Ferritin couples iron and fatty acid metabolism

FASEB Journal

Volumn 26, Issue 6, 2012, Pages 2394-2400

  Bu, Weiming ^a   Liu, Renyu ^a   Cheung Lau, Jasmina C ^b   Dmochowski, Ivan J ^b   Loll, Patrick J ^c   Eckenhoff, Roderic G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Arachidonic acid; Calorimetry; Ferrihydrite; X ray crystallography

Indexed keywords

APOFERRITIN; ARACHIDONIC ACID; FATTY ACID; FERRIC HYDROXIDE; FERRITIN; FREE RADICAL; IRON; OCTANOIC ACID; SOLVENT;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRESS; CONTROLLED STUDY; CRYSTAL; DIFFRACTION; FATTY ACID METABOLISM; IRON METABOLISM; IRON STORAGE; IRON TRANSPORT; ISOTHERMAL MICROCALORIMETRY; LIPID PEROXIDATION; MICROCALORIMETRY; MINERALIZATION; OXIDATION KINETICS; PRIORITY JOURNAL;

APOFERRITINS; ARACHIDONIC ACID; BINDING SITES; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; FATTY ACIDS; FERRITINS; IRON; MODELS, MOLECULAR; OCTANOIC ACIDS;

EQUIDAE;

EID: 84861788364     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-198853     Document Type: Article

References (34)

