A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylan- oligosaccharides enriched bread in healthy volunteers

Nutrition Journal

Volumn 11, Issue 1, 2012, Pages

  Walton, Gemma E ^a   Lu, Congyi ^a   Trogh, Isabel ^b   Arnaut, Filip ^b   Gibson, Glenn R ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b Puratos Group   (Belgium)

Author keywords

Arabinoxylan oligosaccharides; Bifidobacteria; Butyrate; Faecal; Human gut microbiota; Intestine; Prebiotic

Indexed keywords

ARABINOXYLAN; ARABINOXYLAN OLIGOSACCHARIDE; BUTYRIC ACID; FATTY ACID; ISOVALERIC ACID; PLACEBO; SECRETORY IMMUNOGLOBULIN; UNCLASSIFIED DRUG; VOLATILE FATTY ACID;

ADULT; ARTICLE; BIFIDOBACTERIACEAE; BREAD; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; FECES ANALYSIS; FEMALE; FERMENTATION TECHNIQUE; FLUORESCENCE IN SITU HYBRIDIZATION; FOOD INTAKE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN EXPERIMENT; LACTOBACILLUS; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SALIVA ANALYSIS;

ADOLESCENT; ADULT; BIFIDOBACTERIUM; BREAD; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDO-1,4-BETA XYLANASES; FATTY ACIDS, VOLATILE; FECES; FEMALE; FERMENTATION; FOOD ADDITIVES; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; OLIGOSACCHARIDES; PREBIOTICS; XYLANS; YOUNG ADULT;

MURINAE;

EID: 84861693090     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-11-36     Document Type: Article

References (68)

