Prolonged analgesia from Bupisome and Bupigel formulations: From design and fabrication to improved stability

Journal of Controlled Release

Volumn 160, Issue 2, 2012, Pages 346-352

  Cohen, Rivka ^a   Kanaan, Hiba ^a   Grant, Gilbert J ^b   Barenholz, Yechezkel ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alginate hydrogel; Bupivacaine; Controlled slow release; Local anesthetic

Indexed keywords

ALGINATE HYDROGELS; BULK SOLUTIONS; BUPIVACAINE; CA-ALGINATE; CROSS-LINKED HYDROGELS; LIPID COMPOSITION; LOCAL ANESTHETICS; NET LOSS; PLASMA CONCENTRATION; RESIDENCE TIME; SLOW RELEASE;

ANESTHETICS; LIPOSOMES;

MAMMALS;

BUPIGEL; BUPISOME; BUPIVACAINE; CALCIUM ALGINATE; CHITOSAN; LIPOSOME; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CROSS LINKING; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG STABILITY; ELECTROSTIMULATION; ENCAPSULATION; HYDROGEL; LIPID COMPOSITION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALGINATES; ANALGESIA; ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; CHITOSAN; CROSS-LINKING REAGENTS; DRUG CARRIERS; DRUG DESIGN; DRUG STABILITY; DRUG STORAGE; ELECTRIC STIMULATION; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGELS; INJECTIONS, SUBCUTANEOUS; LIPOSOMES; MALE; MICE; TIME FACTORS;

EID: 84861687894     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.12.030     Document Type: Article

References (36)

