High-dose bupivacaine remotely loaded into multivesicular liposomes demonstrates slow drug release without systemic toxic plasma concentrations after subcutaneous administration in humans

Anesthesia and Analgesia

Volumn 110, Issue 4, 2010, Pages 1018-1023

  Davidson, Elyad M ^a   Barenholz, Yechezkel ^b   Cohen, Rivka ^b   Haroutiunian, Simon ^a,c   Kagan, Leonid ^d   Ginosar, Yehuda ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE;

ADULT; ANALGESIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG HALF LIFE; HUMAN; HUMAN EXPERIMENT; LOADING DRUG DOSE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; SLOW DRUG RELEASE;

EID: 77950991933     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3181d26d2a     Document Type: Article

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