Role of hypertriglyceridemia in the pathogenesis of experimental acute pancreatitis in rats

International Journal of Pancreatology

Volumn 20, Issue 3, 1996, Pages 177-184

  Kimura, Wataru ^b   Mössner, Joachim ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

acute pancreatitis; hyperlipidemia; Isolated perfused pancreas; pancreatic duct hypertension; sodium taurocholate

Indexed keywords

TAUROCHOLIC ACID; TRIACYLGLYCEROL;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ENZYME ACTIVITY; HISTOPATHOLOGY; HYPERTRIGLYCERIDEMIA; LIPOLYSIS; MALE; NONHUMAN; PANCREAS BIOPSY; PATHOGENESIS; PRIORITY JOURNAL; RAT;

EID: 0030472154     PISSN: 01694197     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02803766     Document Type: Article

References (49)

1. Opie EL. The etiology of acute hemorragic pancreatitis. Bull Johns Hopkins Hosp 1901; 12: 182-192.
2. Acosta JM, Ledesma CL. Gallstone migration as a cause of acute pancreatitis. N Engl J Med 1974; 290: 484-487.
3. Harvey MH, Cates MC, Reber HA. Possible mechanisms of acute pancreatitis induced by ethanol. Am J Surg 1988; 155: 49-56.
4. Malagelada J-R. The pathophysiology of alcoholic pancreatitis. Pancreas 1986; 1: 270-278.
5. Geokas MC, Baltaxe HA, Banks PA, Silva J Jr, Frey CF. Acute pancreatitis. Davis conference. Ann Int Med 1985; 103: 86-100.
6. Adler G. Kern HF, Scheele GA. Experimental models and concepts in acute pancreatitis, in: The Exocrine Pancreas: Biology, Pathobiology, and Diseases. Go VLW, Gardner JD, Brooks FP, Lebenthal E, DiMagno EP, Scheele GA, eds. Raven, New York, 1986; pp. 407-421.
7. Niederau C, Liddle RA, Ferrell LD, Grendell JH. Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. J Clin Invest 1986; 78: 1056-1063.
8. Guice KS, Miller DE, Oldham KT, Townsend CM Jr, Thompson JC. Superoxide dismutase and catalase: a possible role in established pancreatitis. Am J Surg 1986; 151: 163-169.
9. Rutledge PL, Saluja AK, Powers RE, Steer ML. Role of oxygen-derived free radicals in diet-induced hemorrhagic pancreatitis in mice. Gastroenterology 1987; 93: 41-47.
10. Closa D, Hotter G, Bulbena O, Gelpi E, Roselló-Catafau J. Calcium channel blockers in experimental acute pancreatitis: effect of tissue prostanoids and oxygen free radicals. Pancreas 1996; 12: 178-182.
11. Ito T, Nakao A, Kishimoto W, Nakano M, Takagi H. The involvement and sources of active oxygen in experimentally induced acute pancreatitis. Pancreas 1996; 12: 173-177.
12. Peralta J, Reides C, Garcia S, Llesuy S, Pargament G, Carreras MC, Catz S, Poderoso JJ. Oxidative stress in rodent closed duodenal loop pancreatitis. Int J Pancreatol 1996; 19: 61-69.
13. Wedgwood KR, Farmer RC, Reber HA. A model of hemorrhagic pancreatitis in cats. Role of 16, 16-Dimethylprostaglandin E2. Gastroenterology 1986; 90: 32-39.
14. Chiari H. Über Selbstverdauung des menschlichen Pankreas. Z Heilk 1896; 17: 69-96.
15. Rinderknecht H. Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation. Dig Dis Sci 1986; 31: 314-321.
16. Odaira C, Berger Z, Iovanna JL, Sarles H. Localized necrohemorrhagic pancreatitis in the rat after pancreatic interstitial trypsin injection. Regressive pseudochronic lesions. Digestion 1986; 34: 68-77.
17. Yamaguchi H, Kimura T, Mimura K, Nawata H. Activation of proteases in caerulein-induced pancreatitis. Pancreas 1989; 4: 565-571.
18. Leach SD, Modlin IM, Scheele GA, Gorelick FS. Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin. J Clin Invest 1991; 87: 356-366.
19. Bialek R, Willemer S, Arnold R, Adler G. Evidence of intracellular activation of serine proteases in acute caerulein-induced pancreatitis in rats. Scand J Gastroenterol 1991; 26: 190-196.
20. Nakae Y, Naruse S, Kitagawa M, Hirao S, Yamamoto R, Hayakawa T. Activation of trypsinogen in experimental models of acute pancreatitis. Pancreas 1995; 10: 306-313.
21. Steer ML, Meldolesi J, Figarella C. Pancreatitis: The role of lysosomes. Dig Dis Sci 1984; 29: 934-938.
22. Koike H, Steer ML, Meldolesi J. Pancreatic effects of ethionine. Blockade of exocytosis and appearance of crinophagy precede cellular necrosis. Am J Physiol 1982; 242: G297-G307.
23. Niederau C, Grendell JH. Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment. J Clin Invest 1988; 81: 229-236.
24. Greenbaum LM, Hischkowitz A, Shoichet I. The activation of trypsinogen by cathepsin B. J Biol Chem 1959; 234: 2885-2890.
