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Volumn 10, Issue 2, 2012, Pages 84-92

Development of novel immune interventions for prostate cancer

Author keywords

Immune checkpoints blockade; Immunotherapy; Prostate cancer; Vaccine therapy

Indexed keywords

AP 1903; BPX 101; CANCER VACCINE; CV 9103; CYCLOPHOSPHAMIDE; DENDRITIC CELL VACCINE; DNA VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2; IPILIMUMAB; MKC 1106 PP; PEPTIDE VACCINE; RNA VACCINE; SIPULEUCEL T; TICILIMUMAB; TUMOR CELL VACCINE; UNCLASSIFIED DRUG;

EID: 84862107423     PISSN: 15587673     EISSN: 19380682     Source Type: Journal    
DOI: 10.1016/j.clgc.2012.01.012     Document Type: Review
Times cited : (16)

References (73)
  • 1
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • A. Iwasaki, R. Medzhitov Regulation of adaptive immunity by the innate immune system Science 327 2010 291 295
    • (2010) Science , vol.327 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 3
    • 33751363704 scopus 로고    scopus 로고
    • Tumor escape mechanisms in prostate cancer
    • DOI 10.1007/s00262-005-0110-x
    • A.M. Miller, P. Pisa Tumor escape mechanisms in prostate cancer Cancer Immunol Immunother 56 2007 81 87 (Pubitemid 44812449)
    • (2007) Cancer Immunology, Immunotherapy , vol.56 , Issue.1 , pp. 81-87
    • Miller, A.M.1    Pisa, P.2
  • 4
    • 70349964695 scopus 로고    scopus 로고
    • Enhancing the efficacy of cancer vaccines in urologic oncology: New directions
    • S. Kusmartsev, J. Vieweg Enhancing the efficacy of cancer vaccines in urologic oncology: new directions Nat Rev Urol 6 2009 540 549
    • (2009) Nat Rev Urol , vol.6 , pp. 540-549
    • Kusmartsev, S.1    Vieweg, J.2
  • 5
    • 79959614640 scopus 로고    scopus 로고
    • T cell coinhibition in prostate cancer: New immune evasion pathways and emerging therapeutics
    • [E-pub ahead of print]
    • Y.S. Barach, J.S. Lee, X. Zang T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics Trends Mol Med Oct 21, 2010 [E-pub ahead of print]
    • (2010) Trends Mol Med
    • Barach, Y.S.1    Lee, J.S.2    Zang, X.3
  • 6
    • 0028818052 scopus 로고
    • Loss of HLA class i expression in prostate cancer: Implications for immunotherapy
    • discussion 686-7
    • R.A. Blades, P.J. Keating, L.J. McWilliam Loss of HLA class I expression in prostate cancer: implications for immunotherapy Urology 46 1995 681 686 discussion 686-7
    • (1995) Urology , vol.46 , pp. 681-686
    • Blades, R.A.1    Keating, P.J.2    McWilliam, L.J.3
  • 7
    • 3042701410 scopus 로고    scopus 로고
    • Concordant down-regulation of proto-oncogene PML and major histocompatibility antigen HLA class i expression in high-grade prostate cancer
    • H. Zhang, J. Melamed, P. Wei Concordant down-regulation of proto-oncogene PML and major histocompatibility antigen HLA class I expression in high-grade prostate cancer Cancer Immun 3 2003 2
    • (2003) Cancer Immun , vol.3 , pp. 2
    • Zhang, H.1    Melamed, J.2    Wei, P.3
  • 8
    • 85027921556 scopus 로고    scopus 로고
    • Hla antigen and NK cell activating ligand expression in malignant cells: A story of loss or acquisition
    • M. Campoli, S. Ferrone Hla antigen and NK cell activating ligand expression in malignant cells: a story of loss or acquisition Semin Immunopathol 33 2011 321 334
    • (2011) Semin Immunopathol , vol.33 , pp. 321-334
    • Campoli, M.1    Ferrone, S.2
  • 9
    • 0033840037 scopus 로고    scopus 로고
    • Analysis of type T1 and T2 cytokines in patients with prostate cancer
    • X. Filella, J. Alcover, M.A. Zarco Analysis of type T1 and T2 cytokines in patients with prostate cancer Prostate 44 2000 271 274
