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Volumn 404, Issue 2, 1999, Pages 183-196

μ- and δ-opioid receptor mRNAS are expressed in spinally projecting serotonergic and nonserotonergic neurons of the rostral ventromedial medulla

Author keywords

Cell counts; Fluorescent dyes; Immunohistochemistry; In situ hybridization; Neural pathways; Pain

Indexed keywords

DELTA OPIATE RECEPTOR; FLUOROGOLD; MESSENGER RNA; MU OPIATE RECEPTOR; SEROTONIN; URIDINE TRIPHOSPHATE;

EID: 0033535124     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19990208)404:2<183::AID-CNE4>3.0.CO;2-N     Document Type: Article
Times cited : (40)

References (88)
  • 1
    • 0023681062 scopus 로고
    • The role of descending inhibition in morphine-induced analgesia
    • Advokat C. 1988. The role of descending inhibition in morphine-induced analgesia. Trends Pharmacol Sci 9:330-334.
    • (1988) Trends Pharmacol Sci , vol.9 , pp. 330-334
    • Advokat, C.1
  • 2
    • 0028985492 scopus 로고
    • Delta (δ)-opioid receptor immunoreactivity: Distribution in brain stem and spinal cord and relationship to biogenic amines and enkephalin
    • Arvidsson U, Dado RJ, Law P-Y, Loh HH, Elde R, Wessendorf MW. 1995a. Delta (δ)-opioid receptor immunoreactivity: distribution in brain stem and spinal cord and relationship to biogenic amines and enkephalin. J Neurosci 15:1215-1235.
    • (1995) J Neurosci , vol.15 , pp. 1215-1235
    • Arvidsson, U.1    Dado, R.J.2    Law, P.-Y.3    Loh, H.H.4    Elde, R.5    Wessendorf, M.W.6
  • 4
    • 0021799577 scopus 로고
    • Response of serotonin-containing neurons in nucleus raphe magnus to morphine, noxious stimuli, and periaqueductal gray stimulation in freely moving cats
    • Auerbach S, Fornal C, Jacobs BL. 1985. Response of serotonin-containing neurons in nucleus raphe magnus to morphine, noxious stimuli, and periaqueductal gray stimulation in freely moving cats. Exp Neurol 88:609-628.
    • (1985) Exp Neurol , vol.88 , pp. 609-628
    • Auerbach, S.1    Fornal, C.2    Jacobs, B.L.3
  • 5
    • 0020045352 scopus 로고
    • The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique
    • Azami J, Llewelyn MB, Roberts MH. 1982. The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique. Pain 12:229-246.
    • (1982) Pain , vol.12 , pp. 229-246
    • Azami, J.1    Llewelyn, M.B.2    Roberts, M.H.3
  • 6
    • 0025091887 scopus 로고
    • Involvement of central mu and delta opioid receptors in mediating the reinforcing effects of beta-endorphin in the rat
    • Bals-Kubik R, Shippenberg TS, Herz A. 1990. Involvement of central mu and delta opioid receptors in mediating the reinforcing effects of beta-endorphin in the rat. Eur J Pharmacol 175:63-69.
    • (1990) Eur J Pharmacol , vol.175 , pp. 63-69
    • Bals-Kubik, R.1    Shippenberg, T.S.2    Herz, A.3
  • 7
    • 0022620182 scopus 로고
    • Putative pain modulating neurons in the rostral ventral medulla: Reflex-related activity predicts effects of morphine
    • Barbaro NM, Heinricher MM, Fields HL. 1986. Putative pain modulating neurons in the rostral ventral medulla: reflex-related activity predicts effects of morphine. Brain Res 366:203-210.
    • (1986) Brain Res , vol.366 , pp. 203-210
    • Barbaro, N.M.1    Heinricher, M.M.2    Fields, H.L.3
  • 8
    • 0021288912 scopus 로고
    • Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry
    • Basbaum AI, Fields HL. 1984. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7:309-338.
    • (1984) Annu Rev Neurosci , vol.7 , pp. 309-338
    • Basbaum, A.I.1    Fields, H.L.2
  • 9
    • 0021353503 scopus 로고
    • The effect of morphine on the potassium evoked release of tritiated 5-hydroxytryptamine from spinal cord slices in the rat
    • Bineau-Thurotte M, Godefroy F, Weil-Fugazza J, Besson J-M. 1984. The effect of morphine on the potassium evoked release of tritiated 5-hydroxytryptamine from spinal cord slices in the rat. Brain Res 291:293-299.
    • (1984) Brain Res , vol.291 , pp. 293-299
    • Bineau-Thurotte, M.1    Godefroy, F.2    Weil-Fugazza, J.3    Besson, J.-M.4
  • 10
    • 0018837955 scopus 로고
    • Electrical stimulation of the nucleus raphe magnus in the rat. Effects on 5-HT metabolism in the spinal cord
    • Bourgoin S, Oliveras JL, Bruxelle J, Hamon M, Besson JM. 1980. Electrical stimulation of the nucleus raphe magnus in the rat. Effects on 5-HT metabolism in the spinal cord. Brain Res 194:377-389.
