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Volumn 1003, Issue , 2003, Pages 176-184

NMDA Receptor Antagonism and the Ethanol Intoxication Signal: From Alcoholism Risk to Pharmacotherapy

Author keywords

Alcohol dependence; Alcoholism; Alcoholism vulnerability; Ethanol; Glutamate; Ketamine; N methyl D aspartate receptor; Pharmacotherapy; Phenotype

Indexed keywords

ACAMPROSATE; ALCOHOL; ANTICONVULSIVE AGENT; BENZODIAZEPINE; CYCLOSERINE; DEXTROMETHORPHAN; GLUTAMATE RECEPTOR; GLYCINE; KETAMINE; LAMOTRIGINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NALTREXONE; OPIATE ANTAGONIST; PHENCYCLIDINE;

EID: 0347722464     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1300.010     Document Type: Conference Paper
Times cited : (122)

References (35)
  • 1
    • 0038452492 scopus 로고    scopus 로고
    • Ethanol abuse, dependence, and withdrawal: Neurobiology and clinical implications
    • K.L. Davis, D.S. Charney, J.T. Coyle & C. Nemeroff, Eds.: Lippincott Williams and Wilkins. Philadelphia
    • KRYSTAL, J.H., B. TABAKOFF. 2002. Ethanol abuse, dependence, and withdrawal: neurobiology and clinical implications. In Psychopharmacology: A Fifth Generation of Progress. K.L. Davis, D.S. Charney, J.T. Coyle & C. Nemeroff, Eds.: 1425-1443. Lippincott Williams and Wilkins. Philadelphia.
    • (2002) Psychopharmacology: A Fifth Generation of Progress , pp. 1425-1443
    • Krystal, J.H.1    Tabakoff, B.2
  • 2
    • 0029187835 scopus 로고
    • Cellular and behavioral neurobiology of alcohol: Receptor-mediated neuronal processes
    • GRANT, K.A. & D.M. LOVINGER. 1995. Cellular and behavioral neurobiology of alcohol: receptor-mediated neuronal processes. Clin. Neurosci. 3(3): 155-164.
    • (1995) Clin. Neurosci. , vol.3 , Issue.3 , pp. 155-164
    • Grant, K.A.1    Lovinger, D.M.2
  • 3
    • 0027521151 scopus 로고
    • Discriminative stimulus effects of ethanol: Effect of training dose on the substitution of N-methyl-D-aspartate antagonists
    • GRANT, K.A. & G. COLOMBO. 1993. Discriminative stimulus effects of ethanol: effect of training dose on the substitution of N-methyl-D-aspartate antagonists. J. Pharmacol. Exp. Ther. 264(3): 1241-1247.
    • (1993) J. Pharmacol. Exp. Ther. , vol.264 , Issue.3 , pp. 1241-1247
    • Grant, K.A.1    Colombo, G.2
  • 4
    • 0027903914 scopus 로고
    • Pharmacological analysis of the mixed discriminative stimulus effects of ethanol
    • GRANT, K.A. & G. COLOMBO. 1993. Pharmacological analysis of the mixed discriminative stimulus effects of ethanol. Alcohol Alcohol. Suppl. 2: 445-449.
    • (1993) Alcohol Alcohol. Suppl. , vol.2 , pp. 445-449
    • Grant, K.A.1    Colombo, G.2
  • 5
    • 0032192345 scopus 로고    scopus 로고
    • Evidence for overshadowing by components of the heterogeneous discriminative stimulus effects of ethanol
    • GREEN, K.L. & K.A. GRANT. 1998. Evidence for overshadowing by components of the heterogeneous discriminative stimulus effects of ethanol. Drug Alcohol Depend. 52(2): 149-159.
    • (1998) Drug Alcohol Depend. , vol.52 , Issue.2 , pp. 149-159
    • Green, K.L.1    Grant, K.A.2
  • 6
    • 0037526206 scopus 로고    scopus 로고
    • N-methyl-D-aspartate glutamate receptors and alcoholism: Reward, dependence, treatment, and vulnerability
    • KRYSTAL, J.H., I.L. PETRAKIS, G. MASON, et al. 2003. N-methyl-D- aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol. Ther. 99(1): 79-94.
    • (2003) Pharmacol. Ther. , vol.99 , Issue.1 , pp. 79-94
    • Krystal, J.H.1    Petrakis, I.L.2    Mason, G.3
  • 8
    • 0028323167 scopus 로고
    • Subanesthetic effects of the non-competitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
    • KRYSTAL, J.H., L.P. KARPER, J.P. SEIBYL, et al. 1994. Subanesthetic effects of the non-competitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch. Gen. Psychiatry 51(3): 199-214.
    • (1994) Arch. Gen. Psychiatry , vol.51 , Issue.3 , pp. 199-214