1. Part 2-Prebiotics: New medicines for the colon, health benefits. Dubert-Ferrandon A, Newburg DS, Walker WA, Nutr Today 2009 44 85 91 10.1097/NT.0b013e31819df7bc
2. Prebiotics or probiotics for lactose intolerance: a question of adaptation. Szilagyi A, Am J Clin Nutr 1999 70 1 105 106 10393148 (Pubitemid 29461121)
3. Uremic toxins originating from colonic microbial metabolism. Evenepoel P, Meijers BK, Bammens BR, Verbeke K, Kidney Int 2009 144 Suppl 12 19
4. Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. Ooi L, Liong M, Int J Mol Sci 2010 11 2499 2522 10.3390/ijms11062499 20640165
5. A combination of prebiotic short and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ, Am J Clin Nutr 2005 82 471 476 16087995
6. Antigenotoxicity of probiotics and prebiotics on faecal water-induced DNA damage in human colon adenocarcinoma cells. Burns AJ, Rowland IR, Muta Res 2004 551 233 243 10.1016/j.mrfmmm.2004.03.010 (Pubitemid 38833511)
7. Faecal water genotoxicity is predictive of tumor preventive activities by inulin-like oligofructoses, probiotics (Lactobacillus rhamnosus and Bifidobacterium lactis) and their synbiotic combination. Klinder A, Förster A, Caderni G, Femia AP, Pool-Zobel BL, Nutr Cancer 2004 49 144 155 10.1207/s15327914nc4902-5 15489207 (Pubitemid 39487873)
8. Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data. Pool-Zobel BL, Br J Nutr 2005 93 Suppl 73 90 15705228
9. Cl inical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Silk DB, Davis A, Vulevic J, Tzortzis G, Gibson GR, Aliment Pharmacol Ther 2009 29 508 518 10.1111/j.1365-2036.2008.03911.x 19053980
10. Probiotics and prebiotics and their function. Gibson GR, Funct Nutr 2003 2 11 13
11. Prebiotics and probiotics: are they functional foods? Roberfroid MB, Am J Clin Nutr 2000 71 Suppl 6 1682 1687
12. The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides - a human volunteer study. Tuohy KM, Kolida S, Lustenberger AM, Gibson GR, Br J Nutr 2001 86 341 348 10.1079/BJN2001394 11570986 (Pubitemid 32916191)
13. A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects. Costabile A, Kolida S, Klinder A, Gietl E, Bäuerlein M, Frohberg C, Landschütze V, Gibson GR, Br J Nutr 2010 104 1007 1017 10.1017/S0007114510001571 20591206
14. A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans. Kolida S, Meyer D, Gibson GR, Eu J Clin Nutr 2007 61 1189 1195 10.1038/sj.ejcn.1602636 (Pubitemid 47521550)
15. Prebiotic effect of fruit and vegetable shots containing Jerusalem artichoke inulin: a human intervention study. Ramnani P, Gaudier E, Bingham M, Bruggen P, Van Tuohy KM, Gibson GR, Br J Nutr 2010 104 233 240 10.1017/S000711451000036X 20187995
16. Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Vulevic J, Drakoularakou A, Yaqoob P, Tzortzis G, Gibson GR, Am J Clin Nutr 2008 88 1438 1446 18996881
17. Arabinoxylans and Endoxylanases in Wheat Flour Bread-making. Courtin CM, Delcour JA, J Cereal Sci 2002 35 225 243 10.1006/jcrs.2001.0433 (Pubitemid 34757820)
18. Van Haesendonck IPH, Broekaert WF, Georis J, Delcour J, Courtin C, Filip A, Bread with increased arabinoxylo-oligosaccharide content Geneva: WIPO Publication no 2008 Publication no. WO08087167
19. Kamp JWVD, Asp NG, Jones JM, Schaafsma G, Dietary Fibre bio-active carbohydrates for food and feed The Netherlands: Wageningen Academic Publishers 2004 23015603
20. Structurally different wheat-derived arabinoxylooligosaccharides have different prebiotic and fermentation properties in rats. Van Craeyveld V, Swennen K, Dornez E, Van de Wiele T, Marzorati M, Verstraete W, Delaedt Y, Onagbesan O, Decuypere E, Buyse J, De Ketelaere B, Broekaert WF, Delcour JA, Courtin CM, Am J Clin Nutr 2008 138 2348 2355
21. In vitro fermentation by human fecal microflora of wheat arabinoxylans. Hughes SA, Shewry PR, Li L, Gibson GR, Sanz ML, Rastall RA, J Agric Food Chem 2007 55 4589 4595 10.1021/jf070293g 17488118 (Pubitemid 46932659)
