Connexin 40 mediates the tubuloglomerular feedback contribution to renal blood flow autoregulation

Journal of the American Society of Nephrology

Volumn 20, Issue 7, 2009, Pages 1577-1585

  Just, Armin ^a,e   Kurtz, Lisa ^c   De Wit, Cor ^d   Wagner, Charlotte ^c   Kurtz, Armin ^c   Arendshorst, William J ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d UNIVERSITY OF LÜBECK   (Germany)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CONNEXIN 40; N(G) NITROARGININE METHYL ESTER; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; GAP JUNCTION; GENOTYPE; HISTOLOGY; KIDNEY BLOOD FLOW; KIDNEY VASCULAR RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 67649739081     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008090943     Document Type: Article

References (44)

1. Figueroa XF, Isakson BE, Duling BR: Connexins: Gaps in our knowledge of vascular function. Physiology (Bethesda) 19: 277-284, 2004 (Pubitemid 39472639)
2. Wagner C: Function of connexins in the renal circulation. Kidney Int 73: 547-555, 2008 (Pubitemid 351264110)
3. de Wit C, Roos F, Bolz SS, Kirchhoff S, Kruger O, Willecke K, Pohl U: Impaired conduction of vasodilation along arterioles in connexin40- deficient mice. Circ Res 86: 649-655, 2000 (Pubitemid 30208432)
4. Figueroa XF, Paul DL, Simon AM, Goodenough DA, Day KH, Damon DN, Duling BR: Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo. Circ Res 92: 793-800, 2003 (Pubitemid 36457645)
5. de Wit C, Roos F, Bolz SS, Pohl U: Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion. Physiol Genomics 13: 169-177, 2003 (Pubitemid 37129181)
6. Wagner C, de Wit C, Kurtz L, Grunberger C, Kurtz A, Schweda F: Connexin40 is essential for the pressure control of renin synthesis and secretion. Circ Res 100: 556-563, 2007 (Pubitemid 46673265)
7. Krattinger N, Capponi A, Mazzolai L, Aubert J-F, Caille D, Nicod P, Waeber G, Meda P, Haefliger JA: Connexin40 regulates renin production and blood pressure. Kidney Int 72: 814-822, 2007 (Pubitemid 47462074)
8. Kansui Y, Fujii K, Nakamura K, Goto K, Oniki H, Abe I, Shibata Y, Iida M: Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats. Am J Physiol Heart Circ Physiol 287: H216-H224, 2004 (Pubitemid 38802356)
9. Taugner R, Schiller A, Kaissling B, Kriz W: Gap junctional coupling between the JGA and the glomerular tuft. Cell Tissue Res 186: 279-285, 1978 (Pubitemid 8252554)
10. Haefliger JA, Demotz S, Braissant O, Suter E, Waeber B, Nicod P, Meda P: Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension. Kidney Int 60: 190-201, 2001 (Pubitemid 32587554)
11. Arensbak B, Mikkelsen HB, Gustafsson F, Christensen T, Holstein- Rathlou NH: Expression of connexin 37, 40, and 43 mRNA and protein in renal preglomerular arterioles. Histochem Cell Biol 115: 479-487, 2001 (Pubitemid 32662423)
12. Takenaka T, Inoue T, Kanno Y, Okada H, Meaney KR, Hill CE, Suzuki H: Expression and role of connexins in the rat renal vasculature. Kidney Int 73: 415-422, 2008 (Pubitemid 351186284)
13. Kurtz L, Schweda F, de Wit C, Kriz W, Witzgall R, Warth R, Sauter A, Kurtz A, Wagner C: Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium. J Am Soc Nephrol 18: 1103-1111, 2007 (Pubitemid 46536896)
14. De Vriese AS, Van de Voorde J, Lameire NH: Effects of connexinmimetic peptides on nitric oxide synthase- and cyclooxygenase-independent renal vasodilation. Kidney Int 61: 177-185, 2002 (Pubitemid 34075145)
15. Just A: Mechanisms of renal blood flow autoregulation: dynamics and contributions. Am J Physiol Regul Integr Comp Physiol 292: R1-R17, 2007 (Pubitemid 46089813)
16. Just A, Arendshorst WJ: A novel mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in mice. Am J Physiol Renal Physiol 293: F1489-F1500, 2007 (Pubitemid 350085984)
17. Ren Y, Carretero OA, Garvin JL: Role of mesangial cells and gap junctions in tubuloglomerular feedback. Kidney Int 62: 525-531, 2002 (Pubitemid 34779763)
18. Peti-Peterdi J: Calcium wave of tubuloglomerular feedback. Am J Physiol Renal Physiol 291: F473-F480, 2006 (Pubitemid 44148137)
19. Lagaud G, Karicheti V, Knot HJ, Christ GJ, Laher I: Inhibitors of gap junctions attenuate myogenic tone in cerebral arteries. Am J Physiol Heart Circ Physiol 283: H2177-H2186, 2002 (Pubitemid 35345917)
20. Earley S, Resta TC, Walker BR: Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries. Am J Physiol Heart Circ Physiol 287: H2677-H2686, 2004 (Pubitemid 39557140)
21. 1-adrenergic contractility in isolated vascular tissues by heptanol: a functional demonstration of the potential importance of intercellular communication to vascular response generation. Life Sci 56: 709-721, 1995