    • (1980) Brain Res , vol.194 , pp. 377-389
    • Bourgoin, S.1    Oliveras, J.L.2    Bruxelle, J.3    Hamon, M.4    Besson, J.M.5
  • 11
    • 0023951898 scopus 로고
    • Distribution of mu-opioid receptors in the nucleus raphe magnus and nucleus gigantocellularis: A quantitative autoradiographic study
    • Bowker RM, Dilts RP. 1988. Distribution of mu-opioid receptors in the nucleus raphe magnus and nucleus gigantocellularis: a quantitative autoradiographic study. Neurosci Lett 88:247-252.
    • (1988) Neurosci Lett , vol.88 , pp. 247-252
    • Bowker, R.M.1    Dilts, R.P.2
  • 12
    • 0019837585 scopus 로고
    • Origins of serotonergic projections to the spinal cord in rat: An immunocytochemical-retrograde transport study
    • Bowker RM, Westlund KN, Coulter JD. 1981. Origins of serotonergic projections to the spinal cord in rat: an immunocytochemical-retrograde transport study. Brain Res 226:187-199.
    • (1981) Brain Res , vol.226 , pp. 187-199
    • Bowker, R.M.1    Westlund, K.N.2    Coulter, J.D.3
  • 13
    • 0021087674 scopus 로고
    • Descending serotonergic, peptidergic and cholinergic pathways from the raphe nuclei: A multiple transmitter complex
    • Bowker RM, Westlund KN, Sullivan MC, Wilber JF, Coulter JD. 1983. Descending serotonergic, peptidergic and cholinergic pathways from the raphe nuclei: a multiple transmitter complex. Brain Res 288:33-48.
    • (1983) Brain Res , vol.288 , pp. 33-48
    • Bowker, R.M.1    Westlund, K.N.2    Sullivan, M.C.3    Wilber, J.F.4    Coulter, J.D.5
  • 14
    • 0028153207 scopus 로고
    • Presynaptic location of delta-opioid receptor immunoreactivity in dorsal horn of the rat spinal cord
    • Cheng PY, Svingos AL, Clarke CL, Inturrisi CE, Jenab S, Pickel VM. 1994. Presynaptic location of delta-opioid receptor immunoreactivity in dorsal horn of the rat spinal cord. Regul Peptides 54:57-58.
    • (1994) Regul Peptides , vol.54 , pp. 57-58
    • Cheng, P.Y.1    Svingos, A.L.2    Clarke, C.L.3    Inturrisi, C.E.4    Jenab, S.5    Pickel, V.M.6
  • 15
    • 0029027070 scopus 로고
    • Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of delta-opioid receptor within both enkephalin-and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord
    • Cheng PY, Svingos AL, Wang H, Clarke CL, Jenab S, Beczkowska IW, Inturrisi CE, Pickel VM. 1995. Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of delta-opioid receptor within both enkephalin-and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord. J Neurosci 15:5976-5988.
    • (1995) J Neurosci , vol.15 , pp. 5976-5988
    • Cheng, P.Y.1    Svingos, A.L.2    Wang, H.3    Clarke, C.L.4    Jenab, S.5    Beczkowska, I.W.6    Inturrisi, C.E.7    Pickel, V.M.8
  • 16
    • 0021888511 scopus 로고
    • Differential responses of serotonergic and non-serotonergic neurons in nucleus raphe magnus to systemic morphine in rats
    • Chiang CY, Pan ZZ. 1985. Differential responses of serotonergic and non-serotonergic neurons in nucleus raphe magnus to systemic morphine in rats. Brain Res 337:146-150.
    • (1985) Brain Res , vol.337 , pp. 146-150
    • Chiang, C.Y.1    Pan, Z.Z.2
  • 17
    • 0020035023 scopus 로고
    • Pharmacological evidence for the involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC)
    • Chitour D, Dickenson AH, Le Bars D. 1982. Pharmacological evidence for the involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC). Brain Res 236:329-337.
    • (1982) Brain Res , vol.236 , pp. 329-337
    • Chitour, D.1    Dickenson, A.H.2    Le Bars, D.3
  • 18
    • 0025116245 scopus 로고
    • Evidence that fluoro-gold can be transported avidly through fibers of passage
    • Dado RJ, Burstein R, Cliffer KD, Giesler GJ Jr. 1991. Evidence that Fluoro-Gold can be transported avidly through fibers of passage. Brain Res 533:329-333.
    • (1991) Brain Res , vol.533 , pp. 329-333
    • Dado, R.J.1    Burstein, R.2    Cliffer, K.D.3    Giesler G.J., Jr.4
  • 19
    • 0027769878 scopus 로고
    • Immunofluorescent identification of a δ (delta)-opioid receptor on primary afferent nerve terminals
    • Dado RJ, Law PY, Loh HH, Elde R. 1993. Immunofluorescent identification of a δ (delta)-opioid receptor on primary afferent nerve terminals. NeuroReport 5:341-344.
    • (1993) NeuroReport , vol.5 , pp. 341-344
    • Dado, R.J.1    Law, P.Y.2    Loh, H.H.3    Elde, R.4
  • 20
    • 0001989283 scopus 로고
    • Evidence for the existence of monoamine neurons in the central nervous system. I. Demonstration of monoamines in cell bodies of brain stem neurons
    • Dahlström A, Fuxe K. 1964. Evidence for the existence of monoamine neurons in the central nervous system. I. Demonstration of monoamines in cell bodies of brain stem neurons. Acta Physiol Scand Suppl 232 62:1-55.
