Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 2 56-2, 2004, Pages

  Jensen, Lotte ^a   Pilegaard, Henriette ^b   Neufer, P Darrell ^c   Hellsten, Ylva ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Transient transcriptional activation; Vascular endothelial growth factor165

Indexed keywords

COMPLEMENTARY DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; RNA; VASCULOTROPIN;

ADULT; ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; EXERCISE; GENE EXPRESSION; HUMAN; HUMAN EXPERIMENT; LEG EXERCISE; LEG MUSCLE; MALE; MUSCLE BIOPSY; MUSCLE BLOOD FLOW; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; TRAINING; VASTUS LATERALIS MUSCLE;

ADULT; ALTERNATIVE SPLICING; BIOPSY; EXERCISE; HUMANS; MALE; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 3242748986     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00071.2004     Document Type: Article

References (34)

1. Andersen P, Adams RP, Sjogaard G, Thorboe A, and Saltin B. Dynamic knee extension as model for study of isolated exercising muscle in humans. J Appl Physiol 59: 1647-1653, 1985.
2. Annex BH, Torgan CE, Lin P, Taylor DA, Thompson MA, Peters KG, and Kraus WE. Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle. Am J Physiol Heart Circ Physiol 274: H860-H867, 1998.
3. Bergström J. Muscle electrolytes in man, obtaining the muscle samples. Scand J Clin Lab Invest 14: 11-17, 1962.
4. Breen EC, Johnson EC, Wagner H, Tseng HM, Sung LA, and Wagner PD. Angiogenic growth factor mRNA responses in muscle to a single bout of exercise. J Appl Physiol 81: 355-361, 1996.
5. Charnock-Jones DS, Sharkey AM, Rajput-Williams J, Burch D, Schofield JP, Fountain SA, Boocock CA, and Smith SK. Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines. Biol Reprod 48: 1120-1128, 1993.
6. Cheung CY, Singh M, Ebaugh MJ, and Brace RA. Vascular endothelial growth factor gene expression in ovine placenta and fetal membranes. Am J Obstet Gynecol 173: 753-759, 1995.
7. Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
8. Cohen T, Gitay-Goren H, Sharon R, Shibuya M, Halaban R, Levi BZ, and Neufeld G. VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells. J Biol Chem 270: 11322-11326, 1995.
9. Ferrara N and Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161: 851-858, 1989.
10. Gavin TP, Robinson CB, Yeager RC, England JA, Nifong LW, and Hickner RC. Angiogenic growth factor response to acute systemic exercise in human skeletal muscle. J Appl Physiol 96: 19-24, 2004.
11. Gustafsson T, Bodin K, Sylven C, Gordon A, Tyni-Lenne R, and Jansson E. Increased expression of VEGF following exercise training in patients with heart failure. Eur J Clin Invest 31: 362-366, 2001.
12. Gustafsson T, Knutsson A, Puntschart A, Kaijser L, Nordqvist AC, Sundberg CJ, and Jansson E. Increased expression of vascular endothelial growth factor in human skeletal muscle in response to short-term one-legged exercise training. Pflügers Arch 444: 752-759, 2002.
13. Gustafsson T, Puntschart A, Kaijser L, Jansson E, and Sundberg CJ. Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. Am J Physiol Heart Circ Physiol 276: H679-H685, 1999.
14. Hiscock N, Fischer CP, Pilegaard H, and Pedersen BK. Vascular endothelial growth factor mRNA expression and arteriovenous balance in response to prolonged, submaximal exercise in humans. Am J Physiol Heart Circ Physiol 285: H1759-H1763, 2003.
15. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, and Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5: 1806-1814, 1991.
16. Ishii H, Oota I, Arakawa T, and Takuma T. Differential gene expression of vascular endothelial growth factor isoforms and their receptors in the development of the rat masseter muscle. Arch Oral Biol 47: 505-510, 2002.
17. Jensen L, Bangsbo J, and Hellsten Y. Effect of high intensity training on capillarisation and presence of angiogenic factors in human skeletal muscle. J Phys 2004.
18. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, and Connolly DT. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309-1312, 1989.
19. Kusters B, de Waal RM, Wesseling P, Verrijp K, Maass C, Heerschap A, Barentsz JO, Sweep F, Ruiter DJ, and Leenders WP. Differential effects of vascular endothelial growth factor A isoforms in a mouse brain metastasis model of human melanoma. Cancer Res 63: 5408-5413, 2003.
20. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, and Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306-1309, 1989.
21. Neufeld G, Cohen T, Gitay-Goren H, Poltorak Z, Tessler S, Sharon R, Gengrinovitch S, and Levi BZ. Similarities and differences between the vascular endothelial growth factor (VEGF) splice variants. Cancer Metastasis Rev 15: 153-158, 1996.
22. Ng YS, Rohan R, Sunday ME, Demello DE, and D'Amore PA. Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn 220: 112-121, 2001.
23. Park JE, Keller GA, and Ferrara N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 4: 1317-1326, 1993.
24. Pilegaard H, Keller C, Steensberg A, Helge JW, Pedersen BK, Saltin B, and Neufer PD. Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes. J Physiol 541: 261-271, 2002.
25. Pilegaard H, Ordway GA, Saltin B, and Neufer PD. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab 279: E806-E814, 2000.
26. Poltorak Z, Cohen T, and Neufeld G. The VEGF splice variants: properties, receptors, and usage for the treatment of ischemic diseases. Herz 25: 126-129, 2000.
27. Poltorak Z, Cohen T, Sivan R, Kandelis Y, Spira G, Vlodavsky I, Keshet E, and Neufeld G. VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem 272: 7151-7158, 1997.
28. Richardson RS, Wagner H, Mudaliar SR, Henry R, Noyszewski EA, and Wagner PD. Human VEGF gene expression in skeletal muscle: effect of acute normoxic and hypoxic exercise. Am J Physiol Heart Circ Physiol 277: H2247-H2252, 1999.
29. Richardson RS, Wagner H, Mudaliar SR, Saucedo E, Henry R, and Wagner PD. Exercise adaptation attenuates VEGF gene expression in human skeletal muscle. Am J Physiol Heart Circ Physiol 279: H772-H778, 2000.
30. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, and Abraham JA. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266: 11947-11954, 1991.
31. Vincenti V, Cassano C, Rocchi M, and Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation 93: 1493-1495, 1996.
32. Vogt M, Puntschart A, Geiser J, Zuleger C, Billeter R, and Hoppeler H. Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions. J Appl Physiol 91: 173-182, 2001.
33. Wang H and Keiser JA. Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1. Circ Res 83: 832-840, 1998.
34. Wellmann S, Taube T, Paal K, Graf VE, Geilen W, Seifert G, Eckert C, Henze G, and Seeger K. Specific reverse transcription-PCR quantification of vascular endothelial growth factor (VEGF) splice variants by LightCycler technology. Clin Chem 47: 654-660, 2001.