22. Griffith TM: Endothelium-dependent smooth muscle hyperpolarization: Do gap junctions provide a unifying hypothesis? Br J Pharmacol 141: 881-903, 2004
23. Wolfle SE, Schmidt VJ, Hoepfl B, Gebert A, Alcolea S, Gros D, de Wit C: Connexin45 cannot replace the function of connexin40 in conducting endothelium-dependent dilations along arterioles. Circ Res 101: 1292-1299, 2008 (Pubitemid 350294646)
24. Rodenwaldt B, Pohl U, de Wit C: Endogenous and exogenous NO attenuates conduction of vasoconstrictions along arterioles in the microcirculation. Am J Physiol Heart Circ Physiol 292: H2341-H2348, 2007 (Pubitemid 47084616)
25. Kameritsch P, Khandoga N, Nagel W, Hundhausen C, Lidington D, Pohl U: Nitric oxide specifically reduces the permeability of Cx37- containing gap junctions to small molecules. J Cell Physiol 203: 233-242, 2005 (Pubitemid 40328190)
26. Palkovits M, Zaborszky L: Neuroanatomy of central cardiovascular control. Nucleus tractus solitarii: Afferent and efferent neuronal connections in relation to the baroreceptor reflex arc. Prog Brain Res 47: 9-34, 1977
27. Just A, Arendshorst WJ: Nitric oxide blunts myogenic autoregulation in rat renal but not skeletal muscle circulation via tubuloglomerular feedback. J Physiol 569: 959-974, 2005 (Pubitemid 41830236)
28. Shi Y, Wang X, Chon KH, Cupples WA: Tubuloglomerular feedbackdependent modulation of renal myogenic autoregulation by nitric oxide. Am J Physiol Regul Integr Comp Physiol 290: R982-R991, 2006
29. Just A, Ehmke H, Toktomambetova L, Kirchheim HR: Dynamic characteristics and underlying mechanisms of renal blood flow autoregulation in the conscious dog. Am J Physiol Renal Physiol 280: F1062-F1071, 2001 (Pubitemid 32566466)
30. Just A, Arendshorst WJ: Dynamics and contribution of mechanisms mediating renal blood flow autoregulation. Am J Physiol Regul Integr Comp Physiol 285: R619-R631, 2003 (Pubitemid 37040570)
31. Guan Z, Osmond DA, Inscho EW: P2X receptors as regulators of the renal microvasculature. Trends Pharmacol Sci 28: 646-652, 2007 (Pubitemid 350166576)
32. Schnermann J, Briggs JP: Tubuloglomerular feedback: Mechanistic insights from gene-manipulated mice. Kidney Int 74: 418 426, 2008
33. Moore LC, Iijima K, Rich A, Casellas D, Goligorsky MS: Communication of the tubuloglomerular feedback signal in the JGA. Kidney Int Suppl 32: S45-S50, 1991
34. Toma I, Bansal E, Meer EJ, Kang JJ, Vargas SL, Peti-Peterdi J: Connexin 40 and ATP-dependent intercellular calcium wave in renal glomerular endothelial cells. Am J Physiol Regul Integr Comp Physiol 294: R1769-R1776, 2008
35. Rackauskas M, Verselis VK, Bukauskas FF: Permeability of homotypic and heterotypic gap junction channels formed of cardiac connexins mCx30.2, Cx40, Cx43, and Cx45. Am J Physiol Heart Circ Physiol 293: H1729-H1736, 2007 (Pubitemid 47367221)
36. Delmar M: Connexin diversity: Discriminating the message. Circ Res 91: 85-86, 2002 (Pubitemid 34827216)
37. Kim SM, Mizel D, Huang YG, Briggs JP, Schnermann J: Adenosine as a mediator of macula densa-dependent inhibition of renin secretion. Am J Physiol Renal Physiol 290: F1016-F1023, 2006 (Pubitemid 43724900)
38. Just A, Ehmke H, Wittmann U, Kirchheim HR: Role of angiotensin II in dynamic renal blood flow autoregulation of the conscious dog. J Physiol 538: 167-177, 2002 (Pubitemid 35190046)
39. Yao J, Hiramatsu N, Zhu Y, Morioka T, Takeda M, Oite T, Kitamura M: Nitric oxide-mediated regulation of connexin43 expression and gap junctional intercellular communication in mesangial cells. J Am Soc Nephrol 16: 58-67, 2005 (Pubitemid 43073157)
40. Kirchhoff S, Nelles E, Hagendorff A, Kruger O, Traub O, Willecke K: Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol 8: 299-302, 1998 (Pubitemid 28111463)
41. Alcolea S, Jarry-Guichard T, de Bakker J, Gonzalez D, Lamers W, Coppen S, Barrio L, Jongsma H, Gros D, van Rijen H: Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction. Circ Res 94: 100-109, 2004 (Pubitemid 38064104)
42. Schweda F, Kurtz L, de Wit C, Janssen-Bienhold U, Kurtz A, Wagner C: Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension. Kidney Int 75: 482-489, 2009
43. Dedek K, Schultz K, Pieper M, Dirks P, Maxeiner S, Willecke K, Weiler R, Janssen-Bienhold U: Localization of heterotypic gap junctions composed of connexin45 and connexin36 in the rod pathway of the mouse retina. Eur J Neurosci 24: 1675-1686, 2006 (Pubitemid 44427536)
44. Savitzky A, Golay MJE: Smoothing and differentiation of data by simplified least squares procedures. Anal Chem 36: 1627-1639, 1964