Active site binding and catalytic role of bicarbonate in 1,4-dihydroxy-2-naphthoyl coenzyme a synthases from vitamin K biosynthetic pathways

Biochemistry

Volumn 51, Issue 22, 2012, Pages 4580-4589

  Sun, Yueru ^a   Song, Haigang ^a   Li, Jie ^b   Jiang, Ming ^a,c   Li, Yan ^b,d   Zhou, Jiahai ^b   Guo, Zhihong ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^c the State University of New York   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANION BINDING; ASPARTATE RESIDUE; BIOSYNTHETIC PATHWAY; CARBON-CARBON BOND FORMATION REACTIONS; CATALYTIC BASE; CATALYTIC ROLE; CHLORIDE IONS; COENZYME A; COFACTORS; ELECTROSTATIC ATTRACTIONS; ENOLATES; ENZYMATIC ACTIVITIES; ENZYME ACTIVE SITES; HYDROPHOBIC INTERACTIONS; ORTHOLOGUES; SIDE-CHAINS; STRUCTURAL BASIS; SYNECHOCYSTIS SP; SYNTHASES; VITAMIN K; VITAMIN K1;

BIOCHEMISTRY; CARBOXYLATION; CHLORINE COMPOUNDS; ENZYMES; ESCHERICHIA COLI; HYDROGEN BONDS; OLEFINS; PLANTS (BOTANY);

IONS;

1,4 DIHYDROXY 2 NAPHTHOYL COENZYME A; ASPARTIC ACID; BICARBONATE; CHLORIDE ION; COENZYME A; HOLOENZYME; NITRATE; UNCLASSIFIED DRUG; VITAMIN K GROUP;

ARTICLE; BIOSYNTHESIS; CATALYST; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ESCHERICHIA COLI; HYDROGEN BOND; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; STATIC ELECTRICITY; SYNECHOCYSTIS;

AMINO ACID SEQUENCE; ASPARTIC ACID; BICARBONATES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NITRATES; OXO-ACID-LYASES; PROTEIN BINDING; SEQUENCE ALIGNMENT; SYNECHOCYSTIS; VITAMIN K;

ESCHERICHIA COLI; SYNECHOCYSTIS SP.;

EID: 84861910725     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300486j     Document Type: Article

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