    • (1964) Acta Physiol Scand Suppl , vol.232 , Issue.62 , pp. 1-55
    • Dahlström, A.1    Fuxe, K.2
  • 21
    • 0001989279 scopus 로고
    • Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal neuron systems
    • Dahlström A, Fuxe K. 1965. Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal neuron systems. Acta Physiol Scand Suppl 247 64:1-36.
    • (1965) Acta Physiol Scand Suppl , vol.247 , Issue.64 , pp. 1-36
    • Dahlström, A.1    Fuxe, K.2
  • 22
    • 0018146892 scopus 로고
    • Involvement of the periaqueductal grey matter and spinal 5-hydroxytryptaminergic pathways in morphine analgesia: Effects of lesions and 5-hydroxytryptamine depletion
    • Deakin JF, Dostrovsky JO. 1978. Involvement of the periaqueductal grey matter and spinal 5-hydroxytryptaminergic pathways in morphine analgesia: effects of lesions and 5-hydroxytryptamine depletion. Br J Pharmacol 63:159-165.
    • (1978) Br J Pharmacol , vol.63 , pp. 159-165
    • Deakin, J.F.1    Dostrovsky, J.O.2
  • 23
    • 0018358829 scopus 로고
    • Role of the nucleus raphe magnus in opiate analgesia as studied by the microinjection technique in the rat
    • Dickenson AH, Oliveras JL, Besson JM. 1979. Role of the nucleus raphe magnus in opiate analgesia as studied by the microinjection technique in the rat. Brain Res 170:95-111.
    • (1979) Brain Res , vol.170 , pp. 95-111
    • Dickenson, A.H.1    Oliveras, J.L.2    Besson, J.M.3
  • 24
    • 0019494187 scopus 로고
    • Diffuse noxious inhibitory controls (DNIC) in the rat with or without pCPA pretreatment
    • Dickenson AH, Rivot JP, Chaouch A, Besson JM, Le Bars D. 1981. Diffuse noxious inhibitory controls (DNIC) in the rat with or without pCPA pretreatment. Brain Res 216:313-321.
    • (1981) Brain Res , vol.216 , pp. 313-321
    • Dickenson, A.H.1    Rivot, J.P.2    Chaouch, A.3    Besson, J.M.4    Le Bars, D.5
  • 25
    • 0021238817 scopus 로고
    • Inhibition of nociceptive neuronal responses in the cat's spinal dorsal horn by electrical stimulation and morphine microinjection in nucleus raphe magnus
    • Du HJ, Kitahata LM, Thalhammer JG, Zimmermann M. 1984. Inhibition of nociceptive neuronal responses in the cat's spinal dorsal horn by electrical stimulation and morphine microinjection in nucleus raphe magnus. Pain 19:249-257.
    • (1984) Pain , vol.19 , pp. 249-257
    • Du, H.J.1    Kitahata, L.M.2    Thalhammer, J.G.3    Zimmermann, M.4
  • 26
    • 0021051234 scopus 로고
    • Electrophysiology of opioids
    • Duggan AW, North RA. 1984. Electrophysiology of opioids. Pharmacol Rev 35:219-281.
    • (1984) Pharmacol Rev , vol.35 , pp. 219-281
    • Duggan, A.W.1    North, R.A.2
  • 28
    • 0025959669 scopus 로고
    • Neurotransmitters in nociceptive modulatory circuits
    • Fields HL, Heinricher MM, Mason P. 1991. Neurotransmitters in nociceptive modulatory circuits. Annu Rev Neurosci 14:219-245.
    • (1991) Annu Rev Neurosci , vol.14 , pp. 219-245
    • Fields, H.L.1    Heinricher, M.M.2    Mason, P.3
  • 29
    • 0028843805 scopus 로고
    • Dorsal horn projection targets of on and off cells in the rostral ventromedial medulla
    • Fields HL, Malick A, Burstein R. 1995. Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J Neurophysiol 74:1742-1759.
    • (1995) J Neurophysiol , vol.74 , pp. 1742-1759
    • Fields, H.L.1    Malick, A.2    Burstein, R.3
  • 30
    • 0030175125 scopus 로고    scopus 로고
    • Met-enkephalin inhibits 5-hydroxytryptamine release from the rat ventral spinal cord via delta opioid receptors
    • Franck J, Nylander I, Rosen A. 1996. Met-enkephalin inhibits 5-hydroxytryptamine release from the rat ventral spinal cord via delta opioid receptors. Neuropharmacology 35:743-749.
    • (1996) Neuropharmacology , vol.35 , pp. 743-749
    • Franck, J.1    Nylander, I.2    Rosen, A.3
  • 31
    • 0001989279 scopus 로고
    • Evidence for the existence of monoamine neurons in the central nervous system. IV. Distribution of monoamine nerve terminals in the central nervous system
    • Fuxe K. 1965. Evidence for the existence of monoamine neurons in the central nervous system. IV. Distribution of monoamine nerve terminals in the central nervous system. Acta Physiol Scand Suppl 247 64: 37-84.
