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Volumn 33, Issue 8, 2012, Pages 1579-1590

HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits

Author keywords

Aging; Amyloid; Blood brain barrier; HIV 1; HIV 1 infection; Inflammation; Tight junction proteins

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GELATINASE B; HYDROXYFASUDIL; PRESENILIN 1; PROTEIN ZO1; TRANSACTIVATOR PROTEIN;

EID: 84861910953     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2011.06.004     Document Type: Article
Times cited : (14)

References (56)
  • 1
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott N.J., Rönnbäck L., Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci 2006, 7:41-53.
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 3
    • 77952542137 scopus 로고    scopus 로고
    • HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures
    • Aksenov M.Y., Aksenova M.V., Mactutus C.F., Booze R.M. HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures. Neurosci. Lett 2010, 475:174-178.
    • (2010) Neurosci. Lett , vol.475 , pp. 174-178
    • Aksenov, M.Y.1    Aksenova, M.V.2    Mactutus, C.F.3    Booze, R.M.4
  • 4
    • 73249132000 scopus 로고    scopus 로고
    • HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin
    • András I.E., Eum S.Y., Huang W., Zhong Y., Hennig B., Toborek M. HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin. Mol. Cell. Neurosci 2010, 43:232-243.
    • (2010) Mol. Cell. Neurosci , vol.43 , pp. 232-243
    • András, I.E.1    Eum, S.Y.2    Huang, W.3    Zhong, Y.4    Hennig, B.5    Toborek, M.6
  • 5
    • 24944459847 scopus 로고    scopus 로고
    • Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells
    • András I.E., Pu H., Tian J., Deli M.A., Nath A., Hennig B., Toborek M. Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. J. Cereb. Blood Flow Metab 2005, 25:1159-1170.
    • (2005) J. Cereb. Blood Flow Metab , vol.25 , pp. 1159-1170
    • András, I.E.1    Pu, H.2    Tian, J.3    Deli, M.A.4    Nath, A.5    Hennig, B.6    Toborek, M.7
  • 6
    • 42449095035 scopus 로고    scopus 로고
    • Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells
    • András I.E., Rha G., Huang W., Eum S., Couraud P.O., Romero I.A., Hennig B., Toborek M. Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells. Mol. Pharmacol 2008, 73:1424-1433.
    • (2008) Mol. Pharmacol , vol.73 , pp. 1424-1433
    • András, I.E.1    Rha, G.2    Huang, W.3    Eum, S.4    Couraud, P.O.5    Romero, I.A.6    Hennig, B.7    Toborek, M.8
  • 7
    • 77956894555 scopus 로고    scopus 로고
    • Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(-)/(-) mice
    • Austin S.A., Combs C.K. Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(-)/(-) mice. Neurobiol. Aging 2010, 31:1854-1866.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1854-1866
    • Austin, S.A.1    Combs, C.K.2
  • 8
    • 8444227370 scopus 로고    scopus 로고
    • HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cells
    • Avraham H.K., Jiang S., Lee T.H., Prakash O., Avraham S. HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cells. J. Immunol 2004, 173:6228-6233.
    • (2004) J. Immunol , vol.173 , pp. 6228-6233
    • Avraham, H.K.1    Jiang, S.2    Lee, T.H.3    Prakash, O.4    Avraham, S.5
  • 9
    • 33745848134 scopus 로고    scopus 로고
    • The blood-brain barrier in neuroAIDS
    • Banks W.A., Ercal N., Price T.O. The blood-brain barrier in neuroAIDS. Curr. HIV Res 2006, 4:259-266.
    • (2006) Curr. HIV Res , vol.4 , pp. 259-266
    • Banks, W.A.1    Ercal, N.2    Price, T.O.3
  • 10
    • 0028816076 scopus 로고
    • A non-isotopic, highly sensitive, fluorimetric, cell-cell adhesion microplate assay using calcein AM-labeled lymphocytes
    • Braut-Boucher F., Pichon J., Rat P., Adolphe M., Aubery M., Font J. A non-isotopic, highly sensitive, fluorimetric, cell-cell adhesion microplate assay using calcein AM-labeled lymphocytes. J. Immunol. Methods 1995, 178:41-51.
    • (1995) J. Immunol. Methods , vol.178 , pp. 41-51
    • Braut-Boucher, F.1    Pichon, J.2    Rat, P.3    Adolphe, M.4    Aubery, M.5    Font, J.6
  • 12
    • 0008616767 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta; 2007
    • HIV/AIDS Surveillance Report 2005, US Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta; 2007.
