Cardiovascular disease in children and adolescents with diabetes: Where are we, and where are we going?

Diabetes Technology and Therapeutics

Volumn 14, Issue SUPPL. 1, 2012, Pages

  Truong, Uyen T ^a   Maahs, David M ^a,b   Daniels, Stephen R ^a  

^a Children's Hospital Colorado   (United States)

^b UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN KINASE C; TRIACYLGLYCEROL;

ADOLESCENT; ARTERIAL STIFFNESS; ARTERIAL WALL THICKNESS; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTICLE; BODY MASS; BRACHIAL ARTERY ECHOGRAPHY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR RISK; CHILD; CIGARETTE SMOKING; COMPUTER ASSISTED TOMOGRAPHY; DIABETIC CARDIOMYOPATHY; DIET RESTRICTION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DYSLIPIDEMIA; ECHOCARDIOGRAPHY; ECHOGRAPHY; ELECTRON BEAM TOMOGRAPHY; ENZYME ACTIVATION; FAMILY HISTORY; GLYCEMIC CONTROL; HUMAN; HYPERTENSION; IMMOBILIZATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; MEDICAL ASSESSMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; PRACTICE GUIDELINE; PREDICTION; PREVALENCE; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; RISK ASSESSMENT; RISK FACTOR; SMOKING CESSATION; SODIUM RESTRICTION; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; VEIN OCCLUSION PLETHYSMOGRAPHY; WEIGHT REDUCTION;

ADOLESCENT; BODY MASS INDEX; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHILD; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; EARLY DIAGNOSIS; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; OBESITY; PRACTICE GUIDELINES AS TOPIC; PREVALENCE; RISK FACTORS; SEDENTARY LIFESTYLE; VASCULAR STIFFNESS; YOUNG ADULT;

EID: 84861853730     PISSN: 15209156     EISSN: 15578593     Source Type: Journal    
DOI: 10.1089/dia.2012.0018     Document Type: Article

References (84)