    • (2000) Prostate , vol.44 , pp. 271-274
    • Filella, X.1    Alcover, J.2    Zarco, M.A.3
  • 10
    • 17444444046 scopus 로고    scopus 로고
    • Different Basal Expression of Type T1 and T2 Cytokines in Peripheral Lymphocytes of Patients with Adenocarcinomas and Benign Hyperplasia of the Prostate
    • U. Elsässer-Beile, D. Gierschner, P. Jantscheff Different basal expression of type T1 and T2 cytokines in peripheral lymphocytes of patients with adenocarcinomas and benign hyperplasia of the prostate Anticancer Res 23 2003 4027 4031 (Pubitemid 37474360)
    • (2003) Anticancer Research , vol.23 , Issue.A , pp. 4027-4031
    • Elsasser-Beile, U.1    Gierschner, D.2    Jantscheff, P.3    Schultze-Seemann, W.4    Katzenwadel, A.5    Wetterauer, U.6
  • 11
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • A. Mantovani, P. Allavena, A. Sica Cancer-related inflammation Nature 454 2008 436 444
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3
  • 12
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • C. Murdoch, M. Muthana, S.B. Coffelt The role of myeloid cells in the promotion of tumour angiogenesis Nat Rev Cancer 8 2008 618 631
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3
  • 13
    • 77956216884 scopus 로고    scopus 로고
    • Tivozanib, a pan-VEGFR tyrosine kinase inhibitor for the potential treatment of solid tumors
    • A. De Luca, N. Normanno Tivozanib, a pan-VEGFR tyrosine kinase inhibitor for the potential treatment of solid tumors IDrugs 13 2010 636 645
    • (2010) IDrugs , vol.13 , pp. 636-645
    • De Luca, A.1    Normanno, N.2
  • 15
    • 34848831575 scopus 로고    scopus 로고
    • The B7 family and cancer therapy: Costimulation and coinhibition
    • DOI 10.1158/1078-0432.CCR-07-1030
    • X. Zang, J.P. Allison The B7 family and cancer therapy: costimulation and coinhibition Clin Cancer Res 13 2007 5271 5279 (Pubitemid 47510350)
    • (2007) Clinical Cancer Research , vol.13 , Issue.18 , pp. 5271-5279
    • Zang, X.1    Allison, J.P.2
  • 16
    • 37649013179 scopus 로고    scopus 로고
    • B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
    • X. Zang, R.H. Thompson, H.A. Al-Ahmadie B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome Proc Natl Acad Sci U S A 104 2007 19458 19463
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19458-19463
    • Zang, X.1    Thompson, R.H.2    Al-Ahmadie, H.A.3
  • 17
    • 63549150834 scopus 로고    scopus 로고
    • Expression of immunosuppressive B7-H3 ligand by hormone-treated prostate cancer tumors and metastases
    • G. Chavin, Y. Sheinin, P.L. Crispen Expression of immunosuppressive B7-H3 ligand by hormone-treated prostate cancer tumors and metastases Clin Cancer Res 15 2009 2174 2180
    • (2009) Clin Cancer Res , vol.15 , pp. 2174-2180
    • Chavin, G.1    Sheinin, Y.2    Crispen, P.L.3
  • 19
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • DOI 10.1038/ni1178
    • + regulatory T cells in immunological tolerance to self and non-self Nat Immunol 6 2005 345 352 (Pubitemid 41716771)
    • (2005) Nature Immunology , vol.6 , Issue.4 , pp. 345-352
    • Sakaguchi, S.1
  • 20
    • 16844361893 scopus 로고    scopus 로고
    • Altered immunity accompanies disease progression in a mouse model of prostate dysplasia
    • DOI 10.1158/0008-5472.CAN-04-3271
    • A.H. Tien, L. Xu, C.D. Helgason Altered immunity accompanies disease progression in a mouse model of prostate dysplasia Cancer Res 65 2005 2947 2955 (Pubitemid 40490100)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2947-2955
    • Tien, A.H.1    Xu, L.2    Helgason, C.D.3
  • 21
    • 77954951895 scopus 로고    scopus 로고
