Alveolar macrophages in diabetes: Friends or foes?

Journal of Leukocyte Biology

Volumn 91, Issue 6, 2012, Pages 871-876

  Sunahara, Karen K S ^a   Martins, Joilson O ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Adaptive immunity; Cytokines; Diabetes mellitus; Innate immunity; Insulin; M1; M2; Macrophage polarization; Phagocytosis

Indexed keywords

ANTIBIOTIC AGENT; CD11B ANTIGEN; CD14 ANTIGEN; CD63 ANTIGEN; CD68 ANTIGEN; CD69 ANTIGEN; CORTICOSTEROID; DECTIN 1; DEXAMETHASONE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 6; MANNOSE RECEPTOR; SCAVENGER RECEPTOR; SIALOADHESIN; TUMOR NECROSIS FACTOR ALPHA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AUTOIMMUNITY; BONE MARROW CELL; CANCER CELL; CANCER PATIENT; CELL DIFFERENTIATION; CELL FUNCTION; CHEMOTAXIS; DIABETES MELLITUS; DIABETIC PATIENT; GLUCOSE TRANSPORT; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LUNG ALVEOLUS MACROPHAGE; MONONUCLEAR CELL; MYCOBACTERIUM TUBERCULOSIS; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS INFECTION; REVIEW; TISSUE REPAIR; TUMOR MICROENVIRONMENT; WISTAR RAT;

ADAPTIVE IMMUNITY; ANIMALS; DIABETES MELLITUS; HUMANS; HYPERGLYCEMIA; IMMUNITY, INNATE; MACROPHAGES, ALVEOLAR; T-LYMPHOCYTES;

EID: 84861957411     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0911488     Document Type: Review

References (59)