    • (1965) Acta Physiol Scand Suppl , vol.247 , Issue.64 , pp. 37-84
    • Fuxe, K.1
  • 32
    • 0031941587 scopus 로고    scopus 로고
    • Involvement of the caudal medulla in negative feedback mechanisms triggered by spatial summation of nociceptive inputs
    • Gall O, Bouhassira D, Chitour D, Le Bars D. 1998. Involvement of the caudal medulla in negative feedback mechanisms triggered by spatial summation of nociceptive inputs. J Neurophysiol 79:304-311.
    • (1998) J Neurophysiol , vol.79 , pp. 304-311
    • Gall, O.1    Bouhassira, D.2    Chitour, D.3    Le Bars, D.4
  • 33
    • 0032031560 scopus 로고    scopus 로고
    • Activation of serotonergic neurons in the raphe magnus is not necessary for morphine analgesia
    • Gao K, Chen DO, Genzen JR, Mason P. 1998. Activation of serotonergic neurons in the raphe magnus is not necessary for morphine analgesia. J Neurosci 18:1860-1868.
    • (1998) J Neurosci , vol.18 , pp. 1860-1868
    • Gao, K.1    Chen, D.O.2    Genzen, J.R.3    Mason, P.4
  • 34
    • 0029609871 scopus 로고
    • Buprenorphine blocks diffuse noxious inhibitory controls in the rat
    • Guirimand F, Chauvin M, Willer JC, Le Bars D. 1995. Buprenorphine blocks diffuse noxious inhibitory controls in the rat. Eur J Pharmacol 294:651-659.
    • (1995) Eur J Pharmacol , vol.294 , pp. 651-659
    • Guirimand, F.1    Chauvin, M.2    Willer, J.C.3    Le Bars, D.4
  • 35
    • 0032103124 scopus 로고    scopus 로고
    • Mu and kappa opioid receptors in periaqueductal gray and rostral ventromedial medulla
    • Gutstein HB, Mansour A, Watson SJ, Akil H, Fields HL. 1998. Mu and kappa opioid receptors in periaqueductal gray and rostral ventromedial medulla. NeuroReport 9:1777-1781.
    • (1998) NeuroReport , vol.9 , pp. 1777-1781
    • Gutstein, H.B.1    Mansour, A.2    Watson, S.J.3    Akil, H.4    Fields, H.L.5
  • 36
    • 0000956236 scopus 로고
    • Detection of viral nucleic acids by in situ hybridization
    • New York: Academic Press
    • Haase A, Brahic M, Stowring L, Blum H, editors. 1984. Detection of viral nucleic acids by in situ hybridization. Methods in virology. New York: Academic Press.
    • (1984) Methods in Virology
    • Haase, A.1    Brahic, M.2    Stowring, L.3    Blum, H.4
  • 37
    • 0021895370 scopus 로고
    • Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla
    • Lond
    • Hammond DL, Tyce GM, Yaksh TL. 1985. Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla. J Physiol (Lond) 359:151-162.
    • (1985) J Physiol , vol.359 , pp. 151-162
    • Hammond, D.L.1    Tyce, G.M.2    Yaksh, T.L.3
  • 38
    • 0026576472 scopus 로고
    • Direct and indirect actions of morphine on medullary neurons that modulate nociception
    • Heinricher MM, Morgan MM, Fields HL. 1992. Direct and indirect actions of morphine on medullary neurons that modulate nociception. Neuroscience 48:533-543.
    • (1992) Neuroscience , vol.48 , pp. 533-543
    • Heinricher, M.M.1    Morgan, M.M.2    Fields, H.L.3
  • 39
    • 0022558916 scopus 로고
    • Comparison of the antinociceptive action of mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique
    • Jensen TS, Yaksh TL. 1986. Comparison of the antinociceptive action of mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique. Brain Res 372:301-312.
    • (1986) Brain Res , vol.372 , pp. 301-312
    • Jensen, T.S.1    Yaksh, T.L.2
  • 40
    • 0017280931 scopus 로고
    • The effect of morphine on the activity evoked in ventrolateral tract axons of the cat spinal cord
    • Jurna I, Grossman W. 1976. The effect of morphine on the activity evoked in ventrolateral tract axons of the cat spinal cord. Exp Brain Res 24:473-484.
    • (1976) Exp Brain Res , vol.24 , pp. 473-484
    • Jurna, I.1    Grossman, W.2
  • 41
    • 0032536895 scopus 로고    scopus 로고
    • Relationship of μ-and δ-opioid receptors to GABAergic neurons in the central nervous system, including antinociceptive brainstem circuits
    • Kalyuzhny AE, Wessendorf MW. 1998. Relationship of μ-and δ-opioid receptors to GABAergic neurons in the central nervous system, including antinociceptive brainstem circuits. J Comp Neurol 392:528-547.
    • (1998) J Comp Neurol , vol.392 , pp. 528-547
    • Kalyuzhny, A.E.1    Wessendorf, M.W.2
  • 42
    • 0029846914 scopus 로고    scopus 로고
    • μ-opioid and δ-opioid receptors are expressed in brainstem antinociceptive circuits: Studies using immunocytochemistry and retrograde tract-tracing
    • Kalyuzhny AE, Arvidsson U, Wu W, Wessendorf MW. 1996. μ-Opioid and δ-opioid receptors are expressed in brainstem antinociceptive circuits: studies using immunocytochemistry and retrograde tract-tracing. J Neurosci 16:6490-6503.
