-
1
-
-
77953694980
-
Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges
-
Law CL, Grewal IS, (2009) Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges. Adv Exp Med Biol 647: 8-36.
-
(2009)
Adv Exp Med Biol
, vol.647
, pp. 8-36
-
-
Law, C.L.1
Grewal, I.S.2
-
2
-
-
70349148591
-
The Janus faces of CD40 in cancer
-
Loskog AS, Eliopoulos AG, (2009) The Janus faces of CD40 in cancer. Semin Immunol 21: 301-307.
-
(2009)
Semin Immunol
, vol.21
, pp. 301-307
-
-
Loskog, A.S.1
Eliopoulos, A.G.2
-
3
-
-
33947223664
-
Prospect of targeting the CD40 pathway for cancer therapy
-
Vonderheide RH, (2007) Prospect of targeting the CD40 pathway for cancer therapy. Clin Cancer Res 13: 1083-1088.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1083-1088
-
-
Vonderheide, R.H.1
-
4
-
-
70449522042
-
Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction
-
Margolles-Clark E, Umland O, Kenyon NS, Ricordi C, Buchwald P, (2009) Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction. J Mol Med 87: 1133-1143.
-
(2009)
J Mol Med
, vol.87
, pp. 1133-1143
-
-
Margolles-Clark, E.1
Umland, O.2
Kenyon, N.S.3
Ricordi, C.4
Buchwald, P.5
-
5
-
-
33644779799
-
Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse
-
Nanji SA, Hancock WW, Luo B, Schur CD, Pawlick RL, et al. (2006) Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse. Diabetes 55: 27-33.
-
(2006)
Diabetes
, vol.55
, pp. 27-33
-
-
Nanji, S.A.1
Hancock, W.W.2
Luo, B.3
Schur, C.D.4
Pawlick, R.L.5
-
6
-
-
68149156979
-
Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand
-
Wyzgol A, Muller N, Fick A, Munkel S, Grigoleit GU, et al. (2009) Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand. J Immunol 183: 1851-1861.
-
(2009)
J Immunol
, vol.183
, pp. 1851-1861
-
-
Wyzgol, A.1
Muller, N.2
Fick, A.3
Munkel, S.4
Grigoleit, G.U.5
-
7
-
-
0036326804
-
Participation of protease-activated receptor-1 in thrombin-induced microglial activation
-
Suo Z, Wu M, Ameenuddin S, Anderson HE, Zoloty JE, et al. (2002) Participation of protease-activated receptor-1 in thrombin-induced microglial activation. J Neurochem 80: 655-666.
-
(2002)
J Neurochem
, vol.80
, pp. 655-666
-
-
Suo, Z.1
Wu, M.2
Ameenuddin, S.3
Anderson, H.E.4
Zoloty, J.E.5
-
9
-
-
67349103904
-
The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes
-
Poggi M, Jager J, Paulmyer-Lacroix O, Peiretti F, Gremeaux T, et al. (2009) The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes. Diabetologia 52: 1152-1163.
-
(2009)
Diabetologia
, vol.52
, pp. 1152-1163
-
-
Poggi, M.1
Jager, J.2
Paulmyer-Lacroix, O.3
Peiretti, F.4
Gremeaux, T.5
-
10
-
-
67349266245
-
The co-evolution of our understanding of CD40 and inflammation
-
Wagner DH Jr, (2009) The co-evolution of our understanding of CD40 and inflammation. Diabetologia 52: 997-999.
-
(2009)
Diabetologia
, vol.52
, pp. 997-999
-
-
Wagner Jr., D.H.1
-
11
-
-
0033194297
-
Increased expression of CD40 on thymocytes and peripheral T cells in autoimmunity: a mechanism for acquiring changes in the peripheral T cell receptor repertoire
-
Wagner DH Jr, Newell E, Sanderson RJ, Freed JH, Newell MK, (1999) Increased expression of CD40 on thymocytes and peripheral T cells in autoimmunity: a mechanism for acquiring changes in the peripheral T cell receptor repertoire. Int J Mol Med 4: 231-242.