    • DNA vaccine encoding prostatic acid phosphatase (PAP) elicits long-term T-cell responses in patients with recurrent prostate cancer
    • J.T. Becker, B.M. Olson, L.E. Johnson DNA vaccine encoding prostatic acid phosphatase (PAP) elicits long-term T-cell responses in patients with recurrent prostate cancer J Immunother 33 2010 639 647
    • (2010) J Immunother , vol.33 , pp. 639-647
    • Becker, J.T.1    Olson, B.M.2    Johnson, L.E.3
  • 22
    • 77955080349 scopus 로고    scopus 로고
    • New therapies for castration-resistant prostate cancer
    • D.L. Longo New therapies for castration-resistant prostate cancer N Engl J Med 363 2010 479 481
    • (2010) N Engl J Med , vol.363 , pp. 479-481
    • Longo, D.L.1
  • 23
    • 79957645278 scopus 로고    scopus 로고
    • Emerging vaccine therapy approaches for prostate cancer
    • G. Sonpavde, K.M. Slawin, D.M. Spencer Emerging vaccine therapy approaches for prostate cancer Rev Urol 12 2010 25 34
    • (2010) Rev Urol , vol.12 , pp. 25-34
    • Sonpavde, G.1    Slawin, K.M.2    Spencer, D.M.3
  • 25
    • 0034554863 scopus 로고    scopus 로고
    • Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells
    • E.J. Small, P. Fratesi, D.M. Reese Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells J Clin Oncol 18 2000 3894 3903
    • (2000) J Clin Oncol , vol.18 , pp. 3894-3903
    • Small, E.J.1    Fratesi, P.2    Reese, D.M.3
  • 26
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • P.W. Kantoff, C.S. Higano, N.D. Shore Sipuleucel-T immunotherapy for castration-resistant prostate cancer N Engl J Med 363 2010 411 422
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 27
    • 68549135290 scopus 로고    scopus 로고
    • Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
    • C.S. Higano, P.F. Schellhammer, E.J. Small Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer Cancer 115 2009 3670 3679
    • (2009) Cancer , vol.115 , pp. 3670-3679
    • Higano, C.S.1    Schellhammer, P.F.2    Small, E.J.3
  • 28
    • 79960337024 scopus 로고    scopus 로고
    • Randomized trial of autologous cellular immunotherapy with sipuleucel-T in androgen-dependent prostate cancer
    • T.M. Beer, G.T. Bernstein, J.M. Corman Randomized trial of autologous cellular immunotherapy with sipuleucel-T in androgen-dependent prostate cancer Clin Cancer Res 17 2011 4558 4567
    • (2011) Clin Cancer Res , vol.17 , pp. 4558-4567
    • Beer, T.M.1    Bernstein, G.T.2    Corman, J.M.3
  • 29
    • 84862090434 scopus 로고    scopus 로고
    • An open label, phase 2 trial of immunotherapy with sipuleucel-T (Provenge®) as neoadjuvant treatment in men with localized prostate cancer NCT00715104. Accessed: January 5, 2012
    • An open label, phase 2 trial of immunotherapy with sipuleucel-T (Provenge®) as neoadjuvant treatment in men with localized prostate cancer http://www.Clinicaltrials.gov NCT00715104. Accessed: January 5, 2012
  • 30
    • 84862108630 scopus 로고    scopus 로고
    • A pilot study to test the feasibility and immunologic impact of sipuleucel-T (Provenge) administered with or without anti-PD-1 mAb (CT-011) and low dose cyclophosphamide in men with advanced NCT01420965. Accessed: January 5, 2012
    • A pilot study to test the feasibility and immunologic impact of sipuleucel-T (Provenge) administered with or without anti-PD-1 mAb (CT-011) and low dose cyclophosphamide in men with advanced castrate-resistant prostate cancer http://www/Clinicaltrials.gov NCT01420965. Accessed: January 5, 2012
    • Castrate-resistant Prostate Cancer
  • 31
    • 84862108665 scopus 로고    scopus 로고
    • A randomized, open-label, phase 2 trial examining the sequencing of sipuleucel-T and androgen deprivation therapy in men with non-metastatic prostate cancer and a rising NCT01431391. Accessed: January 5, 2012
