Adenovirus expressing shRNA to IGF-1R enhances the chemosensitivity of lung cancer cell lines by blocking IGF-1 pathway

Lung Cancer

Volumn 55, Issue 3, 2007, Pages 279-286

  Lee, Yoon Jin ^a,b   Imsumran, Arisa ^c   Park, Mi Young ^a,b   Kwon, Sung Youn ^a,b   Yoon, Ho Il ^a,b   Lee, Jae Ho ^a,b   Yoo, Chul Gyu ^a   Kim, Young Whan ^a   Han, Sung Koo ^a   Shim, Young Soo ^a   Piao, Wenhua ^c   Yamamoto, Hiroyuki ^c   Adachi, Yasushi ^c   Carbone, David P ^d   Lee, Choon Taek ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c SAPPORO MEDICAL UNIVERSITY   (Japan)

^d VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Adenovirus; IGF 1R; Lung cancer; shRNA; siRNA

Indexed keywords

ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; FLUOROURACIL; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; SOMATOMEDIN; SOMATOMEDIN C RECEPTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER THERAPY; CARCINOGENICITY; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG TARGETING; FLUORESCENCE ACTIVATED CELL SORTING; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADENOVIRIDAE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE SEQUENCE; CASPASE 3; CELL LINE, TUMOR; GENE THERAPY; HUMANS; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RECEPTOR, IGF TYPE 1; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA, VIRAL; SIGNAL TRANSDUCTION; TRANSDUCTION, GENETIC;

EID: 33847421317     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2006.10.020     Document Type: Article

References (22)

1. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 6669 (1998) 806-811
2. Hannon G.J. RNA interference. Nature 418 6894 (2002) 244-251
3. Tuschl T., and Borkhardt A. Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy. Mol Interv 2 3 (2002) 158-167
4. Tuschl T. Functional genomics: RNA sets the standard. Nature 421 6920 (2003) 220-221
5. Tong A.W., Zhang Y.A., and Nemunaitis J. Small interfering RNA for experimental cancer therapy. Curr Opin Mol Ther 7 2 (2005) 114-124
6. Bohula E.A., Salisbury A.J., Sohail M., Playford M.P., Riedemann J., Southern E.M., et al. The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript. J Biol Chem 278 18 (2003) 15991-15997
7. Lee C.T., Wu S., Gabrilovich D., Chen H., Nadaf-Rahrov S., Ciernik I.F., et al. Antitumor effects of an adenovirus expressing antisense insulin-like growth factor I receptor on human lung cancer cell lines. Cancer Res 56 13 (1996) 3038-3041
8. Lee C.T., Park K.H., Adachi Y., Seol J.Y., Yoo C.G., Kim Y.W., et al. Recombinant adenoviruses expressing dominant negative insulin-like growth factor-I receptor demonstrate antitumor effects on lung cancer. Cancer Gene Ther 10 1 (2003) 57-63
9. Elbashir S.M., Harborth J., Weber K., and Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26 2 (2002) 199-213
10. Brummelkamp T.R., Bernards R., and Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296 5567 (2002) 550-553
11. Adachi Y., Lee C.T., Coffee K., Yamagata N., Ohm J.E., Park K.H., et al. Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines. Gastroenterology 123 4 (2002) 1191-1204
12. Min Y., Adachi Y., Yamamoto H., Ito H., Itoh F., Lee C.T., et al. Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer. Cancer Res 63 19 (2003) 6432-6441
13. Min Y., Adachi Y., Yamamoto H., Imsumran A., Arimura Y., Endo T., et al. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts. Gut 54 5 (2005) 591-600
14. Lee C.T., Park K.H., Yanagisawa K., Adachi Y., Ohm J.E., Nadaf S., et al. Combination therapy with conditionally replicating adenovirus and replication defective adenovirus. Cancer Res 64 18 (2004) 6660-6665
15. Baserga R., Peruzzi F., and Reiss K. The IGF-1 receptor in cancer biology. Int J Cancer 107 6 (2003) 873-877
16. Bohula E.A., Playford M.P., and Macaulay V.M. Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment. Anticancer Drugs 14 9 (2003) 669-682
17. Bahr C., and Groner B. The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res 14 4 (2004) 287-295
18. Peruzzi F., Prisco M., Dews M., Salomoni P., Grassilli E., Romano G., et al. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol 19 10 (1999) 7203-7215
19. Prisco M., Romano G., Peruzzi F., Valentinis B., Baserga R., and Insulin. IGF-I receptors signaling in protection from apoptosis. Horm Metab Res 31 2-3 (1999) 80-89
20. Arts G.J., Langemeijer E., Tissingh R., Ma L., Pavliska H., Dokic K., et al. Adenoviral vectors expressing siRNAs for discovery and validation of gene function. Genome Res 13 10 (2003) 2325-2332
21. Shinomiya N., Gao C.F., Xie Q., Gustafson M., Waters D.J., Zhang Y.W., et al. RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival. Cancer Res 64 21 (2004) 7962-7970
22. Carette J.E., Overmeer R.M., Schagen F.H., Alemany R., Barski O.A., Gerritsen W.R., et al. Conditionally replicating adenoviruses expressing short hairpin RNAs silence the expression of a target gene in cancer cells. Cancer Res 64 8 (2004) 2663-2667