    • Krystal, J.H.1    Karper, L.P.2    Seibyl, J.P.3
  • 9
    • 0031945082 scopus 로고    scopus 로고
    • Dose-related ethanol-like effects of the NMDA antagonist, ketamine, in recently detoxified alcoholics
    • KRYSTAL, J.H., I.L. PETRAKIS, E. WEBB, et al. 1998. Dose-related ethanol-like effects of the NMDA antagonist, ketamine, in recently detoxified alcoholics. Arch. Gen. Psychiatry 55(4): 354-360.
    • (1998) Arch. Gen. Psychiatry , vol.55 , Issue.4 , pp. 354-360
    • Krystal, J.H.1    Petrakis, I.L.2    Webb, E.3
  • 10
    • 0035669463 scopus 로고    scopus 로고
    • Attenuation of ketamine effects by nimodipine in recently detoxified ethanol dependent men: Psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists
    • KRUPITSKY, E.M., A.M. BURAKOV, T.N. ROMANOVA, et al. 2001. Attenuation of ketamine effects by nimodipine in recently detoxified ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists. Neuropsychopharmacology 25: 936-947.
    • (2001) Neuropsychopharmacology , vol.25 , pp. 936-947
    • Krupitsky, E.M.1    Burakov, A.M.2    Romanova, T.N.3
  • 11
    • 0034014701 scopus 로고    scopus 로고
    • Dextromethorphan challenge in alcohol-dependent patients and controls
    • SCHUTZ, C.G. & M. SOYKA. 2000. Dextromethorphan challenge in alcohol-dependent patients and controls. Arch. Gen. Psychiatry 57(3): 291-292.
    • (2000) Arch. Gen. Psychiatry , vol.57 , Issue.3 , pp. 291-292
    • Schutz, C.G.1    Soyka, M.2
  • 12
    • 0038452491 scopus 로고    scopus 로고
    • Altered responses to agonists of the strychnine-insensitive glycine NMDA coagonist (SIGLY) site in recently detoxified alcoholics
    • KRYSTAL, J., I. PETRAKIS, S. KRASNICKI, et al. 1999. Altered responses to agonists of the strychnine-insensitive glycine NMDA coagonist (SIGLY) site in recently detoxified alcoholics. Alcohol. Clin. Exp. Res. 22: 94A.
    • (1999) Alcohol. Clin. Exp. Res. , vol.22
    • Krystal, J.1    Petrakis, I.2    Krasnicki, S.3
  • 13
    • 0037775701 scopus 로고    scopus 로고
    • Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism
    • In review
    • PETRAKIS, I.L., D. LIMONCELLI, R. GUERGUIEVA, et al. 2003. Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. Am. J. Psychiatry. In review.
    • (2003) Am. J. Psychiatry
    • Petrakis, I.L.1    Limoncelli, D.2    Guerguieva, R.3
  • 14
    • 0034040943 scopus 로고    scopus 로고
    • NMDA receptor challenge with dextromethorphan - Subjective response, neuroendocrinological findings and possible clinical implications
    • SOYKA, M., B. BONDY, B. EISENBURG & C.G. SCHUTZ. 2000. NMDA receptor challenge with dextromethorphan - subjective response, neuroendocrinological findings and possible clinical implications. J. Neural Transm. 107(6): 701-714.
    • (2000) J. Neural Transm. , vol.107 , Issue.6 , pp. 701-714
    • Soyka, M.1    Bondy, B.2    Eisenburg, B.3    Schutz, C.G.4
  • 15
    • 0026393998 scopus 로고
    • The contribution of voltage-gated and NMDA receptor-gated calcium channels to ethanol withdrawal seizures
    • HOFFMAN, P.L. & B. TABAKOFF. 1991. The contribution of voltage-gated and NMDA receptor-gated calcium channels to ethanol withdrawal seizures. Alcohol Alcohol. Suppl. 1: 171-175.
    • (1991) Alcohol Alcohol. Suppl. , vol.1 , pp. 171-175
    • Hoffman, P.L.1    Tabakoff, B.2
  • 16
    • 0031959272 scopus 로고    scopus 로고
    • The role of glutamatergic neurotransmission in the pathophysiology of alcoholism
    • TSAI, G. & J.T. COYLE. 1998. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu. Rev. Med. 49: 173-184.
    • (1998) Annu. Rev. Med. , vol.49 , pp. 173-184
    • Tsai, G.1    Coyle, J.T.2
  • 17
    • 0037775703 scopus 로고    scopus 로고
    • Altered NMDA glutamate receptor antagonist response in recovering ethanol dependent patients
    • In press
    • KRYSTAL, J.H., I.L. PETRAKIS, D. LIMONCELLI, et al. 2003. Altered NMDA glutamate receptor antagonist response in recovering ethanol dependent patients. Neuropsychopharmacology. In press.
