Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part II: Particle transport and deposition

European Journal of Mechanics, B/Fluids

Volumn 26, Issue 5, 2007, Pages 650-668

  Li, Zheng ^a   Kleinstreuer, Clement ^a   Zhang, Zhe ^a  

^a North Carolina State University   (United States)

Author keywords

3 D microparticle transport simulations; Asymmetric upper airways; Matching inlet Reynolds number; Particle depositions and segmental correlations

Indexed keywords

3-D MICROPARTICLE TRANSPORT SIMULATIONS; ASYMMETRIC UPPER AIRWAYS; MATCHING INLET REYNOLDS NUMBER; PARTICLE DEPOSITIONS; SEGMENTAL CORRELATIONS;

COMPUTATIONAL FLUID DYNAMICS; FLOW MEASUREMENT; FLUID MECHANICS; REYNOLDS NUMBER;

RESPIRATORY SYSTEM;

EID: 34447259548     PISSN: 09977546     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euromechflu.2007.02.004     Document Type: Article

References (34)

1. International Commission on Radiological Protection (ICRP), Human Respiratory Tract Model for Radiological Protection, Publication 66, Ann. ICRP, Pergamon Press, Oxford, 1994, p. 456
2. Pope C.A., Dockery D.W., and Schwartz J. Review of epidemiological evidence of health effects of particulate air pollution. Inhal. Toxicol. 7 (1995) 1
3. Smith S.J., and Bernstein J.A. Therapeutic uses of lung aerosols. In: Hickey A.J. (Ed). Inhalation Aerosol: Physical and Biological Basis for Therapy (1996), M. Dekker, New York 233
4. Gonda I. Particle deposition in the human respiratory tract. In: Crystal R.G., West J.B., Weibel E.R., and Barnes P.J. (Eds). The Lung: Scientific Foundations (1997), Lippincott-Raven Publishers, Philadelphia 2289
5. Kinsara A.A., Tompson R.V., and Loyalka S.K. Computational flow and aerosol concentration profiles in lung bifurcations. Health Phys. 64 (1993) 13
6. B. Gatlin, C. Cuicchi, J. Hammersley, D. Olson, R. Reddy, G. Burnside, Particle path and wall deposition patterns in laminar flow through a bifurcation, in: ASME FED SM97, Vancounver, British Columbia, Canada, 1997, p. 1
7. Heistracher T., and Hofmann W. Flow and deposition patterns in successive airway bifurcations. Ann. Occup. Hyg. 41 (1997) 537
8. Zhang L., Asgharian B., and Anjilvel S. Inertial deposition of particles in the human upper airway bifurcation. Aerosol Sci. Technol. 26 (1997) 97
9. Comer J.K., Kleinstreuer C., and Kim C.S. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition. J. Fluid Mech. 435 (2001) 55
10. Oldham M.J., Phalen R.F., and Heistracher T. Computational fluid dynamics predictions and experimental results for particle deposition in an airway model. Aerosol Sci. 32 (2000) 61
11. Zhang Z., Kleinstreuer C., and Kim C.S. Aerosol deposition efficiencies and upstream release positions for different inhalation modes in an upper bronchial airway model. Aerosol Sci. Technol. 36 (2002) 135
12. Weibel E.R. Morphometry of the Human Lung (1963), Academic, New York
13. Ertbruggen C.V., Hirsch C., and Paiva M. Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. J. Appl. Physiol. 98 (2005) 970
14. Horsfield K., Dart G., and Olson D.E. Models of the human bronchial tree. J. Appl. Physiol. 21 2 (1971) 207
15. Johnston J.R., Isles K.D., and Muri D.C.F. Inertial deposition of particles in human branching airways. In: Walton W.H. (Ed). Inhaled Particles IV (1977), Pergamon
16. Kim C.S., and Iglesias A.J. Deposition of inhaled particles in bifurcating airways models: I. inspiratory deposition. J. Aerosol. Medicine 2 (1989) 1
17. Kim C.S., Fisher D.M., Lutz D.J., and Gerrity T.R. Particle deposition in bifurcating airway models with varying airway geometry. Aerosol. Sci. Technol. 25 (1994) 567
18. Kim C.S., and Fisher D.M. Deposition characteristics of aerosol particles in successively bifurcating airway models. Aerosol. Sci. Technol. 31 (1999) 198
19. Zhou Y., and Cheng Y.-S. Particle deposition in a cast of human tracheobronchial airways. Aerosol Sci. Technol. 39 (2005) 492
20. Zhang Y., and Finlay W.H. Measurement of the effect of cartilaginous rings on particle deposition in a proximal lung bifurcation model. Aerosol Sci. Technol. 39 (2005) 394-399
21. Kim C.S., Hu S.C., Dewitt P., and Gerrity T.R. Assessment of regional deposition of inhaled particles in human lungs by serial bolus delivery method. J. Appl. Physiol. 81 (1996) 2203
22. Zhang Z., and Kleinstreuer C. Transient airflow structures and particle transport in a sequentially branching lung airway model. Phys. Fluids 14 2 (2002) 862
23. Scherer P.W., and Haselton F.R. Convective exchange in oscillatory flow through bronchial-tree models. J. Appl. Physiol. 53 (1982) 1023
24. S. Mochizuki, Convective mass transport during ventilation in a model of branched airways of human lungs, in: Proceedings of PSFVIP-4, Chamonix, France, 2003
25. O.G. Raabe, H.C. Yeh, G.M. Schum, R.F. Phalen, Tracheobronchial geometry, i.e. human, dog, rat, hamster LF-53, Lovelace Foundation for medical Education and Research, Albuquerque, NM, 1976
26. Clift R., Grace J.R., and Weber M.E. Bubbles, Drops, and Particles (1978), Academic Press, New York
27. J.R. Buchanan, Computational particle hemodynamics in the rabbit abdominal aorta, Ph.D. dissertation, MAE Dept., NC State University, Raleigh, NC, 2000
28. P.W. Longest, Computational analyses of transient particle hemodynamics with applications to femoral bypass graft designs, Ph.D. dissertation, MAE Dept., NC State University, Raleigh, NC, 2002
29. Longest P.W., Kleinstreuer C., and Buchanan J.R. Efficient computation of micro-particle dynamics including wall effects. Computers and Fluids 36 (2004) 577
30. Zhang Z., Kleinstreuer C., Donohue J.F., and Kim C.S. Comparison of micro- and nano-size particle depositions in a human upper airway model. Aerosol Sci. 36 (2005) 211
31. Zhang Z., Kleinstreuer C., and Kim C.S. Aerosol deposition fractions and upstream release positions for different inhalation modes in an upper bronchial airway model. Aerosol Sci. Technol. 36 (2002) 828
32. Comer J.K., Kleinstreuer C., and Kim C.S. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition. J. Fluid Mech. 435 (2001) 55
33. Cai F.S., and Yu P.C. Inertial and interceptional deposition of spherical particles and fibers in a bifurcating airway. J. Aerosol Sci. 19 (1988) 679
34. Michaelides E.E. Review - the transient equation of motion for particles, bubbles and droplets. J. Fluids Engrg. 119 (1997) 233