Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism

Psychopharmacology

Volumn 222, Issue 1, 2012, Pages 129-140

  Jamadar, S ^a   DeVito, E E ^b   Jiantonio, R E ^a   Meda, S A ^a,d   Stevens, M C ^a,b   Potenza, M N ^b,c   Krystal, J H ^b,e,f   Pearlson, G D ^a,b  

^a INSTITUTE OF LIVING   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^f YALE NEW HAVEN HOSPITAL   (United States)

Author keywords

fMRI; Genetic risk of alcoholism; Go No Go; Memantine; NMDA receptor antagonist; Response execution; Response inhibition

Indexed keywords

MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PLACEBO;

ADULT; ALCOHOLISM; ANTERIOR CINGULATE; AREA UNDER THE CURVE; ARTICLE; BASAL GANGLION; BEHAVIOR; CAUDATE NUCLEUS; CEREBELLUM VERMIS; CINGULATE GYRUS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRINKING BEHAVIOR; FAMILY HISTORY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUSIFORM GYRUS; GENETIC RISK; HIGH RISK BEHAVIOR; HUMAN; IMPULSIVENESS; INFERIOR TEMPORAL GYRUS; INSULA; LINGUAL GYRUS; MALE; MIDDLE FRONTAL GYRUS; NO GO PEFORMANCE; POSTERIOR CINGULATE; PRECUNEUS; PRIORITY JOURNAL; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL; RIGHT HANDEDNESS; SUPPLEMENTARY MOTOR AREA; TASK PERFORMANCE; TEMPORAL CORTEX;

ADOLESCENT; ADULT; ALCOHOLISM; CAUDATE NUCLEUS; DOUBLE-BLIND METHOD; EXCITATORY AMINO ACID ANTAGONISTS; FAMILY HEALTH; FEMALE; GYRUS CINGULI; HUMANS; IMPULSIVE BEHAVIOR; INHIBITION (PSYCHOLOGY); MAGNETIC RESONANCE IMAGING; MALE; MEMANTINE; YOUNG ADULT;

EID: 84861852880     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2628-2     Document Type: Article

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