Brainstem facilitations and descending serotonergic controls contribute to visceral nociception but not pregabalin analgesia in rats

Neuroscience Letters

Volumn 519, Issue 1, 2012, Pages 31-36

  Sikandar, Shafaq ^a   Bannister, Kirsty ^a   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

5 HT; Pregabalin; Rostral ventromedial medulla (RVM); Visceral nociception; Visceromotor response (VMR)

Indexed keywords

CALCIUM CHANNEL; DERMORPHIN; MU OPIATE RECEPTOR; ONDANSETRON; PREGABALIN; SAPORIN; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CELLULAR DISTRIBUTION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL; NEUROPATHY; NONHUMAN; OSTEOARTHRITIS; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; VISCERAL PAIN;

ANALGESICS; ANIMALS; BRAIN STEM; EFFERENT PATHWAYS; GAMMA-AMINOBUTYRIC ACID; LONG-TERM POTENTIATION; MALE; NOCICEPTION; RATS; RATS, SPRAGUE-DAWLEY; SEROTONERGIC NEURONS; SEROTONIN; VISCERAL PAIN;

EID: 84861827970     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.05.009     Document Type: Article

References (29)

1. Bannister K., Sikandar S., Bauer C.S., Dolphin A.C., Porreca F., Dickenson A.H. Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. Anesthesiology 2011, 115:144-152.
2. Bauer C.S., Nieto-Rostro M., Rahman W., Tran-Van-Minh A., Ferron L., Douglas L., Kadurin I., Sri Ranjan Y., Fernandez-Alacid L., Millar N.S., Dickenson A.H., Lujan R., Dolphin A.C. The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin. Journal of Neuroscience 2009, 29:4076-4088.
3. Bee L.A., Dickenson A.H. Descending facilitation from the brainstem determines behavioural and neuronal hypersensitivity following nerve injury and efficacy of pregabalin. Pain 2008, 140:209-223.
4. Bergamaschi G., Perfetti V., Tonon L., Novella A., Lucotti C., Danova M., Glennie M.J., Merlini G., Cazzola M. Saporin, a ribosome-inactivating protein used to prepare immunotoxins, induces cell death via apoptosis. British Journal of Haematology 1996, 93:789-794.
5. Brink T.S., Mason P. Raphe magnus neurons respond to noxious colorectal distension. Journal of Neurophysiology 2003, 89:2506-2515.
6. Gao K., Mason P. Serotonergic Raphe magnus cells that respond to noxious tail heat are not ON or OFF cells. Journal of Neurophysiology 2000, 84:1719-1725.
7. Green G.M., Scarth J., Dickenson A. An excitatory role for 5-HT in spinal inflammatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT(3) receptors in the anaesthetized rat. Pain 2000, 89:81-88.
8. Hayashida K., Obata H., Nakajima K., Eisenach J.C. Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology 2008, 109:1077-1084.
9. Heinricher M.M., Morgan M.M., Fields H.L. Direct and indirect actions of morphine on medullary neurons that modulate nociception. Neuroscience 1992, 48:533-543.
10. Kwiat G.C., Basbaum A.I. The origin of brainstem noradrenergic and serotonergic projections to the spinal cord dorsal horn in the rat. Somatosensory and Motor Research 1992, 9:157-173.
11. Marinelli S., Vaughan C.W., Schnell S.A., Wessendorf M.W., Christie M.J. Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes. Journal of Neuroscience 2002, 22:10847-10855.
12. Ness T.J., Gebhart G.F. Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat. Brain Research 1988, 450:153-169.
13. Olesen S.S., Graversen C., Olesen A.E., Frokjaer J.B., Wilder-Smith O., van Goor H., Valeriani M., Drewes A.M. Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. Alimentary Pharmacology and Therapeutics 2011, 34:878-887.
14. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2005, Academic Press, San Diego.
15. Porreca F., Burgess S.E., Gardell L.R., Vanderah T.W., Malan T.P., Ossipov M.H., Lappi D.A., Lai J. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. Journal of Neuroscience 2001, 21:5281-5288.
16. Rahman W., Bauer C.S., Bannister K., Vonsy J.L., Dolphin A.C., Dickenson A.H. Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. Molecular Pain 2009, 5:45.
17. Rahman W., Suzuki R., Webber M., Hunt S.P., Dickenson A.H. Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation. Pain 2006, 123:264-274.
18. Ravnefjord A., Brusberg M., Larsson H., Lindstrom E., Martinez V. Effects of pregabalin on visceral pain responses and colonic compliance in rats. British Journal of Pharmacology 2008, 155:407-416.
19. Sikandar S., Dickenson A.H. Pregabalin modulation of spinal and brainstem visceral nociceptive processing. Pain 2011, 152:2312-2322.
20. Skagerberg G., Bjorklund A. Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat. Neuroscience 1985, 15:445-480.
21. Sung B., Na H.S., Kim Y.I., Yoon Y.W., Han H.C., Nahm S.H., Hong S.K. Supraspinal involvement in the production of mechanical allodynia by spinal nerve injury in rats. Neuroscience Letters 1998, 246:117-119.
22. Vera-Portocarrero L.P., Xie J.Y., Kowal J., Ossipov M.H., King T., Porreca F. Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology 2006, 130:2155-2164.
23. Vera-Portocarrero L.P., Zhang E.T., Ossipov M.H., Xie J.Y., King T., Lai J., Porreca F. Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience 2006, 140:1311-1320.
24. Wang H., Wessendorf M.W. Mu- and delta-opioid receptor mRNAs are expressed in spinally projecting serotonergic and nonserotonergic neurons of the rostral ventromedial medulla. Journal of Comparative Neurology 1999, 404:183-196.
25. Wei F., Dubner R., Zou S., Ren K., Bai G., Wei D., Guo W. Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain. Journal of Neuroscience 2010, 30:8624-8636.
26. Zeitz K.P., Guy N., Malmberg A.B., Dirajlal S., Martin W.J., Sun L., Bonhaus D.W., Stucky C.L., Julius D., Basbaum A.I. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. Journal of Neuroscience 2002, 22:1010-1019.
27. Zhang L., Sykes K.T., Buhler A.V., Hammond D.L. Electrophysiological heterogeneity of spinally projecting serotonergic and nonserotonergic neurons in the rostral ventromedial medulla. Journal of Neurophysiology 2006, 95:1853-1863.
28. Zhuo M., Sengupta J.N., Gebhart G.F. Biphasic modulation of spinal visceral nociceptive transmission from the rostroventral medial medulla in the rat. Journal of Neurophysiology 2002, 87:2225-2236.
29. Zimmerman M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110.