1. Takahashi, K. (2000) Development and differentiation of macrophages and related cells: historical review and current concepts. J. Clin. Exp. Hematopathol. 41, 1-33.
2. Gorochov, G., Neumann, A. U. (1998) Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat. Med. 4, 215-221.
3. Plata, F., Autran, B., Martins, L. P., Wain-Hobson, S., Raphael, M., Maynaud, C., Denis, M., Guillon, J. M., Debre, P. (1987) AIDS virus-specific cytotoxic T lymphocytes in lung disorders. Nature 328, 348-351.
4. Costa, C. A., Oliveira de Castro Jr., D., Jezler, S., Santiago, M. (2004) Shrinking lung syndrome in systemic lupus erythematosus. J. Bras. Pneumol. 30, 260-263.
5. Bowden, D. H. (1984) The alveolar macrophage. Environ. Health Perspect. 55, 327-341.
6. Redente, E. F., Higgins, D. M., Dwyer-Nield, L. D. (2010) Differential polarization of alveolar macrophages and bone derived monocytes following chemically and pathogen induced chronic lung inflammation. J. Leukoc. Biol. 88, 159-168.
7. Pouniotis, D. S., Plebanski, M., Apostolopoulos, V., McDonald, C. F. (2006) Alveolar macrophage function is altered in patients with lung cancer. Clin. Exp. Immunol. 143, 363-372.
8. Solinas, G., Germano, G., Mantovani, A., Allavena, P. (2009) Tumorassociated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol. 86, 1065-1073.
9. Takeo, S., Yasumoto, K., Nagashima, A., Nakahashi, H., Sugimachi, K., Nomoto, K. (1986) Role of tumor-associated macrophages in lung cancer. Cancer Res. 46, 3179-3182.
10. Shih, J. H., Yuan, A., Jeremy, J., Chen, W., Yang, P. C. (2006) Tumorassociated macrophage: its role in cancer invasion and metastasis. J. Cancer Mol. 2, 101-106.
11. Mo, Y., Wan, R., Wang, J., Chien, S., Tollerud, D. J., Zhang, Q. (2009) Diabetes is associated with increased sensitivity of alveolar macrophages to urban particulate matter exposure. Toxicology 262, 130-137.
12. Mantovani, A., Locati, M. (2009) Orchestration of macrophage polarization. Blood 114, 3135-3136.
13. Mantovani, A., Sica, A., Locati, M. (2005) Macrophage polarization comes of age. Immunity 23, 344-346.
14. Gea-Sorli, S., Guillamat, R., Semano-Mollar, A., Closa, D. (2001) Activation of lung macrophage subpopulations in experimental acute pancreatitis. J. Pathol. 223, 417-424.
15. Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., Honma, K., Matsuyama, T., Yui, K., Tsujimura, T., Standley, D. M., Nakanishi, K., Nakai, K., Akira, S. (2010) The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat. Immunol. 11, 936-944.
16. Ginderachter, J. O., Liu, Y., Devoogt, N., Noel, W., Brys, L., Hassanzadeh, G. H. G., Raes, G., Geldhof, A., Beschin, A., Revets, H., De Baetselier, P. (2008) Classical and alternative activation of macrophages: different pathways of macrophage mediated tumor promotion. In Selected Aspects of Cancer Progression, Metastasis, Apoptosis and Immune Response (Kaiser, H. E. Nasir, eds.), A. Springer Science Business Media, Germany, 139-156.
17. Hofkens, W., Storm, G., Van Den Berg, W., Van Lent, P. (2011) Inhibition of M1 macrophage activation in favour of M2 differentiation by liposomal targeting of glucocorticoids to the synovial lining during experimental arthritis. Ann. Rheum. Dis. 70, A40.
18. Lin, H. H., Faunce, D. E., Stacey, M., Terajewicz, A., Nakamura, T., Zhang-Hoover, J., Kerley, M., Mucenski, M., Gordon, S., Stein-Streilein, J. (2005) The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J. Exp. Med. 201, 1615-1625.
19. Davis, H. M., Carpenter, D. C., Stahl, J. M., Zhang, W., Hynickaa, W. P., Griswold, D. E. (2000) Human granulocyte CD11b expression as a pharmacodynamic biomarker of inflammation. J. Immunol. Methods 240, 125-132.
20. Lundahl, J., Halld́ n, G., Skold, C. M. (1996) Human blood monocytes, but not alveolar macrophages, reveal increased CD11b/CD18 expression and adhesion properties upon receptor-dependent activation. Eur. Respir. J. 9, 1188-1194.