    • (1996) J Neurosci , vol.16 , pp. 6490-6503
    • Kalyuzhny, A.E.1    Arvidsson, U.2    Wu, W.3    Wessendorf, M.W.4
  • 43
    • 0026041886 scopus 로고
    • Hyperalgesia during acute opioid abstinence: Evidence for a nociceptive facilitating function of the rostral ventromedial medulla
    • Kaplan H, Fields HL. 1991. Hyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla. J Neurosci 11:1433-1439.
    • (1991) J Neurosci , vol.11 , pp. 1433-1439
    • Kaplan, H.1    Fields, H.L.2
  • 44
    • 0027221176 scopus 로고
    • Medullary mu and delta opioid receptors modulate mesencephalic morphine analgesia in rats
    • Kiefel JM, Rossi GC, Bodnar RJ. 1993. Medullary mu and delta opioid receptors modulate mesencephalic morphine analgesia in rats. Brain Res 624:151-161.
    • (1993) Brain Res , vol.624 , pp. 151-161
    • Kiefel, J.M.1    Rossi, G.C.2    Bodnar, R.J.3
  • 45
    • 0027052952 scopus 로고
    • The delta-opioid receptor: Isolation of a cDNA by expression cloning and pharmacological characterization
    • Kieffer BL, Befort K, Gaveriaux RC, Hirth CG. 1992. The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl Acad Sci USA 89:12048-12052.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 12048-12052
    • Kieffer, B.L.1    Befort, K.2    Gaveriaux, R.C.3    Hirth, C.G.4
  • 46
    • 0020082230 scopus 로고
    • Behavioral model for diffuse noxious inhibitory controls (DNIC): Potentiation by 5-hydroxytryptophan
    • Kraus E, Besson JM, Le Bars D. 1982. Behavioral model for diffuse noxious inhibitory controls (DNIC): potentiation by 5-hydroxytryptophan. Brain Res 231:461-465.
    • (1982) Brain Res , vol.231 , pp. 461-465
    • Kraus, E.1    Besson, J.M.2    Le Bars, D.3
  • 47
    • 0025075092 scopus 로고
    • Organization of tyrosine hydroxylase-and serotonin-immunoreactive brainstem neurons with axon collaterals to the periaqueductal gray and the spinal cord in the rat
    • Kwiat GC, Basbaum AI. 1990. Organization of tyrosine hydroxylase-and serotonin-immunoreactive brainstem neurons with axon collaterals to the periaqueductal gray and the spinal cord in the rat. Brain Res 528:83-94.
    • (1990) Brain Res , vol.528 , pp. 83-94
    • Kwiat, G.C.1    Basbaum, A.I.2
  • 48
    • 0019515790 scopus 로고
    • The effect of systemic morphine upon diffuse noxious inhibitory controls (DNIC) in the rat: Evidence for a lifting of certain descending inhibitory controls of dorsal horn convergent neurones
    • Le Bars D, Chitour D, Kraus E, Clot AM, Dickenson AH, Besson JM. 1981. The effect of systemic morphine upon diffuse noxious inhibitory controls (DNIC) in the rat: evidence for a lifting of certain descending inhibitory controls of dorsal horn convergent neurones. Brain Res 215:257-274.
    • (1981) Brain Res , vol.215 , pp. 257-274
    • Le Bars, D.1    Chitour, D.2    Kraus, E.3    Clot, A.M.4    Dickenson, A.H.5    Besson, J.M.6
  • 49
    • 0026527651 scopus 로고
    • Morphine blocks descending pain inhibitory controls in humans
    • Le Bars D, Willer JC, De Broucker T. 1992. Morphine blocks descending pain inhibitory controls in humans. Pain 48:13-20.
    • (1992) Pain , vol.48 , pp. 13-20
    • Le Bars, D.1    Willer, J.C.2    De Broucker, T.3
  • 50
    • 0018773313 scopus 로고
    • Analgesia produced by microinjection of baclofen and morphine at brain stem sites
    • Levy RA, Proudfit HK. 1979. Analgesia produced by microinjection of baclofen and morphine at brain stem sites. Eur J Pharmacol 57:43-55.
    • (1979) Eur J Pharmacol , vol.57 , pp. 43-55
    • Levy, R.A.1    Proudfit, H.K.2
  • 51
    • 0021024273 scopus 로고
    • Bulbar raphe neurones with projections to the trigeminal nucleus caudalis and the lumbar cord in the rat: A fluorescence double-labelling study
    • Lovick TA, Robinson JP. 1983. Bulbar raphe neurones with projections to the trigeminal nucleus caudalis and the lumbar cord in the rat: a fluorescence double-labelling study. Exp Brain Res 50:299-308.
    • (1983) Exp Brain Res , vol.50 , pp. 299-308
    • Lovick, T.A.1    Robinson, J.P.2
  • 52
    • 0027999375 scopus 로고
    • Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study
    • Mansour A, Fox CA, Burke S, Meng F, Thompson RC, Akil H, Watson SJ. 1994. Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. J Comp Neurol 350:412-438.
    • (1994) J Comp Neurol , vol.350 , pp. 412-438
    • Mansour, A.1    Fox, C.A.2    Burke, S.3    Meng, F.4    Thompson, R.C.5    Akil, H.6    Watson, S.J.7
  • 53
    • 0026552431 scopus 로고
    • Do opioids evoke the release of serotonin in the spinal cord? An in vivo microdialysis study of the regulation of extracellular serotonin in the rat
    • Matos FF, Rollema H, Brown JL, Basbaum AI. 1992. Do opioids evoke the release of serotonin in the spinal cord? An in vivo microdialysis study of the regulation of extracellular serotonin in the rat. Pain 48:439-447.
