메뉴 건너뛰기




Volumn 7, Issue 6, 2012, Pages

Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CYTOKINE; ECALECTIN; HYBRID PROTEIN;

EID: 84862007833     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038708     Document Type: Article
Times cited : (50)

References (43)
  • 1
    • 77953694980 scopus 로고    scopus 로고
    • Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges
    • Law CL, Grewal IS, (2009) Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges. Adv Exp Med Biol 647: 8-36.
    • (2009) Adv Exp Med Biol , vol.647 , pp. 8-36
    • Law, C.L.1    Grewal, I.S.2
  • 2
    • 70349148591 scopus 로고    scopus 로고
    • The Janus faces of CD40 in cancer
    • Loskog AS, Eliopoulos AG, (2009) The Janus faces of CD40 in cancer. Semin Immunol 21: 301-307.
    • (2009) Semin Immunol , vol.21 , pp. 301-307
    • Loskog, A.S.1    Eliopoulos, A.G.2
  • 3
    • 33947223664 scopus 로고    scopus 로고
    • Prospect of targeting the CD40 pathway for cancer therapy
    • Vonderheide RH, (2007) Prospect of targeting the CD40 pathway for cancer therapy. Clin Cancer Res 13: 1083-1088.
    • (2007) Clin Cancer Res , vol.13 , pp. 1083-1088
    • Vonderheide, R.H.1
  • 4
    • 70449522042 scopus 로고    scopus 로고
    • Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction
    • Margolles-Clark E, Umland O, Kenyon NS, Ricordi C, Buchwald P, (2009) Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction. J Mol Med 87: 1133-1143.
    • (2009) J Mol Med , vol.87 , pp. 1133-1143
    • Margolles-Clark, E.1    Umland, O.2    Kenyon, N.S.3    Ricordi, C.4    Buchwald, P.5
  • 5
    • 33644779799 scopus 로고    scopus 로고
    • Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse
    • Nanji SA, Hancock WW, Luo B, Schur CD, Pawlick RL, et al. (2006) Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse. Diabetes 55: 27-33.
    • (2006) Diabetes , vol.55 , pp. 27-33
    • Nanji, S.A.1    Hancock, W.W.2    Luo, B.3    Schur, C.D.4    Pawlick, R.L.5
  • 6
    • 68149156979 scopus 로고    scopus 로고
    • Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand
    • Wyzgol A, Muller N, Fick A, Munkel S, Grigoleit GU, et al. (2009) Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand. J Immunol 183: 1851-1861.
    • (2009) J Immunol , vol.183 , pp. 1851-1861
    • Wyzgol, A.1    Muller, N.2    Fick, A.3    Munkel, S.4    Grigoleit, G.U.5
  • 7
    • 0036326804 scopus 로고    scopus 로고
    • Participation of protease-activated receptor-1 in thrombin-induced microglial activation
    • Suo Z, Wu M, Ameenuddin S, Anderson HE, Zoloty JE, et al. (2002) Participation of protease-activated receptor-1 in thrombin-induced microglial activation. J Neurochem 80: 655-666.
    • (2002) J Neurochem , vol.80 , pp. 655-666
    • Suo, Z.1    Wu, M.2    Ameenuddin, S.3    Anderson, H.E.4    Zoloty, J.E.5
  • 9
    • 67349103904 scopus 로고    scopus 로고
    • The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes
    • Poggi M, Jager J, Paulmyer-Lacroix O, Peiretti F, Gremeaux T, et al. (2009) The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes. Diabetologia 52: 1152-1163.
    • (2009) Diabetologia , vol.52 , pp. 1152-1163
    • Poggi, M.1    Jager, J.2    Paulmyer-Lacroix, O.3    Peiretti, F.4    Gremeaux, T.5
  • 10
    • 67349266245 scopus 로고    scopus 로고
    • The co-evolution of our understanding of CD40 and inflammation
    • Wagner DH Jr, (2009) The co-evolution of our understanding of CD40 and inflammation. Diabetologia 52: 997-999.
    • (2009) Diabetologia , vol.52 , pp. 997-999
    • Wagner Jr., D.H.1
  • 11
    • 0033194297 scopus 로고    scopus 로고
    • Increased expression of CD40 on thymocytes and peripheral T cells in autoimmunity: a mechanism for acquiring changes in the peripheral T cell receptor repertoire
    • Wagner DH Jr, Newell E, Sanderson RJ, Freed JH, Newell MK, (1999) Increased expression of CD40 on thymocytes and peripheral T cells in autoimmunity: a mechanism for acquiring changes in the peripheral T cell receptor repertoire. Int J Mol Med 4: 231-242.