21. Kunisch, E., Fuhrmann, R., Roth, A., Winter, R., Lungershausen, W., Kinne, R. W. (2004) Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry. Ann. Rheum. Dis. 63, 774-784.
22. Thenappan, T., Ankush, G., Glenn, M., Fang, Y-H., Zhang, H. J., Toth, P., Kajimoto, H., Hong, Z., Jonathan, P., Wietholt, C., Pogoriler, J., Piao, L., Rehman, J., Archer, S. L. (2011) A central role for CD68(+) macrophages in hepatopulmonary syndrome: reversal by macrophage depletion. Am. J. Respir. Crit. Care Med. 183, 1080-1091.
23. Taylor, P.R., Martinez-Pomares, L., Stacey, M., Lin, H-H., Brown, G. D. (2005) Macrophage receptors and immune recognition. Annu. Rev. Immunol. 23, 901-944.
24. Crocker, P. R., Vark, A. (2001) Siglecs in the immune system. Immunology 103, 137-145.
25. Rothberger, H., McGee, M. P., Lee, T. K. (1984) Tissue factor activity: a marker for alveolar macrophages in rabbits. Effects of granulomatous pneumonitis. J. Clin. Invest. 73, 1524-1531.
26. Sancho, D., Gómez, M., Viedma, F., Esplugues, E., Gordón-Alonso, M., García-López, M. A., Fuente, H., Martínez, C., Lauzurica, P., Sánchez-Madrid, F. (2003) CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis. J. Clin. Invest. 112, 872-882.
27. Dobrovolskaia, M. A., Vogel, S. N. (2002) Toll receptors, CD14, and macrophage activation and deactivation by LPS. Microbes Infect. 4, 903-914.
28. Fadok, V. F., Warner, M. L., Bratton, D. L., Henson, P. M. (1998) CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (αvβ3). J. Immunol. 161, 6250-6257.
29. Sica, A., Mantovani, A. (2009) Macrophage fusion cuisine. Blood 114, 4609-4610.
30. Xia, M., Sui, Z. (2009) Recent developments in CCR2 antagonists. Expert Opin. Ther. Pat. 19, 295-303.
31. Martins, J. O., Ferracini, M., Ravanelli, N., Landgraf, R. G., Jancar, S. (2008) Insulin inhibits LPS-induced signaling pathways in alveolar macrophages. Cell. Physiol. Biochem. 21, 297-304.
32. Martins, J. O. (2011) Can PKCδ be a novel therapeutic target? J. Leukoc. Biol. 89, 1-2.
33. Martins, J. O., Ferracini, M., Ravanelli, N., Landgraf, R. G., Jancar, S. (2008) Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-κB activation in alveolar macrophages. Cell. Physiol. Biochem. 22, 279-286.
34. Honiden, S., Gong, M. N. (2009) Diabetes, insulin, and development of acute lung injury. Crit. Care Med. 37, 2455-2464.
35. Ljubic, S., Balachandran, A., Pavlic-Renar, I., Barada, A., Matelko, Z. (2004) Pulmonary infections in diabetes mellitus. Diabetol. Croat. 33, 115-123.
36. Alba-Loureiro, T. C., Munhoz, C. D., Martins, J. O., Cerchiaro, G. A., Scavone, C., Curi, R., Sannomiya, P. (2007) Neutrophil function and metabolism in individuals with diabetes mellitus. Braz. J. Med. Biol. Res. 40, 1037-1044.
37. Sunahara, K. K. S., Sannomiya, P., Martins, J. O. (2012) Briefs on insulin and innate immune response. Cell. Physiol. Biochem., doi:10.1159/000337579 [Epub ahead of print].
38. Panneerselvam, S., Govindasamy, S. (2003) Sodium molybdate improves the phagocytic function in alloxan induced diabetic rats. Chem. Biol. Interact. 145, 159-163.
39. Ferracini, M., Martins, J. O., Campos, M. R. M., Anger, D., Jancar, S. (2010) Impaired phagocytosis by alveolar macrophages from diabetic rats is related to the deficient coupling of LTs to the FcgR signaling cascade. Mol. Immunol. 47, 1974-1980.
40. Anjos-Valotta, E. A., Martins, J. O., Oliveira, M. A., Casolari, D. A., Britto, L. R., Tostes, R. C., Fortes, Z. B., Sannomiya, P. (2006) Inhibition of tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression in diabetic rats: role of insulin. Inflamm. Res. 55, 16-22.
41. De Oliveira Martins, J., Meyer-Pflug, A. R., Alba-Loureiro, T. C., Melbostad, H., Cruz, J. W. M. C., Coimbra, R., Curi, R., Sannomiya, P. (2006) Modulation of lipopolysaccharide-induced acute lung inflammation: role of insulin. Shock 25, 260-266.
