Exercise in Patients with Intermittent Claudication Elicits Signs of Inflammation and Angiogenesis

European Journal of Vascular and Endovascular Surgery

Volumn 38, Issue 6, 2009, Pages 689-696

  Palmer Kazen, U ^a,b   Religa, P ^a   Wahlberg, E ^a,b,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Angiogenesis; Arteriogenesis; Claudication; Exercise; Growth factors

Indexed keywords

C REACTIVE PROTEIN; FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CARDIOVASCULAR INFLAMMATION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; EXERCISE TEST; FEMALE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; HUMAN; INTERMITTENT CLAUDICATION; ISCHEMIA; MALE; MUSCLE BIOPSY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREADMILL EXERCISE;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BIOPSY; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; EXERCISE; EXERCISE TEST; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTERMITTENT CLAUDICATION; MALE; MIDDLE AGED; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 71649111647     PISSN: 10785884     EISSN: 15322165     Source Type: Journal    
DOI: 10.1016/j.ejvs.2009.08.005     Document Type: Article

References (35)

1. Sigvant B., Wiberg-Hedman K., Bergqvist D., Rolandsson O., Andersson B., Persson E., et al. A population-based study of peripheral arterial disease prevalence with special focus on critical limb ischemia and sex differences. J Vasc Surg 45 (2007) 1185-1191
2. Leng G.C., Lee A.J., Fowkes F.G., et al. Incidence, natural history and cardiovascular events in symptomatic and asymptomatic peripheral arterial disease in the general population. Int J Epidemiol 25 6 (1996) 1172-1181
3. Cassar K., Bachoo P., Ford I., Greaves M., and Brittenden J. Markers of coagulation activation, endothelial stimulation and inflammation in patients with peripheral arterial disease. Eur J Vasc Endovasc Surg 29 2 (2005) 171-176
4. Cassar K., Bachoo P., Ford I., Greaves M., and Brittenden J. Platelet activation is increased in peripheral arterial disease. J Vasc Surg 38 1 (2003) 99-103
5. Signorelli S.S., Mazzarino M.C., Di Pino L., et al. High circulating levels of cytokines (IL-6 and TNFalpha), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test. Vasc Med 8 1 (2003) 15-19
6. Gardner A.W., Katzel L.I., Sorkin J., et al. Exercise rehabilitation improves functional outcomes and peripheral circulation in patients with intermittent claudication: a randomized controlled trial. J Am Geriatr Soc 49 6 (2001) 755-762
7. McGuigan M.R., Bronks R., Newton R.U., et al. Resistance training in patients with peripheral arterial disease: effects on myosin isoforms, fiber type distribution, and capillary supply to skeletal muscle. J Gerontol A Biol Sci Med Sci 56 7 (2001) B302-B310
8. Heil M., and Schaper W. Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis). Circ Res 95 5 (2004) 449-458
9. Ito W.D., Arras M., Scholz D., et al. Angiogenesis but not collateral growth is associated with ischemia after femoral artery occlusion. Am J Physiol 273 3 Pt 2 (1997) H1255-H1265
10. Luo F., Wariaro D., Lundberg G., Blegen H., and Wahlberg E. Vascular growth factor expression in a rat model of severe limb ischemia. J Surg Res 108 2 (2002) 258-267
11. Gustafsson T., et al. Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. Am J Physiol 276 2 Pt 2 (1999) H679-H685
12. Palmer-Kazen U., Wariaro D., Luo F., and Wahlberg E. Vascular endothelial cell growth factor and fibroblast growth factor 2 expression in patients with critical limb ischemia. J Vasc Surg 39 3 (2004) 621-628
13. Rohovsky S., Kearney M., Pieczek A., Rosenfield K., Schainfeld R., D'Amore P.A., et al. Elevated levels of basic fibroblast growth factor in patients with limb ischemia. Am Heart J 132 5 (1996) 1015-1019
14. Hasdai D., Barak V., Leibovitz E., Herz I., Sclarovsky S., Elder M., et al. Serum basic fibroblast growth factor levels in patients with ischemic heart disease. Int J Cardiol 59 2 (1997) 133-138