    • A randomized, open-label, phase 2 trial examining the sequencing of sipuleucel-T and androgen deprivation therapy in men with non-metastatic prostate cancer and a rising serum prostate specific antigen after primary therapy http://Clinicaltrials.gov NCT01431391. Accessed: January 5, 2012
    • Serum Prostate Specific Antigen after Primary Therapy
  • 32
    • 84874841901 scopus 로고    scopus 로고
    • A randomized, controlled phase III global trial comparing sipuleucel-T T plus androgen deprivation therapy versus androgen deprivation therapy alone in men with metastatic androgen dependent (hormone sensitive) prostate cancer
    • abstract TPS188
    • K. Fizazi, T. Powles, D.J. George A randomized, controlled phase III global trial comparing sipuleucel-T T plus androgen deprivation therapy versus androgen deprivation therapy alone in men with metastatic androgen dependent (hormone sensitive) prostate cancer J Clin Oncol 29 suppl 2011 abstract TPS188
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Fizazi, K.1    Powles, T.2    George, D.J.3
  • 33
    • 79959861428 scopus 로고    scopus 로고
    • Recent advances in immunotherapy for the treatment of prostate cancer
    • G. Sonpavde, N. Agarwal, T.K. Choueiri Recent advances in immunotherapy for the treatment of prostate cancer Expert Opin Biol Ther 11 2011 997 1009
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 997-1009
    • Sonpavde, G.1    Agarwal, N.2    Choueiri, T.K.3
  • 34
    • 84862090617 scopus 로고    scopus 로고
    • Results of a phase I/II clinical trial of BPX-101, a novel drug-activated dendritic cell (DC) vaccine for metastatic castration-resistant prostate cancer (mCRPC)
    • abstract 4670
    • K.M. Slawin, G. Sonpavde, J.D. McMannis Results of a phase I/II clinical trial of BPX-101, a novel drug-activated dendritic cell (DC) vaccine for metastatic castration-resistant prostate cancer (mCRPC) J Clin Oncol 29 suppl 2011 abstract 4670
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Slawin, K.M.1    Sonpavde, G.2    McMannis, J.D.3
  • 37
    • 77955375829 scopus 로고    scopus 로고
    • Strategies for cancer vaccine development
    • [e-pub ahead of print]
    • M. Vergati, C. Intrivici, N.Y. Huen Strategies for cancer vaccine development J Biomed Biotechnol July 11, 2010 [e-pub ahead of print]
    • (2010) J Biomed Biotechnol
    • Vergati, M.1    Intrivici, C.2    Huen, N.Y.3
  • 38
    • 77954939175 scopus 로고    scopus 로고
    • Prostate cancer as a model for tumour immunotherapy
    • C.G. Drake Prostate cancer as a model for tumour immunotherapy Nat Rev Immunol 10 2010 580 593
    • (2010) Nat Rev Immunol , vol.10 , pp. 580-593
    • Drake, C.G.1
  • 39
    • 28844501899 scopus 로고    scopus 로고
    • Pox viral vaccine approaches
    • DOI 10.1053/j.seminoncol.2005.09.006, PII S009377540500360X, Gene Therapy of Cancer
    • P.M. Arlen, H.L. Kaufman, R.S. DiPaola Pox viral vaccine approaches Semin Oncol 32 2005 549 555 (Pubitemid 41772682)
    • (2005) Seminars in Oncology , vol.32 , Issue.6 , pp. 549-555
    • Arlen, P.M.1    Kaufman, H.L.2    DiPaola, R.S.3
  • 40
    • 0036118394 scopus 로고    scopus 로고
    • Recombinant vaccinia virus-induced T-cell immunity: Quantitation of the response to the virus vector and the foreign epitope
    • DOI 10.1128/JVI.76.7.3329-3337.2002
    • L.E. Harrington, RvR. Most, J.L. Whitton Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope J Virol 76 2002 3329 3337 (Pubitemid 34224535)
    • (2002) Journal of Virology , vol.76 , Issue.7 , pp. 3329-3337
    • Harrington, L.E.1    Van Der Most, R.2    Whitton, J.L.3    Ahmed, R.4
