Perfluorooctanoic acid affects the activity of the hepatocyte nuclear factor 4 alpha (HNF4α)

Toxicology Letters

Volumn 212, Issue 2, 2012, Pages 106-112

  Scharmach, E ^a   Buhrke, T ^a   Lichtenstein, D ^a   Lampen, A ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

HepG2; HNF4 ; PFOA; Proteomics

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PERFLUOROOCTANOIC ACID;

ARTICLE; CARCINOMA CELL; CYTOTOXICITY; DOWN REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIPID METABOLISM; LIVER CELL; LIVER CELL CARCINOMA; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEOMICS; SIGNAL TRANSDUCTION; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

FLUOROCARBONS; GENE EXPRESSION; HEP G2 CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; HUMANS; OCTANOIC ACIDS; PROTEOME;

ANIMALIA; RODENTIA;

EID: 84861878591     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.05.007     Document Type: Article

References (36)

1. Biegel L.B., Hurtt M.E., Frame S.R., O'Connor J.C., Cook J.C. Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats. Toxicological Sciences 2001, 60:44-55.
2. Bjork J.A., Butenhoff J.L., Wallace K.B. Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes. Toxicology 2011, 288:8-17.
3. Bjork J.A., Wallace K.B. Structure-activity relationships and human relevance for perfluoroalkyl acid-induced transcriptional activation of peroxisome proliferation in liver cell cultures. Toxicological Sciences 2009, 111:89-99.
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976, 72:248-254.
5. Chen W.S., Manova K., Weinstein D.C., Duncan S.A., Plump A.S., Prezioso V.R., Bachvarova R.F., Darnell J.E. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes and Development 1994, 8:2466-2477.
6. Cheng X., Klaassen C.D. Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. Toxicological Sciences 2008, 106:29-36.
7. Ding X., Lichti K., Kim I., Gonzalez F.J., Staudinger J.L. Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. Journal of Biological Chemistry 2006, 281:26540-26551.
8. Eriksen K.T., Raaschou-Nielsen O., Sorensen M., Roursgaard M., Loft S., Moller P. Genotoxic potential of the perfluorinated chemicals PFOA, PFOS, PFBS, PFNA and PFHxA in human HepG2 cells. Mutation Research 2010, 700:39-43.
9. Fang X., Wei Y., Liu Y., Wang J., Dai J. The identification of apolipoprotein genes in rare minnow (Gobiocypris rarus) and their expression following perfluorooctanoic acid exposure. Comparative Biochemistry and Physiology. Part C: Toxicology and Pharmacology 2010, 151:152-159.
10. Gonzalez F.J. Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription. Drug Metabolism and Pharmacokinetics 2008, 23:2-7.
11. Gorg A., Obermaier C., Boguth G., Harder A., Scheibe B., Wildgruber R., Weiss W. The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 2000, 21:1037-1053.
12. Hampf M., Gossen M. A protocol for combined Photinus and Renilla luciferase quantification compatible with protein assays. Analytical Biochemistry 2006, 356:94-99.
13. Harris A.J., Dial S.L., Casciano D.A. Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells. Mutation Research 2004, 549:79-99.
14. Kennedy G.L., Butenhoff J.L., Olsen G.W., O'Connor J.C., Seacat A.M., Perkins R.G., Biegel L.B., Murphy S.R., Farrar D.G. The toxicology of perfluorooctanoate. Critical Reviews in Toxicology 2004, 34:351-384.
15. Kudo N., Kawashima Y. Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals. Journal of Toxicological Sciences 2003, 28:49-57.
16. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
17. Lau C., Thibodeaux J.R., Hanson R.G., Narotsky M.G., Rogers J.M., Lindstrom A.B., Strynar M.J. Effects of perfluorooctanoic acid exposure during pregnancy in the mouse. Toxicological Sciences 2006, 90:510-518.
18. Lausen J., Thomas H., Lemm I., Bulman M., Borgschulze M., Lingott A., Hattersley A.T., Ryffel G.U. Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree. Nucleic Acids Research 2000, 28:430-437.
19. Lucas B., Grigo K., Erdmann S., Lausen J., Klein-Hitpass L., Ryffel G.U. HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma. Oncogene 2005, 24:6418-6431.
20. Maloney E.K., Waxman D.J. Trans-activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicology and Applied Pharmacology 1999, 161:209-218.
21. Martin G., Schoonjans K., Lefebvre A.M., Staels B., Auwerx J. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. Journal of Biological Chemistry 1997, 272:28210-28217.
22. Mogilenko D.A., Dizhe E.B., Shavva V.S., Lapikov I.A., Orlov S.V., Perevozchikov A.P. Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells. Biochemistry 2009, 48:11950-11960.
23. Palmer C.N., Hsu M.H., Griffin K.J., Raucy J.L., Johnson E.F. Peroxisome proliferator activated receptor-alpha expression in human liver. Molecular Pharmacology 1998, 53:14-22.
24. Peters J.M., Aoyama T., Cattley R.C., Nobumitsu U., Hashimoto T., Gonzalez F.J. Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. Carcinogenesis 1998, 19:1989-1994.
25. Rabilloud T. Detecting proteins separated by 2-D gel electrophoresis. Analytical Chemistry 2000, 72:48A-55A.
26. Ren H., Vallanat B., Nelson D.M., Yeung L.W., Guruge K.S., Lam P.K., Lehman-McKeeman L.D., Corton J.C. Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species. Reproductive Toxicology 2009, 27:266-277.
27. Rosen M.B., Abbott B.D., Wolf D.C., Corton J.C., Wood C.R., Schmid J.E., Das K.P., Zehr R.D., Blair E.T., Lau C. Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid. Toxicologic Pathology 2008, 36:592-607.
28. Rosen M.B., Lee J.S., Ren H., Vallanat B., Liu J., Waalkes M.P., Abbott B.D., Lau C., Corton J.C. Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. Toxicological Sciences 2008, 103:46-56.
29. Shin M., Kim I., Inoue Y., Kimura S., Gonzalez F.J. Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha. Molecular Pharmacology 2006, 70:1281-1290.
30. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., Klenk D.C. Measurement of protein using bicinchoninic acid. Analytical Biochemistry 1985, 150:76-85.
31. Suja F., Pramanik B.K., Zain S.M. Contamination, bioaccumulation and toxic effects of perfluorinated chemicals (PFCs) in the water environment: a review paper. Water Science and Technology 2009, 60:1533-1544.
32. Tian J.M., Schibler U. Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. Genes Development 1991, 5:2225-2234.
33. Tirona R.G., Lee W., Leake B.F., Lan L.B., Cline C.B., Lamba V., Parviz F., Duncan S.A., Inoue Y., Gonzalez F.J., Schuetz E.G., Kim R.B. The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nature Medicine 2003, 9:220-224.
34. Vanden Heuvel J.P. Perfluorodecanoic acid as a useful pharmacologic tool for the study of peroxisome proliferation. General Pharmacology 1996, 27:1123-1129.
35. Wolf D.C., Moore T., Abbott B.D., Rosen M.B., Das K.P., Zehr R.D., Lindstrom A.B., Strynar M.J., Lau C. Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice. Toxicologic Pathology 2008, 36:632-639.
36. Yuan X., Ta T.C., Lin M., Evans J.R., Dong Y., Bolotin E., Sherman M.A., Forman B.M., Sladek F.M. Identification of an endogenous ligand bound to a native orphan nuclear receptor. PLoS One 2009, 4:e5609.