Cardiotoxic local anesthetics increasingly interact with biomimetic membranes under ischemia-like acidic conditions

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 6, 2012, Pages 988-992

  Tsuchiya, Hironori ^a   Mizogami, Maki ^b   Ueno, Takahiro ^a   Shigemi, Kenji ^b  

^a ASAHI UNIVERSITY   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

Author keywords

Acidosis; Cardiotoxicity; Ischemia; Local anesthetic; Membrane interaction

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; BIOMIMETIC MATERIAL; BUFFER; BUPIVACAINE; CARDIOLIPIN; CHOLESTEROL; DIOLEOYLPHOSPHATIDYLSERINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID; SPHINGOMYELIN;

ACIDITY; ANIMAL CELL; ARTICLE; CARDIOTOXICITY; CHANNEL GATING; CHEMICAL INTERACTION; CONCENTRATION RESPONSE; DOG; FLUORESCENCE POLARIZATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; LAMELLAR BODY; LIPID MEMBRANE; MEMBRANE FLUIDITY; MEMBRANE INTERACTION; MITOCHONDRIAL MEMBRANE; NERVE CELL; NONHUMAN; PH;

ANESTHETICS, LOCAL; BUPIVACAINE; CARDIOLIPINS; CARDIOTOXINS; CELL MEMBRANE; GLYCEROPHOSPHOLIPIDS; HYDROGEN-ION CONCENTRATION; ISCHEMIA; LIDOCAINE; MEMBRANE FLUIDITY; MEMBRANES, ARTIFICIAL; MITOCHONDRIA; PHOSPHATIDYLINOSITOLS; SPHINGOMYELINS;

EID: 84861918861     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.988     Document Type: Article

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