    • (1999) Int J Mol Med , vol.4 , pp. 231-242
    • Wagner Jr., D.H.1    Newell, E.2    Sanderson, R.J.3    Freed, J.H.4    Newell, M.K.5
  • 13
    • 44349086299 scopus 로고    scopus 로고
    • High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity
    • Vaitaitis GM, Wagner DH Jr, (2008) High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity. PLoS One 3: e2076.
    • (2008) PLoS One , vol.3
    • Vaitaitis, G.M.1    Wagner Jr., D.H.2
  • 14
    • 2942752011 scopus 로고    scopus 로고
    • Peripheral CD4loCD40+ auto-aggressive T cell expansion during insulin-dependent diabetes mellitus
    • Waid DM, Vaitaitis GM, Wagner DH Jr, (2004) Peripheral CD4loCD40+ auto-aggressive T cell expansion during insulin-dependent diabetes mellitus. Eur J Immunol 34: 1488-1497.
    • (2004) Eur J Immunol , vol.34 , pp. 1488-1497
    • Waid, D.M.1    Vaitaitis, G.M.2    Wagner Jr., D.H.3
  • 15
    • 34447298600 scopus 로고    scopus 로고
    • A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes
    • Waid DM, Wagner RJ, Putnam A, Vaitaitis GM, Pennock ND, et al. (2007) A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes. Clin Immunol 124: 138-148.
    • (2007) Clin Immunol , vol.124 , pp. 138-148
    • Waid, D.M.1    Wagner, R.J.2    Putnam, A.3    Vaitaitis, G.M.4    Pennock, N.D.5
  • 16
    • 48649106615 scopus 로고    scopus 로고
    • Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes
    • Waid DM, Vaitaitis GM, Pennock ND, Wagner DH Jr, (2008) Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes. J Leukoc Biol 84: 431-439.
    • (2008) J Leukoc Biol , vol.84 , pp. 431-439
    • Waid, D.M.1    Vaitaitis, G.M.2    Pennock, N.D.3    Wagner Jr., D.H.4
  • 17
    • 77955424415 scopus 로고    scopus 로고
    • CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity
    • Vaitaitis GM, Wagner DH Jr, (2010) CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity. Mol Immunol 47: 2303-2313.
    • (2010) Mol Immunol , vol.47 , pp. 2303-2313
    • Vaitaitis, G.M.1    Wagner Jr., D.H.2
  • 18
    • 0031279105 scopus 로고    scopus 로고
    • CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice
    • Balasa B, Krahl T, Patstone G, Lee J, Tisch R, et al. (1997) CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J Immunol 159: 4620-4627.
    • (1997) J Immunol , vol.159 , pp. 4620-4627
    • Balasa, B.1    Krahl, T.2    Patstone, G.3    Lee, J.4    Tisch, R.5
  • 19
    • 54949106904 scopus 로고    scopus 로고
    • Mammalian glycosylation in immunity
    • Marth JD, Grewal PK, (2008) Mammalian glycosylation in immunity. Nat Rev Immunol 8: 874-887.
    • (2008) Nat Rev Immunol , vol.8 , pp. 874-887
    • Marth, J.D.1    Grewal, P.K.2
  • 20
    • 34547122512 scopus 로고    scopus 로고
    • Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis
    • Grigorian A, Lee SU, Tian W, Chen IJ, Gao G, et al. (2007) Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem 282: 20027-20035.
    • (2007) J Biol Chem , vol.282 , pp. 20027-20035
    • Grigorian, A.1    Lee, S.U.2    Tian, W.3    Chen, I.J.4    Gao, G.5
  • 21
    • 10344249912 scopus 로고    scopus 로고
    • N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells
    • Morgan R, Gao G, Pawling J, Dennis JW, Demetriou M, et al. (2004) N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells. J Immunol 173: 7200-7208.
    • (2004) J Immunol , vol.173 , pp. 7200-7208
    • Morgan, R.1    Gao, G.2    Pawling, J.3    Dennis, J.W.4    Demetriou, M.5
  • 22
    • 0035825644 scopus 로고    scopus 로고
    • Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
    • Demetriou M, Granovsky M, Quaggin S, Dennis JW, (2001) Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 409: 733-739.