22. Arabinoxylan-oligosaccharides (AXOS) affects the protein/carbohydrate fermentation balance and microbial population dynamics of the simulator of human intestinal microbial ecosystem. Sanchez JI, Marzorati M, Grootaert C, Baran M, Van Craeyveld V, Courtin CM, Broekaert WF, Delcour JA, Verstraete W, Van de Wiele T, Microb Biotechnol 2009 2 101 113 10.1111/j.1751-7915.2008.00064.x 21261885
23. Effects of dietary inclusion of xylooligosaccharides, arabinoxylooligosaccharides and soluble arabinoxylan on the microbial composition of caecal contents of chickens. Courtin CM, Swennen K, Broekaert WF, Swennen Q, Buyse J, Decuypere E, Michiels CW, De Ketelaere B, Delcour JA, J Sci Food Agric 2008 88 2517 2522 10.1002/jsfa.3373
24. Tolerance of arabinoxylan-oligosaccharides and their prebiotic activity in healthy subjects: a randomised, placebo-controlled cross-over study. Cloetens L, Broekaert WF, Delaedt Y, Ollevier F, Courtin CM, Delcour JA, Rutgeerts P, Verbeke K, Br J Nutr 2010 103 703 713 10.1017/S0007114509992248 20003568
25. Arabinoxylooligosaccharides from wheat bran inhibit Salmonella colonization in broiler chickens. Eeckhaut V, Van Immerseel F, Dewulf J, Pasmans F, Haesebrouck F, Ducatelle R, Courtin CM, Delcour JA, Broekaert WF, Poult Sci 2008 87 2329 2334 10.3382/ps.2008-00193 18931184
26. Dose-response effect of arabinoxylooligosaccharides on gastrointestinal motility and on colonic bacterial metabolism in healthy volunteers. Cloetens L, De Preter V, Swennen K, Broekaert WF, Courtin CM, Delcour JA, Rutgeerts P, Verbeke K, J Am Coll Nutr 2008 27 512 518 18978172
27. Structurally different wheat-derived arabinoxylooligosaccharides have different prebiotic and fermentation properties in rats. Van Craeyveld V, Swennen K, Dornez E, Van de Wiele T, Marzorati M, Verstraete W, Delaedt Y, Onagbesan O, Decuypere E, Buyse J, De Ketelaere B, Broekaert WF, Delcour JA, Courtin CM, J Nutr 2008 138 2348 2355 10.3945/jn.108.094367 19022956
28. Differential antineoplastic effects of butyrate in cells with and without a functioning DNA mismatch repair. Dronamraju SS, Coxhead JM, Kelly SB, Mathers JC, Nutr Cancer 2010 62 105 115 20043265
29. A randomized controlled trial of a probiotic Lactobacillus strain in healthy adults: assessment of its delivery, transit and influence on microbial flora and enteric immunity. Collins JK, Dunne C, Murphy L, Morrissey D, O'Mahony L, O'Sullivan E, Fitzgerald G, Kiely B, O'Sullivan GC, Daly C, Marteau P, Shanahan F, Microb Ecol Health Dis 2002 14 81 89 10.1080/08910600260081720 (Pubitemid 34832421)
30. Determination of reducing end sugar residues in oligo- and polysaccharides by gas-liquid chromatography. Courtin CM, Van den Broeck H, Delcour JA, J Chromatogr 2000 866 97 104 10.1016/S0021-9673(99)01064-X (Pubitemid 30001852)
31. Consumption of breads containing in situ-produced arabinoxylan oligosaccharides alters gastrointestinal effects in healthy volunteers. Damen B, Cloetens L, Broekaert WF, François I, Lescroart O, Trogh I, Arnaut F, Welling GW, Wijffels J, Delcour JA, Verbeke K, Courtin CM, J Nutr 2012 142 470 477 10.3945/jn.111.146464 22298569
32. In vitro fermentation of carbohydrates by porcine faecal inocula and their influence on Salmonella Typhimurium growth in batch culture systems. Martín-Peláez S, Gibson GR, Martín-Orúe SM, Klinder A, Rastall RA, La Ragione RM, Woodward MJ, Costabile A, FEMS Microbiol Ecol 2008 66 3 608 619 10.1111/j.1574-6941.2008.00610.x 19049655
33. Development of 16S rRNA-based probes for the Coriobacterium group and the Atopobium cluster and their application for enumeration of Coriobacteriaceae in human faeces from volunteers of different age groups. Harmsen HJM, Wildeboer-Veloo ACM, Grijpstra J, Knol J, Degener JE, Welling GW, Appl Environ Microbiol 2000 66 4523 4527 10.1128/AEM.66.10.4523-4527.2000 11010909
34. Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment. Manz W, Amann R, Ludwig W, Vancanneyt M, Schleifer KH, Microbiol 1996 142 1097 1106 10.1099/13500872-142-5-1097 (Pubitemid 26154919)
35. Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific16S rRNA-targeted probes and its application in faecal samples. Langendijk PS, Schut F, Jansen GJ, Raangs GC, Kamphuis GR, Wilkinson MH, Welling GW, Appl Environ Microbiol 1995 61 3069 3075 7487040