    • (1992) Pain , vol.48 , pp. 439-447
    • Matos, F.F.1    Rollema, H.2    Brown, J.L.3    Basbaum, A.I.4
  • 54
    • 0021176449 scopus 로고
    • Serotoninergic axonal contacts on identified cat spinal dorsal horn neurons and their correlation with nucleus raphe magnus stimulation
    • Miletic V, Hoffert MJ, Ruda MA, Dubner R, Shigenaga Y. 1984. Serotoninergic axonal contacts on identified cat spinal dorsal horn neurons and their correlation with nucleus raphe magnus stimulation. J Comp Neurol 228:129-141.
    • (1984) J Comp Neurol , vol.228 , pp. 129-141
    • Miletic, V.1    Hoffert, M.J.2    Ruda, M.A.3    Dubner, R.4    Shigenaga, Y.5
  • 55
    • 0019276823 scopus 로고
    • Effect of selective destruction of serotonergic neurons in nucleus raphe magnus on morphine-induced antinociception
    • Mohrland JS, Gebhart GF. 1980. Effect of selective destruction of serotonergic neurons in nucleus raphe magnus on morphine-induced antinociception. Life Sci 27:2627-2632.
    • (1980) Life Sci , vol.27 , pp. 2627-2632
    • Mohrland, J.S.1    Gebhart, G.F.2
  • 56
    • 0017642876 scopus 로고
    • The topographical distribution of serotoninergic terminals in the spinal cord of the cat: Biochemical mapping by the combined use of microdissection and microassay procedures
    • Oliveras JL, Bourgoin S, Hery F, Besson JM, Hamon M. 1977. The topographical distribution of serotoninergic terminals in the spinal cord of the cat: biochemical mapping by the combined use of microdissection and microassay procedures. Brain Res 138:393-406.
    • (1977) Brain Res , vol.138 , pp. 393-406
    • Oliveras, J.L.1    Bourgoin, S.2    Hery, F.3    Besson, J.M.4    Hamon, M.5
  • 57
    • 0029089550 scopus 로고
    • Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat
    • Ossipov MH, Kovelowski CJ, Nichols ML, Hruby VJ, Porreca F. 1995. Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat. Pain 62:287-293.
    • (1995) Pain , vol.62 , pp. 287-293
    • Ossipov, M.H.1    Kovelowski, C.J.2    Nichols, M.L.3    Hruby, V.J.4    Porreca, F.5
  • 58
    • 0025141063 scopus 로고
    • Opioid actions on single nucleus raphe magnus neurons from rat and guinea pig in vitro
    • Lond
    • Pan ZZ, Williams JT, Osborne P. 1990. Opioid actions on single nucleus raphe magnus neurons from rat and guinea pig in vitro. J Physiol (Lond) 427:519-532.
    • (1990) J Physiol , vol.427 , pp. 519-532
    • Pan, Z.Z.1    Williams, J.T.2    Osborne, P.3
  • 59
    • 0027251356 scopus 로고
    • Modulation by serotonin of the neurons in rat nucleus raphe magnus in vitro
    • Pan ZZ, Wessendorf MW, Williams JT. 1993. Modulation by serotonin of the neurons in rat nucleus raphe magnus in vitro. Neuroscience 54:421-429.
    • (1993) Neuroscience , vol.54 , pp. 421-429
    • Pan, Z.Z.1    Wessendorf, M.W.2    Williams, J.T.3
  • 60
    • 0028202756 scopus 로고
    • Serotonin immunoreactivity is contained in one physiological cell class in the rat rostral ventromedial medulla
    • Potrebic SB, Fields HL, Mason P. 1994. Serotonin immunoreactivity is contained in one physiological cell class in the rat rostral ventromedial medulla. J Neurosci 14:1655-1665.
    • (1994) J Neurosci , vol.14 , pp. 1655-1665
    • Potrebic, S.B.1    Fields, H.L.2    Mason, P.3
  • 61
    • 0021186313 scopus 로고
    • Antinociception from a stereospecific action of morphine microinjected into the brainstem: A local or distant site of action?
    • Prado WA, Roberts MH. 1984. Antinociception from a stereospecific action of morphine microinjected into the brainstem: a local or distant site of action? Br J Pharmacol 82:877-882.
    • (1984) Br J Pharmacol , vol.82 , pp. 877-882
    • Prado, W.A.1    Roberts, M.H.2
  • 62
    • 0019494361 scopus 로고
    • Alterations in nociceptive threshold and morphine-induced analgesia produced by intrathecally administered amine antagonists
    • Proudfit HK, Hammond DL. 1981. Alterations in nociceptive threshold and morphine-induced analgesia produced by intrathecally administered amine antagonists. Brain Res 218:393-399.
    • (1981) Brain Res , vol.218 , pp. 393-399
    • Proudfit, H.K.1    Hammond, D.L.2
  • 63
    • 0023900990 scopus 로고
    • Morphine increases 5-HT metabolism in the nucleus raphe magnus: An in vivo study in freely moving rats using 5-hydroxyindole electrochemical detection
    • Rivot JP, Pointis D, Besson JM. 1988. Morphine increases 5-HT metabolism in the nucleus raphe magnus: an in vivo study in freely moving rats using 5-hydroxyindole electrochemical detection. Brain Res 446:333-342.
