Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training

Vascular Medicine (United Kingdom)

Volumn 17, Issue 2, 2012, Pages 94-100

  Jones, W Schuyler ^a,b   Duscha, Brian D ^a   Robbins, Jennifer L ^a   Duggan, Natasha N ^c   Regensteiner, Judith G ^d   Kraus, William E ^a   Hiatt, William R ^d   Dokun, Ayotunde O ^c   Annex, Brian H ^c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

angiogenesis; peripheral artery disease; vascular endothelial growth factor (VEGF)

Indexed keywords

ACETYLSALICYLIC ACID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN RECEPTOR 1;

ADULT; ARTICLE; CELL LYSATE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; FEMALE; GASTROCNEMIUS MUSCLE; HUMAN; HUMAN TISSUE; INTERMITTENT CLAUDICATION; MALE; MUSCLE BIOPSY; PRIORITY JOURNAL; SKELETAL MUSCLE;

AGED; ANALYSIS OF VARIANCE; BIOPSY; CAPILLARIES; COLORADO; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXERCISE THERAPY; EXERCISE TOLERANCE; FEMALE; HUMANS; INTERMITTENT CLAUDICATION; MALE; MIDDLE AGED; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; NORTH CAROLINA; PERIPHERAL ARTERIAL DISEASE; RECOVERY OF FUNCTION; TIME FACTORS; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84861814587     PISSN: 1358863X     EISSN: 14770377     Source Type: Journal    
DOI: 10.1177/1358863X11436334     Document Type: Article

References (30)

1. Hirsch AT, Haskal ZJ, Hertzer NR, et al. ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. Circulation. 2006 ; 113: e463-654
2. McDermott MM, Greenland P, Liu K, et al. Leg symptoms in peripheral arterial disease: associated clinical characteristics and functional impairment. JAMA. 2001 ; 286: 1599-1606 (Pubitemid 33010284)
3. Mays RJ, Casserly IP, Kohrt WM, et al. Assessment of functional status and quality of life in claudication. J Vasc Surg. 2011 ; 53: 1410-1421
4. Robbins JL, Jones WS, Duscha BD, et al. Relationship between leg muscle capillary density and blood flow with endurance capacity in peripheral artery disease. J Appl Physiol. 2011 ; 111: 81-86
5. Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003 ; 9: 653-660 (Pubitemid 36749213)
6. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000 ; 6: 389-395 (Pubitemid 30208155)
7. Andersen P, Henriksson J. Capillary supply of the quadriceps femoris muscle of man: adaptive response to exercise. J Physiol. 1977 ; 270: 677-690 (Pubitemid 8170342)
8. Gavin TP, Drew JL, Kubik CJ, Pofahl WE, Hickner RC. Acute resistance exercise increases skeletal muscle angiogenic growth factor expression. Acta Physiol (Oxf). 2007 ; 191: 139-146 (Pubitemid 47390299)
9. Gavin TP, Ruster RS, Carrithers JA, et al. No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged men. J Physiol. 2007 ; 585: 231-239 (Pubitemid 350131115)
10. Duscha BD, Robbins JL, Jones WS, et al. Angiogenesis in skeletal muscle precede improvements in peak oxygen uptake in peripheral artery disease patients. Arterioscler Thromb Vasc Biol. 2011 ; 31: 2742-2748
11. Waters RE, Rotevatn S, Li P, Annex BH, Yan Z. Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle. Am J Physiol Cell Physiol. 2004 ; 287: C1342-1348
12. Hoier B, Rufener N, Bojsen-Moller J, Bangsbo J, Hellsten Y. The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle. J Physiol. 2010 ; 588: 3833-3845
13. Hansen AH, Nielsen JJ, Saltin B, Hellsten Y. Exercise training normalizes skeletal muscle vascular endothelial growth factor levels in patients with essential hypertension. J Hypertens. 2010 ; 28: 1176-1185
14. Nowak DG, Amin EM, Rennel ES, et al. Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. J Biol Chem. 2010 ; 285: 5532-5540
15. Dokun AO, Annex BH. The VEGF165b 'ICE-o-form' puts a chill on the VEGF story. Circ Res. 2011 ; 109: 246-247
16. Manetti M, Guiducci S, Romano E, et al. Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis. Circ Res. 2011 ; 109: e14-26
17. Mitchell RG, Duscha BD, Robbins JL, et al. Increased levels of apoptosis in gastrocnemius skeletal muscle in patients with peripheral arterial disease. Vasc Med. 2007 ; 12: 285-290
18. Jensen L, Pilegaard H, Neufer PD, Hellsten Y. Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2004 ; 287: R397-402
19. Croley AN, Zwetsloot KA, Westerkamp LM, et al. Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young women. J Appl Physiol. 2005 ; 99: 1872-1879 (Pubitemid 41547186)
20. Gustafsson T, Rundqvist H, Norrbom J, Rullman E, Jansson E, Sundberg CJ. The influence of physical training on the angiopoietin and VEGF-A systems in human skeletal muscle. J Appl Physiol. 2007 ; 103: 1012-1020 (Pubitemid 47358888)
21. Gustafsson T, Ameln H, Fischer H, Sundberg CJ, Timmons JA, Jansson E. VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise. J Appl Physiol. 2005 ; 98: 2137-2146 (Pubitemid 40726908)
22. Richardson RS, Wagner H, Mudaliar SR, Saucedo E, Henry R, Wagner PD. Exercise adaptation attenuates VEGF gene expression in human skeletal muscle. Am J Physiol Heart Circ Physiol. 2000 ; 279: H772-778
23. Palmer-Kazen U, Wariaro D, Luo F, Wahlberg E. Vascular endothelial cell growth factor and fibroblast growth factor 2 expression in patients with critical limb ischemia. J Vasc Surg. 2004 ; 39: 621-628 (Pubitemid 38298634)
24. Choksy S, Pockley AG, Wajeh YE, Chan P. VEGF and VEGF receptor expression in human chronic critical limb ischaemia. Eur J Vasc Endovasc Surg. 2004 ; 28: 660-669 (Pubitemid 39462661)
25. Palmer-Kazen U, Religa P, Wahlberg E. Exercise in patients with intermittent claudication elicits signs of inflammation and angiogenesis. Eur J Vasc Endovasc Surg. 2009 ; 38: 689-696
26. Wood RE, Sanderson BE, Askew CD, Walker PJ, Green S, Stewart IB. Effect of training on the response of plasma vascular endothelial growth factor to exercise in patients with peripheral arterial disease. Clin Sci (Lond). 2006 ; 111: 401-409 (Pubitemid 44902298)
27. Hazarika S, Dokun AO, Li Y, Popel AS, Kontos CD, Annex BH. Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. Circ Res. 2007 ; 101: 948-956 (Pubitemid 350287182)
28. Waltenberger J, Mayr U, Pentz S, Hombach V. Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia. Circulation. 1996 ; 94: 1647-1654 (Pubitemid 26320271)
29. Wu FTH, Stefanini MO, Mac Gabhann F, Kontos CD, Annex BH, Popel AS. VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model. Am J Physiol Heart Circ Physiol. 2010 ; 298: H2174-2191
30. Rissanen TT, Vajanto I, Hiltunen MO, et al. Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration. Am J Pathol. 2002 ; 160: 1393-1403 (Pubitemid 34411643)