1. Meigs JB: Epidemiology of cardiovascular complications in type 2 diabetes mellitus. Acta Diabetol 2003;40(Suppl 2): S358-S361.
2. Donahue RP, Orchard TJ: Giabetes mellitus and macrovascular complications. An epidemiological perspective. Diabetes Care 1992;15:1141-1155.
3. Laing SP, Swerdlow AJ, Slater SD, Botha JL, Burden AC, Waugh NR, Smith AW, Hill RD, Bingley PJ, Patterson CC, Qiao Z, Keen H: The British Diabetic Association Cohort Study. II: Cause-specific mortality in patients with insulintreated diabetes mellitus. Diabet Med 1999;16:466-471.
4. Mahgoub MA, Abd-Elfattah AS: Giabetes mellitus and cardiac function. Mol Cell Biochem 1998;180:59-64.
5. Soltesz G, Patterson CC, Dahlquist G: Worldwide childhood type 1 diabetes incidence-what can we learn from epidemiology? Pediatr Diabetes 2007;8(Suppl 6):6-14.
6. Liese AD, D'Agostino RB Jr, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, Loots B, Linder B, Marcovina S, Rodriguez B, Standiford D, Williams DE: The burden of diabetes mellitus among US youth: Prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics 2006;118:1510-1518.
7. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006;295:1549-1555.
8. Nadeau KJ, Maahs DM, Daniels SR, Eckel RH: Childhood obesity and cardiovascular disease: Links and prevention strategies. Nat Rev Cardiol 2011;8:513-525.
9. Enos WF, Holmes RH, Beyer J: Coronary disease among United States soldiers killed in action in Korea; preliminary report. JAMA 1953;152:1090-1093.
10. Newman WP 3rd, Freedman DS, Voors AW, Gard PD, Srinivasan SR, Cresanta JL, Williamson GD, Webber LS, Berenson GS: Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. The Bogalusa Heart Study. N Engl J Med 1986;314:138-144.
11. Strong JP, Malcom GT, McMahan CA, Tracy RE, Newman WP 3rd, Herderick EE, Cornhill JF: Prevalence and extent of atherosclerosis in adolescents and young adults: Implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA 1999;281:727-735.
12. Tardif JC, Heinonen T, Orloff D, Libby P: Vascular biomarkers and surrogates in cardiovascular disease. Circulation 2006;113:2936-2942.
13. Fleming TR, DeMets DL: Surrogate end points in clinical trials: Are we being misled? Ann Intern Med 1996;125: 605-613.
14. Goldstein JL, Hazzard WR, Schrott HG, Bierman EL, Motulsky AG: Hyperlipidemia in coronary heart disease I Lipid levels in 500 survivors of myocardial infarction. J Clin Invest 1973;52:1533-1543.
15. Castelli WP, Garrison RJ, Wilson PW, Abbott RD, Kalousdian S, Kannel WB: Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham study. JAMA 1986;256:2835-2838.
16. Krolewski AS, Kosinski EJ, Warram JH, Leland OS, Busick EJ, Asmal AC, Rand LI, Christlieb AR, Bradley RF, Kahn CR: Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus. Am J Cardiol 1987;59:750-755.
17. Laing SP, Swerdlow AJ, Slater SD, Burden AC, Morris A, Waugh NR, Gatling W, Bingley PJ, Patterson CC: Mortality from heart disease in a cohort of 23,000 patients with insulintreated diabetes. Diabetologia 2003;46:760-765.
18. Dorman JS, Laporte RE, Kuller LH, Cruickshanks KJ, Orchard TJ, Wagener DK, Becker DJ, Cavender DE, Drash AL: The Pittsburgh Insulin-Dependent Diabetes Mellitus (IDDM) Morbidity and Mortality Study. Mortality results. Diabetes 1984;33:271-276.
19. Orchard TJ: From diagnosis and classification to complications and therapy. DCCT. Part II? Diabetes Control and Complications Trial. Diabetes Care 1994;17:326-338.
20. Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B: Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005;353:2643-2653.
21. Prince CT, Becker DJ, Costacou T, Miller RG, Orchard TJ: Changes in glycaemic control and risk of coronary artery disease in type 1 diabetes mellitus: Findings from the Pittsburgh Epidemiology of Diabetes Complications Study (EDC). Diabetologia 2007;50:2280-2288.
22. Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH: Longterm morbidity and mortality of overweight adolescents. A follow-up of the harvard growth study of 1922 to 1935. N Engl J Med 1992;327:1350-1355.