    • (2003) Neuropsychopharmacology
    • Krystal, J.H.1    Petrakis, I.L.2    Limoncelli, D.3
  • 18
    • 0021799735 scopus 로고
    • Ethanol-induced changes in body sway in men at high alcoholism risk
    • SCHUCKIT, M.A. 1985. Ethanol-induced changes in body sway in men at high alcoholism risk. Arch. Gen. Psychiatry 42(4): 375-379.
    • (1985) Arch. Gen. Psychiatry , vol.42 , Issue.4 , pp. 375-379
    • Schuckit, M.A.1
  • 19
    • 0029883218 scopus 로고    scopus 로고
    • Alcohol challenges in young men from alcoholic pedigrees and control families: A report from the COGA project
    • SCHUCKIT, M.A., J.W. TSUANG, R.M. ANTHENELLI, et al. 1996. Alcohol challenges in young men from alcoholic pedigrees and control families: a report from the COGA project. J. Stud. Alcohol 57(4): 368-377.
    • (1996) J. Stud. Alcohol , vol.57 , Issue.4 , pp. 368-377
    • Schuckit, M.A.1    Tsuang, J.W.2    Anthenelli, R.M.3
  • 20
    • 0028305067 scopus 로고
    • Anticipated biphasic effects of alcohol vary with risk for alcoholism: A preliminary report
    • EARLEYWINE, M. 1994. Anticipated biphasic effects of alcohol vary with risk for alcoholism: a preliminary report. Alcohol. Clin. Exp. Res. 18(3): 711-714.
    • (1994) Alcohol. Clin. Exp. Res. , vol.18 , Issue.3 , pp. 711-714
    • Earleywine, M.1
  • 21
    • 0034846034 scopus 로고    scopus 로고
    • Positive and negative associations with alcohol and familial risk for alcoholism
    • ERBLICH, J. & M. EARLEYWINE & B. ERBLICH. 2001. Positive and negative associations with alcohol and familial risk for alcoholism. Psychol. Addict. Behav. 15(3): 204-209.
    • (2001) Psychol. Addict. Behav. , vol.15 , Issue.3 , pp. 204-209
    • Erblich, J.1    Earleywine, M.2    Erblich, B.3
  • 22
    • 0029983168 scopus 로고    scopus 로고
    • The electroencephalogram after alcohol administration in high-risk men and the development of alcohol use disorders 10 years later
    • VOLAVKA, J., P. CZOBOR, D.W. GOODWIN, et al. 1996. The electroencephalogram after alcohol administration in high-risk men and the development of alcohol use disorders 10 years later. Arch. Gen. Psychiatry 53(3): 258-263.
    • (1996) Arch. Gen. Psychiatry , vol.53 , Issue.3 , pp. 258-263
    • Volavka, J.1    Czobor, P.2    Goodwin, D.W.3
  • 23
    • 0029866658 scopus 로고    scopus 로고
    • An 8-year follow-up of 450 sons of alcoholic and control subjects
    • SCHUCKIT, M.A. & T.L. SMITH. 1996. An 8-year follow-up of 450 sons of alcoholic and control subjects. Arch. Gen. Psychiatry 53(3): 202-210.
    • (1996) Arch. Gen. Psychiatry , vol.53 , Issue.3 , pp. 202-210
    • Schuckit, M.A.1    Smith, T.L.2
  • 24
    • 0029744877 scopus 로고    scopus 로고
    • Alcohol dependence: A commentary on mechanisms
    • HOFFMAN, P.L. & B. TABAKOFF. 1996. Alcohol dependence: a commentary on mechanisms. Alcohol Alcohol. 31(4): 333-340.
    • (1996) Alcohol Alcohol. , vol.31 , Issue.4 , pp. 333-340
    • Hoffman, P.L.1    Tabakoff, B.2
  • 25
    • 0031745777 scopus 로고    scopus 로고
    • Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal
    • TSAI, G.E., P. RAGAN, R. CHANG, et al. 1998. Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal. Am. J. Psychiatry 155(6): 726-732.
    • (1998) Am. J. Psychiatry , vol.155 , Issue.6 , pp. 726-732
    • Tsai, G.E.1    Ragan, P.2    Chang, R.3
  • 26
    • 24844437954 scopus 로고    scopus 로고
    • The effects of lorazepam and carbamazepine on single vs. multiple previous alcohol withdrawals in an outpatient randomized trial
    • MALCOLM, R., H. MYRICK, J.S. ROBERTS & R. ANTON. 2000. The effects of lorazepam and carbamazepine on single vs. multiple previous alcohol withdrawals in an outpatient randomized trial. Alcohol. Clin. Exp. Res. 24(5): 38A.
    • (2000) Alcohol. Clin. Exp. Res. , vol.24 , Issue.5
    • Malcolm, R.1    Myrick, H.2    Roberts, J.S.3    Anton, R.4
