Interaction of lidocaine with the cardiac sodium channel. Effects of low extracellular pH are consistent with an external blocking site

Life Sciences

Volumn 67, Issue 22, 2000, Pages 2759-2766

  Tan, Joy H C ^a   Saint, David A ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Cardiac sodium channel; Class I antiarrythmic; Ischaemia; Lidocaine

Indexed keywords

ANTIARRHYTHMIC AGENT; LIDOCAINE; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; HEART ARRHYTHMIA; HEART MUSCLE CELL; NONHUMAN; PH; RAT; SODIUM CURRENT;

ANIMALIA;

EID: 0034692901     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(00)00855-9     Document Type: Article

References (20)

1. Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs
2. Effects of hyperkalaemia on the depression of maximum rate of depolarization by class I antiarrhythmic agents in guinea-pig myocardium
3. pKa does not predict pH potentiation of sodium channel blockade by lidocaine and W6211 in guinea pig ventricular myocardium
4. pH-dependent electrophysiological effects of quinidine and lidocaine on canine cardiac purkinje fibers
5. The influence of pH On th electrophysiological effects of lidocaine in guinea pig ventricular myocardium
6. Importance of physico-chemical properties in determining the kinetics of the effects of Class I antiarrhythmic drugs on maximum rate of depolarization in guinea-pig ventricle
7. Two components of use-dependent block of sodium current by lidocaine voltage clamped cardiac Purkinje cells
8. Evidence for two components of sodium channel block by lidocaine in isolated cardiac myocytes
9. Dissecting lidocaine action: Diethylamide and phenol mimic modes of lidocaine block of sodium channels from heart and skeletal muscle
10. Molecular determinants of state-dependent block of Na+ channels by local anesthetics
11. Is there a second external lidocaine binding site on mammalian cardiac cells?
12. Fast lidocaine block of cardiac and skeletal muscle sodium channels: One site with two routes of access
13. A persistent sodium current in rat ventricular myocytes
14. Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
15. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels
16. Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle
17. pH dependence of kinetics and steady-state block of cardiac sodium channels by lidocaine
18. External site for local anesthetic block of cardiac Na+ channels
19. Use of ionic currents to identify and estimate parameters in models of channel blockade
20. Ionic blockage of sodium channels in nerve