Short sleep as an environmental exposure: A preliminary study associating 5-HTTLPR genotype to self-reported sleep duration and depressed mood in first-year university students

Sleep

Volumn 35, Issue 6, 2012, Pages 791-796

  Carskadon, Mary A ^a,b   Sharkey, Katherine M ^a,c   Knopik, Valerie S ^a,c   McGeary, John E ^a,c,d  

^a BROWN UNIVERSITY   (United States)

^b E P BRADLEY HOSPITAL   (United States)

^c BROWN UNIVERSITY   (United States)

^d PROVIDENCE VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

5 HTTLPR; Depression; Genetics; Serotonin; Sleep; Undergraduate students

Indexed keywords

ADULT; ALLELE; ARTICLE; ASIAN; CONTROLLED STUDY; DNA DETERMINATION; DNA POLYMORPHISM; ENVIRONMENTAL EXPOSURE; FEMALE; GENE; GENOTYPE; HUMAN; MALE; MOOD; NIGHT SLEEP; PHENOTYPE; PRIORITY JOURNAL; SELF REPORT; SLC6A4 GENE; SLEEP QUALITY; UNIVERSITY STUDENT;

ADOLESCENT; DEPRESSION; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SLEEP; STUDENTS;

EID: 84861854173     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.1876     Document Type: Article

References (45)

