Management of severe hypertriglyceridemia in the hospital: A review

Journal of Hospital Medicine

Volumn 7, Issue 5, 2012, Pages 431-438

  Schaefer, Eric W ^a   Leung, Alicia ^a   Kravarusic, Jelena ^a   Stone, Neil J ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FENOFIBRATE; HEMOGLOBIN A1C; INSULIN; LIPOPROTEIN LIPASE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OMEGA 3 ACID ETHYL ESTER; PREDNISONE; RAPAMYCIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ABDOMINAL PAIN; ALCOHOL CONSUMPTION; CANCER REGRESSION; CLINICAL ASSESSMENT; DIABETES MELLITUS; DIARRHEA; DIET RESTRICTION; DISEASE SEVERITY; FAMILY HISTORY; GRAFT VERSUS HOST REACTION; HOSPITALIZATION; HUMAN; HYPERTRIGLYCERIDEMIA; IMMUNOSUPPRESSIVE TREATMENT; LIFESTYLE MODIFICATION; MYELOID LEUKEMIA; PANCREATITIS; PATIENT COMPLIANCE; PATIENT COUNSELING; PHYSICAL EXAMINATION; PLASMAPHERESIS; PRIORITY JOURNAL; REVIEW; RISK; STEM CELL TRANSPLANTATION; TOTAL PARENTERAL NUTRITION; TRIACYLGLYCEROL BLOOD LEVEL;

DISEASE MANAGEMENT; FEMALE; HOSPITALIZATION; HUMANS; HYPERTRIGLYCERIDEMIA; MIDDLE AGED; SEVERITY OF ILLNESS INDEX;

EID: 84861967839     PISSN: 15535592     EISSN: 15535606     Source Type: Journal    
DOI: 10.1002/jhm.995     Document Type: Review

References (45)