    • (1988) Brain Res , vol.446 , pp. 333-342
    • Rivot, J.P.1    Pointis, D.2    Besson, J.M.3
  • 64
    • 0024393064 scopus 로고
    • A comparison of the effects of morphine on 5-HT metabolism in the periaqueductal gray, ventromedial medulla and medullary dorsal horn: In vivo electrochemical studies in freely moving rats
    • Rivot JP, Pointis D, Besson JM. 1989. A comparison of the effects of morphine on 5-HT metabolism in the periaqueductal gray, ventromedial medulla and medullary dorsal horn: in vivo electrochemical studies in freely moving rats. Brain Res 495:140-144.
    • (1989) Brain Res , vol.495 , pp. 140-144
    • Rivot, J.P.1    Pointis, D.2    Besson, J.M.3
  • 65
    • 0021707631 scopus 로고
    • 5-hydroxytryptamine and antinociception
    • Roberts MH. 1984. 5-Hydroxytryptamine and antinociception. Neuropharmacology 23:1529-1536.
    • (1984) Neuropharmacology , vol.23 , pp. 1529-1536
    • Roberts, M.H.1
  • 66
    • 0028047065 scopus 로고
    • Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medulla
    • Rossi GC, Pasternak GW, Bodnar RJ. 1994. Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medulla. Brain Res 665:85-93.
    • (1994) Brain Res , vol.665 , pp. 85-93
    • Rossi, G.C.1    Pasternak, G.W.2    Bodnar, R.J.3
  • 67
    • 0022503229 scopus 로고
    • Fluoro-gold: A new fluorescent retrograde axonal tracer with numerous unique properties
    • Schmued LC, Fallon JH. 1986. Fluoro-Gold: a new fluorescent retrograde axonal tracer with numerous unique properties. Brain Res 377:147-154.
    • (1986) Brain Res , vol.377 , pp. 147-154
    • Schmued, L.C.1    Fallon, J.H.2
  • 68
    • 0023895763 scopus 로고
    • Fentanyl isothiocyanate reveals the existence of physically associated mu-and delta-opioid receptors mediating inhibition of adenylate cyclase in rat neostriatum
    • Schoffelmeer AN, Rice KC, Heijna MH, Hogenboom F, Mulder AH. 1988. Fentanyl isothiocyanate reveals the existence of physically associated mu-and delta-opioid receptors mediating inhibition of adenylate cyclase in rat neostriatum. Eur J Pharmacol 149:179-182.
    • (1988) Eur J Pharmacol , vol.149 , pp. 179-182
    • Schoffelmeer, A.N.1    Rice, K.C.2    Heijna, M.H.3    Hogenboom, F.4    Mulder, A.H.5
  • 70
    • 0021862734 scopus 로고
    • Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat
    • Skagerberg G, Bjorklund A. 1985. Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat. Neuroscience 15:445-480.
    • (1985) Neuroscience , vol.15 , pp. 445-480
    • Skagerberg, G.1    Bjorklund, A.2
  • 71
    • 0020523544 scopus 로고
    • Spinal vs supraspinal actions of morphine on cat spinal cord multireceptive neurons
    • Soja PJ, Sinclair JG. 1983. Spinal vs supraspinal actions of morphine on cat spinal cord multireceptive neurons. Brain Res 273:1-7.
    • (1983) Brain Res , vol.273 , pp. 1-7
    • Soja, P.J.1    Sinclair, J.G.2
  • 72
    • 0027304804 scopus 로고
    • Raphe magnus stimulation-induced antinociception in the cat is associated with release of amino acids as well as serotonin in the lumbar dorsal horn
    • Sorkin LS, McAdoo DJ, Willis WD. 1993. Raphe magnus stimulation-induced antinociception in the cat is associated with release of amino acids as well as serotonin in the lumbar dorsal horn. Brain Res 618:95-108.
    • (1993) Brain Res , vol.618 , pp. 95-108
    • Sorkin, L.S.1    McAdoo, D.J.2    Willis, W.D.3
  • 73
    • 0026471079 scopus 로고
    • Mu-delta opioid interactions. II: Beta-FNA inhibits DPDPE-induced increases in morphine EEG and EEG spectral power
    • Stamidis H, Young GA. 1992. Mu-delta opioid interactions. II: beta-FNA inhibits DPDPE-induced increases in morphine EEG and EEG spectral power. Peptides 13:755-760.
    • (1992) Peptides , vol.13 , pp. 755-760
    • Stamidis, H.1    Young, G.A.2
  • 74
    • 0019464864 scopus 로고
    • Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals
    • Steinbusch HW. 1981. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6:557-618.
    • (1981) Neuroscience , vol.6 , pp. 557-618
    • Steinbusch, H.W.1
  • 75
    • 0021234096 scopus 로고
    • The unbiased estimation of number and sizes of arbitrary particles using the disector
    • Sterio DC. 1984. The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134:127-136.