1. Risch N, Herrell R, Lehner T, et al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression. JAMA 2009;301:2462-71.
2. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386-9. (Pubitemid 36877077)
3. Wilhelm K, Mitchell PB, Niven H, et al. Life events, first depression onset and the serotonin transporter gene. Br J Psychiatry 2006;188:210-15. (Pubitemid 43341646)
4. Cervilla JA, Molina E, Rivera M, et al. The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter HTTLPR genotype: evidence from the Spanish PREDICT-Gene cohort. Mol Psychiatry 2007;12:748-55.
5. Perlis ML, Giles DE, Buysse DJ, Tu X, Kupfer DJ. Self-reported sleep disturbance as a prodromal symptom in recurrent depression. J Affect Disord 1997;42:209-12. (Pubitemid 27170166)
6. Benca RM, Obermeyer WH, Thisted RA, Gillin JC. Sleep and psychiatric disorders: a meta-analysis. Arch Gen Psychiatry 1992;49:651-68; discussion 69-70.
7. Ford DE, Kamerow DB. Epidemiologic study of sleep disturbances and psychiatric disorders: an opportunity for prevention? JAMA 1989;262:1479-84. (Pubitemid 19220042)
8. Benca RM, Okawa M, Uchiyama M, et al. Sleep and mood disorders. Sleep Med Rev 1997;1:45-56. (Pubitemid 127674869)
9. Hawkins DR, Taub JM, Van de Castle RL. Extended sleep (hypersomnia) in young depressed patients. Am J Psychiatry 1985;142:905-10. (Pubitemid 15240230)
10. Breslau N, Roth T, Rosenthal L, Andreski P. Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry 1996;39:411-8. (Pubitemid 26124560)
11. National Sleep Foundation. Sleep in America Poll - Teens and Sleep. 2006 [cited 2011 September 29]; Available from: http://www.sleepfoundation.org/ article/sleep-america-polls/2006-teens-and-sleep
12. Fitzgerald CT, Messias E, Buysse DJ. Teen sleep and suicidality: results from the youth risk behavior surveys of 2007 and 2009. J Clin Sleep Med 2011;7:351-6.
13. Fuller RW, Wong DT. Effects of antidepressants on uptake and receptor systems in the brain. Prog Neuropsychopharmacol Biol Psychiatry 1985;9:485-90. (Pubitemid 16148248)
14. Monti JM. Serotonin control of sleep-wake behavior. Sleep Med Rev 2011;15:269-81.
15. Monti JM. The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep. Sleep Med Rev 2010;14:319-27.
16. Lydic R, McCarley RW, Hobson JA. Serotonin neurons and sleep. II. Time course of dorsal raphe discharge, PGO waves, and behavioral states. Arch Ital Biol 1987;126:1-28.
17. Lydic R, McCarley RW, Hobson JA. Serotonin neurons and sleep. I. Long term recordings of dorsal raphe discharge frequency and PGO waves. Arch Ital Biol 1987;125:317-43. (Pubitemid 18028719)
18. Steiger A, Kimura M. Wake and sleep EEG provide biomarkers in depression. J Psychiatr Res 2009;44:242-52.
19. Kupfer DJ. REM latency: a psychobiologic marker for primary depressive disease. Biol Psychiatry 1976;11:159-74.
20. Vogel GW, Traub AC, Ben-Horin P, Meyers GM. REM deprivation. II. The effects on depressed patients. Arch Gen Psychiatry 1968;18:301-11.
21. Giedke H, Schwarzler F. Therapeutic use of sleep deprivation in depression. Sleep Med Rev 2002;6:361-77. (Pubitemid 36529360)
22. Roman V, Walstra I, Luiten PG, Meerlo P. Too little sleep gradually desensitizes the serotonin 1A receptor system. Sleep 2005;28:1505-10. (Pubitemid 41747077)
23. Paykel ES. Life events and affective disorders. Acta Psychiatr Scand Suppl 2003:61-6.
24. Hicks T, Heastie S. High school to college transition: a profile of the stressors, physical and psychological health issues that affect the first-year on-campus college student. J Cult Divers 2008;15:143-7.
25. Dyson R, Renk K. Freshmen adaptation to university life: depressive symptoms, stress, and coping. J Clin Psychol 2006;62:1231-44. (Pubitemid 44569372)
26. Levine B, Roehrs T, Zorick F, Roth T. Daytime sleepiness in young adults. Sleep 1988;11:39-46.
27. Carskadon M, Davis S. Sleep-wake patterns in the high school-to-college transition: preliminary data. Sleep Research 1989;18:113.
28. Lench N, Stanier P, Williamson R. Simple non-invasive method to obtain DNA for gene analysis. Lancet 1988;1:1356-8.
29. Freeman B, Powell J, Ball D, Hill L, Craig I, Plomin R. DNA by mail: an inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations. Behav Genet 1997;27:251-7.
30. Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-31. (Pubitemid 26403928)
31. Wigg KG, Takhar A, Ickowicz A, et al. Gene for the serotonin transporter and ADHD: no association with two functional polymorphisms. Am J Med Genet B Neuropsychiatr Genet 2006;141B:566-70. (Pubitemid 44434655)
32. Zalsman G, Huang YY, Oquendo MA, et al. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 2006;163:1588-93. (Pubitemid 44465760)
33. Guo SW, Thompson EA. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 1992;48:361-72.
34. Radloff L. The CES-D scale: a self-report depression scale for research in the general population. Applied Psychological Measurement 1977;1:385-401.
35. Gibb B, Beevers C, McGeary J. Towards an integration of cognitive and genetic models of risk for depression. Cognit Emot in press.
36. Belsky J, Pluess M. Beyond diathesis stress: differential susceptibility to environmental influences. Psychol Bull 2009;135:885-908.
37. Hannon J, Hoyer D. Molecular biology of 5-HT receptors. Behav Brain Res 2008;195:198-213.
38. Lemonde S, Turecki G, Bakish D, et al. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 2003;23:8788-99. (Pubitemid 37176660)
39. Li Q, Wichems C, Heils A, Lesch KP, Murphy DL. Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences. J Neurosci 2000;20:7888-95.
40. David SP, Murthy NV, Rabiner EA, et al. A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci 2005;25:2586-90. (Pubitemid 40365170)
41. Magee L, Hale L. Longitudinal associations between sleep duration and subsequent weight gain: a systematic review. Sleep Med Rev 2011; Epub ahead of print, PMID:21784678.
42. Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J 2011;32:1484-92.
43. Yen CF, King BH, Tang TC. The association between short and long nocturnal sleep durations and risky behaviours and the moderating factors in Taiwanese adolescents. Psychiatry Res 2010;179:69-74.
44. John U, Meyer C, Rumpf HJ, Hapke U. Relationships of psychiatric disorders with sleep duration in an adult general population sample. J Psychiatr Res 2005;39:577-83. (Pubitemid 41278624)
45. Paavonen EJ, Raikkonen K, Lahti J, et al. Short sleep duration and behavioral symptoms of attention-deficit/hyperactivity disorder in healthy 7- to 8-year-old children. Pediatrics 2009;123:e857-64.