The leukotriene B4 receptor antagonist ONO-4057 inhibits mesangioproliferative changes in anti-Thy-1 nephritis

Nephrology Dialysis Transplantation

Volumn 20, Issue 12, 2005, Pages 2697-2703

  Kawasaki, Yukihiko ^a   Tanji, Mieko ^a   Takano, Kei ^a   Fukuda, Yutaka ^a   Isome, Masato ^a   Nozawa, Ruriko ^a   Suzuki, Hitoshi ^a   Hosoya, Mitsuaki ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Leukotriene B4 receptor antagonist; ONO 4057; Thy 1 nephritis

Indexed keywords

5 [2 (2 CARBOXYETHYL) 3 [6 (4 METHOXYPHENYL) 5 HEXENYLOXY]PHENOXY]VALERIC ACID; LEUKOTRIENE B4; LEUKOTRIENE B4 RECEPTOR ANTAGONIST; LYMPHOCYTE ANTIBODY; PLACEBO; THY 1 ANTIGEN;

ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYTOLYSIS; DEGRANULATION; DRUG MECHANISM; FEMALE; KIDNEY FUNCTION; MACROPHAGE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MESANGIUM CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAT; RAT STRAIN; SCORING SYSTEM; URINALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; DISEASE MODELS, ANIMAL; FEMALE; GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; ISOANTIBODIES; KIDNEY GLOMERULUS; PHENYLPROPIONATES; RATS; RATS, WISTAR; RECEPTORS, LEUKOTRIENE B4;

EID: 27944477337     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfi169     Document Type: Article

References (19)

1. Bagchus WM, Hoedemaeker PJ, Rozing J, Bakker WW. Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies: A sequential histological and ultrastructural study in the rat. Lab Invest 1986; 55: 680-687
2. Yamamoto T, Wilson CB. Quantitative and qualitative studies of antibody-induced mesangial cell damage in the rat. Kidney Int 1987; 32: 514-525
3. Yamamoto T, Wilson CB. Complement dependence of antibody-induced mesangial cell injury in the rat. J Immunol 1987; 138: 3758-3765
4. Yokomizo T, Izumi T, Shimizu T. Leukotriene B4: Metabolism and signal transduction. Arch Biochem Biophys 2001; 385: 231-241
5. Kishikawa K, Nakao S, Matsumoto S, Konda K, Hamanaka N. Estimation of antagonistic activity of ONO-4057 against leukotriene B4 in humans. Adv Prostaglandin Thromboxane Leukot Res 1995; 23: 279-281
6. Suzuki S, Kuroda T, Kazama J et al. The leukotriene B4 receptor antagonist ONO-4057 inhibits nephrotoxic serum nephritis in WKY rats. J Am Soc Nephrol 1999; 10: 264-270
7. Lianos EA. Bresnahan BA, Pan C. Mesangial cell immune injury: Synthesis, origin, and role of eicosanoids. J Clin Invest 1991; 88: 623-631
8. William JD, Czop JK, Austen KF. Release of leukotrienes by human monocytes on stimulation of their phagocytic receptor for particulate activators. J Immunol 1984; 132: 3034-3040
9. Brady HR, Denton MA, Jimenez W, Takata S, Palliser D, Brenner BM. Chemoattractants provoke monocyte adhesion to human mesangial cells and mesangial cell injury. Kidney Int 1992; 42: 480-487
10. Floege J, Burg M, Hugo C et al. Endogenous fibroblast growth factor-2 mediates cytotoxicity in experimental mesangioproliferative glomerulonephritis. J Am Soc Nephrol 1998; 9: 792-801
11. Sato T, Van Dixhoom MG, Schroeijers WE et al. Apoptosis of cultured rat glomerular mesangial cells induced by IgG2a monoclonal anti-Thy-1 antibodies. Kidney Int 1996; 49: 403-412
12. Van Dixhoom MG, Timmerman JJ, van Gijlswik-Janssen DJ et al. Characterization of complement C6 deficiency in a PVG/c rat strain. Clin Exp immunol 1997; 109: 387-396
13. Brandt J, Pippin J, Schuize M et al. Role of the complement membrane attack complex (C5b-9) in mediating experimental mesangioproliferative glomerulonephritis. Kidney Int 1996; 49: 335-343
14. Floege J, Eng E, Young BA, Johnson RJ. Factors involved in the regulation of mesangial cell proliferation in vitro and vivo. Kidney Int 1993; 39 [Suppl]: S47-54
15. Rehan A, Johnson KJ, Wiggins RC, Kunkel RG, Ward PA. Evidence for the role of oxygen radicals in acute nephrotoxic nephritis. Lab Invest 1984; 51: 396-403
16. Van Dixhoorn MG, Gorter A, Sato T et al. Induction of microhematuria by an IgA isotype switch variant of a monoclonal anti-Thy-1.1 antibody in the rat. Kidney Int 1996; 50: 1612-1623
17. Yared A, Albrightson-Winslow C, Griswold D, Takahashi K, Fogo A, Badr KF. Functional significance of leukotriene B4 in normal and glomerulonephritis rat kidneys. J Am Soc Nephrol 1991; 2: 45-56
18. Allendorf DJ, Yan J, Ross GD et al. C5a-mediated leukotriene B4-amplified neutrophil chemotaxis is essential in tumor immunotherapy facilitated by anti-tumor monoclonal antibody and beta-glucan. J Immunol 2005; 174: 7050-7056
19. Lizuka Y, Yokomizo T, Terawaki K, Komine M, Tamaki K, Shimizu T. Characterization of a Mouse Second Leukotriene B4 Receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem 2005; 280: 24816-24823