1. G.J. Grant, and M. Bansinath Liposomal delivery systems for local anesthetics Reg. Anesth. Pain Med. 26 1 2001 61 63
2. K. Karashima, M. Taniguchi, T. Nakamura, M. Takasaki, K. Matsuo, M. Irikura, and T. Irie Prolongation of intrathecal and sciatic nerve blocks using a complex of levobupivacaine with maltosyl-beta-cyclodextrin in rats Anesth. Analg. 104 5 2007 1121 1128
3. C.F. Weiniger, M. Golovanevski, M. Sokolsky-Papkov, and A.J. Domb Review of prolonged local anesthetic action Expert Opin. Drug Deliv. 7 6 2010 737 752
4. G.J. Grant, K. Vermeulen, L. Langerman, M. Zakowski, and H. Turndorf Prolonged analgesia with liposomal bupivacaine in a mouse model Reg. Anesth. 19 4 1994 264 269
5. H.Y. Yu, S.D. Li, and P. Sun Kinetic and dynamic studies of liposomal bupivacaine and bupivacaine solution after subcutaneous injection in rats J. Pharm. Pharmacol. 54 9 2002 1221 1227
6. G.J. Grant, K. Vermeulen, M.I. Zakowski, M. Stenner, H. Turndorf, and L. Langerman Prolonged analgesia and decreased toxicity with liposomal morphine in a mouse model Anesth. Analg. 79 4 1994 706 709
7. G.J. Grant, Y. Barenholz, B. Piskoun, M. Bansinath, H. Turndorf, and E.M. Bolotin DRV liposomal bupivacaine: preparation, characterization, and in vivo evaluation in mice Pharm. Res. 18 3 2001 336 343
8. G.J. Grant, J. Lax, L. Susser, M. Zakowski, T.E. Weissman, and H. Turndorf Wound infiltration with liposomal bupivacaine prolongs analgesia in rats Acta Anaesthesiol. Scand. 41 2 1997 204 207
9. J.J. Mowat, M.J. Mok, B.A. MacLeod, and T.D. Madden Liposomal bupivacaine. Extended duration nerve blockade using large unilamellar vesicles that exhibit a proton gradient Anesthesiology 85 3 1996 635 643
10. T. Mashimo, I. Uchida, M. Pak, A. Shibata, S. Nishimura, Y. Inagaki, and I. Yoshiya Prolongation of canine epidural anesthesia by liposome encapsulation of lidocaine Anesth. Analg. 74 6 1992 827 834
11. J. Boogaerts, N. Lafont, M. Donnay, H. Luo, and F.J. Legros Motor blockade and absence of local nerve toxicity induced by liposomal bupivacaine injected into the brachial plexus of rabbits Acta Anaesthesiol. Belg. 46 1 1995 19 24
12. S. Mantripragada A lipid based depot (DepoFoam technology) for sustained release drug delivery Prog. Lipid Res. 41 5 2002 392 406
13. G.J. Grant, Y. Barenholz, E.M. Bolotin, M. Bansinath, H. Turndorf, B. Piskoun, and E.M. Davidson A novel liposomal bupivacaine formulation to produce ultralong-acting analgesia Anesthesiology 101 1 2004 133 137
14. N.D. Lafont, F.J. Legros, and J.G. Boogaerts Use of liposome-associated bupivacaine in a cancer pain syndrome Anaesthesia 51 6 1996 578 579
15. E.M. Davidson, Y. Barenholz, R. Cohen, S. Haroutiunian, L. Kagan, and Y. Ginosar High-dose bupivacaine remotely loaded into multivesicular liposomes demonstrates slow drug release without systemic toxic plasma concentrations after subcutaneous administration in humans Anesth. Analg. 110 4 2010 1018 1023
16. J.G. Boogaerts, N.D. Lafont, A.G. Declercq, H.C. Luo, E.T. Gravet, J.A. Bianchi, and F.J. Legros Epidural administration of liposome-associated bupivacaine for the management of postsurgical pain: a first study J. Clin. Anesth. 6 4 1994 315 320
17. http://www.pacira.com.
18. G.J. Grant, B. Piskoun, and M. Bansinath Analgesic duration and kinetics of liposomal bupivacaine after subcutaneous injection in mice Clin. Exp. Pharmacol. Physiol. 30 12 2003 966 968
19. G. Haran, R. Cohen, L.K. Bar, and Y. Barenholz Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases Biochim. Biophys. Acta 1151 2 1993 201 215
20. D. Zucker, D. Marcus, Y. Barenholz, and A. Goldblum Liposome drugs' loading efficiency: a working model based on loading conditions and drug's physicochemical properties J. Control. Release 139 1 2009 73 80
21. L. Xing, C. Dawei, X. Liping, and Z. Rongqing Oral colon-specific drug delivery for bee venom peptide: development of a coated calcium alginate gel beads-entrapped liposome J. Control. Release 93 3 2003 293 300
22. J.C. Richardson, P.W. Dettmar, F.C. Hampson, and C.D. Melia A simple, high throughput method for the quantification of sodium alginates on oesophageal mucosa Eur. J. Pharm. Biopharm. 57 2 2004 299 305
23. S. Amselem, and Y. Barenholz Quality control assays in the development and clinical use of liposome-based formulations G. Gregoriadis, second ed. Liposome Technology Vol. 1 1993 CRC Press Boca Raton, FL 527 616
24. O. Even-Or, S. Samira, E. Rochlin, S. Balasingam, A.J. Mann, R. Lambkin-Williams, J. Spira, I. Goldwaser, R. Ellis, and Y. Barenholz Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine Vaccine 28 39 2010 6527 6541
25. G.J. Grant, B. Piskoun, A. Lin, and M. Bansinath An in vivo method for the quantitative evaluation of local anesthetics J. Pharmacol. Toxicol. Methods 43 1 2000 69 72
26. J. de Gier Osmotic behaviour and permeability properties of liposomes Chem. Phys. Lipids 64 1-3 1993 187 196
27. R. Hertz, and Y. Barenholz Permeability and integrity properties of lecithin-sphingomyelin liposomes Chem. Phys. Lipids 15 2 1975 138 156
28. Y. Barenholz, G. Grant, H. Turndorf, B. Piskoun, E. Bolotin, Liposomal Analgesic Drug Composotions Prepared in GMV Using an Ammonium Sulfate Gradient, U.S. Patent 7357944, April 15 2008.
29. W.D. Stein Transport and Diffusion across Cell Membranes 1986 Academic Press Orlando, FL
30. Scifinder Calculated using Advanced Chemistry Development (ACD/Labs) Software V8.14 for Solaris 1994-2009
31. O.G. Mouritsen, and K. Jorgensen A new look at lipid-membrane structure in relation to drug research Pharm. Res. 15 10 1998 1507 1519
32. Y. Barenholz Sphingomyelin and cholesterol: from membrane biophysics and rafts to potential medical applications P.J. Quinn, Membrane Dynamics and Domains, Subcellular Biochemistry Vol. 37 2004 Kluwer Academic/Plenum New York and London 167 215
33. Y. Barenholz, and G. Cevc Structure and properties of membranes A. Baszkin, W.N. Physical Chemistry of Biological Surfaces 2000 Marcel Dekker New York 171 241
34. O.G. Mouritsen D. Dragoman, M. Dragoman, A.C. Elitzur, M.P. Silverman, J. Tuszynski, H.D. Zeh, Life as a Matter of Fat: the Emerging Science of Lipidomics 2005 Springer Berlin 129 136
35. Y. Barenholz Liposome application: problems and prospects Curr. Opin. Colloid Interface Sci. 6 2001 66 77
36. I.V. Zhigaltsev, N. Maurer, Q.F. Akhong, R. Leone, E. Leng, J. Wang, S.C. Semple, and P.R. Cullis Liposome-encapsulated vincristine, vinblastine and vinorelbine: a comparative study of drug loading and retention J. Control. Release 104 1 2005 103 111