  • 41
    • 77949895922 scopus 로고    scopus 로고
    • Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
    • P.W. Kantoff, T.J. Schuetz, B.A. Blumenstein Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer J Clin Oncol 28 2010 1099 1105
    • (2010) J Clin Oncol , vol.28 , pp. 1099-1105
    • Kantoff, P.W.1    Schuetz, T.J.2    Blumenstein, B.A.3
  • 46
    • 68349152636 scopus 로고    scopus 로고
    • + T cell immune responses compared to intramuscular injection and intradermal gene gun delivery
    • + T cell immune responses compared to intramuscular injection and intradermal gene gun delivery Vaccine 27 2009 5450 5459
    • (2009) Vaccine , vol.27 , pp. 5450-5459
    • Best, S.R.1    Peng, S.2    Juang, C.M.3
  • 47
    • 70249126960 scopus 로고    scopus 로고
    • Safety and immunological efficacy of a DNA vaccine encoding prostatic acid phosphatase in patients with stage D0 prostate cancer
    • D.G. McNeel, E.J. Dunphy, J.G. Davies Safety and immunological efficacy of a DNA vaccine encoding prostatic acid phosphatase in patients with stage D0 prostate cancer J Clin Oncol 27 2009 4047 4054
    • (2009) J Clin Oncol , vol.27 , pp. 4047-4054
    • McNeel, D.G.1    Dunphy, E.J.2    Davies, J.G.3
  • 48
    • 33750110852 scopus 로고    scopus 로고
    • Vaccination with messenger RNA
    • S. Pascolo Vaccination with messenger RNA Methods Mol Med 127 2006 23 40
    • (2006) Methods Mol Med , vol.127 , pp. 23-40
    • Pascolo, S.1
  • 49
    • 84870924928 scopus 로고    scopus 로고
    • Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self-adjuvanted mRNA
    • abstract 4535
    • H. Kübler, T. Maurer, A. Stenzl Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self-adjuvanted mRNA J Clin Oncol 29 suppl 2011 abstract 4535
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Kübler, H.1    Maurer, T.2    Stenzl, A.3
  • 50
    • 80051550377 scopus 로고    scopus 로고
    • A phase 1 study of a vaccine targeting preferentially expressed antigen in melanoma and prostate-specific membrane antigen in patients with advanced solid tumors
    • J.S. Weber, N.J. Vogelzang, M.S. Ernstoff A phase 1 study of a vaccine targeting preferentially expressed antigen in melanoma and prostate-specific membrane antigen in patients with advanced solid tumors J Immunother 34 2011 556 567
    • (2011) J Immunother , vol.34 , pp. 556-567
    • Weber, J.S.1    Vogelzang, N.J.2    Ernstoff, M.S.3
  • 53
    • 78449256966 scopus 로고    scopus 로고
    • Update on immunologic therapy with anti-CTLA-4 antibodies in melanoma: Identification of clinical and biological response patterns, immune-related adverse events, and their management
    • K.C. Kaehler, S. Piel, E. Livingstone Update on immunologic therapy with anti-CTLA-4 antibodies in melanoma: identification of clinical and biological response patterns, immune-related adverse events, and their management Semin Oncol 37 2010 485 498
    • (2010) Semin Oncol , vol.37 , pp. 485-498
    • Kaehler, K.C.1    Piel, S.2    Livingstone, E.3
  • 54
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • F.S. Hodi, S.J. O'Day, D.F. McDermott Improved survival with ipilimumab in patients with metastatic melanoma N Engl J Med 363 2010 711 723
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 55
    • 34548191221 scopus 로고    scopus 로고
    • Update on anti-CTLA-4 antibodies in clinical trials
    • DOI 10.1517/14712598.7.8.1245
    • L.F. Langer, T.M. Clay, M.A. Morse Update on anti-CTLA-4 antibodies in clinical trials Expert Opin Biol Ther 7 2007 1245 1256 (Pubitemid 47305249)
    • (2007) Expert Opinion on Biological Therapy , vol.7 , Issue.8 , pp. 1245-1256
