Kidney-Specific Inactivation of the Megalin Gene Impairs Trafficking of Renal Inorganic Sodium Phosphate Cotransporter (NaPi-IIa)

Journal of the American Society of Nephrology

Volumn 15, Issue 4, 2004, Pages 892-900

  Bachmann, Sebastian ^a   Schlichting, Uwe ^a   Geist, Beate ^a   Mutig, Kerim ^a   Petsch, Thomas ^a   Bacic, Desa ^c   Wagner, Carsten A ^c   Kaissling, Brigitte ^c   Biber, Jürg ^c   Murer, Heini ^c   Willnow, Thomas E ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COTRANSPORTER; MEGALIN; MESSENGER RNA; PARATHYROID HORMONE; SODIUM PHOSPHATE COTRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOCYTOSIS; ENDOSOME; GENE INACTIVATION; GENETIC DISORDER; HISTOCHEMISTRY; IN VITRO STUDY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; MEMBRANE; MOUSE; NONHUMAN; PHOSPHATURIA; PRIORITY JOURNAL; STEADY STATE; WESTERN BLOTTING;

EID: 12144288118     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000120389.09938.21     Document Type: Article

References (27)

1. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS: Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci U S A 95: 5372-5377, 1998
2. Custer M, Lotscher M, Biber J, Murer H, Kaissling B: Expression of Na-P(i) cotransport in rat kidney: Localization by RT-PCR and immunohistochemistry. Am J Physiol 266: F767-F774, 1994
3. Murer H: Functional domains in the renal type IIa Na/P(i)-cotransporter. Kidney Int 62: 375-382, 2002
4. Pfister MF, Ruf I, Stange G, Ziegler U, Lederer E, Biber J, Murer H: Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter. Proc Natl Acad Sci U S A 95: 1909-1914, 1998
5. Keusch I, Traebert M, Lotscher M, Kaissling B, Murer H, Biber J: Parathyroid hormone and dietary phosphate provoke a lysosomal routing of the proximal tubular Na/Pi-cotransporter type II. Kidney Int 54: 1224-1232, 1998
6. Lotscher M, Scarpetta Y, Levi M, Halaihel N, Wang H, Zajicek HK, Biber J, Murer H, Kaissling B: Rapid downregulation of rat renal Na/P(i) cotransporter in response to parathyroid hormone involves microtubule rearrangement. J Clin Invest 104: 483-494, 1999
7. Cui S, Mata L, Maunsbach AB, Christensen EI: Ultrastructure of the vacuolar apparatus in the renal proximal tubule microinfused in vivo with the cytological stain light green. Exp Nephrol 6: 359-367, 1998
8. Hatae T, Fujita M, Sagara H, Okuyama K: Formation of apical tubules from large endocytic vacuoles in kidney proximal tubule cells during absorption of horseradish peroxidase. Cell Tissue Res 246: 271-278, 1986
9. - channel disruption impairs endocytosis in a mouse model for Dent's disease. Nature 408: 369-373, 2000
10. Christensen EI, Birn H: Megalin and cubilin: Multifunctional endocytic receptors. Nat Rev Mol Cell Biol 3: 256-266, 2002
11. Murer H, Hernando N, Forster I, Biber J: Proximal tubular phosphate reabsorption: Molecular mechanisms. Physiol Rev 80: 1373-1409, 2000
12. Gunther W, Piwon N, Jentsch TJ: The ClC-5 chloride channel knock-out mouse - An animal model for Dent's disease. Pflügers Arch 445: 456-462, 2003
13. Hilpert J, Nykjaer A, Jacobsen C, Wallukat G, Nielsen R, Moestrup SK, Haller H, Luft FC, Christensen EI, Willnow TE: Megalin antagonizes activation of the parathyroid hormone receptor. J Biol Chem 274: 5620-5625, 1999
14. Christensen EI, Devuyst O, Dom G, Nielsen R, Van der SP, Verroust P, Leruth M, Guggino WB, Courtoy PJ: Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Proc Natl Acad Sci U S A 100: 8472-8477, 2003
15. Birn H, Vorum H, Verroust PJ, Moestrup SK, Christensen EI: Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules. J Am Soc Nephrol 11: 191-202, 2000
16. Bacic D, Capuano P, Gisler SM, Pribanic S, Christensen EI, Biber J, Loffing J, Kaissling B, Wagner CA, Murer H: Impaired PTH-induced endocytotic down-regulation of the renal type IIa Na(+)/P(i)-cotransporter in RAP-deficient mice with reduced megalin expression. Pflügers Arch 446: 475-484, 2003
17. + exchanger isoform NHE3 in the proximal tubule. J Biol Chem 274: 17518-17524, 1999
18. Leheste JR, Melsen F, Wellner M, Jansen P, Schlichting U, Renner-Muller I, Andreassen TT, Wolf E, Bachmann S, Nykjaer A, Willnow TE: Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J 17: 247-249, 2003
19. Biber J, Stieger B, Haase W, Murer H: A high yield preparation for rat kidney brush border membranes: Different behaviour of lysosomal markers. Biochim Biophys Acta 647: 169-176, 1981
20. de Toledo FG, Thompson MA, Bolliger C, Tyce GM, Dousa TP: Gamma-L-glutamyl-L-DOPA inhibits Na(+)-phosphate cotransport across renal brush border membranes and increases renal excretion of phosphate. Kidney Int 55: 1832-1842, 1999
21. Kelly MH, Hamilton JR: A micro-technique for the assay of intestinal alkaline phosphatase: Results in normal children and in children with celiac disease. Clin Biochem 3: 33-43, 1970
22. Schmitt R, Ellison DH, Farman N, Rossier BC, Reilly RF, Reeves WB, Oberbaumer I, Tapp R, Bachmann S: Developmental expression of sodium entry pathways in rat nephron. Am J Physiol 276: F367-F381, 1999
23. Bachmann S, Bosse HM, Mundel P: Topography of nitric oxide synthesis by localizing constitutive NO synthases in mammalian kidney. Am J Physiol 268: F885-F898, 1995
24. Traebert M, Roth J, Biber J, Murer H, Kaissling B: Internalization of proximal tubular type II Na-P(i) cotransporter by PTH: Immunogold electron microscopy. Am J Physiol 278: F148-F154, 2000
25. Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, Melsen F, Christensen EI, Willnow TE: An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 96: 507-515, 1999
26. Leheste JR, Rolinski B, Vorum H, Hilpert J, Nykjaer A, Jacobsen C, Aucouturier P, Moskaug JO, Otto A, Christensen EI, Willnow TE: Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol 155: 1361-1370, 1999
27. Hernando N, Karim-Jimenez Z, Biber J, Murer H: Molecular determinants for apical expression and regulatory membrane retrieval of the type IIa Na/Pi cotransporter. Kidney Int 60: 431-435, 2001