Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part I: Airflow patterns

European Journal of Mechanics, B/Fluids

Volumn 26, Issue 5, 2007, Pages 632-649

  Li, Zheng ^a   Kleinstreuer, Clement ^a   Zhang, Zhe ^a  

^a North Carolina State University   (United States)

Author keywords

Asymmetric upper airways; Local velocity distributions; Parabolic and realistic velocity inlet conditions; Transient 3 D airflow simulations

Indexed keywords

ASYMMETRIC UPPER AIRWAYS; LOCAL VELOCITY DISTRIBUTIONS; REALISTIC VELOCITY INLET CONDITIONS; TRANSIENT 3-D AIRFLOW SIMULATIONS;

COMPUTATIONAL FLUID DYNAMICS; FLOW MEASUREMENT; LAMINAR FLOW; REYNOLDS NUMBER; VELOCITY MEASUREMENT;

RESPIRATORY SYSTEM;

EID: 34447273151     PISSN: 09977546     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euromechflu.2007.02.003     Document Type: Article

References (26)

1. Weibel E.R. Morphometry of the Human Lung (1963), Academic, New York
2. Horsfield K., Dart G., and Olson D.E. Models of the human bronchial tree. J. Appl. Physiol. 21 2 (1971) 207
3. Ley S., Mayer D., Brook B.S., Van Beek E.J.R., Heussel C.P., Rinck D., Hose R., Markstaller K., and Kauczor H.-U. Radiological imaging as the basis for a simulation software of ventilation in the tracheo-bronchial tree. Eur. Radiol. 12 (2002) 2218
4. Tawhai M.H., Hunter P., Tschirren J., Reinhardt J., McLennan G., and Hoffman E.A. CT-based geometry analysis and finite element models of the human and ovine bronchial tree. J. Appl. Physiol. 97 (2004) 2310
5. Cebral J.R., and Summer R.M. Tracheal and central bronchial aerodynamics using virtual bronchoscopy and computational fluid dynamics. IEEE Trans. Medical Imaging 23 8 (2004) 1021
6. O.G. Raabe, H.C. Yeh, G.M. Schum, R.F. Phalen, Tracheobronchial geometry, i.e. human, dog, rat, hamster LF-53, Lovelace Foundation for medical Education and Research, Albuquerque, NM, 1976
7. Comer J.K., Kleinstreuer C., and Zhang Z. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields. J. Fluid Mech. 435 (2001) 25
8. Zhang Z., and Kleinstreuer C. Transient airflow structures and particle transport in a sequentially branching lung airway model. Phys. Fluids 14 2 (2002) 862
9. Zhang Z., Kleinstreuer C., and Kim C.S. Aerosol deposition efficiencies and upstream release positions for different inhalation modes in an upper bronchial airway model. Aerosol Sci. Technol. 36 (2002) 135
10. Zhang Z., and Kleinstreuer C. Airflow structures and nano-particle deposition in a human upper airway model. J. Comput. Phys. 198 (2004) 178
11. Zhang Z., Kleinstreuer C., Donohue J.F., and Kim C.S. Comparison of micro- and nano-size particle depositions in a human upper airway model. Aerosol Sci. 36 (2005) 211
12. Nowak N., Kakade P.P., and Annapragada A.V. Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs. Ann. Biomedical Engrg. 31 (2003) 374
13. Liu Y., So R.M.C., and Zhang C.H. Modeling the bifurcating flow in an asymmetric human lung airway. J. Biomech. 36 (2003) 951
14. Calay R.K., Kurujareon J., and Holdo A.E. Numerical simulation of respiratory flow patterns within human lung. Respiratory Physiology and Neurobiology 130 (2002) 201
15. Ertbruggen C.V., Hirsch C., and Paiva M. Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. J. Appl. Physiol. 98 (2005) 970
16. Zhao Y., and Lieber B.B. Steady inspiratory flow in a model symmetric bifurcation. Trans. ASME, J. Biomech. Engrg. 116 (1994) 488
17. Lieber B.B., and Zhao Y. Oscillatory flow in a symmetric bifurcation airway model. Ann. Biomedical Engrg. 26 5 (1998) 821
18. Tanaka G., Ogata T., Oka K., and Tanishita K. Spatial and temporal variation of secondary flow during oscillatory flow in model human central airways. J. Biomech. Engrg. 121 (1999) 565
19. Zhang Y., and Finlay W.H. Measurement of the effect of cartilaginous rings on Particle Deposition in a Proximal Lung Bifurcation Model. Aerosol Sci. Technol. 39 (2005) 394
20. Scherer P.W., and Haselton F.R. Convective exchange in oscillatory flow through bronchial-tree models. J. Appl. Physiol. 53 (1982) 1023
21. S. Mochizuki, Convective mass transport during ventilation in a model of branched airways of human lungs, in: Proceedings of PSFVIP-4, Chamonix, France, 2003
22. Kim C.S., Hu S.C., Dewitt P., and Gerrity T.R. Assessment of regional deposition of inhaled particles in human lungs by serial bolus delivery method. J. Appl. Physiol. 81 (1996) 2203
23. Edwards J.R. A low-diffusion flux-splitting scheme for Navier-Stokes calculations. Computers & Fluids 26 6 (1997) 635
24. Edwards J.R., and Liou M.-S. Low-diffusion flux-splitting methods for flows at all speeds. AIAA J. 36 9 (1998) 1610
25. J.-I. Choi, R.C. Oberoi, J.R. Edwards, J.A. Rosati, An immersed boundary method for complex incompressible flows, J. Comput. Phys., in press (available online)
26. Chorin A. A numerical method for solving incompressible viscous flow problem. J. Comput. Phys. 2 (1967) 12