    • (2005) HIV/AIDS Surveillance Report
  • 13
    • 65849265212 scopus 로고    scopus 로고
    • Vessel microport technique for applications in cerebrovascular research
    • Chen L., Swartz K.R., Toborek M. Vessel microport technique for applications in cerebrovascular research. J. Neurosci. Res 2009, 87:1718-1727.
    • (2009) J. Neurosci. Res , vol.87 , pp. 1718-1727
    • Chen, L.1    Swartz, K.R.2    Toborek, M.3
  • 14
    • 33747195035 scopus 로고    scopus 로고
    • Recent evidence for an involvement of rho-kinase in cerebral vascular disease
    • Chrissobolis S., Sobey C.G. Recent evidence for an involvement of rho-kinase in cerebral vascular disease. Stroke 2006, 37:2174-2180.
    • (2006) Stroke , vol.37 , pp. 2174-2180
    • Chrissobolis, S.1    Sobey, C.G.2
  • 16
    • 0032881663 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia
    • Conant K., McArthur J.C., Griffin D.E., Sjulson L., Wahl L.M., Irani D.N. Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia. Ann. Neurol 1999, 46:391-398.
    • (1999) Ann. Neurol , vol.46 , pp. 391-398
    • Conant, K.1    McArthur, J.C.2    Griffin, D.E.3    Sjulson, L.4    Wahl, L.M.5    Irani, D.N.6
  • 17
    • 33750079287 scopus 로고    scopus 로고
    • Tat peptides inhibit neprilysin
    • Daily A., Nath A., Hersh L.B. Tat peptides inhibit neprilysin. J. Neurovirol 2006, 12:153-160.
    • (2006) J. Neurovirol , vol.12 , pp. 153-160
    • Daily, A.1    Nath, A.2    Hersh, L.B.3
  • 20
    • 32544437823 scopus 로고    scopus 로고
    • CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS
    • Eugenin E.A., Osiecki K., Lopez L., Goldstein H., Calderon T.M., Berman J.W. CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS. J. Neurosci 2006, 26:1098-1106.
    • (2006) J. Neurosci , vol.26 , pp. 1098-1106
    • Eugenin, E.A.1    Osiecki, K.2    Lopez, L.3    Goldstein, H.4    Calderon, T.M.5    Berman, J.W.6
  • 21
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • Farkas E., Luiten P.G. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol 2001, 64:575-611.
    • (2001) Prog. Neurobiol , vol.64 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.2
  • 22
    • 58549098084 scopus 로고    scopus 로고
    • Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis
    • Farrall A.J., Wardlaw J.M. Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis. Neurobiol. Aging 2009, 30:337-352.
    • (2009) Neurobiol. Aging , vol.30 , pp. 337-352
    • Farrall, A.J.1    Wardlaw, J.M.2
  • 23
    • 11444257052 scopus 로고    scopus 로고
    • Developmental origins of aging in brain and blood vessels: an overview
    • Finch C.E. Developmental origins of aging in brain and blood vessels: an overview. Neurobiol. Aging 2005, 26:281-291.
    • (2005) Neurobiol. Aging , vol.26 , pp. 281-291
    • Finch, C.E.1
  • 24
    • 67349175704 scopus 로고    scopus 로고
    • The neuropsychology of HIV/AIDS in older adults
    • Hardy D.J., Vance D.E. The neuropsychology of HIV/AIDS in older adults. Neuropsychol. Rev 2009, 19:263-272.
    • (2009) Neuropsychol. Rev , vol.19 , pp. 263-272
    • Hardy, D.J.1    Vance, D.E.2
  • 25
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman S.E., Allison E.K., El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J. Neurosci 2008, 28:8354-8360.
    • (2008) J. Neurosci , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 26
    • 0035971219 scopus 로고    scopus 로고
    • Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms
    • Hirase T., Kawashima S., Wong E.Y., Ueyama T., Rikitake Y., Tsukita S., Yokoyama M., Staddon J.M. Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms. J. Biol. Chem 2001, 276:10423-10431.
    • (2001) J. Biol. Chem , vol.276 , pp. 10423-10431
    • Hirase, T.1    Kawashima, S.2    Wong, E.Y.3    Ueyama, T.4    Rikitake, Y.5    Tsukita, S.6    Yokoyama, M.7    Staddon, J.M.8
  • 27
    • 70349329335 scopus 로고    scopus 로고
    • PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities
    • Huang W., Eum S.Y., András I.E., Hennig B., Toborek M. PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities. FASEB J 2009, 23:1596-1606.
    • (2009) FASEB J , vol.23 , pp. 1596-1606
    • Huang, W.1    Eum, S.Y.2    András, I.E.3    Hennig, B.4    Toborek, M.5
  • 28