    • (2001) Nature , vol.409 , pp. 733-739
    • Demetriou, M.1    Granovsky, M.2    Quaggin, S.3    Dennis, J.W.4
  • 23
    • 36348954543 scopus 로고    scopus 로고
    • N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration
    • Lee SU, Grigorian A, Pawling J, Chen IJ, Gao G, et al. (2007) N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration. J Biol Chem 282: 33725-33734.
    • (2007) J Biol Chem , vol.282 , pp. 33725-33734
    • Lee, S.U.1    Grigorian, A.2    Pawling, J.3    Chen, I.J.4    Gao, G.5
  • 24
    • 70349526715 scopus 로고    scopus 로고
    • Galectins
    • Hoboken, New Jersey, John Wiley & Sons, Inc
    • Klyosov AA, Witczak ZJ, Platt D, (2008) Galectins. Hoboken, New Jersey John Wiley & Sons, Inc.
    • (2008)
    • Klyosov, A.A.1    Witczak, Z.J.2    Platt, D.3
  • 25
    • 0029900083 scopus 로고    scopus 로고
    • Expression of galectin-3 modulates T-cell growth and apoptosis
    • Yang RY, Hsu DK, Liu FT, (1996) Expression of galectin-3 modulates T-cell growth and apoptosis. Proc Natl Acad Sci U S A 93: 6737-6742.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6737-6742
    • Yang, R.Y.1    Hsu, D.K.2    Liu, F.T.3
  • 26
    • 64249146003 scopus 로고    scopus 로고
    • Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis
    • Wang J, Lu ZH, Gabius HJ, Rohowsky-Kochan C, Ledeen RW, et al. (2009) Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J Immunol 182: 4036-4045.
    • (2009) J Immunol , vol.182 , pp. 4036-4045
    • Wang, J.1    Lu, Z.H.2    Gabius, H.J.3    Rohowsky-Kochan, C.4    Ledeen, R.W.5
  • 27
    • 30044434075 scopus 로고    scopus 로고
    • The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    • Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6: 1245-1252.
    • (2005) Nat Immunol , vol.6 , pp. 1245-1252
    • Zhu, C.1    Anderson, A.C.2    Schubart, A.3    Xiong, H.4    Imitola, J.5
  • 28
    • 70349245383 scopus 로고    scopus 로고
    • Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice
    • Chou FC, Shieh SJ, Sytwu HK, (2009) Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice. Eur J Immunol 39: 2403-2411.
    • (2009) Eur J Immunol , vol.39 , pp. 2403-2411
    • Chou, F.C.1    Shieh, S.J.2    Sytwu, H.K.3
  • 29
    • 80052673578 scopus 로고    scopus 로고
    • Galectin-9 regulates T helper cell function independently of Tim-3
    • Su EW, Bi S, Kane LP, (2010) Galectin-9 regulates T helper cell function independently of Tim-3. Glycobiology 21: 1258-1265.
    • (2010) Glycobiology , vol.21 , pp. 1258-1265
    • Su, E.W.1    Bi, S.2    Kane, L.P.3
  • 30
    • 50649121583 scopus 로고    scopus 로고
    • Solution structure of the integral human membrane protein VDAC-1 in detergent micelles
    • Hiller S, Garces RG, Malia TJ, Orekhov VY, Colombini M, et al. (2008) Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science 321: 1206-1210.
    • (2008) Science , vol.321 , pp. 1206-1210
    • Hiller, S.1    Garces, R.G.2    Malia, T.J.3    Orekhov, V.Y.4    Colombini, M.5
  • 31
    • 0022548222 scopus 로고
    • Transient modulation and internalization of T4 antigen induced by phorbol esters
    • Hoxie JA, Matthews DM, Callahan KJ, Cassel DL, Cooper RA, (1986) Transient modulation and internalization of T4 antigen induced by phorbol esters. J Immunol 137: 1194-1201.
    • (1986) J Immunol , vol.137 , pp. 1194-1201
    • Hoxie, J.A.1    Matthews, D.M.2    Callahan, K.J.3    Cassel, D.L.4    Cooper, R.A.5
  • 32
    • 33846234751 scopus 로고    scopus 로고
    • A costimulatory function for T cell CD40
    • Munroe ME, Bishop GA, (2007) A costimulatory function for T cell CD40. J Immunol 178: 671-682.
