A422T mutation in HERG potassium channel retained in ER is rescurable by pharmacologic or molecular chaperones

Biochemical and Biophysical Research Communications

Volumn 422, Issue 2, 2012, Pages 305-310

  Guo, Jia ^a,b   Zhang, XiangMei ^a   Hu, ZhenSheng ^a   Zhuang, Zhong ^a   Zhu, ZhongHua ^a   Chen, Zhong ^a   Chen, Wen ^a   Zhao, ZhongZhong ^a   Zhang, ChaoYing ^a   Zhang, Zhao ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

HERG; Long QT syndrome; Patch clamp; Potassium channel; Protein trafficking

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; POTASSIUM CHANNEL HERG;

ARTICLE; CELL MIGRATION; CELL STRAIN HEK293; CYTOPLASM; ELECTROPHYSIOLOGY; ENDOPLASMIC RETICULUM; HUMAN; IMMUNOCYTOCHEMISTRY; INCUBATION TEMPERATURE; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

AMINO ACID SUBSTITUTION; APOPTOSIS; COLD TEMPERATURE; ENDOPLASMIC RETICULUM; ETHER-A-GO-GO POTASSIUM CHANNELS; HEK293 CELLS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR CHAPERONES; MUTATION, MISSENSE; NITRILES; PIPERIDINES; PROTEIN TRANSPORT;

EID: 84861705454     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.04.153     Document Type: Article

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