25. Figarella C, Misczuk-Jamska B, Barrett AJ. Possible lysosomal activation of pancreatic zymogens. Biol Chem Hoppe Seyler 1988; 369 (Suppl): 293-298.
26. Lerch MM, Saluja AK, Dawra R, Saluja M, Steer ML. The effect of chloroquine administration on two experimental models of acute pancreatitis. Gastroenterology 1993; 104: 1768-1779.
27. Blackstone MO. Acinar-cell or interstitial space: where is pancreatitis initiated? N Engl J Med 1987; 317: 319,320.
28. Schmidt H, Creutzfeldt W. The possible role of phospholipase A in the pathogenesis of acute pancreatitis. Scand J Gastroenterol 1969; 4: 39-48.
29. Nevalainen TJ. The role of phospholipase A2 in acute pancreatitis. Scand J Gastroenterol 1980; 15: 641-650.
30. Kloppel G, Dreyer T, Willemer S, Kem HF, Adler G. Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells. Virchows Arch Pathol Anat 1986; 409: 791-803.
31. Nagai H, Henrich H, Wünsch PH, Fischbach W, Mössner J. Role of pancreatic enzymes and their substrates in autodigestion of the pancreas - In vitro studies with isolated rat pancreatic acini. Gastroenterology 1989; 96: 838-847.
32. Kimura W, Secknus R, Fischbach WC, Mössner J. Role of phospholipase A2 in pancreatic acinar cell damage and possibilities of inhibition. Studies with isolated rat pancreatic acini. Pancreas 1992; 8: 70-79.
33. Kimura W, Meyer F, Hess D, Kirchner Th, Fischbach W, Mössner J. Comparison of different treatment modalities in experimental pancreatitis: Inhibition of proteases, inhibition of lipase, albumin. Gastroenterology 1992; 103: 1916-1924.
34. Mössner J, Bödeker H, Kimura W, Secknus R, Pusch B, Meyer F, Fischbach W. Potential role of lipase in the pathogenesis of acinar cell destruction. Int J Pancreatol 1992; 12: 285-296.
35. Rünzi M, Saluja A, Lerch MM, Dawra R, Nishino H, Steer ML. Early ductal decompression prevents the progression of biliary pancreatitis: an experimental study in the opossum. Gastroenterology 1993; 105: 157-164.
36. Neoptolemos JP, Carr-Locke DL, London N, Bailey I, James D, Fossard DP. Results of a prospective randomized trial of ERCP and endoscopic sphincterotomy (ES) in acute pancreatitis due to gallstones. Gut 1988; 29: 266-272.
37. Fan S-T, Lai ECS, Mok FPT, Lo C-M, Zheng S-S, Wong J. Early treatment of acute biliary pancreatitis by endoscopic papillotomy. N Engl J Med 1993; 328: 228-232.
38. Dumont AK, Martelli AB. Pathogenesis of pancreatic edema following exocrine duct obstruction. Ann Surg 1968; 168: 302-307.
39. Farmer RC, Tweedie J, Maslin S, Reber HA, Adler G, Kern H. Effects of bile salts on permeability and morphology of main pancreatic duct in cats. Dig Dis Sci 1984; 29: 740-751.
40. Lankisch PG, Ihse I. Bile-induced acute experimental pancreatitis. Scand J Gastroenterol 1987; 22: 257-260.
41. Müller MK, Kessel B, Hütt T, Kath R, Layer P, Goebell H. Effects of somatostatin-14 on gastric and pancreatic responses to hormonal and neural stimulation using an isolated perfused rat stomach and pancreas preparation. Pancreas 1988; 3: 303-310.
42. Creutzleldt W, Schmidt H. Aetiology and pathogenesis of pancreatitis. Scand J Gastroenterol 1970; 5 (Suppl 6): 47-62.
43. Saharia P, Margolis S, Zuidema GD, Cameron JL. Acute pancreatitis with hyperlipidemia: Studies with an isolated perfused canine pancreas. Surgery 1977; 82: 60-67.
44. Lee PC, Nakashima Y, Appert HE, Howard JM. Lipase and colipase in canine pancreatic juice as etiologic factors in fat necrosis. Surg Gynecol Obstet 1979; 148: 39-44.
45. 2 lecithin mixtures, and its relevance to the pathogenesis of acute necrotising pancreatitis. Clin Chim Acta 1985; 150: 151-163.
46. Klöppel G, Dreyer T, Willemer S, Kern HF, Adler G. Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells. Virchows Arch Pathol Anat 1986; 409: 791-803.
47. Arnesjö B. The formation of lysolecithin in rat pancreas after experimentally induced bile salt pancreatitis. Acta Chir Scand 1971; 137: 351-354.
48. Meyer F, Kimura W, Marczok V, Pusch B, Fischbach W, Mössner J. Stimulus secretion coupling and regeneration in various animal models of acute pancreatitis. Eur J Gastroenterol Hepatol 1993; 5: 275-282.
49. Lerch MM, Saluja AK, Dawra R, Saluja M, Steer ML. The effect of chloroquine administration on two experimental models of acute pancreatitis. Gastroenterology 1993; 104: 1768-1779.