36. Variations of bacterial populations in human faeces measured by fluorescence in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Franks AH, Harmsen HJM, Raangs GC, Jansen GJ, Schut F, Welling GW, Appl Environ Microbiol 1998 64 3336 3345 9726880 (Pubitemid 28411456)
37. A16S rRNA-targeted probe for detection of lactobacilli and enterococci in faecal samples by fluorescence in situ hybridization. Harmsen HJM, Elfferich P, Schut F, Welling GW, Microb Ecol Health Dis 1999 11 3 12 10.1080/ 089106099435862 (Pubitemid 29248950)
38. Spatial distribution of Escherichia coli in the mouse large intestine inferred from rRNA in situ hybridization. Poulsen LK, Lan F, Kristensen CS, Hobolth P, Molin S, Krogfelt KA, Infect Immun 1994 62 5191 5194 7927805 (Pubitemid 24332836)
39. McWilliam Leitch EC, Child MW, Flint HJ: pH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon. Walker AW, Duncan SH, Appl Environ Microbiol 2005 71 3692 3670 10.1128/AEM.71.7.3692-3700.2005 16000778 (Pubitemid 40980536)
40. Fusobacterium prausnitzii and related species represent a dominant group within the human fecal flora. Suau A, Rochet V, Sghir A, Gramet G, Brewaeys S, Sutren M, RigottierGois L, Dore J, Systems Appl Microbiol 2001 24 139 145 10.1078/0723-2020-00015 (Pubitemid 32433703)
41. The domain-specific probe EUB338 is insufficient for the detection of all Bacteria: development and evaluation of a more comprehensive probe set. Daims H, Brühl A, Amann R, Schleifer KH, Wagner M, Syst Appl Microbiol 1999 22 434 444 10.1016/S0723-2020(99)80053-8 10553296 (Pubitemid 29485930)
42. Simultaneous determination of volatile and non-volatile acid fermentation products of anaerobes by capillary gas chromatography. Richardson AJ, Calder AG, Stewart CS, Smith A, Lett Appl Microbiol 1989 9 5 8 10.1111/j.1472-765X. 1989.tb00278.x (Pubitemid 19204482)
43. Butyrate modulates oxidative stress in the colonic mucosa of healthy humans. Hamer HM, Jonkers DM, Bast A, Vanhoutvin SA, Fischer MA, Kodde A, Troost FJ, Venema K, Brummer RJ, Clin Nutr 2009 28 88 93 10.1016/j.clnu.2008.11.002 19108937
44. Singer MV: Butyrate modulates intestinal epithelial cell-mediated neutrophil migration. Böcker U, Nebe T, Herweck F, Holt L, Panja A, Jobin C, Rossol SB, Sartor R, Clin Exp Immunol 2003 131 53 60 10.1046/j.1365-2249. 2003.02056.x 12519386 (Pubitemid 36098822)
45. Colonic fermentation of ispaghula, wheat bran, glucose, and albumin to short-chain fatty acids and ammonia evaluated in vitro in 50 subjects. Mortensen PB, Clausen MR, Bonnén H, Hove H, Holtug K, PEN J Parenter Enteral Nutr 1992 16 433 439 10.1177/0148607192016005433
46. Dietary prebiotics: current status and new definition. Gibson GR, Scott KP, Rastall RA, Tuohy KM, Hotchkiss A, Dubert-Ferrandon A, Gareau M, Murphy EF, Saulnier D, Loh G, Macfarlane S, Delzenne N, Ringel Y, Kozianowski G, Dickmann R, Lenoir-Wijnkook I, Walker C, Buddington R, IFIS Func Foods Bull 2010 7 1 19
47. In vitro fermentation of cereal dietary fibre carbohydrates by probiotic and intestinal bacteria. Crittenden R, Karppinen S, Ojanen S, Tenkanen M, Fagerstrom R, Mättö J, Saarela M, Mattila-Sandholm T, Poutanen K, J Sci Food Agric 2002 82 781 789 10.1002/jsfa.1095 (Pubitemid 34589465)
48. The isolation of lactic acid bacteria from human colonic biopsies after enrichment on lactose derivatives and rye arabinoxylo-oligosaccharides. Kontula P, Suihko ML, Suortti T, Tenkanen M, Mattila-Sandholm T, von Wright A, Food Microbiol 2000 17 13 22 10.1006/fmic.1999.0268 (Pubitemid 30105046)
49. Fermentation of plant cell wall derived polysaccharides and their corresponding oligosaccharides by intestinal bacteria. Van Laere KMJ, Hartemink R, Bosveld M, Schols HA, Voragen AGJ, J Agric Food Chem 2000 48 1644 1652 10.1021/jf990519i 10820072 (Pubitemid 30331502)
50. Oat beta-glucan and xylan hydrolysates as selective substrates for Bifidobacterium and Lactobacillus strains. Jaskari J, Kontula P, Siitonen A, Jousimies-Somer H, Mattila-Sandholm T, Poutanen K, Appl Microbiol and Biotech 1998 49 175 181 10.1007/s002530051155 (Pubitemid 28098678)
