83 (Pubitemid 23104066)
17. FRT Oliveira JR Ferreira CMC Dos Santos LEM Macedo RB De Olivera JA Rodrigues JLM Do Nascimento LRF Faro DLWP Diniz 2006 Estradiol reduces cumulative mercury and associated disturbances in the hypothalamus-pituitary axis of ovariectomized rats Ecotoxicol Environ Saf 63 488 493
18. MA Boujbiha K Hamden F Guermazi A Bouslama A Omezzine A Kammoun A El Feki 2009 Testicular toxicity in mercuric chloride-treated rats: association with oxidative stress Reprod Toxicol 28 81 89
19. M Shinyashiki Y Kumagai H Nakajima J Nagafune S Homma-Takeda M Sagai N Shimojo 1998 Differential changes in rat brain nitric oxide synthase in vivo and in vitro by methylmercury Brain Res 798 147 155 (Pubitemid 28342030)
20. K Asada M Takahashi M Nagate 1974 Assay and inhibitors of spinach superoxide dismutase Agric Biol Chem 38 471 473
21. H Aebi 1974 Catalase Meth Enzym Anal 2 673 684
22. L Flohe WA Gunzler 1984 Analysis of glutathione peroxidase Meth Enzymol 105 114 121
23. H Esterbauer J Gebicki H Puhl G Jurgens 1992 The role of lipid peroxidation and antioxidants in oxidative modification of LDL Free Radic Biol Med 13 341 390
24. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275
25. EP Evans G Breckon CE Forf 1963 An air-drying method for meiotic preparations from mammalian testes Cytogenetics 3 289 294
26. MK Sharma R Patni M Kumar A Kumar 2005 Modification of mercury-induced biochemical alterations in blood of Swiss albino mice by Spirulina fusiformis Environ Toxicol Pharmacol 20 289 296 (Pubitemid 41058783)
27. M Valko H Morris MTD Cronin 2005 Metals, toxicity and oxidative stress Curr Med Chem 12 1161 1208 (Pubitemid 40655271)
28. MJ Gonzalez-Munoz I Meseguer MI Sanchez-Reus A Schultz R Olivero J Benedí FJ Sanchez-Muniz 2008 Beer consumption reduces cerebral oxidation caused by aluminum toxicity by normalizing gene expression of tumor necrotic factor alpha and several antioxidant enzymes Food Chem Toxicol 3 1111 1118
29. H Tapiero KD Tew L Gate D Machover 2001 Prevention of pathologies associated with oxidative stress and dietary intake deficiencies: folate deficiency and requirements Biomed Pharmacother 55 381 390 (Pubitemid 32900538)
30. Cheng YT (1998) Changes of redox status in folic acid deprivation-induced apoptosis: a possible role for homocysteine. MS-thesis, Department of Medical Technology, Graduate Institute of Basic Medicine, Chang Gung University, Taiwan
31. AN Harvey ND Costa JR Savage J Thacker 1997 Chromosomal aberrations induced by defined DNA double-strand breaks: the origin of achromatic lesions Somat Cell Mol Genet 23 211 219 (Pubitemid 27444325)
32. WF Morgan J Corcoranj A Hartmann MI Kaplan CL Limoli B Ponnaiya 1998 DNA double-strand breaks, chromosomal rearrangements, and genomic instability Mutat Res 404 125 128 (Pubitemid 29037831)
33. M Akiyama H Oshima M Nakamura 2001 Genotoxicity of mercury used in chromosomal aberration tests Toxicol in Vitro 15 463 467 (Pubitemid 32889674)
34. R Rozgaj V Kasuba M Blanusa 2005 Mercury chloride genotoxicity in rats following oral exposure, evaluated by comet assay and micronucleus test Arch Hiq Rada Toksikol 56 9 15 (Pubitemid 40445942)
35. C Ehrenstein P Shu EB Wickenheiser AV Hirner M Dolfen H Emons G Obe 2002 Methyl mercury uptake and associations with the induction of chromosomal aberrations in Chinese hamster (CHO) cells Chem Biol Interact 141 259 274 (Pubitemid 35217764)