    • Langer, L.F.1    Clay, T.M.2    Morse, M.A.3
  • 60
    • 13844294372 scopus 로고    scopus 로고
    • PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
    • DOI 10.1093/intimm/dxh194
    • Y. Iwai, S. Terawaki, T. Honjo PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells Int Immunol 17 2005 133 144 (Pubitemid 40246578)
    • (2005) International Immunology , vol.17 , Issue.2 , pp. 133-144
    • Iwai, Y.1    Terawaki, S.2    Honjo, T.3
  • 63
    • 0033571105 scopus 로고    scopus 로고
    • + T cells: A common basis between tumor immunity and autoimmunity
    • + T cells: a common basis between tumor immunity and autoimmunity J Immunol 163 1999 5211 5218
    • (1999) J Immunol , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 65
    • 77957273591 scopus 로고    scopus 로고
    • Improved endpoints for cancer immunotherapy trials
    • A. Hoos, A.M. Eggermont, S. Janetzki Improved endpoints for cancer immunotherapy trials J Natl Cancer Inst 102 2010 1388 1397
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1388-1397
    • Hoos, A.1    Eggermont, A.M.2    Janetzki, S.3
  • 68
    • 51649128403 scopus 로고    scopus 로고
    • Analysis of overall survival in patients with nonmetastatic castration-resistant prostate cancer treated with vaccine, nilutamide, and combination therapy
    • R.A. Madan, J.L. Gulley, J. Schlom Analysis of overall survival in patients with nonmetastatic castration-resistant prostate cancer treated with vaccine, nilutamide, and combination therapy Clin Cancer Res 14 2008 4526 4531
    • (2008) Clin Cancer Res , vol.14 , pp. 4526-4531
    • Madan, R.A.1    Gulley, J.L.2    Schlom, J.3
  • 69
    • 58349090027 scopus 로고    scopus 로고
    • Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF
    • L. Fong, S.S. Kwek, S. O'Brien Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF Cancer Res 69 2009 609 615
    • (2009) Cancer Res , vol.69 , pp. 609-615
    • Fong, L.1    Kwek, S.S.2    O'Brien, S.3
  • 70
    • 34250223096 scopus 로고    scopus 로고
    • A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
    • DOI 10.1158/1078-0432.CCR-06-2318
    • E.J. Small, N.S. Tchekmedyian, B.I. Rini A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer Clin Cancer Res 13 2007 1810 1815 (Pubitemid 46952950)
    • (2007) Clinical Cancer Research , vol.13 , Issue.6 , pp. 1810-1815
    • Small, E.J.1    Tchekmedyian, N.S.2    Rini, B.I.3    Fong, L.4    Lowy, I.5    Allison, J.P.6
  • 72
    • 77951443592 scopus 로고    scopus 로고
    • Initial phase II experience of ipilimumab (IPI) alone and in combination with radiotherapy (XRT) in patients with metastatic castration-resistant prostate cancer (mCRPC)
    • S.F. Slovin, T.M. Beer, C.S. Higano Initial phase II experience of ipilimumab (IPI) alone and in combination with radiotherapy (XRT) in patients with metastatic castration-resistant prostate cancer (mCRPC) J Clin Oncol 27 suppl 2009 15s
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Slovin, S.F.1    Beer, T.M.2    Higano, C.S.3
  • 73
    • 57349099926 scopus 로고    scopus 로고
    • Expanded phase i combination trial of GVAX immunotherapy for prostate cancer and ipilimumab in patients with metastatic hormone-refractory prostate cancer (mHPRC)
    • abstract 5146
    • W. Gerritsen, A.J. van den Eertwegh, T. de Gruijl Expanded phase I combination trial of GVAX immunotherapy for prostate cancer and ipilimumab in patients with metastatic hormone-refractory prostate cancer (mHPRC) J Clin Oncol 26 suppl 2008 abstract 5146
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Gerritsen, W.1    Van Den Eertwegh, A.J.2    De Gruijl, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.