Novel quinolyl-thienyl chalcones and their 2-pyrazoline derivatives with diverse substitution pattern as antileishmanial agents against Leishmania major

Medicinal Chemistry Research

Volumn 21, Issue 7, 2012, Pages 1322-1333

  Rizvi, Syed Umar Farooq ^a   Siddiqui, Hamid Latif ^a   Ahmad, Muhammad Nisar ^b   Ahmad, Matloob ^a   Bukhari, Mujahid Hussain ^a  

^a UNIVERSITY OF THE PUNJAB   (Pakistan)

^b UNIVERSITY OF PESHAWAR   (Pakistan)

Author keywords

Acetylthiophenes; Antileishmanial activity; Chalcones; Formylquinolines; Pyrazolines

Indexed keywords

2 CHLORO 3[3(2,5 DICHLOROTHIOPHEN 3 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 7 METHYLQUINOLINE; 2 CHLORO 3[3(2,5 DICHLOROTHIOPHEN 3 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 8 METHYLQUINOLINE; 2 CHLORO 3[3(2,5 DIMETHYLTHIOPHEN 3 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 7 METHYLQUINOLINE; 2 CHLORO 3[3(2,5 DIMETHYLTHIOPHEN 3 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 8 METHYLQUINOLINE; 2 CHLORO 3[3(3 CHLOROTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 7 METHYLQUINOLINE; 2 CHLORO 3[3(3 CHLOROTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 8 METHYLQUINOLINE; 2 CHLORO 3[3(5 CHLOROTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 7 METHYLQUINOLINE; 2 CHLORO 3[3(5 CHLOROTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 8 METHYLQUINOLINE; 2 CHLORO 3[3(5 IODOTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 7 METHYLQUINOLINE; 2 CHLORO 3[3(5 IODOTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 8 METHYLQUINOLINE; 2 CHLORO 7 METHYL 3(3 THIOPHEN 3 YL 4,5 DIHYDRO 1H PYRAZOL 5 YL) QUINOLINE; 2 CHLORO 7 METHYL 3[3(3 METHYLTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] QUINOLINE; 2 CHLORO 7 METHYL 3[3(4 METHYLTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] QUINOLINE; 2 CHLORO 7 METHYL 3[3(5 METHYLTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] QUINOLINE; 2 CHLORO 8 METHYL 3(3 THIOPHEN 3 YL 4,5 DIHYDRO 1H PYRAZOL 5 YL) QUINOLINE; 2 CHLORO 8 METHYL 3[3(3 METHYLTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] QUINOLINE; 2 CHLORO 8 METHYL 3[3(4 METHYLTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] QUINOLINE; 2 PYRAZOLINE DERIVATIVE; 3[3(3 BROMOTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 2 CHLORO 7 METHYLQUINOLINE; 3[3(5 BROMOTHIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 2 CHLORO 7 METHYLQUINOLINE; ACETYLTHIOPHENE DERIVATIVE; AMPHOTERICIN B; ANTILEISHMANIAL AGENT; CHALCONE DERIVATIVE; FORMYLQUINOLINE DERIVATIVE; PYRAZOLINE DERIVATIVE; QUINOLINE DERIVATIVE; QUINOLYLTHIENYL CHALCONE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTILEISHMANIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; IC 50; INFRARED SPECTROSCOPY; LEISHMANIA MAJOR; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SUBSTITUTION REACTION;

EID: 84861910144     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9647-8     Document Type: Article

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