15. Wahlberg E. Angiogenesis and arteriogenesis in limb ischemia. J Vasc Surg 38 1 (2003) 198-203
16. Xu C.Z.X., Potter B.J., Wang W., et al. TNF-alfa contributes to endothelial dysfunction in ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol 26 (2006) 475-480
17. Minetto M.A., Rainoldi A., Gazzoni M., et al. Interleukin-6 response to isokinetic exercise in elite athletes: relationships to adrenocortical function and to mechanical and myoelectric fatigue. Eur J Appl Physiol 98 4 (2006) 373-382
18. Welker J.A., Henshaw R.M., Jelinek J., et al. The percutaneous needle biopsy is safe and recommended in the diagnosis of musculoskeletal masses. Cancer 89 12 (2000) 2677-2686
19. Hayot M., Michaud A., Koechlin C., et al. Skeletal muscle microbiopsy: a validation study of a minimally invasive technique. Eur Respir J 25 3 (2005) 431-440
20. Buschmann I., Heil M., Jost M., et al. Influence of inflammatory cytokines on arteriogenesis. Microcirculation 10 3-4 (2003) 371-379
21. Tisi P.V., and Shearman C.P. Biochemical and inflammatory changes in the exercising claudicant. Vasc Med 3 3 (1998) 189-198
22. Vainas T., Stassen F.R., de Graaf R., Twiss E.L.L., Herngreen S.B., Welten R.J.Th.J., et al. C-reactive protein in peripheral arterial disease: relation to severity of the disease and to future cardiovascular events. J Vasc Surg 42 2 (2005) 243-251
23. Fiotti N., Giansante C., Ponte E., et al. Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease. Atherosclerosis 145 1 (1999) 51-60
24. Collins P., Ford I., Ball D., Macauley E., Greaves M., and Brittenden J. A preliminary study on the effects of exercising to maximum walking distance on platelet and endothelial function in patients with intermittent claudication. Eur J Vasc Endovasc Surg 31 3 (2006 Mar) 266-273
25. van den Burg P.J., Hospers J.E., Mosterd W.L., et al. Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products. J Appl Physiol 88 (2000) 1558-1564
26. Woodburn K.R., Rumley A., Murtagh A., and Lowe G.D.O. Acute exercise and markers of endothelial injury in peripheral arterial disease. Eur J Vasc Endovasc Surg 14 2 (1997) 140-142
27. Lewis D.R., Day A., Jeremy J.Y., Baird R.N., Smith F.C.T., and Lamont P.M. The systemic effects of intermittent claudication are reversed by angioplasty. Eur J Vasc Endovasc Surg 22 4 (2001) 326-330
28. Turton E.P., Spark J.I., Mercer K.G., Berridge D.C., Kent P.J., Kestes R.C., et al. Exercise-induced neutrophil activation in claudicants: a physiological or pathological response to exhaustive exercise?. Eur J Vasc Endovasc Surg 16 3 (1998) 192-196
29. Nawaz S., Walker R.D., Wilkinson C.H., Saxton J.M., Pockley A.G., and Wood RFM. The inflammatory response to upper and lower limb exercise and the effects of exercise training in patients with claudication. J Vasc Surg 33 2 (2001) 392-399
30. Hoefer I.E., van Royen N., Rectenwald J.E., et al. Arteriogenesis proceeds via ICAM-1/Mac-1-mediated mechanisms. Circ Res 94 9 (2004) 1179-1185
31. Comerota A.J., Throm R.C., Kelly P., and Jaff M. Tissue (muscle) oxygen saturation (StO2): a new measure of symptomatic lower-extremity arterial disease. J Vasc Surg 38 4 (2003) 724-729
32. Shweiki D., Itin A., Soffer D., et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359 6398 (1992) 843-845
33. Gustafsson T., Bodin K., Sylvén C., et al. Increased expression of VEGF following exercise training in patients with heart failure. Eur J Clin Invest 31 4 (2001) 362-366
34. Wood R.E., Sanderson B.E., Askew C.D., et al. Effect of training on the response of plasma vascular endothelial growth factor to exercise in patients with peripheral arterial disease. Clin Sci 111 6 (2006 Dec) 401-409
35. Soulet L., Chevet E., Lemaitre G., et al. FGFs and their receptors, in vitro and in vivo studies: new FGF receptor in the brain, FGF-1 in muscle, and the use of functional analogues of low-affinity heparin-binding growth factor receptors in tissue repair. Mol Reprod Dev 39 1 (1994) 49-54