Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression

Journal of Biological Chemistry

Volumn 287, Issue 24, 2012, Pages 20122-20131

  Li, Zhiqiang ^a,b   Ding, Tingbo ^b,d   Pan, Xiaoyue ^b   Li, Yan ^b   Li, Ruohan ^b   Sanders, Philip E ^c   Kuo, Ming Shang ^c   Hussain, M Mahmood ^b   Cao, Guoqing ^c   Jiang, Xian Cheng ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SUNY Downstate Medical Center   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL-COA; CONCENTRATION-DEPENDENT; HEPATOMA CELLS; ISOFORMS; KEY ENZYMES; LYSOPHOSPHATIDYL-CHOLINE; MECHANISTIC STUDIES; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEINS; PHOSPHATIDYLCHOLINE; PLASMA TRIGLYCERIDES; PROTEIN LEVEL; VERY LOW DENSITY LIPOPROTEINS;

BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; MAMMALS; PHOSPHOLIPIDS; PHYSIOLOGY;

PROTEINS;

1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE; ACYLTRANSFERASE; APOLIPOPROTEIN B; LIPOPROTEIN; LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 3; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PHOSPHATIDYLCHOLINE; TRIGLYCERIDE RICH APOLIPOPROTEIN B CONTAINING LIPOPROTEIN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; GENE SILENCING; LIPOPROTEIN METABOLISM; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; TRIACYLGLYCEROL BLOOD LEVEL;

1-ACYLGLYCEROPHOSPHOCHOLINE O-ACYLTRANSFERASE; ANIMALS; APOLIPOPROTEIN A-I; APOLIPOPROTEINS B; CARRIER PROTEINS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; LIPOPROTEINS, VLDL; LIVER; LYSOPHOSPHATIDYLCHOLINES; MALE; MICE; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TRIGLYCERIDES;

MUS;

EID: 84862017120     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.334664     Document Type: Article

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