-
(1999)
Int J Mol Med
, vol.4
, pp. 231-242
-
-
Wagner Jr., D.H.1
Newell, E.2
Sanderson, R.J.3
Freed, J.H.4
Newell, M.K.5
-
12
-
-
0037133579
-
Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes
-
Wagner DH Jr, Vaitaitis G, Sanderson R, Poulin M, Dobbs C, et al. (2002) Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes. Proc Natl Acad Sci U S A 99: 3782-3787.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 3782-3787
-
-
Wagner Jr., D.H.1
Vaitaitis, G.2
Sanderson, R.3
Poulin, M.4
Dobbs, C.5
-
13
-
-
44349086299
-
High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity
-
Vaitaitis GM, Wagner DH Jr, (2008) High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity. PLoS One 3: e2076.
-
(2008)
PLoS One
, vol.3
-
-
Vaitaitis, G.M.1
Wagner Jr., D.H.2
-
14
-
-
2942752011
-
Peripheral CD4loCD40+ auto-aggressive T cell expansion during insulin-dependent diabetes mellitus
-
Waid DM, Vaitaitis GM, Wagner DH Jr, (2004) Peripheral CD4loCD40+ auto-aggressive T cell expansion during insulin-dependent diabetes mellitus. Eur J Immunol 34: 1488-1497.
-
(2004)
Eur J Immunol
, vol.34
, pp. 1488-1497
-
-
Waid, D.M.1
Vaitaitis, G.M.2
Wagner Jr., D.H.3
-
15
-
-
34447298600
-
A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes
-
Waid DM, Wagner RJ, Putnam A, Vaitaitis GM, Pennock ND, et al. (2007) A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes. Clin Immunol 124: 138-148.
-
(2007)
Clin Immunol
, vol.124
, pp. 138-148
-
-
Waid, D.M.1
Wagner, R.J.2
Putnam, A.3
Vaitaitis, G.M.4
Pennock, N.D.5
-
16
-
-
48649106615
-
Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes
-
Waid DM, Vaitaitis GM, Pennock ND, Wagner DH Jr, (2008) Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes. J Leukoc Biol 84: 431-439.
-
(2008)
J Leukoc Biol
, vol.84
, pp. 431-439
-
-
Waid, D.M.1
Vaitaitis, G.M.2
Pennock, N.D.3
Wagner Jr., D.H.4
-
17
-
-
77955424415
-
CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity
-
Vaitaitis GM, Wagner DH Jr, (2010) CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity. Mol Immunol 47: 2303-2313.
-
(2010)
Mol Immunol
, vol.47
, pp. 2303-2313
-
-
Vaitaitis, G.M.1
Wagner Jr., D.H.2
-
18
-
-
0031279105
-
CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice
-
Balasa B, Krahl T, Patstone G, Lee J, Tisch R, et al. (1997) CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J Immunol 159: 4620-4627.
-
(1997)
J Immunol
, vol.159
, pp. 4620-4627
-
-
Balasa, B.1
Krahl, T.2
Patstone, G.3
Lee, J.4
Tisch, R.5
-
19
-
-
54949106904
-
Mammalian glycosylation in immunity
-
Marth JD, Grewal PK, (2008) Mammalian glycosylation in immunity. Nat Rev Immunol 8: 874-887.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 874-887
-
-
Marth, J.D.1
Grewal, P.K.2
-
20
-
-
34547122512
-
Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis
-
Grigorian A, Lee SU, Tian W, Chen IJ, Gao G, et al. (2007) Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem 282: 20027-20035.
-
(2007)
J Biol Chem
, vol.282
, pp. 20027-20035
-
-
Grigorian, A.1
Lee, S.U.2
Tian, W.3
Chen, I.J.4
Gao, G.5
-
21
-
-
10344249912
-
N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells
-
Morgan R, Gao G, Pawling J, Dennis JW, Demetriou M, et al. (2004) N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells. J Immunol 173: 7200-7208.
-
(2004)
J Immunol
, vol.173
, pp. 7200-7208
-
-
Morgan, R.1
Gao, G.2
Pawling, J.3
Dennis, J.W.4
Demetriou, M.5
-
22
-
-
0035825644
-
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
-
Demetriou M, Granovsky M, Quaggin S, Dennis JW, (2001) Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 409: 733-739.
