The ROS scavenger, NAC, regulates hepatic Vα14iNKT cells signaling during Fas mAB-dependent fulminant liver failure

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Downs, Isaac ^a   Liu, Jianfeng ^a   Aw, Tak Yee ^a   Adegboyega, Patrick A ^b   Ajuebor, Maureen N ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Louisiana State University Health Sciences Center at Shreveport   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ACETYLCYSTEINE; FAS ANTIBODY; GAMMA INTERFERON; GLUTATHIONE; MONOCLONAL ANTIBODY; REACTIVE OXYGEN METABOLITE; SCAVENGER; FAS LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE COURSE; DRUG MECHANISM; FULMINANT HEPATIC FAILURE; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INFLAMMATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; ACUTE LIVER FAILURE; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; LIVER; METABOLISM; MOUSE MUTANT; NATURAL KILLER T CELL; NICK END LABELING; PHYSIOLOGY; WESTERN BLOTTING;

MUS;

ACETYLCYSTEINE; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; BLOTTING, WESTERN; FAS LIGAND PROTEIN; FLOW CYTOMETRY; FREE RADICAL SCAVENGERS; GLUTATHIONE; IN SITU NICK-END LABELING; INTERFERON-GAMMA; LIVER; LIVER FAILURE, ACUTE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NATURAL KILLER T-CELLS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84862005995     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038051     Document Type: Article

References (57)

1. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, et al. (1993) Lethal effect of the anti-Fas antibody in mice. Nature 364: 806-809.
2. Song E, Lee SK, Wang J, Ince N, Ouyang N, et al. (2003) RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 9: 347-351.
3. Ryo K, Kamogawa Y, Ikeda I, Yamauchi K, Yonehara S, et al. (2000) Significance of Fas antigen-mediated apoptosis in human fulminant hepatic failure. Am J Gastroenterol 95: 2047-2055.
4. Chiba A, Dascher CC, Besra GS, Brenner MB, (2008) Rapid NKT cell responses are self-terminating during the course of microbial infection. J Immunol 181: 2292-2302.
5. Ajuebor MN, Chen Q, Strieter RM, Adegboyega PA, Aw TY, (2010) V(alpha)14iNKT cells promote liver pathology during adenovirus infection by inducing CCL5 production: implications for gene therapy. J Virol 84: 8520-8529.
6. Faouzi S, Burckhardt BE, Hanson JC, Campe CB, Schrum LW, et al. (2001) Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. J Biol Chem 276: 49077-49082.
7. Matute-Bello G, Winn RK, Jonas M, Chi EY, Martin TR, et al. (2001) Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Am J Pathol 158: 153-161.
8. Rensing-Ehl A, Hess S, Ziegler-Heitbrock HW, Riethmuller G, Engelmann H, (1995) Fas/Apo-1 activates nuclear factor kappa B and induces interleukin-6 production. J Inflamm 45: 161-174.
9. Saas P, Boucraut J, Quiquerez AL, Schnuriger V, Perrin G, et al. (1999) CD95 (Fas/Apo-1) as a receptor governing astrocyte apoptotic or inflammatory responses: a key role in brain inflammation? J Immunol 162: 2326-2333.
10. Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ, Van Kaer L, (2004) NKT cells: what's in a name? Nat Rev Immunol 4: 231-237.
11. Gumperz JE, Roy C, Makowska A, Lum D, Sugita M, et al. (2000) Murine CD1d-restricted T cell recognition of cellular lipids. Immunity 12: 211-221.
12. Brutkiewicz RR, (2006) CD1d ligands: the good, the bad, and the ugly. J Immunol 177: 769-775.
13. Porubsky S, Speak AO, Luckow B, Cerundolo V, Platt FM, et al. (2007) From the Cover: Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci U S A 104: 5977-5982.
14. Speak AO, Salio M, Neville DC, Fontaine J, Priestman DA, et al. (2007) Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals. Proc Natl Acad Sci U S A 104: 5971-5976.
15. Matsuda JL, Naidenko OV, Gapin L, Nakayama T, Taniguchi M, et al. (2000) Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med 192: 741-754.
16. Ajuebor MN, Aspinall AI, Zhou F, Le T, Yang Y, et al. (2005) Lack of Chemokine Receptor CCR5 Promotes Murine Fulminant Liver Failure by Preventing the Apoptosis of Activated CD1d-Restricted NKT Cells. J Immunol 174: 8027-8037.
17. Matsuda JL, Mallevaey T, Scott-Browne J, Gapin L, (2008) CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system. Curr Opin Immunol 20: 358-368.
18. Tyznik AJ, Tupin E, Nagarajan NA, Her MJ, Benedict CA, et al. (2008) Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. J Immunol 181: 4452-4456.
19. Nagarajan NA, Kronenberg M, (2007) Invariant NKT cells amplify the innate immune response to lipopolysaccharide. J Immunol 178: 2706-2713.
20. Gardner TR, Chen Q, Jin Y, Ajuebor MN, (2010) Toll-Like Receptor 3 Ligand Dampens Liver Inflammation by Stimulating V{alpha}14 Invariant Natural Killer T Cells to Negatively Regulate {gamma}{delta}T Cells. Am J Pathol 176: 1779-1789.
21. Johansson S, Berg L, Hall H, Hoglund P, (2005) NK cells: elusive players in autoimmunity. Trends Immunol 26: 613-618.
22. Carnaud C, Lee D, Donnars O, Park SH, Beavis A, et al. (1999) Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol 163: 4647-4650.
23. Ajuebor MN, Wondimu Z, Hogaboam CM, Le T, Proudfoot AE, et al. (2007) CCR5 deficiency drives enhanced natural killer cell trafficking to and activation within the liver in murine T cell-mediated hepatitis. Am J Pathol 170: 1975-1988.
24. Taniguchi M, Seino K, Nakayama T, (2003) The NKT cell system: bridging innate and acquired immunity. Nat Immunol 4: 1164-1165.
25. Van Kaer L, (2005) alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles. Nat Rev Immunol 5: 31-42.
26. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB, (2003) Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol 4: 1230-1237.
27. Cui J, Shin T, Kawano T, Sato H, Kondo E, et al. (1997) Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science 278: 1623-1626.
28. Wang X, Lu Y, Cederbaum AI, (2005) Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice. Hepatology 42: 400-410.
29. Cazanave S, Vadrot N, Tinel M, Berson A, Letteron P, et al. (2008) Ibuprofen administration attenuates serum TNF-alpha levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation. Toxicol Appl Pharmacol 231: 336-343.
