Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men

Journal of Hypertension

Volumn 24, Issue 2, 2006, Pages 325-330

  Firouzi, Mehran ^a,b   Kok, Bart ^a   Spiering, Wilko ^c   Busjahn, Andreas ^d   Bezzina, Connie R ^e   Ruijter, Jan M ^e   Koeleman, Bobby P C ^a   Schipper, Maria ^f   Groenewegen, W Antoinette ^a   Jongsma, Habo J ^a   De Leeuw, Peter W ^c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b JEROEN BOSCH HOSPITAL   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d HealthTwist GmbH   (Germany)

^e ACADEMIC MEDICAL CENTER   (Netherlands)

^f UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Blood pressure; Connexin40; Gap junction; Hypertension

Indexed keywords

AGED; ALLELE; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR RISK; COMPARATIVE STUDY; CONNEXIN 40 GENE; CONTROLLED STUDY; DIZYGOTIC TWINS; DNA POLYMORPHISM; GENE; GENOTYPE; HUMAN; HYPERTENSION; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; PRIORITY JOURNAL; PROMOTER REGION; SYSTOLIC BLOOD PRESSURE;

EID: 33644810177     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.hjh.0000200512.40818.47     Document Type: Article

References (34)

1. August P. Initial treatment of hypertension. N Engl J Med 2003; 348:610-617.
2. Melander O. Genetic factors in hypertension - what is known and what does it mean? Blood Press 2001; 10:254-270.
3. Pausova Z, Tremblay J, Hamet P. Gene-environment interactions in hypertension. Curr Hypertens Rep 1999; 1:42-50.
4. Luft FC. Molecular genetics of human hypertension. J Hypertens 1998; 16:1871-1878.
5. Haefliger JA, Nicod P, Meda P. Contribution of connexins to the function of the vascular wall. Cardiovasc Res 2004; 62:345-356.
6. Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC. Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 2003; 83:1359-1400.
7. Hill CE, Rummery N, Hickey H, Sandow SL. Heterogeneity in the distribution of vascular gap junctions and connexins: implications for function. Clin Exp Pharmacol Physiol 2002; 29:620-625.
8. Christ GJ, Spray DC, el-Sabban M, Moore LK, Brink PR. Gap junctions in vascular tissues. Evaluating the role of intercellular communication in the modulation of vasomotor tone. Circ Res 1996; 79:631-646.
9. Ryan MJ, Liu B, Herbowy MT, Gross KW, Hajduczok G. Intercellular communication between renin expressing As4.1 cells, endothelial cells and smooth muscle cells. Life Sci 2003; 72:1289-1301.
10. van Kempen MJ, Jongsma HJ. Distribution of connexin37, connexin40 and connexin43 in the aorta and coronary artery of several mammals. Histochem Cell Biol 1999; 112:479-486.
11. Jongsma HJ, Wilders R. Gap junctions in cardiovascular disease. Circ Res 2000; 86:1193-1197.
12. de Wit C, Roos F, Bolz SS, Kirchhoff S, Kruger O, Willecke K, et al. Impaired conduction of vasodilation along arterioles in connexin40-deficient mice. Circ Res 2000; 86:649-655.
13. de Wit C, Roos F, Bolz SS, Pohl U. Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion. Physiol Genomics 2003; 13:169-177.
14. Figueroa XF, Paul DL, Simon AM, Goodenough DA, Day KH, Damon DN, et al. Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo. Circ Res 2003; 92:793-800.
15. Rummery NM, McKenzie KU, Whitworth JA, Hill CE. Decreased endothelial size and connexin expression in rat caudal arteries during hypertension. J Hypertens 2002; 20:247-253.
16. De Vriese AS, Van de Voorde J, Lameire NH. Effects of connexin-mimetic peptides on nitric oxide synthase- and cyclooxygenase-independent renal vasodilation. Kidney Int 2002; 61:177-185.
17. Groenewegen WA, Firouzi M, Bezzina CR, Vliex S, van Langen IM, Sandkuijl L, et al. A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill. Circ Res 2003; 92:14-22.
18. Firouzi M, Ramanna H, Kok B, Jongsma H, Koeleman B, Doevendans P, et al. Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation. Circ Res 2004; 95:e29-e33.
19. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16:31-41.
20. Busjahn A, Faulhaber HD, Viken RJ, Rose RJ, Luft FC. Genetic influences on blood pressure with the cold-pressor test: a twin study. J Hypertens 1996; 14:1195-1199.
21. Busjahn A, Knoblauch H, Knoblauch M, Bohlender J, Menz M, Faulhaber H, et al. Angiotensin-converting enzyme and angiotensinogen gene polymorphisms, plasma levels, cardiac dimensions. A twin study. Hypertension 1997; 29:165-170.
22. Bezzina CR, Verkerk AO, Busjahn A, Jeron A, Erdmann J, Koopmann TT, et al. A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization. Cardiovasc Res 2003; 59:27-36.
23. Fisher NDL, Ferri C, Bellini C, Santucci A, Gleason R, Williams GH, et al. Age, gender, and non-modulation. A sexual dimorphism in essential hypertension. Hypertension 1997; 29:980-985.
24. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999; 340:1801-1811.
25. Huang A, Sun D, Koller A, Kaley G. Gender difference in flow-induced dilation and regulation of shear stress: role of estrogen and nitric oxide. Am J Physiol 1998; 275:R1571-R1577.
26. Zhu Y, Bian Z, Lu P, Karas RH, Bao L, Cox D, et al. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science 2002; 295:505-508.
27. Saruta T, Saade GA, Kaplan NM. A possible mechanism for hypertension induced by oral contraceptives. Diminished feedback suppression of renin release. Arch Intern Med 1970; 126:621-626.
28. Owens JF, Stoney CM, Matthews KA. Menopausal status influences ambulatory blood pressure levels and blood pressure changes during mental stress. Circulation 1993; 88:2794-2802.
29. Reckelhoff JF, Zhang H, Srivastava K. Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin system. Hypertension 2000; 35:480-483.
30. Higaki J, Baba S, Katsuya T, Sato N, Ishikawa K, Mannami T, et al. Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in japanese men. The Suita Study. Circulation 2000; 101:2060-2065.
31. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, et al. Evidence for association and genetic linkage of the angiotensin- converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998; 97:1766-1772.
32. Boerma M, Forsberg L, Van Zeijl L, Morgenstern R, De Faire U, Lemne C, et al. A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development. J Intern Med 1999; 246:211-218.
33. Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 2002; 347:1916-1923.
34. Rocchini AP. Obesity hypertension. Am J Hypertens 2002; 15(2 pt 2): 50S-52S.