Ibuprofen administration attenuates serum TNF-α levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation

Toxicology and Applied Pharmacology

Volumn 231, Issue 3, 2008, Pages 336-343

  Cazanave, Sophie ^a,b   Vadrot, Nathalie ^a,b   Tinel, Marina ^a,b   Berson, Alain ^a,b   Lettéron, Philippe ^a,b   Larosche, Isabelle ^a,b   Descatoire, Véronique ^a,b   Feldmann, Gérard ^a,b   Robin, Marie Anne ^a,b   Pessayre, Dominique ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Apoptosis; Cyclooxygenase 1 inhibitor; Cyclooxygenase 2 inhibitor; Fas; Ibuprofen; Liver; Mitochondria; Tumor necrosis factor

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ALANINE AMINOTRANSFERASE; CASPASE; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; FAS ANTIBODY; FAS ANTIGEN; GLUTATHIONE; IBUPROFEN; INFLIXIMAB; JO2 ANTIBODY; MYELOPEROXIDASE; NONSTEROID ANTIINFLAMMATORY AGENT; PENTOXIFYLLINE; PROTEIN BID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNOSTIMULATION; LIVER CELL; LIVER INJURY; MACROPHAGE ACTIVATION; MALE; MEMBRANE RUPTURE; MITOCHONDRIAL MEMBRANE; MORTALITY; MOUSE; NEUTROPHIL; NONHUMAN;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; GLUTATHIONE; HEPATITIS; HEPATOCYTES; IBUPROFEN; MALE; MICE; MICE, INBRED ICR; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MUS;

EID: 51049093792     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.05.010     Document Type: Article

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