23. Libby P, Plutzky J: Giabetic macrovascular disease: The glucose paradox? Circulation 2002;106:2760-2763.
24. Guy J, Ogden L, Wadwa RP, Hamman RF, Mayer-Davis EJ, Liese AD, D'Agostino R Jr, Marcovina S, Dabelea D: Lipid and lipoprotein profiles in youth with and without type 1 diabetes: The SEARCH for Diabetes in Youth case-control study. Diabetes Care 2009;32:416-420
25. Orchard TJ, Costacou T: When are type 1 diabetic patients at risk for cardiovascular disease? Curr Diabetes Rep 2010;10: 48-54.
26. Ebara T, Conde K, Kako Y, Liu Y, Xu Y, Ramakrishnan R, Goldberg IJ, Shachter NS: Gelayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice. J Clin Invest 2000;105: 1807-1818.
27. Schauer IE, Snell-Bergeon JK, Bergman BC, Maahs DM, Kretowski A, Eckel RH, Rewers M: Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study. Diabetes 2011;60:306-314.
28. Nadeau KJ, Reusch JE: Cardiovascular function/dysfunction in adolescents with type 1 diabetes. Curr Diabetes Rep 2011; 11:185-192.
29. Hassouna A, Loubani M, Matata BM, Fowler A, Standen NB, Galinanes M: Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium. Cardiovasc Res 2006;69:450-458.
30. Trost S, LeWinter M: Giabetic cardiomyopathy. Curr Treat Options Cardiovasc Med 2001;3:481-492.
31. Brownlee M: The pathobiology of diabetic complications: A unifying mechanism. Diabetes 2005;54:1615-1625.
32. American Diabetes Association: Management of dyslipidemia in children and adolescents with diabetes. Diabetes Care 2003;26:2194-2197.
33. Betteridge DJ: Giabetic dyslipidemia. Am J Med 1994;96: 25S-31S.
34. Siegel RD, Cupples A, Schaefer EJ, Wilson PW: Lipoproteins, apolipoproteins, and low-density lipoprotein size among diabetics in the Framingham Offspring Study. Metabolism 1996;45:1267-1272.
35. Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA: Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998;338:1650-1656.
36. Lauer RM, Clarke WR: Use of cholesterol measurements in childhood for the prediction of adult hypercholesterolemia. The Muscatine Study. JAMA 1990;264:3034-3038.
37. Orchard TJ, Forrest KY, Kuller LH, Becker DJ: Lipid and blood pressure treatment goals for type 1 diabetes: 10-year incidence data from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes Care 2001;24:1053-1059.
38. Rosenbloom AL, Silverstein JH, Amemiya S, Zeitler P, Klingensmith GJ: Type 2 diabetes in children and adolescents. Pediatr Diabetes 2009;10(Suppl 12):17-32.
39. Kavey RE, Allada V, Daniels SR, Hayman LL, McCrindle BW, Newburger JW, Parekh RS, Steinberger J: Cardiovascular risk reduction in high-risk pediatric patients: A scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics. Circulation 2006; 114:2710-2738.
40. Reynolds K, Liese AD, Anderson AM, Dabelea D, Standiford D, Daniels SR, Waitzfelder B, Case D, Loots B, Imperatore G, Lawrence JM: Prevalence of tobacco use and association between cardiometabolic risk factors and cigarette smoking in youth with type 1 or type 2 diabetes mellitus. J Pediatr 2011;158:594-601.
41. American Diabetes Association: Standards of medical care in diabetes-2010. Diabetes Care 2010;33(Suppl 1):S11-S61.
42. McCrindle BW, Urbina EM, Dennison BA, Jacobson MS, Steinberger J, Rocchini AP, Hayman LL, Daniels SR: Grug therapy of high-risk lipid abnormalities in children and adolescents: A scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. Circulation 2007;115:1948-1967.
43. Kendall DM. Blood pressure targets in diabetes: Is this the time for change? J Clin Hypertens (Greenwich) 2011;13: 258-262.
44. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: Summary report. Pediatrics 2011;128(Suppl 5): S213-S256.
45. Genuth S, Ismail-Beigi F: Clinical implications of the ACCORD trial. J Clin Endocrinol Metab 2012;97:41-48.
46. Hamet P: What matters in ADVANCE and ADVANCE-ON. Diabetes Obes Metab 2012;14(Suppl 1):20-29.
