Birth dating of midbrain dopamine neurons identifies A9 enriched tissue for transplantation into Parkinsonian mice

Experimental Neurology

Volumn 236, Issue 1, 2012, Pages 58-68

  Bye, Christopher R ^a   Thompson, Lachlan H ^a   Parish, Clare L ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

A9 neuron; Birth dating; Dopamine; Girk2; Transplantation

Indexed keywords

A9 NERVE CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC INNERVATION; BIRTH DATING; CELL LINE; CELL MATURATION; CELL SELECTION; CELL SUBPOPULATION; CELL THERAPY; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; EMBRYO; FEMALE; MESENCEPHALON; MITOSIS; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM PARAMETERS; NEUROBLAST; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; SEROTONINERGIC NERVE CELL; STEM CELL; TISSUE GRAFT; TISSUE TRANSPLANTATION; VENTRAL TEGMENTUM;

ANIMALS; BRAIN TISSUE TRANSPLANTATION; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; FEMALE; FETAL TISSUE TRANSPLANTATION; MICE; MICE, TRANSGENIC; NEUROGENESIS; PARKINSONIAN DISORDERS; PRIMARY CELL CULTURE; SUBSTANTIA NIGRA;

EID: 84861682123     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.04.002     Document Type: Article

References (46)

1. Abercrombie M. Estimation of nuclear populaton from microtome sections. Anat. Rec. 1946, 94:239-247.
2. Agid Y., et al. Are dopaminergic neurons selectively vunerable to Parkinson's Disease? 1993, Vol. 60. Raven Press, New York.
3. Altman J., Bayer S.A. Development of the brain stem in the rat. V. Thymidine-radiographic study of the time of origin of neurons in the midbrain tegmentum. J. Comp. Neurol. 1981, 198:677-716.
4. Bayer S.A., et al. Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse. Exp. Brain Res. 1995, 105:191-199.
5. Bayer S.A., et al. Systematic differences in time of dopaminergic neuron origin between normal mice and homozygous weaver mutants. Exp. Brain Res. 1995, 105:200-208.
6. Bjorklund A., Dunnett S.B. Dopamine neuron systems in the brain: an update. Trends Neurosci. 2007, 30:194-202.
7. Blaess S., et al. Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei. Neural Dev. 2011, 6:29.
8. Blakely B.D., et al. Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS One 2011, 6:e18373.
9. Brooks D.J., et al. Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Ann. Neurol. 1990, 28:547-555.
10. Brundin P., Isacson O., Bjorklund A. Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival. Brain Res. 1985, 331:251-259.
11. Carlsson T., et al. Serotonin neuron transplants exacerbate l-DOPA-induced dyskinesias in a rat model of Parkinson's disease. J. Neurosci. 2007, 27:8011-8022.
12. Dahlstrom A., Fuxe K. Evidence for existence of monoamine-containing neurons in central nervous system. I. Demonstration of monoamines in cell bodies of brain stem neurons. Acta Physiol. Scand. Supplementum:SUPPL 1964, 232:1-55.
13. Dunnett S.B., Bjorklund A. Basic neural transplantation techniques. I. Dissociated cell suspension grafts of embryonic ventral mesencephalon in the adult rat brain. Brain Res. Brain Res. Protoc. 1997, 1:91-99.
14. Franklin K.B.J., Paxinos G. The Mouse Brain in Stereotaxic Coordinates 1997, Academic Press, San Diego, Vol.
15. Freeman T.B., et al. The influence of donor age on the survival of solid and suspension intraparenchymal human embryonic nigral grafts. Cell Transplant. 1995, 4:141-154.
16. Fricker-Gates R.A., Dunnett S.B. Rewiring the Parkinsonian brain. Nat. Med. 2002, 8:105-106.
17. Galter D., et al. ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia. Neurobiol. Dis. 2003, 14:637-647.
18. Gates M.A., et al. Spatially and temporally restricted chemoattractive and chemorepulsive cues direct the formation of the nigro-striatal circuit. Eur. J. Neurosci. 2004, 19:831-844.
19. Gates M.A., et al. Re-examining the ontogeny of substantia nigra dopamine neurons. Eur. J. Neurosci. 2006, 23:1384-1390.
20. Grealish S., et al. The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease. Brain 2010, 133:482-495.
21. Hahn M., Timmer M., Nikkhah G. Survival and early functional integration of dopaminergic progenitor cells following transplantation in a rat model of Parkinson's disease. J. Neurosci. Res. 2009, 87:2006-2019.
22. Hanaway J., McConnell J.A., Netsky M.G. Histogenesis of the substantia nigra, ventral tegmental area of Tsai and interpeduncular nucleus: an autoradiographic study of the mesencephalon in the rat. J. Comp. Neurol. 1971, 142:59-73.
23. Hayes L., et al. Timing of Sonic hedgehog and Gli1 expression segregates midbrain dopamine neurons. J. Comp. Neurol. 2011, 519:3001-3018.
24. Jacobs F.M., et al. Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency. Development 2007, 134:2673-2684.
25. Joksimovic M., et al. Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:19185-19190.
26. Kawasaki H., et al. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 2000, 28:31-40.
27. Kim J.H., et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 2002, 418:50-56.
28. Kriks S., et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 2011, 480:547-551.
29. Kuan W.L., et al. The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesias. Neurobiol. Dis. 2007, 25:594-608.
30. Lauder J.M., Bloom F.E. Ontogeny of monoamine neurons in the locus coeruleus, Raphe nuclei and substantia nigra of the rat. I. Cell differentiation. J. Comp. Neurol. 1974, 155:469-481.
31. Marti J., et al. A combined immunohistochemical and autoradiographic method to detect midbrain dopaminergic neurons and determine their time of origin. Brain Res. Brain Res. Protoc. 2002, 9:197-205.
32. McCaffery P., Drager U.C. High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:7772-7776.
33. Mendez I., et al. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain 2005, 128:1498-1510.
34. O'Keeffe F.E., et al. Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease. Brain 2008, 131:630-641.
35. Parish C.L., Thompson L.H. Neural progenitor cell transplantation in Parkinson's disease models. Neural Progenitor Cells: Methods and Protocols 2012, vol. 24. Human Press. L. Deleyrolle, B. Reynolds (Eds.).
36. Parish C.L., et al. The role of dopamine receptors in regulating the size of axonal arbors. J. Neurosci. 2001, 21:5147-5157.
37. Parish C.L., et al. Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. J. Clin. Invest. 2008, 118:149-160.
38. Politis M., et al. Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants. Sci. Transl. Med. 2010, 2:38ra46.
39. Sawamoto K., et al. Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:6423-6428.
40. Sinclair S.R., Fawcett J.W., Dunnett S.B. Dopamine cells in nigral grafts differentiate prior to implantation. Eur. J. Neurosci. 1999, 11:4341-4348.
41. Studer L., Tabar V., McKay R.D. Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nat. Neurosci. 1998, 1:290-295.
42. Thompson L., et al. Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. J. Neurosci. 2005, 25:6467-6477.
43. Torres E.M., et al. Improved survival of young donor age dopamine grafts in a rat model of Parkinson's disease. Neuroscience 2007, 146:1606-1617.
44. Van den Heuvel D.M., Pasterkamp R.J. Getting connected in the dopamine system. Prog. Neurobiol. 2008, 85:75-93.
45. Wernig M., et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:5856-5861.
46. Winkler C., Kirik D., Bjorklund A. Cell transplantation in Parkinson's disease: how can we make it work?. Trends Neurosci. 2005, 28:86-92.