Synthesis and Biological Evaluation of N-aryl-4-aryl-1,3-Thiazole-2-Amine Derivatives as Direct 5-Lipoxygenase Inhibitors

Chemical Biology and Drug Design

Volumn 80, Issue 1, 2012, Pages 89-98

  Suh, Jeehee ^a,b   Yum, Eul Kgun ^b   Cheon, Hyae Gyeong ^c   Cho, Young Sik ^d  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Chungnam National University   (South Korea)

^c Gachon University   (South Korea)

^d Keimyung University   (South Korea)

Author keywords

5 lipoxygenase; Anti inflammation; Leukotriene B4; Neutrophil; Thiazole scaffold

Indexed keywords

ANTIINFLAMMATORY AGENT; LIPOXYGENASE INHIBITOR; N (2 AMINOPHENYL) 4 (4 CHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (2 HYDROXYPHENYL) 4 (4 CHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (2,3,5 TRIMETHYL 4 HYDROXYPHENYL) 4 (4 FLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (2,5 DIMETHYL 4 HYDROXYPHENYL) 4 (4 FLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (3 AMINOPHENYL) 4 (4 CHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (3 CHLORO 4 HYDROXY 5 DIMETHYL PHENYL) 4 (4 FLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (3 HYDROXYPHENYL) 4 (4 CHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (3,5 DICHLORO 4 HYDROXYPHENYL) 4 (4 CHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (3,5 DICHLORO 4 HYDROXYPHENYL) 4 (4 FLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (3,5 DIMETHYL 4 HYDROXYPHENYL) 4 (4 CHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (3,5 DIMETHYLPHENYL) 4 (4 CHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 AMINOPHENYL) 4 (2,4 DIFLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 AMINOPHENYL) 4 (2,5 DICHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 AMINOPHENYL) 4 (4 BROMOPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 AMINOPHENYL) 4 (4 CHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 AMINOPHENYL) 4 (4 FLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 AMINOPHENYL) 4 (4 NITROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 AMINOPHENYL) 4 (PHENYL) 1,3 THIAZOLE 2 AMINE; N (4 HYDROXYPHENYL) 4 (2 FLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 HYDROXYPHENYL) 4 (2,4 DIFLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 HYDROXYPHENYL) 4 (2,5 DICHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 HYDROXYPHENYL) 4 (3 FLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 HYDROXYPHENYL) 4 (4 BROMOPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 HYDROXYPHENYL) 4 (4 CHLOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 HYDROXYPHENYL) 4 (4 FLUOROPHENYL) 1,3 THIAZOLE 2 AMINE; N (4 HYDROXYPHENYL) 4 (4 NITROPHENYL) 1,3 THIAZOLE 2 AMINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OTITIS; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; AMINES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; CELL LINE, TUMOR; EDEMA; LIPOXYGENASE INHIBITORS; MICE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84862138672     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2012.01371.x     Document Type: Article

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