51. Prebiotics: an update. Venter CS, JFECS 2007 35 17 25
52. Fructan content of rye and rye products. Karppinen S, Myllymäki O, Forssell P, Poutanen K, Cereal Chem 2003 80 168 171 10.1094/CCHEM.2003.80.2.168 (Pubitemid 36337391)
53. A dose dependent impact of prebiotic galactooligosaccharides on the intestinal microbiota of healthy adults. Davis LM, Martínez I, Walter J, Hutkins R, Intl J Food Microbiol 2010 44 285 292
54. Lactobacillus frumenti sp. nov., a new lactic acid bacterium isolated from rye-bran fermentations with a long fermentation period. Muller MRA, Ehrmann M, Vogel RF, Int J Syst Evol Micr 2000 50 2127 2133 10.1099/00207713-50-6-2127 (Pubitemid 32049565)
55. Identification of lactobacilli from sourdough and description of Lactobacillus pontis sp. nov. Vogel RF, Böcker G, Stolz P, Ehrmann M, Fanta D, Ludwig W, Pot B, Kersters K, Schleifer KH, Hammes WP, Int J Syst Bacteriol 1994 44 223 229 10.1099/00207713-44-2-223 8186088 (Pubitemid 24116288)
56. Degradation of rye arabinoxylans in the large intestine of pigs. Glitso LV, Gruppen H, Schols HA, Hojsgaard S, Sandstrom B, Knudsen KEB, J Sci Food Agric 1999 79 61 969
57. Characterization of the xylan-degrading microbial community from human faeces. Chassard C, Goumy V, Leclerc M, Delhomme C, Bernalier-Donadille A, FEMS Microbiol Ecol 2007 61 121 131 10.1111/j.1574-6941.2007.00314.x 17391327 (Pubitemid 46889818)
58. Prebiotic and other health-related effects of cereal-derived arabinoxylans, arabinoxylan-oligosaccharides, and xylooligosaccharides. Broekaert WF, Courtin CM, Verbeke K, Van de Wiele T, Verstraete W, Delcour JA, Crit Rev Food Sci Nutr 2011 51 178 194 10.1080/10408390903044768 21328111
59. Enumeration of Bacteroides species in human faeces by fluorescent in situ hybridisation combined with flow cytometry using 16S rRNA probes. Rigottier-Gois L, Rochet V, Garrec N, Suau A, Doré J, Syst Appl Microbiol 2003 26 110 118 10.1078/072320203322337399 12747418 (Pubitemid 36514252)
60. Comparison of prebiotic effects of arabinoxylan oligosaccharides and inulin in a simulator of the human intestinal microbial ecosystem. Grootaert C, Van Den Abbeele P, Marzorati M, Broekaert WF, Courtin CM, Delcour JA, Verstraete W, Van De Wiele T, FEMS Microbiol Ecol 2009 69 231 242 10.1111/j.1574-6941. 2009.00712.x 19508502
61. Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut. Belenguer A, Duncan SH, Calder AG, Holtrop G, Louis P, Lobley GE, Flint HJ, Appl Environ Microbiol 2006 72 3593 3599 10.1128/AEM.72.5.3593-3599.2006 16672507 (Pubitemid 43728015)
62. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. Louis P, Flint HJ, FEMS Microbiol Lett 2009 294 1 8 10.1111/j.1574-6968.2009.01514.x 19222573
63. Effect of different carbohydrates on growth, polysaccharidase and glycosidase production by Bacteroides ovatus, in batch and continuous culture. Macfarlane GT, Hay S, Macfarlane S, Gibson GR, J Appl Bacteriol 1990 68 179 187 10.1111/j.1365-2672.1990.tb02564.x 2318746 (Pubitemid 20129668)
64. Protein degradation by human intestinal bacteria. Macfarlane GT, Cummings JH, Allison C, J Gen Microbiol 1986 132 1647 1656 3543210 (Pubitemid 16062936)
65. Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease. Mortensen PB, Clausen MR, Scand J Gastroenterol 1996 216 Suppl 132 148 (Pubitemid 26129312)
66. Effects of work demands on immunoglobulin A and cortisol in air traffic controllers. Zeier H, Brauchli P, Joller-Jemelka HI, Biol Psychol 1996 42 413 423 10.1016/0301-0511(95)05170-8 8652756 (Pubitemid 26068940)
67. Psychological stress and its influence on salivary flow rate, total protein concentration and IgA, IgG and IgM titers. Matos-Gomes N, Katsurayama M, Makimoto FH, Santana LL, Paredes-Garcia E, Becker MA, Dos-Santos MC, Neuroimmunomodulation 2010 17 396 404 10.1159/000292064 20516721
68. The impact of a 17-day training period for an international championship on mucosal immune parameters in top-level basketball players and staff members. Moreira A, Arsati F, Cury PR, Franciscon C, Simes AC, de Oliveira PR, de Araújo VC, Eur J Oral Sci 2008 116 431 437 10.1111/j.1600-0722.2008. 00558.x 18821985