47. Nathan DM, Lachin J, Cleary P, Orchard T, Brillon DJ, Backlund JY, O'Leary DH, Genuth S: Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus. N Engl J Med 2003;348:2294-2303.
48. Cleary PA, Orchard TJ, Genuth S, Wong ND, Detrano R, Backlund JY, Zinman B, Jacobson A, Sun W, Lachin JM, Nathan DM: The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Diabetes 2006;55:3556-3565.
49. Zarich SW, Arbuckle BE, Cohen LR, Roberts M, Nesto RW: Giastolic abnormalities in young asymptomatic diabetic patients assessed by pulsed Doppler echocardiography. J Am Coll Cardiol 1988;12:114-120.
50. Zhang X, Chen C: A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy. Endocrine 2012 Feb 12 [Epub ahead of print]. DOI: 10.1007/s12020-012-9623-1.
51. Ce GV, Rohde LE, Da Silva AM, Punales MK, De Castro AC, Bertoluci MC: Endothelial dysfunction is related to poor glycemic control in adolescents with type 1 diabetes under 5 years of disease: Evidence of metabolic memory. J Clin Endocrinol Metab 2011;96:1493-1499.
52. Beckman JA, Creager MA, Libby P: Giabetes and atherosclerosis: Epidemiology, pathophysiology, and management. JAMA 2002;287:2570-2581.
53. Giannini C, Mohn A, Chiarelli F, Kelnar CJ: Macrovascular angiopathy in children and adolescents with type 1 diabetes. Diabetes Metab Res Rev 2011;27:436-460.
54. Nadeau KJ, Zeitler PS, Bauer TA, Brown MS, Dorosz JL, Draznin B, Reusch JE, Regensteiner JG: Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocrinol Metab 2009;94:3687-3695.
55. Nadeau KJ, Regensteiner JG, Bauer TA, Brown MS, Dorosz JL, Hull A, Zeitler P, Draznin B, Reusch JE: Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab 2010;95: 513-521.
56. Wang L, Jerosch-Herold M, Jacobs DR, Jr., Shahar E, Detrano R, Folsom AR: Coronary artery calcification and myocardial perfusion in asymptomatic adults: The MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2006;48: 1018-1026.
57. Urbina EM, Williams RV, Alpert BS, Collins RT, Daniels SR, Hayman L, Jacobson M, Mahoney L, Mietus-Snyder M, Rocchini A, Steinberger J, McCrindle B: Noninvasive assessment of subclinical atherosclerosis in children and adolescents: Recommendations for standard assessment for clinical research: A scientific statement from the American Heart Association. Hypertension 2009;54:919-950.
58. Sutton-Tyrrell K, Najjar SS, Boudreau RM, Venkitachalam L, Kupelian V, Simonsick EM, Havlik R, Lakatta EG, Spurgeon H, Kritchevsky S, Pahor M, Bauer D, Newman A: Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 2005;111:3384-3390.
59. Urbina EM, Wadwa RP, Davis C, Snively BM, Dolan LM, Daniels SR, Hamman RF, Dabelea D: Prevalence of increased arterial stiffness in children with type 1 diabetes mellitus differs by measurement site and sex: The SEARCH for Diabetes in Youth Study. J Pediatr 2010;156:731-737, 737.e1.
60. Haller MJ, Samyn M, Nichols WW, Brusko T, Wasserfall C, Schwartz RF, Atkinson M, Shuster JJ, Pierce GL, Silverstein JH: Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes. Diabetes Care 2004;27:2911-2917.
61. Brooks B, Molyneaux L, Yue DK: Augmentation of central arterial pressure in type 1 diabetes. Diabetes Care 1999;22: 1722-1727.
62. Brooks BA, Molyneaux LM, Yue DK: Augmentation of central arterial pressure in type 2 diabetes. Diabet Med 2001; 18:374-380.
63. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr: Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999;340:14-22.
64. Azen SP, Mack WJ, Cashin-Hemphill L, LaBree L, Shircore AM, Selzer RH, Blankenhorn DH, Hodis HN: Progression of coronary artery disease predicts clinical coronary events. Long-Term follow-up from the Cholesterol Lowering Atherosclerosis Study. Circulation 1996;93:34-41.
65. Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, Clegg LX: Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: The Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol 1997;146:483-494.
66. Singh TP, Groehn H, Kazmers A: Vascular function and carotid intimal-medial thickness in children with insulindependent diabetes mellitus. J Am Coll Cardiol 2003;41: 661-665.
