Disulfide bridges remain intact while native insulin converts into amyloid fibrils

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Kurouski, Dmitry ^a   Washington, Jacqueline ^a   Ozbil, Mehmet ^b   Prabhakar, Rajeev ^b   Shekhtman, Alexander ^a   Lednev, Igor K ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b University of Miami   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMYLOID; BOVINE INSULIN; INSULIN; PHENYLALANINE; TYROSINE; DISULFIDE;

ARTICLE; BETA SHEET; CHEMICAL COMPOSITION; DEEP ULTRAVIOLET RESONANCE RAMAN SPECTROSCOPY; DEUTERIUM HYDROGEN EXCHANGE; DISULFIDE BOND; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN STRUCTURE; SPECTROSCOPY; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CATTLE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SOLUTION AND SOLUBILITY;

AMINO ACID SEQUENCE; AMINO ACIDS; AMYLOID; ANIMALS; CATTLE; DEUTERIUM EXCHANGE MEASUREMENT; DISULFIDES; HUMANS; INSULIN; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; SOLUTIONS;

EID: 84861730624     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036989     Document Type: Article

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