Particle Deposition in Oral-tracheal Airway Models with Very Low Inhalation Profiles

Journal of Bionic Engineering

Volumn 9, Issue 2, 2012, Pages 252-261

  Li, Zheng ^a  

^a The University of Texas at Austin   (United States)

Author keywords

Airflow; Airway; CFD; Low inhalation profile; Particle deposition

Indexed keywords

AIRFLOW; BREATHING CONDITION; BREATHING PATTERNS; CIGARETTE SMOKES; DEPOSITION FRACTIONS; GEOMETRIC CHARACTERISTICS; HEALTH EFFECTS; HUMAN BEING; INLET CONDITIONS; LIGHT ACTIVITY; LOW INHALATION PROFILE; MICRO- AND NANO-PARTICLES; ORAL CAVITY; PARTICLE DEPOSITIONS; PARTICLE PROPERTIES; PARTICLE SIZE CHANGE; REALISTIC MODEL; RESIDENCE TIME; SMOKE PARTICLES; ULTRAFINE PARTICLE;

AIR TRANSPORTATION; BROWNIAN MOVEMENT; COMPUTATIONAL FLUID DYNAMICS; FLOW RATE;

DEPOSITION;

EID: 84862068418     PISSN: 16726529     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1672-6529(11)60106-6     Document Type: Article

References (44)

