Bioavailability enhancement studies of amoxicillin with Nigella

Indian Journal of Medical Research

Volumn 135, Issue 4, 2012, Pages 555-559

  Ali, Babar ^a   Amin, Saima ^a   Ahmad, Javed ^a   Ali, Abuzer ^a   Ali, Mohd ^a   Mir, Showkat R ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Absorption enhancement; Amoxicillin; Bioavailability; Everted rat sac; Nigella sativa

Indexed keywords

AMOXICILLIN; HEXANE; METHANOL; NIGELLA SATIVA EXTRACT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLACK CUMIN; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DIFFUSION; DRUG PENETRATION; DRUG POTENTIATION; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE WALL; MASS SPECTROMETRY; NONHUMAN; PLANT SEED; RAT; SPECTROPHOTOMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

AMOXICILLIN; ANIMALS; BIOLOGICAL AVAILABILITY; DRUG INTERACTIONS; GASTROINTESTINAL TRACT; INTESTINAL ABSORPTION; MALE; NIGELLA SATIVA; PERMEABILITY; PLANT EXTRACTS; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

EID: 84861927633     PISSN: 09715916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. The wealth of India: raw materials, vol. VI. Council for Scientifc and Industrial Research, Delhi, India: NISCAIR (PID); 2001. p. 63-65.
2. Burdock GA. Encyclopedia of food and color additives, Boca Raton, Floroda: CRC Press; 1997. p. 230-231.
3. Chi-Yuan W, Leslie ZB. Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classifcation system. Pharm Res 2005; 22: 11-23.
4. Tsuji A, Nakashima E, Kagami I, Yamana T. Intestinal absorption mechanism of amphoteric, β-lactam antibiotics I. Comparative absorption and evidence for saturable transportof amino-, β-lactam antibiotics by in situ rat small intestine. J Pharm Sci 1981; 70: 768-772.
5. Jesus CJ, Jose EP. Francisca TM, Luis G. Low bioavailability of amoxicillin in rats as a consequence of presystemic degradation in the intestine. Antimicrob Agents Chemother 1994; 38: 842-847.
6. Lennernas H, Knutson L, Knutson T, Hussain A, Lesko L, Salmonson T, et al. The effect of amiloride on the in-vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique. Eur J Pharm Sci 2002; 15: 271-277.
7. Rao JP. Infuence of dietary calcium content on intestinal permeability in rat. Indian J Med Res 2009; 129: 681-684.
8. Barthe L, Woodley JF, Kenworthy S, Houin G. An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine. Eur J Drug Metab Pharmacokinet 1998; 23: 313-323.
9. Wilson TH, Wiseman G. The use sacs of everted small intestine for the study of transference of substances from the mucosal to the serosal surface J Physiol 1954; 123: 116-125.
10. Schilling RJ, Mitra AK. Intestinal mucosal transport of insulin. Int J Pharm 1990; 62: 53-64.
11. Juan AQ, Santiago VJ, Segundo P. Penicillin-binding proteins of Bacteroides fragilis and their role in the resistance to imipenem of clinical isolates. J Med Microbiol 2005; 54: 1055-1064.
12. Wen A, Hang T, Chen S, Wang Z, Ding L, Tian Y, et al. Simultaneous determination of amoxicillin and ambroxol in human plasma by LC-MS/MS: validation and application to pharmacokinetic study. J Pharm Biomed Anal 2008; 48: 829-834.
13. Yoon KH, Lee SY, Kim W, Park JS, Kim HJ. Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC-ESI mass spectrometry. J Chromatogr B 2004; 813: 121-127.
14. Kang MJ, Cho JY, Shim BH, Kim DK, Lee J. Bioavailability enhancing activities of natural compounds from medicinal plants. J Med Plants Res 2009; 3: 1204-1211.
15. Tokumura T, Tsushima Y, Tatsuishi K, Kayano M, Machida Y, Nagai T. Enhancement of the oral bioavailability of cinnarizine in oleic acid in beagle dogs. J Pharm Sci 1987; 76: 286-288.
16. Sasaki K, Yonebayashi S, Yoshida M, Shimizu K, Aotsuka T, Takayama K. Improvement in the bioavailability of poorly absorbed glycyrrhizin via various non-vascular administration routes in rats. Int J Pharm 2003; 265: 95-102.
17. Dos-Santos I, Fawaz F, Lagueny AM, Bonini F. Improvement of norfoxacin oral bioavailability by EDTA and sodium caprate. Int J Pharm 2003; 260: 1-4.
18. Chi SC, Park ES, Kim H. Effect of penetration enhancers on furbiprofen permeation through rat skin. Int J Pharm 1995; 126: 267-274.
19. Sinha VR, Kaur MP. Permeation enhancers for transdermal drug delivery. Drug Dev Ind Pharm 2000; 26: 1131-1140.
20. Amin S, Kohli K, Khar RK, Mir SR, Pillai KK. Mechanism of in-vitro percutaneous absorption enhancement of carvedilol by penetration enhancers. Pharm Dev Tech 2008; 13: 533-539.
21. Amin S, Mir SR, Kohli K, Ali B, Ali M. A study of chemical composition of Nigella oil and its effect on penetration enhancement from transdermal formulation. Nat Prod Res 2010; 24: 1151-1157.