30. Cazanave S, Berson A, Haouzi D, Vadrot N, Fau D, et al. (2007) High hepatic glutathione stores alleviate Fas-induced apoptosis in mice. J Hepatol 46: 858-868.
31. Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA, (2007) N-Acetylcysteine-a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol 7: 355-359.
32. Reed DJ, Babson JR, Beatty PW, Brodie AE, Ellis WW, et al. (1980) High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal Biochem 106: 55-62.
33. Okouchi M, Okayama N, Aw TY, (2005) Hyperglycemia potentiates carbonyl stress-induced apoptosis in naive PC-12 cells: relationship to cellular redox and activator protease factor-1 expression. Curr Neurovasc Res 2: 375-386.
34. Okouchi M, Okayama N, Aw TY, (2005) Differential susceptibility of naive and differentiated PC-12 cells to methylglyoxal-induced apoptosis: influence of cellular redox. Curr Neurovasc Res 2: 13-22.
35. Ajuebor MN, Jin Y, Gremillion GL, Strieter RM, Chen Q, et al. (2008) GammadeltaT cells initiate acute inflammation and injury in adenovirus-infected liver via cytokine-chemokine cross talk. J Virol 82: 9564-9576.
36. Haouzi D, Lekehal M, Tinel M, Vadrot N, Caussanel L, et al. (2001) Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice. Hepatology 33: 1181-1188.
37. Minagawa M, Deng Q, Liu ZX, Tsukamoto H, Dennert G, (2004) Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology 126: 1387-1399.
38. Taieb J, Mathurin P, Poynard T, Gougerot-Pocidalo MA, Chollet-Martin S, (1998) Raised plasma soluble Fas and Fas-ligand in alcoholic liver disease. Lancet 351: 1930-1931.
39. Crowe NY, Uldrich AP, Kyparissoudis K, Hammond KJ, Hayakawa Y, et al. (2003) Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol 171: 4020-4027.
40. Wesley JD, Tessmer MS, Chaukos D, Brossay L, (2008) NK cell-like behavior of Valpha14i NK T cells during MCMV infection. PLoS Pathog 4: e1000106.
41. Seino K, Taniguchi M, (2004) Functional roles of NKT cell in the immune system. Front Biosci 9: 2577-2587.
42. Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, et al. (2003) Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A 100: 8395-8400.
43. Matsuda JL, Gapin L, Fazilleau N, Warren K, Naidenko OV, et al. (2001) Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc Natl Acad Sci U S A 98: 12636-12641.
44. Kinjo Y, Wu D, Kim G, Xing GW, Poles MA, et al. (2005) Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434: 520-525.
45. Kinjo Y, Tupin E, Wu D, Fujio M, Garcia-Navarro R, et al. (2006) Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol 7: 978-986.
46. Schroder K, Hertzog PJ, Ravasi T, Hume DA, (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75: 163-189.
47. Sironi JJ, Ouchi T, (2004) STAT1-induced apoptosis is mediated by caspases 2, 3, and 7. J Biol Chem 279: 4066-4074.
48. Cobb D, Hambright D, Smeltz RB T-bet-independent effects of IL-12 family cytokines on regulation of Th17 responses to experimental T. cruzi infection. J Leukoc Biol 88: 965-971.
49. Robinson RT, Wang J, Cripps JG, Milks MW, English KA, et al. (2009) End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-γ but independent of Fas. J Immunol 182: 3278-3284.
50. Ding WX, Ni HM, DiFrancesca D, Stolz DB, Yin XM, (2004) Bid-dependent generation of oxygen radicals promotes death receptor activation-induced apoptosis in murine hepatocytes. Hepatology 40: 403-413.
51. Malassagne B, Ferret PJ, Hammoud R, Tulliez M, Bedda S, et al. (2001) The superoxide dismutase mimetic MnTBAP prevents Fas-induced acute liver failure in the mouse. Gastroenterology 121: 1451-1459.
52. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ, et al. (2000) The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. J Biol Chem 275: 11814-11823.
53. Musallam L, Ethier C, Haddad PS, Denizeau F, Bilodeau M, (2002) Resistance to Fas-induced apoptosis in hepatocytes: role of GSH depletion by cell isolation and culture. Am J Physiol Gastrointest Liver Physiol 283: G709-718.
54. van den Dobbelsteen DJ, Nobel CS, Schlegel J, Cotgreave IA, Orrenius S, et al. (1996) Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J Biol Chem 271: 15420-15427.
55. Hobbs JA, Cho S, Roberts TJ, Sriram V, Zhang J, et al. (2001) Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus. J Virol 75: 10746-10754.
56. Wilson MT, Johansson C, Olivares-Villagomez D, Singh AK, Stanic AK, et al. (2003) The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc Natl Acad Sci U S A 100: 10913-10918.
57. Harada M, Seino K, Wakao H, Sakata S, Ishizuka Y, et al. (2004) Down-regulation of the invariant Valpha14 antigen receptor in NKT cells upon activation. Int Immunol 16: 241-247.