42. Martins, J. O., Zanoni, F. L., Martins, D. O., Coimbra, R., Krieger, J. E., Jancar, S., Sannomiya, P. (2009) Insulin regulated cytokines and intercellular adhesion molecule-1 gene expression through nuclear factor κB activation in LPS-induced acute lung injury in rats. Shock 31, 404-409.
43. Martins, J. O., Ferracini, M., Anger, D. B., Martins, D. O., Ribeiro, L. F., Sannomiya, P., Jancar, S. (2010) Signaling pathways and mediators in LPS-induced lung inflammation in diabetic rats: role of insulin. Shock 33, 76-82.
44. Martins, J. O., Campos, C. A., Cruz, J. W., Manzolli, S., Alves, V. A., Vianna, E. O., Jancar, S., Sannomiya, P. (2010) Insulin modulates cytokine release and selectin expression in the early phase of allergic airway inflammation in diabetic rats. BMC Pulm. Med. 10, 39.
45. Devaraj, S., Dasu, M. R., Rockwood, J., Winter, W., Griffen, S. C. (2008) Increased Toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type I diabetes: further evidence of proinflammatory state. J. Clin. Endocrinol. Metab. 93, 578-583.
46. Mohammad, M. K., Morran, M., Slotterbec, B. (2006) Dysregulated Tolllike receptor expression and signaling in bone marrow derived macrophages at the onset of diabetes in the non-obese diabetic mouse. Int. Immunol. 18, 1101-1113.
47. Thomassen, M. J., Barna, B. P., Wiedemann, H. P., Farmer, M., Ahmad, M. (1988) Human alveolar macrophage function: differences between smokers and nonsmokers. J. Leukoc. Biol. 44, 313-318.
48. Raoust, E., Balloy, V., Garcia-Verdugo, I., Touquil, L., Ramphal, R., Chignar, M. (2009) Pseudomonas aeruginosa LPS or Flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells. PLoS One 4, 1-9.
49. Martins, J. O., Wittlin, B. M., Anger, D. B. C., Martins, D. O., Sannomiya, P., Jancar, S. (2010) Early phase of allergic airway inflammation in diabetic rats: role of insulin on the signaling pathways and mediators. Cell. Physiol. Biochem. 26, 739-748.
50. Bang, B. R., Chun, E., Shim, E. J., Lee, H. S., Lee, S. Y., Cho, S. H., Min, K. U., Kim, Y. Y., Park, H. W. (2011) Alveolar macrophages modulate allergic inflammation in a murine model of asthma. Exp. Mol. Med. 43, 275-280.
51. Milara, J., Navarro, A., Almudéver, P., Lluch, P., Morcillo, E. J., Cortijo, J. (2011) Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages. Clin. Exp. Allergy 41, 535-546.
52. Seaquist, E. R., Damberg, G. S., Tkac, I., Gruetter, R. (2001) The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport metabolism in humans. Diabetes 50, 2203-2209.
53. Flynn, J. L., Chan, J. (2003) Immune evasion by Mycobacterium tuberculosis: living with the enemy. Curr. Opin. Immunol. 15, 450-455.
54. Oliveira, S. C., Harms, J. S., Rech, E. L., Rodarte, R. S., Bocca, A. L., Goes, A. M., Splitter, G. A. (1998) The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection. Braz. J. Med. Biol. Res. 31, 77-84.
55. Jeon, C. Y., Murray, M. B. (2008) Diabetes mellitus increases risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med. 5, 1091-1101.
56. Stevenson, C. R., Forouh, N. G., Roglic, G., Williams, B. G., Lauer, J. A., Dye, C., Unwin, N. (2007) Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence. BMC Public Health 7, 234.
57. Lehuen, A., Julien, D., Zaccone, P., Cooke, A. (2010) Immune cell crosstalk in type 1 diabetes. Nat. Rev. 10, 501-513.
58. Avanzini, M. A., Ciardelli, L., Lenta, E., Castellazzi, A. M., Derosa, G., Dos Santos, C., Oliveri, M., Pistorio, A., Lorini, R., D'Annuzio, G. (2005) IFN-γ low production capacity in type 1 diabetes mellitus patients at onset of disease. Exp. Clin. Endocrinol. Diabetes 113, 313-317.
59. Hur, K. Y., Jung, H. S., Lee, M. S. (2010) Role of autophagy in β cell function and mass. Diabetes Obesity Metab. 12 (Suppl. 2), 20-26.