1. Zimmerman, A. W., van Moerkerk, H. T., and Veerkamp, J. H. (2001) Ligand specificity and conformational stability of human fatty acid-binding proteins. Int. J. Biochem. Cell Biol. 33, 865-876 (Pubitemid 32667495)
2. Chmurzynska, A. (2006) The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J. Appl. Genet. 47, 39-48
3. Zanotti, G., Scapin, G., Spadon, P., Veerkamp, J. H., and Sacchettini, J. C. (1992) Three-dimensional structure of recombinant human muscle fatty acid-binding protein. J. Biol. Chem. 267, 18541-18550
4. Curry, S. (2009) Lessons from the crystallographic analysis of small molecule binding to human serum albumin. Drug Metab. Pharmacokinet. 24, 342-357
5. 2 structure/ function, mechanism, and signaling. J. Lipid Res. 50(Suppl), S237-S242
6. Kell, D. B. (2010) Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. Arch. Toxicol. 84, 825-889
7. Brash, A. R. (2001) Arachidonic acid as a bioactive molecule. J. Clin. Invest. 107, 1339-1345
8. 1 in human monocytes. Evidence for transcriptional and post-transcriptional regulation. Eur. J. Biochem. 264, 736-745
9. Baldi, A., Lombardi, D., Russo, P., Palescandolo, E., De, L. A., Santini, D., Baldi, F., Rossiello, L., Dell'Anna, M. L., Mastrofrancesco, A., Maresca, V., Flori, E., Natali, P. G., Picardo, M., and Paggi, M. G. (2005) Ferritin contributes to melanoma progression by modulating cell growth and sensitivity to oxidative stress. Clin. Cancer Res. 11, 3175-3183 (Pubitemid 40627862)
10. Giordani, A., Haigle, J., Leflon, P., Risler, A., Salmon, S., Aubailly, M., Maziere, J. C., Santus, R., and Morliere, P. (2000) Contrasting effects of excess ferritin expression on the iron-mediated oxidative stress induced by tert-butyl hydroperoxide or ultraviolet-A in human fibroblasts and keratinocytes. J. Photochem. Photobiol. B 54, 43-54 (Pubitemid 30124227)
11. Gillum, R. F. (2001) Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men-the Third National Health and Nutrition Examination Survey. Int. J. Obes. Relat. Metab. Disord. 25, 639-645
12. Iwasaki, T., Nakajima, A., Yoneda, M., Yamada, Y., Mukasa, K., Fujita, K., Fujisawa, N., Wada, K., and Terauchi, Y. (2005) Serum ferritin is associated with visceral fat area and subcutaneous fat area. Diabetes Care 28, 2486-2491 (Pubitemid 41384298)
13. Liu, R., Loll, P. J., and Eckenhoff, R. G. (2005) Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein. FASEB J. 19, 567-576 (Pubitemid 40471248)
14. Vedula, L. S., Brannigan, G., Economou, N. J., Xi, J., Hall, M. A., Liu, R., Rossi, M. J., Dailey, W. P., Grasty, K. C., Klein, M. L., Eckenhoff, R. G., and Loll, P. J. (2009) A unitary anesthetic-binding site at high resolution. J. Biol. Chem. 284, 24176-24184
15. Precigoux, G., Yariv, J., Gallois, B., Courseille, C., and d'Estaintot, B.L. (1994) A crystallographic study of haem binding to ferritin. Acta Crystallogr. D Biol. Crystallogr. 50, 739-743
16. Trikha, J., Theil, E. C., and Allewell, N. M. (1995) High resolution crystal structures of amphibian red-cell L ferritin: potential roles for structural plasticity and solvation in function. J. Mol. Biol. 248, 949-967
17. Bar-Or, D., Rael, L. T., Lau, E. P., Rao, N. K., Thomas, G. W., Winkler, J. V., Yukl, R. L., Kingston, R. G., and Curtis, C. G. (2001) An analog of the human albumin N-terminus (Asp-Ala-His-Lys) prevents formation of copper-induced reactive oxygen species. Biochem. Biophys. Res. Commun. 284, 856-862 (Pubitemid 32926747)
18. Sun, S., Arosio, P., Levi, S., and Chasteen, N. D. (1993) Ferroxidase kinetics of human liver apoferritin, recombinant H-chain apoferritin, and site-directed mutants. Biochemistry 32, 9362-9369 (Pubitemid 23292055)
19. Sun, S., and Chasteen, N. D. (1992) Ferroxidase kinetics of horse spleen apoferritin. J. Biol. Chem. 267, 25160-25166
20. Lawson, D. M., Treffry, A., Artymiuk, P. J., Harrison, P. M., Yewdall, S. J., Luzzago, A., Cesareni, G., Levi, S., and Arosio, P. (1989) Identification of the ferroxidase centre in ferritin. FEBS Lett. 254, 207-210 (Pubitemid 19217880)
21. Hempstead, P. D., Hudson, A. J., Artymiuk, P. J., Andrews, S. C., Banfield, M. J., Guest, J. R., and Harrison, P. M. (1994) Direct observation of the iron binding sites in a ferritin. FEBS Lett. 350, 258-262 (Pubitemid 24268033)
22. Haldar, S., Bevers, L. E., Tosha, T., and Theil, E. C. (2011) Moving iron through ferritin protein nanocages depends on residues throughout each four α-helix bundle subunit. J. Biol. Chem. 286, 25620-25627
23. Wang, Z., Li, C., Ellenburg, M., Soistman, E., Ruble, J., Wright, B., Ho, J. X., and Carter, D. C. (2006) Structure of human ferritin L chain. Acta Crystallogr. D Biol. Crystallogr. 62, 800-806 (Pubitemid 43965906)
24. Hempstead, P. D., Yewdall, S. J., Fernie, A. R., Lawson, D. M., Artymiuk, P. J., Rice, D. W., Ford, G. C., and Harrison, P. M. (1997) Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution. J. Mol. Biol. 268, 424-448 (Pubitemid 27208065)
25. Bou-Abdallah, F., Biasiotto, G., Arosio, P., and Chasteen, N. D. (2004) The putative "nucleation site" in human H-chain ferritin is not required for mineralization of the iron core. Biochemistry 43, 4332-4337 (Pubitemid 38445654)
26. Crichton, R. R., and Declercq, J. P. (2010) X-ray structures of ferritins and related proteins. Biochim. Biophys. Acta 1800, 706-718
27. MacKenzie, E. L., and Tsuji, Y. (2008) Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization. Biochem. J. 411, 107-113 (Pubitemid 351482352)
28. Tsuji, Y. (2005) JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress. Oncogene 24, 7567-7578
29. Festa, M., Ricciardelli, G., Mele, G., Pietropaolo, C., Ruffo, A., and Colonna, A. (2000) Overexpression of H ferritin and up-regulation of iron regulatory protein genes during differentiation of 3T3-L1 pre-adipocytes. J. Biol. Chem. 275, 36708-36712 (Pubitemid 32002076)
30. Araujo, F. B., Barbosa, D. S., Hsin, C. Y., Maranhao, R. C., and Abdalla, D. S. (1995) Evaluation of oxidative stress in patients with hyperlipidemia. Atherosclerosis 117, 61-71
31. Hermans, M. P., Ahn, S. A., Amoussou-Guenou, K. D., Balde, N. M., and Rousseau, M. F. (2010) Do high ferritin levels confer lower cardiovascular risk in men with type 2 diabetes? Diabet. Med. 27, 417-422
32. Ortiz, E., Pasquini, J. M., Thompson, K., Felt, B., Butkus, G., Beard, J., and Connor, J. R. (2004) Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models. J. Neurosci. Res. 77, 681-689 (Pubitemid 39194609)
33. Zacharski, L. R., Chow, B. K., Howes, P. S., Shamayeva, G., Baron, J. A., Dalman, R. L., Malenka, D. J., Ozaki, C. K., and Lavori, P. W. (2007) Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial. JAMA 297, 603-610
34. Knuiman, M. W., Divitini, M. L., Olynyk, J. K., Cullen, D. J., and Bartholomew, H. C. (2003) Serum ferritin and cardiovascular disease: a 17-year follow-up study in Busselton, Western Australia. Am. J. Epidemiol. 158, 144-149 (Pubitemid 36841946)