1. Heyder J, Gebhart J, Rudolf G, Schiller CF, Stahlhofen W Deposition of particles of in the human respiratory-tract in the size range 0.005-15 μm. Journal of Aerosol Science 1986, 17:811-825.
2. Stahlhofen W, Moller W Behaviour of magnetic micro-particles in the human lung. Radiation and Environmental Biophysics 1993, 32:221-238.
3. Johnston JR, Isles KD, Muir DCF Inertial deposition of particles in human branching airways. Inhaled Particles IV 1977, Pergamon, New York, USA. W.H. Walton (Ed.).
4. Kim CS, Fisher DM Deposition characteristics of aerosol particles in sequentially bifurcating airway models. Aerosol Science and Technology 1999, 31:198-220.
5. Kleinstreuer C, Zhang Z Laminar-to-turbulent fluid-particle flows in a human airway model. Journal of Multiphase Flow 2003, 29:271-289.
6. Oldham M Challenges in validating CFD-derived inhaled aerosol deposition predictions. Inhalation Toxicology 2006, 18:781-786.
7. Su WC, Cheng Y Fiber deposition pattern in two human respiratory tract replicas. Inhalation Toxicology 2006, 18:749-760.
8. Heyder J, Rudolf G Mathematical models of particle deposition of particle deposition in the human respiratory tract. Journal of Aerosol Science 1984, 15:697-707.
9. Zhang Z, Kleinstreuer C, Donohue JF, Kim CS Comparison of micro- and nano-size particle depositions in a human upper airway model. Journal of Aerosol Science 2005, 36:211-233.
10. Smith H Human Respiratory Tract Model for Radiological Protection (ICRP Publication 66) 1994, Elsevier, Oxford, UK.
11. Zhang Z, Kleinstreuer C, Kim CS Water vapor transport and its effects on the deposition of hygroscopic droplets in a human upper airway model. Aerosol Science and Technology 2006, 40:1-16.
12. Longest PW, Xi J Effectiveness of direct Lagrangian tracking models for simulating nanoparticle deposition in the upper airways. Aerosol Science and Technology 2007, 41:380-397.
13. Longest W, Oldham MJ Mutual enhancement of CFD modeling and experimental data: A case study of 1-μm particle deposition in a branching airway model. Inhalation Toxicology 2006, 18:761-771.
14. Li Z, Kleinstreuer C, Zhang Z Simulation of airflow fields and microparticle deposition in realistic human lung airway models, Part I: Airflow patterns. European Journal of Mechanics B: Fluids 2007, 26:632-649.
15. Li Z, Kleinstreuer C, Zhang Z Simulation of airflow fields and microparticle deposition in Realistic human lung airway models, Part II: Particle transport and deposition. European Journal of Mechanics B: Fluids 2007, 26:650-668.
16. Cheng YS, Su YF, Yeh HC, Swift DL Deposition of thoron progeny in human head airways. Aerosol Science and Technology 1993, 18:359-375.
17. Cheng KH, Cheng YS, Yeh HC, Swift DL Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage. Journal of Biomechanical Engineering 1997, 119:476-482.
18. Cheng YS Particle deposition in a cast of human oral airways. Aerosol Science and Technology 1999, 31:286-300.
19. Cheng YS Aerosol deposition in the extrathoracic region. Aerosol Science and Technology 2003, 37:659-671.
20. Lin TC, Breysse PN, Laube BL, Swift DL Mouthpiece diameter affects deposition efficiency in cast models of the human oral airways. Journal of Aerosol Medicine: Deposition, Clearance, Effects in the Lung 2001, 14:335-341.
21. Zhang Z, Kleinstreuer C Airflow structures and nano-particle deposition in a human upper airway model. Journal of Computational Physics 2004, 198:178-210.
22. Zhang Z, Kleinstreuer C, Kim CS Micro-particle transport and deposition in a human oral airway model. Journal of Aerosol Science 2002, 33:1635-1652.
23. Bowes SM, Swift DL Deposition of inhaled particles in the oral airway during oronasal breathing. Aerosol Science and Technology 1989, 11:157-167.
24. Becquemin MM, Bertholon JF, Bouchikhi A, Malarbet JL, Roy M Oronasal ventilation partitioning in adults and children: Effect on aerosol deposition in airways. Radiation Protection Dosimetry 1999, 81:221-228.
25. Takano H, Nishida N, Itoh M, Hyo N, Majima Y Inhaled particle deposition in unsteady-state respiratory flow at a numerically constructed model of the human larynx. Journal of Aerosol Medicine: Deposition, Clearance, Effects in the Lung 2006, 19:314-328.
26. ISO Standard 4387. Cigarettes - Determination Of Total And Nicotine-Free Dry Particulate Matter Using A Routine Analytical Smoking Machine 2000, International Organization for Standardization, Geneva, Switzerland. 3rd ed.
27. Canada Government Tobacco Act: Tobacco Reporting Regulations, SOR/2000-273, Part 3: Emissions from Designated Tobacco Products, [2012-2-28] http://www.cctc.ca/cctc/EN/legislation/byregion/federal/tobacco_reporting_regulations/.
28. Li Z, Kleinstreuer C, Zhang Z Particle deposition in the human tracheobronchial airways due to transient inspiratory flow patterns. Journal of Aerosol Science 2007, 38:625-644.
29. Bernstein DM A review of the influence of particle size, puff volume, inhalation pattern on the deposition of cigarette smoke particles in the respiratory tract. Inhalation Toxicology 2004, 16:675-689.
30. Phalen RF, Oldham MJ, Mannix RC, Schum GM Cigarette smoke deposition in the tracheobroncial tree: Evidence for colligative effects. Aerosol Science &. Technology 1994, 20:215-226.
31. Martonen TB, Musante CJ Importance of cloud motion on cigarette smoke deposition in lung airways. Inhalation Toxicology 2000, 12(Suppl 4):S261-S280.
32. Varghese SS, Frankel SH Numerical modeling of pulsatile turbulent flow in stenotic vessels. Journal of Biomechanical Engineering 2003, 125:445-460.
33. Wilcox DC Turbulence Modeling for CFD 1998, DCW Industires Inc, La Candda, CA, USA. 2nd Ed.
34. AEA Technology CFX-4.4: Solver 2001, CFX International, Oxford, UK.
35. Crowe C, Sommerfeld M, Tsuji Y Multiphase Flows with Droplets and Particles 1998, CRC Press, New York, USA.
36. Clift R, Grace JR, Weber ME Bubbles, Drops, and Particles 1978, Academic Press, New York, USA.
37. Ounis H, Ahmadi G, McLaughlin JB Brownian Diffusion of submicrometer particles in the viscous sublayer. Journal of Colloid and Interface Science 1991, 143:266-277.
38. Hinds WC Aerosol Technology: Properties, Behavior, Measurement of Airborne Particles 1999, John Wiley and Sons, New York, USA.
39. Morsi SA, Alexander AJ An investigation of particle trajectories in two-phase flow systems. Journal of Fluid Mechanics 1972, 55:193-208.
40. Vandoormaal JP, Raithby GD Enhancements of the SIMPLE method for predicting incompressible fluid flows. Numerical Heat Transfer A: Applications 1984, 7:147-163.
41. Ingham DB Diffusion of aerosols in the entrance region of a smooth cylindrical pipe. Journal of Aerosol Science 1991, 22:253-257.
42. Pich J Theory of gravitational deposition of particles from laminar flows in channels. Journal of Aerosol Science 1973, 3:351-361.
43. Wang J Diffusional losses in particle sampling systems containing bends and elbows. Journal of Aerosol Science 2002, 33:843-857.
44. Xi J, Longest PW Transport and deposition of micron size aerosols in realistic and simplified models of the oral airway. Annals of Biomedical Engineering 2007, 35:560-581.