    • (2007) J Immunol , vol.178 , pp. 671-682
    • Munroe, M.E.1    Bishop, G.A.2
  • 33
    • 56549110891 scopus 로고    scopus 로고
    • CD40 on NOD CD4 T cells contributes to their activation and pathogenicity
    • Baker RL, Wagner DH Jr, Haskins K, (2008) CD40 on NOD CD4 T cells contributes to their activation and pathogenicity. J Autoimmun 31: 385-392.
    • (2008) J Autoimmun , vol.31 , pp. 385-392
    • Baker, R.L.1    Wagner Jr., D.H.2    Haskins, K.3
  • 34
    • 34547683228 scopus 로고    scopus 로고
    • CD40-mediated enhancement of immune responses against three forms of influenza vaccine
    • Hatzifoti C, Heath AW, (2007) CD40-mediated enhancement of immune responses against three forms of influenza vaccine. Immunology 122: 98-106.
    • (2007) Immunology , vol.122 , pp. 98-106
    • Hatzifoti, C.1    Heath, A.W.2
  • 35
    • 33645240780 scopus 로고    scopus 로고
    • Antibodies against cell surface antigens as very potent immunological adjuvants
    • Barr T, Carlring J, Hatzifoti C, Heath AW, (2006) Antibodies against cell surface antigens as very potent immunological adjuvants. Vaccine 24 (Suppl 2): S2-20-21.
    • (2006) Vaccine , vol.24 , Issue.SUPPL. 2 , pp. 20-21
    • Barr, T.1    Carlring, J.2    Hatzifoti, C.3    Heath, A.W.4
  • 36
    • 4043086357 scopus 로고    scopus 로고
    • CD40 antibody as an adjuvant induces enhanced T cell responses
    • Carlring J, Barr TA, McCormick AL, Heath AW, (2004) CD40 antibody as an adjuvant induces enhanced T cell responses. Vaccine 22: 3323-3328.
    • (2004) Vaccine , vol.22 , pp. 3323-3328
    • Carlring, J.1    Barr, T.A.2    McCormick, A.L.3    Heath, A.W.4
  • 37
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY, (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6: 1142-1151.
    • (2005) Nat Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 38
    • 33947207868 scopus 로고    scopus 로고
    • Re-shaping the T cell repertoire: TCR editing and TCR revision for good and for bad
    • Wagner DH Jr, (2007) Re-shaping the T cell repertoire: TCR editing and TCR revision for good and for bad. Clin Immunol 123: 1-6.
    • (2007) Clin Immunol , vol.123 , pp. 1-6
    • Wagner Jr., D.H.1
  • 39
    • 67649958050 scopus 로고    scopus 로고
    • Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation
    • Niwa H, Satoh T, Matsushima Y, Hosoya K, Saeki K, et al. (2009) Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation. Clin Immunol 132: 184-194.
    • (2009) Clin Immunol , vol.132 , pp. 184-194
    • Niwa, H.1    Satoh, T.2    Matsushima, Y.3    Hosoya, K.4    Saeki, K.5
  • 40
    • 40849120400 scopus 로고    scopus 로고
    • Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis
    • Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, et al. (2008) Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol 127: 78-88.
    • (2008) Clin Immunol , vol.127 , pp. 78-88
    • Seki, M.1    Oomizu, S.2    Sakata, K.M.3    Sakata, A.4    Arikawa, T.5
  • 41
    • 0028041170 scopus 로고
    • Monoclonal antibodies to murine CD40 define two distinct functional epitopes
    • Heath AW, Wu WW, Howard MC, (1994) Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur J Immunol 24: 1828-1834.
    • (1994) Eur J Immunol , vol.24 , pp. 1828-1834
    • Heath, A.W.1    Wu, W.W.2    Howard, M.C.3
  • 42
    • 0030273141 scopus 로고    scopus 로고
    • The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching
    • Rolink A, Melchers F, Andersson J, (1996) The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity 5: 319-330.
    • (1996) Immunity , vol.5 , pp. 319-330
    • Rolink, A.1    Melchers, F.2    Andersson, J.3
  • 43
    • 0033835065 scopus 로고    scopus 로고
    • Fas engagement accelerates liver regeneration after partial hepatectomy
    • Desbarats J, Newell MK, (2000) Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med 6: 920-923.
    • (2000) Nat Med , vol.6 , pp. 920-923
    • Desbarats, J.1    Newell, M.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.