-
(2001)
Nature
, vol.409
, pp. 733-739
-
-
Demetriou, M.1
Granovsky, M.2
Quaggin, S.3
Dennis, J.W.4
-
23
-
-
36348954543
-
N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration
-
Lee SU, Grigorian A, Pawling J, Chen IJ, Gao G, et al. (2007) N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration. J Biol Chem 282: 33725-33734.
-
(2007)
J Biol Chem
, vol.282
, pp. 33725-33734
-
-
Lee, S.U.1
Grigorian, A.2
Pawling, J.3
Chen, I.J.4
Gao, G.5
-
24
-
-
70349526715
-
Galectins
-
Hoboken, New Jersey, John Wiley & Sons, Inc
-
Klyosov AA, Witczak ZJ, Platt D, (2008) Galectins. Hoboken, New Jersey John Wiley & Sons, Inc.
-
(2008)
-
-
Klyosov, A.A.1
Witczak, Z.J.2
Platt, D.3
-
25
-
-
0029900083
-
Expression of galectin-3 modulates T-cell growth and apoptosis
-
Yang RY, Hsu DK, Liu FT, (1996) Expression of galectin-3 modulates T-cell growth and apoptosis. Proc Natl Acad Sci U S A 93: 6737-6742.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 6737-6742
-
-
Yang, R.Y.1
Hsu, D.K.2
Liu, F.T.3
-
26
-
-
64249146003
-
Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis
-
Wang J, Lu ZH, Gabius HJ, Rohowsky-Kochan C, Ledeen RW, et al. (2009) Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J Immunol 182: 4036-4045.
-
(2009)
J Immunol
, vol.182
, pp. 4036-4045
-
-
Wang, J.1
Lu, Z.H.2
Gabius, H.J.3
Rohowsky-Kochan, C.4
Ledeen, R.W.5
-
27
-
-
30044434075
-
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
-
Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6: 1245-1252.
-
(2005)
Nat Immunol
, vol.6
, pp. 1245-1252
-
-
Zhu, C.1
Anderson, A.C.2
Schubart, A.3
Xiong, H.4
Imitola, J.5
-
28
-
-
70349245383
-
Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice
-
Chou FC, Shieh SJ, Sytwu HK, (2009) Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice. Eur J Immunol 39: 2403-2411.
-
(2009)
Eur J Immunol
, vol.39
, pp. 2403-2411
-
-
Chou, F.C.1
Shieh, S.J.2
Sytwu, H.K.3
-
29
-
-
80052673578
-
Galectin-9 regulates T helper cell function independently of Tim-3
-
Su EW, Bi S, Kane LP, (2010) Galectin-9 regulates T helper cell function independently of Tim-3. Glycobiology 21: 1258-1265.
-
(2010)
Glycobiology
, vol.21
, pp. 1258-1265
-
-
Su, E.W.1
Bi, S.2
Kane, L.P.3
-
30
-
-
50649121583
-
Solution structure of the integral human membrane protein VDAC-1 in detergent micelles
-
Hiller S, Garces RG, Malia TJ, Orekhov VY, Colombini M, et al. (2008) Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science 321: 1206-1210.
-
(2008)
Science
, vol.321
, pp. 1206-1210
-
-
Hiller, S.1
Garces, R.G.2
Malia, T.J.3
Orekhov, V.Y.4
Colombini, M.5
-
31
-
-
0022548222
-
Transient modulation and internalization of T4 antigen induced by phorbol esters
-
Hoxie JA, Matthews DM, Callahan KJ, Cassel DL, Cooper RA, (1986) Transient modulation and internalization of T4 antigen induced by phorbol esters. J Immunol 137: 1194-1201.
-
(1986)
J Immunol
, vol.137
, pp. 1194-1201
-
-
Hoxie, J.A.1
Matthews, D.M.2
Callahan, K.J.3
Cassel, D.L.4
Cooper, R.A.5
-
32
-
-
33846234751
-
A costimulatory function for T cell CD40
-
Munroe ME, Bishop GA, (2007) A costimulatory function for T cell CD40. J Immunol 178: 671-682.