67. Jarvisalo MJ, Raitakari M, Toikka JO, Putto-Laurila A, Rontu R, Laine S, Lehtimaki T, Ronnemaa T, Viikari J, Raitakari OT: Endothelial dysfunction and increased arterial intimamedia thickness in children with type 1 diabetes. Circulation 2004;109:1750-1755.
68. Margolis JR, Chen JT, Kong Y, Peter RH, Behar VS, Kisslo JA: The diagnostic and prognostic significance of coronary artery calcification. A report of 800 cases. Radiology 1980;137:609-616.
69. Dabelea D, Kinney G, Snell-Bergeon JK, Hokanson JE, Eckel RH, Ehrlich J, Garg S, Hamman RF, Rewers M: Effect of type 1 diabetes on the gender difference in coronary artery calcification: A role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. Diabetes 2003;52:2833-2839.
70. Starkman HS, Cable G, Hala V, Hecht H, Donnelly CM: Gelineation of prevalence and risk factors for early coronary artery disease by electron beam computed tomography in young adults with type 1 diabetes. Diabetes Care 2003; 26:433-436.
71. Godsland IF, Pavitt D, Okoturo O, Edwards RJ, Rubens MB, Feher MD, Flather MD, Elkeles RS: Can protein biomarkers provide an index of coronary artery calcification in patients with type 2 diabetes? Atherosclerosis 2010;213:570-572.
72. Di Bello V, Talarico L, Picano E, Di Muro C, Landini L, Paterni M, Matteucci E, Giusti C, Giampietro O: Increased echodensity of myocardial wall in the diabetic heart: An ultrasound tissue characterization study. J Am Coll Cardiol 1995;25:1408-1415.
73. Fraser GE, Luke R, Thompson S, Smith H, Carter S, Sharpe N: Comparison of echocardiographic variables between type I diabetics and normal controls. Am J Cardiol 1995;75:141-145.
74. Salem M, El Behery S, Adly A, Khalil D, El Hadidi E: Early predictors of myocardial disease in children and adolescents with type 1 diabetes mellitus. Pediatr Diabetes 2009; 10:513-521.
75. Nagueh SF, Middleton KJ, Kopelen HA, Zoghbi WA, Quinones MA: Goppler tissue imaging: A noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997;30: 1527-1533.
76. Vazeou A, Papadopoulou A, Miha M, Drakatos A, Georgacopoulos D: Cardiovascular impairment in children, adolescents, and young adults with type 1 diabetes mellitus (T1DM). Eur J Pediatr 2008;167:877-884.
77. Karavanaki K, Kazianis G, Konstantopoulos I, Tsouvalas E, Karayianni C: Early signs of left ventricular dysfunction in adolescents with type 1 diabetes mellitus: The importance of impaired circadian modulation of blood pressure and heart rate. J Endocrinol Invest 2008;31:289-296.
78. Mehta SK, Holliday C, Hayduk L, Wiersma L, Richards N, Younoszai A: Comparison of myocardial function in children with body mass indexes ≥ 25 versus those < 25 kg/m2 Am. J. Cardiol. 2004 93 1567-1569
79. Type 2 diabetes in children and adolescents. American Diabetes Association. Pediatrics 2000;105:671-680.
80. Mizushige K, Yao L, Noma T, Kiyomoto H, Yu Y, Hosomi N, Ohmori K, Matsuo H: Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulinresistant prediabetic stage of a type II diabetic rat model. Circulation 2000;101:899-907.
81. Kim EH, Kim YH: Left ventricular function in children and adolescents with type 1 diabetes mellitus. Korean Circ J 2010;40:125-130.
82. Larsen JR, Tsunoda T, Tuzcu EM, Schoenhagen P, Brekke M, Arnesen H, Hanssen KF, Nissen SE, Dahl-Jorgensen K: Intracoronary ultrasound examinations reveal significantly more advanced coronary atherosclerosis in people with type 1 diabetes than in age- and sex-matched non-diabetic controls. Diabetes Vasc Dis Res 2007;4:62-65.
83. Turkbey EB, Backlund JY, Genuth S, Jain A, Miao C, Cleary PA, Lachin JM, Nathan DM, Van Der Geest RJ, Soliman EZ, Liu CY, Lima JA, Bluemke DA: Myocardial structure, function, and scar in patients with type 1 diabetes mellitus. Circulation 2011;124:1737-1746.
84. Esposito L, Saam T, Heider P, Bockelbrink A, Pelisek J, Sepp D, Feurer R, Winkler C, Liebig T, Holzer K, Pauly O, Sadikovic S, Hemmer B, Poppert H: MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis. BMC Med Imaging 2010;10:27.