  • 27
    • 0036109189 scopus 로고    scopus 로고
    • The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxification
    • MALCOLM, R., H. MYRICK, J. ROBERTS, et al. 2002. The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxification. Am. J. Addict. 11(2): 141-150.
    • (2002) Am. J. Addict. , vol.11 , Issue.2 , pp. 141-150
    • Malcolm, R.1    Myrick, H.2    Roberts, J.3
  • 28
    • 0037556330 scopus 로고    scopus 로고
    • Naltrexone and acamprosate: Meta-analysis of two medical treatments for alcoholism
    • HOPKINS, J.S., J.C. GARBUTT, C.L. POOLE, et al. 2002. Naltrexone and acamprosate: meta-analysis of two medical treatments for alcoholism. Alcohol. Clin. Exp. Res. 26(5): 130A.
    • (2002) Alcohol. Clin. Exp. Res. , vol.26 , Issue.5
    • Hopkins, J.S.1    Garbutt, J.C.2    Poole, C.L.3
  • 29
    • 0036797201 scopus 로고    scopus 로고
    • Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus
    • MAYER, S., B.R. HARRIS, D.A. GIBSON, et al. Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. Alcohol. Clin. Exp. Res. 26(10): 1468-1478.
    • Alcohol. Clin. Exp. Res. , vol.26 , Issue.10 , pp. 1468-1478
    • Mayer, S.1    Harris, B.R.2    Gibson, D.A.3
  • 30
    • 0026708455 scopus 로고
    • The involvement of NMDA receptors in acute and chronic effects of ethanol
    • DANYSZ, W., W. DYR, E. JANKOWSKA, et al. 1992. The involvement of NMDA receptors in acute and chronic effects of ethanol. Alcohol. Clin. Exp. Res. 16(3): 499-504.
    • (1992) Alcohol. Clin. Exp. Res. , vol.16 , Issue.3 , pp. 499-504
    • Danysz, W.1    Dyr, W.2    Jankowska, E.3
  • 31
    • 0035215928 scopus 로고    scopus 로고
    • Effects of acamprosate on sensitization to the locomotor-stimulant effects of alcohol in mice selectively bred for high and low alcohol preference
    • CHESTER, J.A., N.J. GRAHAME, T.K. LI, et al. 2001. Effects of acamprosate on sensitization to the locomotor-stimulant effects of alcohol in mice selectively bred for high and low alcohol preference. Behav. Pharmacol. 12(6-7): 535-543.
    • (2001) Behav. Pharmacol. , vol.12 , Issue.6-7 , pp. 535-543
    • Chester, J.A.1    Grahame, N.J.2    Li, T.K.3
  • 32
    • 0036399161 scopus 로고    scopus 로고
    • Acamprosate reduces context-dependent ethanol effects
    • QUERTEMONT, E., C. BRABANT & P. DE WITTE. 2002. Acamprosate reduces context-dependent ethanol effects. Psychopharmacology 164(1): 10-18.
    • (2002) Psychopharmacology , vol.164 , Issue.1 , pp. 10-18
    • Quertemont, E.1    Brabant, C.2    De Witte, P.3
  • 33
    • 0037229412 scopus 로고    scopus 로고
    • Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: A double-blind, placebo-controlled study
    • KIEFER, F., H. JAHN, T. TARNASKE, et al. 2003. Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study. Arch. Gen. Psychiatry 60(1): 92-99.
    • (2003) Arch. Gen. Psychiatry , vol.60 , Issue.1 , pp. 92-99
    • Kiefer, F.1    Jahn, H.2    Tarnaske, T.3
  • 34
    • 0035028059 scopus 로고    scopus 로고
    • Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption
    • STROMBERG, M.F., S.A. MACKLER, J.R. VOLPICELLI & C.P. O'BRIEN. 2001. Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption. Alcohol 23(2): 109-116.
    • (2001) Alcohol , vol.23 , Issue.2 , pp. 109-116
    • Stromberg, M.F.1    Mackler, S.A.2    Volpicelli, J.R.3    O'Brien, C.P.4
  • 35
    • 0346530762 scopus 로고    scopus 로고
    • Combining naltrexone and memantine to block the rewarding effects of alcohol - An experimental pilot study in human subjects
    • SCHÜTZ, C.G., C. MAYER, G. KOLLER, et al. 2002. Combining naltrexone and memantine to block the rewarding effects of alcohol - an experimental pilot study in human subjects. Alcohol. Clin. Exp. Res. 36(5): 130A.
    • (2002) Alcohol. Clin. Exp. Res. , vol.36 , Issue.5
    • Schütz, C.G.1    Mayer, C.2    Koller, G.3


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