    • (1984) J Microsc , vol.134 , pp. 127-136
    • Sterio, D.C.1
  • 76
    • 0031456984 scopus 로고    scopus 로고
    • Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat
    • Thorat SN, Hammond DL. 1997. Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. J Pharmacol Exp Ther 283:1185-1192.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1185-1192
    • Thorat, S.N.1    Hammond, D.L.2
  • 77
    • 0021721703 scopus 로고
    • Tail-flick related activity in medullospinal neurons
    • Vanegas H, Barbaro NM, Fields HL. 1984. Tail-flick related activity in medullospinal neurons. Brain Res 321:135-141.
    • (1984) Brain Res , vol.321 , pp. 135-141
    • Vanegas, H.1    Barbaro, N.M.2    Fields, H.L.3
  • 78
    • 0019985526 scopus 로고
    • Analgesia, development of tolerance, and 5-hydroxytryptamine turnover in the rat after cerebral and systemic administration of morphine
    • Vasko MR, Vogt M. 1982. Analgesia, development of tolerance, and 5-hydroxytryptamine turnover in the rat after cerebral and systemic administration of morphine. Neuroscience 7:1215-1225.
    • (1982) Neuroscience , vol.7 , pp. 1215-1225
    • Vasko, M.R.1    Vogt, M.2
  • 79
    • 0021267603 scopus 로고
    • Involvement of 5-hydroxytryptamine-containing neurons in antinociception produced by injection of morphine into nucleus raphe magnus or onto spinal cord
    • Vasko MR, Pang IH, Vogt M. 1984. Involvement of 5-hydroxytryptamine-containing neurons in antinociception produced by injection of morphine into nucleus raphe magnus or onto spinal cord. Brain Res 306:341-348.
    • (1984) Brain Res , vol.306 , pp. 341-348
    • Vasko, M.R.1    Pang, I.H.2    Vogt, M.3
  • 80
    • 0021247647 scopus 로고
    • Increase in 5-HT synthesis in the dorsal part of the spinal cord, induced by a nociceptive stimulus: Blockade by morphine
    • Weil-Fugazza J, Godefroy F, Le Bars D. 1984. Increase in 5-HT synthesis in the dorsal part of the spinal cord, induced by a nociceptive stimulus: blockade by morphine. Brain Res 297:247-264.
    • (1984) Brain Res , vol.297 , pp. 247-264
    • Weil-Fugazza, J.1    Godefroy, F.2    Le Bars, D.3
  • 81
    • 0025783888 scopus 로고
    • Fluoro-gold: Composition, and mechanism of uptake
    • Wessendorf MW. 1991. Fluoro-Gold: composition, and mechanism of uptake. Brain Res 553:135-148.
    • (1991) Brain Res , vol.553 , pp. 135-148
    • Wessendorf, M.W.1
  • 82
    • 0021067684 scopus 로고
    • Single unit studies of identified bulbospinal serotonergic units
    • Wessendorf MW, Anderson EG. 1983. Single unit studies of identified bulbospinal serotonergic units. Brain Res 279:93-103.
    • (1983) Brain Res , vol.279 , pp. 93-103
    • Wessendorf, M.W.1    Anderson, E.G.2
  • 83
    • 0018761193 scopus 로고
    • Microinjection of morphine into the periaqueductal gray evokes the release of serotonin from spinal cord
    • Yaksh TL, Tyce GM. 1979. Microinjection of morphine into the periaqueductal gray evokes the release of serotonin from spinal cord. Brain Res 171:176-181.
    • (1979) Brain Res , vol.171 , pp. 176-181
    • Yaksh, T.L.1    Tyce, G.M.2
  • 84
    • 0018352151 scopus 로고
    • Spinal serotonin terminal system mediates antinociception
    • Yaksh TL, Wilson PR. 1979. Spinal serotonin terminal system mediates antinociception. J Pharmacol Exp Ther 208:446-453.
    • (1979) J Pharmacol Exp Ther , vol.208 , pp. 446-453
    • Yaksh, T.L.1    Wilson, P.R.2
  • 85
    • 0343144796 scopus 로고    scopus 로고
    • Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: Evidence for association with the membrane of large dense-core vesicles
    • Zhang X, Bao L, Arvidsson U, Elde R, Hokfelt T. 1998. Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: evidence for association with the membrane of large dense-core vesicles. Neuroscience 82:1225-1242.
    • (1998) Neuroscience , vol.82 , pp. 1225-1242
    • Zhang, X.1    Bao, L.2    Arvidsson, U.3    Elde, R.4    Hokfelt, T.5
  • 86
    • 0024992449 scopus 로고
    • Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat
    • Zhuo M, Gebhart GF. 1990. Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Pain 42:337-350.
    • (1990) Pain , vol.42 , pp. 337-350
    • Zhuo, M.1    Gebhart, G.F.2
  • 87
    • 0025763631 scopus 로고
    • Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat
    • Zhuo M, Gebhart GF. 1991. Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Brain Res 550:35-48.
    • (1991) Brain Res , vol.550 , pp. 35-48
    • Zhuo, M.1    Gebhart, G.F.2
  • 88
    • 0026769026 scopus 로고
    • Characterization of descending facilitation and inhibition of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat
    • Zhuo M, Gebhart GF. 1992. Characterization of descending facilitation and inhibition of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. J Neurophysiol 67:1599-1614.
    • (1992) J Neurophysiol , vol.67 , pp. 1599-1614
    • Zhuo, M.1    Gebhart, G.F.2


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