    • 67650498977 scopus 로고    scopus 로고
    • Linking cerebrovascular defense mechanisms in brain ageing and Alzheimer's disease
    • Kalaria R.N. Linking cerebrovascular defense mechanisms in brain ageing and Alzheimer's disease. Neurobiol. Aging 2009, 30:1512-1514.
    • (2009) Neurobiol. Aging , vol.30 , pp. 1512-1514
    • Kalaria, R.N.1
  • 29
    • 70350457524 scopus 로고    scopus 로고
    • Human immunodeficiency virus in an aging population, a complication of success
    • Kirk J.B., Goetz M.B. Human immunodeficiency virus in an aging population, a complication of success. J. Am. Geriatr. Soc 2009, 57:2129-2138.
    • (2009) J. Am. Geriatr. Soc , vol.57 , pp. 2129-2138
    • Kirk, J.B.1    Goetz, M.B.2
  • 30
    • 0031052029 scopus 로고    scopus 로고
    • Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells
    • Ma M., Nath A. Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. J. Virol 1997, 71:2495-2499.
    • (1997) J. Virol , vol.71 , pp. 2495-2499
    • Ma, M.1    Nath, A.2
  • 31
    • 33645299025 scopus 로고    scopus 로고
    • Ageing and neuronal vulnerability
    • Mattson M.P., Magnus T. Ageing and neuronal vulnerability. Nat. Rev. Neurosci 2006, 7:278-294.
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 278-294
    • Mattson, M.P.1    Magnus, T.2
  • 32
    • 18944372230 scopus 로고    scopus 로고
    • Rho kinase, a promising drug target for neurological disorders
    • Mueller B.K., Mack H., Teusch N. Rho kinase, a promising drug target for neurological disorders. Nat. Rev. Drug Discov 2005, 4:387-398.
    • (2005) Nat. Rev. Drug Discov , vol.4 , pp. 387-398
    • Mueller, B.K.1    Mack, H.2    Teusch, N.3
  • 33
    • 63349107691 scopus 로고    scopus 로고
    • Growing old with HIV: the AIDS epidemic and an aging population
    • Myers J.D. Growing old with HIV: the AIDS epidemic and an aging population. JAAPA 2009, 22:20-24.
    • (2009) JAAPA , vol.22 , pp. 20-24
    • Myers, J.D.1
  • 35
    • 77953596007 scopus 로고    scopus 로고
    • Aging and HIV infection: a comparison between older HIV-infected persons and the general population
    • Onen N.F., Overton E.T., Seyfried W., Stumm E.R., Snell M., Mondy K., Tebas P. Aging and HIV infection: a comparison between older HIV-infected persons and the general population. HIV. Clin. Trials 2010, 11:100-109.
    • (2010) HIV. Clin. Trials , vol.11 , pp. 100-109
    • Onen, N.F.1    Overton, E.T.2    Seyfried, W.3    Stumm, E.R.4    Snell, M.5    Mondy, K.6    Tebas, P.7
  • 36
    • 33745094734 scopus 로고    scopus 로고
    • Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)
    • Persidsky Y., Heilman D., Haorah J., Zelivyanskaya M., Persidsky R., Weber G.A., Shimokawa H., Kaibuchi K., Ikezu T. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood 2006, 107:4770-4780.
    • (2006) Blood , vol.107 , pp. 4770-4780
    • Persidsky, Y.1    Heilman, D.2    Haorah, J.3    Zelivyanskaya, M.4    Persidsky, R.5    Weber, G.A.6    Shimokawa, H.7    Kaibuchi, K.8    Ikezu, T.9
  • 37
    • 25144504434 scopus 로고    scopus 로고
    • HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation
    • Pu H., Tian J., Andras I.E., Hayashi K., Flora G., Hennig B., Toborek M. HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation. J. Cereb. Blood Flow Metab 2005, 25:1325-1335.
    • (2005) J. Cereb. Blood Flow Metab , vol.25 , pp. 1325-1335
    • Pu, H.1    Tian, J.2    Andras, I.E.3    Hayashi, K.4    Flora, G.5    Hennig, B.6    Toborek, M.7
  • 38
    • 0141726832 scopus 로고    scopus 로고
    • HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
    • Pu H., Tian J., Flora G., Lee Y.W., Nath A., Hennig B., Toborek M. HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol. Cell. Neurosci 2003, 24:224-237.
    • (2003) Mol. Cell. Neurosci , vol.24 , pp. 224-237
    • Pu, H.1    Tian, J.2    Flora, G.3    Lee, Y.W.4    Nath, A.5    Hennig, B.6    Toborek, M.7
  • 39
    • 67649099340 scopus 로고    scopus 로고
    • HIV regulation of amyloid beta production
    • Pulliam L. HIV regulation of amyloid beta production. J. Neuroimmune. Pharmacol 2009, 4:213-217.
    • (2009) J. Neuroimmune. Pharmacol , vol.4 , pp. 213-217
    • Pulliam, L.1
  • 40
    • 40749103882 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes
    • Ramirez S.H., Heilman D., Morsey B., Potula R., Haorah J., Persidsky Y. Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes. J. Immunol 2008, 180:1854-1865.
    • (2008) J. Immunol , vol.180 , pp. 1854-1865
    • Ramirez, S.H.1    Heilman, D.2    Morsey, B.3    Potula, R.4    Haorah, J.5    Persidsky, Y.6
  • 41
    • 15744363144 scopus 로고    scopus 로고
    • HIV-1 Tat inhibits neprilysin and elevates amyloid beta
    • Rempel H.C., Pulliam L. HIV-1 Tat inhibits neprilysin and elevates amyloid beta. AIDS 2005, 19:127-135.
    • (2005) AIDS , vol.19 , pp. 127-135
    • Rempel, H.C.1    Pulliam, L.2
  • 42
    • 58249126857 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their multiple roles in neurodegenerative diseases
    • Rosenberg G.A. Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurol 2009, 8:205-216.
    • (2009) Lancet Neurol , vol.8 , pp. 205-216
    • Rosenberg, G.A.1
  • 43
    • 77951211094 scopus 로고    scopus 로고
    • Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65
    • Shimada H., Rajagopalan L.E. Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65. J. Biol. Chem 2010, 285:12536-12542.
    • (2010) J. Biol. Chem , vol.285 , pp. 12536-12542
    • Shimada, H.1    Rajagopalan, L.E.2
  • 44
    • 37849188704 scopus 로고    scopus 로고
    • Fasudil, a Rho-kinase inhibitor, inhibits leukocyte adhesion in inflamed large blood vessels in vivo
    • Slotta J.E., Braun O.O., Menger M.D., Thorlacius H. Fasudil, a Rho-kinase inhibitor, inhibits leukocyte adhesion in inflamed large blood vessels in vivo. Inflamm. Res 2006, 55:364-367.
    • (2006) Inflamm. Res , vol.55 , pp. 364-367
    • Slotta, J.E.1    Braun, O.O.2    Menger, M.D.3    Thorlacius, H.4
  • 45
    • 43649085909 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy and its relationship to Alzheimer's disease
    • Thal D.R., Griffin W.S., de Vos R.A., Ghebremedhin E. Cerebral amyloid angiopathy and its relationship to Alzheimer's disease. Acta Neuropathol 2008, 115:599-609.
    • (2008) Acta Neuropathol , vol.115 , pp. 599-609
    • Thal, D.R.1    Griffin, W.S.2    de Vos, R.A.3    Ghebremedhin, E.4
  • 48
    • 0029799186 scopus 로고    scopus 로고
    • Vascular changes in the cerebral cortex in HIV-1 infection: I. A morphometric investigation by light and electron microscopy
    • Weis S., Haug H., Budka H. Vascular changes in the cerebral cortex in HIV-1 infection: I. A morphometric investigation by light and electron microscopy. Clin. Neuropathol 1996, 15:361-366.
    • (1996) Clin. Neuropathol , vol.15 , pp. 361-366
    • Weis, S.1    Haug, H.2    Budka, H.3
  • 52
    • 0035405886 scopus 로고    scopus 로고
    • Metalloproteinases in biology and pathology of the nervous system
    • Yong V.W., Power C., Forsyth P., Edwards D.R. Metalloproteinases in biology and pathology of the nervous system. Nat. Rev. Neurosci 2001, 2:502-511.
    • (2001) Nat. Rev. Neurosci , vol.2 , pp. 502-511
    • Yong, V.W.1    Power, C.2    Forsyth, P.3    Edwards, D.R.4
  • 53
    • 77649275964 scopus 로고    scopus 로고
    • Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells
    • Zhong Y., Hennig B., Toborek M. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. J. Cereb. Blood Flow Metab 2009, 30:522-533.
    • (2009) J. Cereb. Blood Flow Metab , vol.30 , pp. 522-533
    • Zhong, Y.1    Hennig, B.2    Toborek, M.3
  • 54
    • 50349098381 scopus 로고    scopus 로고
    • Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling
    • Zhong Y., Smart E.J., Weksler B., Couraud P.O., Hennig B., Toborek M. Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling. J. Neurosci 2008, 28:7788-7796.
    • (2008) J. Neurosci , vol.28 , pp. 7788-7796
    • Zhong, Y.1    Smart, E.J.2    Weksler, B.3    Couraud, P.O.4    Hennig, B.5    Toborek, M.6
  • 55
    • 62949218521 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy: progressive disruption of the neurovascular unit
    • Zipfel G.J., Han H., Ford A.L., Lee J.M. Cerebral amyloid angiopathy: progressive disruption of the neurovascular unit. Stroke 2009, 40(3 Suppl):S16-S19.
    • (2009) Stroke , vol.40 , Issue.3 SUPPL.
    • Zipfel, G.J.1    Han, H.2    Ford, A.L.3    Lee, J.M.4
  • 56
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


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