-
(2007)
J Immunol
, vol.178
, pp. 671-682
-
-
Munroe, M.E.1
Bishop, G.A.2
-
33
-
-
56549110891
-
CD40 on NOD CD4 T cells contributes to their activation and pathogenicity
-
Baker RL, Wagner DH Jr, Haskins K, (2008) CD40 on NOD CD4 T cells contributes to their activation and pathogenicity. J Autoimmun 31: 385-392.
-
(2008)
J Autoimmun
, vol.31
, pp. 385-392
-
-
Baker, R.L.1
Wagner Jr., D.H.2
Haskins, K.3
-
34
-
-
34547683228
-
CD40-mediated enhancement of immune responses against three forms of influenza vaccine
-
Hatzifoti C, Heath AW, (2007) CD40-mediated enhancement of immune responses against three forms of influenza vaccine. Immunology 122: 98-106.
-
(2007)
Immunology
, vol.122
, pp. 98-106
-
-
Hatzifoti, C.1
Heath, A.W.2
-
35
-
-
33645240780
-
Antibodies against cell surface antigens as very potent immunological adjuvants
-
Barr T, Carlring J, Hatzifoti C, Heath AW, (2006) Antibodies against cell surface antigens as very potent immunological adjuvants. Vaccine 24 (Suppl 2): S2-20-21.
-
(2006)
Vaccine
, vol.24
, Issue.SUPPL. 2
, pp. 20-21
-
-
Barr, T.1
Carlring, J.2
Hatzifoti, C.3
Heath, A.W.4
-
36
-
-
4043086357
-
CD40 antibody as an adjuvant induces enhanced T cell responses
-
Carlring J, Barr TA, McCormick AL, Heath AW, (2004) CD40 antibody as an adjuvant induces enhanced T cell responses. Vaccine 22: 3323-3328.
-
(2004)
Vaccine
, vol.22
, pp. 3323-3328
-
-
Carlring, J.1
Barr, T.A.2
McCormick, A.L.3
Heath, A.W.4
-
37
-
-
27544481941
-
A function for interleukin 2 in Foxp3-expressing regulatory T cells
-
Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY, (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6: 1142-1151.
-
(2005)
Nat Immunol
, vol.6
, pp. 1142-1151
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Gavin, M.A.3
Rudensky, A.Y.4
-
38
-
-
33947207868
-
Re-shaping the T cell repertoire: TCR editing and TCR revision for good and for bad
-
Wagner DH Jr, (2007) Re-shaping the T cell repertoire: TCR editing and TCR revision for good and for bad. Clin Immunol 123: 1-6.
-
(2007)
Clin Immunol
, vol.123
, pp. 1-6
-
-
Wagner Jr., D.H.1
-
39
-
-
67649958050
-
Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation
-
Niwa H, Satoh T, Matsushima Y, Hosoya K, Saeki K, et al. (2009) Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation. Clin Immunol 132: 184-194.
-
(2009)
Clin Immunol
, vol.132
, pp. 184-194
-
-
Niwa, H.1
Satoh, T.2
Matsushima, Y.3
Hosoya, K.4
Saeki, K.5
-
40
-
-
40849120400
-
Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis
-
Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, et al. (2008) Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol 127: 78-88.
-
(2008)
Clin Immunol
, vol.127
, pp. 78-88
-
-
Seki, M.1
Oomizu, S.2
Sakata, K.M.3
Sakata, A.4
Arikawa, T.5
-
41
-
-
0028041170
-
Monoclonal antibodies to murine CD40 define two distinct functional epitopes
-
Heath AW, Wu WW, Howard MC, (1994) Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur J Immunol 24: 1828-1834.
-
(1994)
Eur J Immunol
, vol.24
, pp. 1828-1834
-
-
Heath, A.W.1
Wu, W.W.2
Howard, M.C.3
-
42
-
-
0030273141
-
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching
-
Rolink A, Melchers F, Andersson J, (1996) The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity 5: 319-330.
-
(1996)
Immunity
, vol.5
, pp. 319-330
-
-
Rolink, A.1
Melchers, F.2
Andersson, J.3
-
43
-
-
0033835065
-
Fas engagement accelerates liver regeneration after partial hepatectomy
-
Desbarats J, Newell MK, (2000) Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med 6: 920-923.
-
(2000)
Nat Med
, vol.6
, pp. 920-923
-
-
Desbarats, J.1
Newell, M.K.2
|