1. Hodis HN, Mack WJ, Krauss RM, Alaupovic P. Pathophysiology of triglyceride-rich lipoproteins in atherothrombosis: clinical aspects. Clin Cardiol. 1999; 22: II15-II20.
2. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001; 285: 2486-2497.
3. Brunzell JD, Bierman EL. Chylomicronemia syndrome. Interaction of genetic and acquired hypertriglyceridemia. Med Clin North Am. 1982; 66: 455-468.
4. Miller M, Stone NJ, Ballantyne C, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011; 123: 2292-2333.
5. Brunzell JD. Familial lipoprotein lipase deficiency and other causes of the chylomicronemia syndrome. In: Scriver C, Beaudet A, Sly W, Valle D, eds. The Metabolic and Molecular Basis of Inherited Disease. 7th ed. New York: McGraw-Hill; 1995: 1913-1932.
6. Yuan G, Al-Shali KZ, Hegele RA. Hypertriglyceridemia: its etiology, effects and treatment. CMAJ. 2007; 176: 1113-1120.
7. Beigneux AP, Franssen R, Bensadoun A, et al. Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arterioscler Thromb Vasc Biol. 2009; 29: 956-962.
8. Ma Y, Henderson HE, Murthy V, et al. A mutation in the human lipoprotein lipase gene as the most common cause of familial chylomicronemia in French Canadians. N Engl J Med. 1991; 324: 1761-1766.
9. Priore Oliva C, Pisciotta L, Li Volti G, et al. Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2005; 25: 411-417.
10. Hegele RA, Ban MR, Hsueh N, et al. A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia. Hum Mol Genet. 2009; 18: 4189-4194.
11. Stone NJ. Secondary causes of hyperlipidemia. Med Clin North Am. 1994; 78: 117-141.
12. Sniderman AD, Scantlebury T, Cianflone K. Hypertriglyceridemic hyperapob: the unappreciated atherogenic dyslipoproteinemia in type 2 diabetes mellitus. Ann Intern Med. 2001; 135: 447-459.
13. Toskes PP. Hyperlipidemic pancreatitis. Gastroenterol Clin North Am. 1990; 19: 783-791.
14. Scoppola A, Testa G, Frontoni S, et al. Effects of insulin on cholesterol synthesis in type II diabetes patients. Diabetes Care. 1995; 18: 1362-1369.
15. Parker F, Bagdade JD, Odland GF, Bierman EL. Evidence for the chylomicron origin of lipids accumulating in diabetic eruptive xanthomas: a correlative lipid biochemical, histochemical, and electron microscopic study. J Clin Invest. 1970; 49: 2172-2187.
16. Durrington P. Dyslipidaemia. Lancet. 2003; 362: 717-731.
17. Leaf DA, Illingworth DR, Connor WE. Lymphadenopathy associated with severe hypertriglyceridemia. JAMA. 1990; 264: 727-728.
18. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010; 33(suppl 1): S62-S69.
19. Howard JM, Reed J. Pseudohyponatremia in acute hyperlipemic pancreatitis. A potential pitfall in therapy. Arch Surg. 1985; 120: 1053-1055.
20. Fallat RW, Vester JW, Glueck CJ. Suppression of amylase activity by hypertriglyceridemia. JAMA. 1973; 225: 1331-1334.
21. Anderson F, Thomson SR, Clarke DL, Buccimazza I. Dyslipidaemic pancreatitis clinical assessment and analysis of disease severity and outcomes. Pancreatology. 2009; 9: 252-257.
22. Havel RJ. Pathogenesis, differentiation and management of hypertriglyceridemia. Adv Intern Med. 1969; 15: 117-154.
23. Kimura W, Mossner J. Role of hypertriglyceridemia in the pathogenesis of experimental acute pancreatitis in rats. Int J Pancreatol. 1996; 20: 177-184.
24. Lloret Linares C, Pelletier AL, Czernichow S, et al. Acute pancreatitis in a cohort of 129 patients referred for severe hypertriglyceridemia. Pancreas. 2008; 37: 13-12.
25. Meier R, Ockenga J, Pertkiewicz M, et al. ESPEN Guidelines on Enteral Nutrition: pancreas. Clin Nutr. 2006; 25: 275-284.
26. Rouis M, Dugi KA, Previato L, et al. Therapeutic response to medium-chain triglycerides and omega-3 fatty acids in a patient with the familial chylomicronemia syndrome. Arterioscler Thromb Vasc Biol. 1997; 17: 1400-1406.
27. Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation. 1998; 98: 2088-2093.
28. Neuvonen PJ, Niemi M, Backman JT. Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006; 80: 565-81.
29. Harris WS, Ginsberg HN, Arunakul N, et al. Safety and efficacy of Omacor in severe hypertriglyceridemia. J Cardiovasc Risk. 1997; 4: 385-391.
30. Wierzbicki AS, Reynolds TM, Crook MA. Usefulness of Orlistat in the treatment of severe hypertriglyceridemia. Am J Cardiol. 2002; 89: 229-231.
31. Otokozawa S, Ai M, Van Himbergen T, et al. Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levels. Atherosclerosis. 2009; 205: 197-201.
32. McKenney JM, Davidson MH, Jacobson TA, Guyton JR. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. Am J Cardiol. 2006; 97: 89C-94C.
33. Eckel RH. Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases. N Engl J Med. 1989; 320: 1060-1068.
34. Jabbar MA, Zuhri-Yafi MI, Larrea J. Insulin therapy for a non-diabetic patient with severe hypertriglyceridemia. J Am Coll Nutr. 1998; 17: 458-461.
35. Mikhail N, Trivedi K, Page C, Wali S, Cope D. Treatment of severe hypertriglyceridemia in nondiabetic patients with insulin. Am J Emerg Med. 2005; 23: 415-417.
36. Loo CC, Tan JY. Decreasing the plasma triglyceride level in hypertriglyceridemia-induced pancreatitis in pregnancy: a case report. Am J Obstet Gynecol. 2002; 187: 241-242.
37. Sharma P, Lim S, James D, Orchard RT, Horne M, Seymour CA. Pancreatitis may occur with a normal amylase concentration in hypertriglyceridaemia. BMJ. 1996; 313: 1265.
38. Nasstrom B, Olivecrona G, Olivecrona T, Stegmayr BG. Lipoprotein lipase during continuous heparin infusion: tissue stores become partially depleted. J Lab Clin Med. 2001; 138: 206-13.
39. Betteridge DJ, Bakowski M, Taylor KG, Reckless JP, de Silva SR, Galton DJ. Treatment of severe diabetic hypertriglyceridaemia by plasma exchange. Lancet. 1978; 1: 1368.
40. Chen JH, Yeh JH, Lai HW, Liao CS. Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis. World J Gastroenterol. 2004; 10: 2272-2274.
41. Kadikoylu G, Yavasoglu I, Bolaman Z. Plasma exchange in severe hypertriglyceridemia a clinical study. Transfus Apher Sci. 2006; 34: 253-257.
42. Kyriakidis AV, Raitsiou B, Sakagianni A, et al. Management of acute severe hyperlipidemic pancreatitis. Digestion. 2006; 73: 259-264.
43. Tsuang W, Navaneethan U, Ruiz L, Palascak JB, Gelrud A. Hypertriglyceridemic pancreatitis: presentation and management. Am J Gastroenterol. 2009; 104: 984-991.
44. Szczepiorkowski ZM, Winters JL, Bandarenko N, et al. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis. J Clin Apher. 2010; 25: 83-177.
45. Gerhard GT, Ahmann A, Meeuws K, McMurry MP, Duell PB, Connor WE. Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes. Am J Clin Nutr. 2004; 80: 668-673.