Combining microwave resonance technology to multivariate data analysis as a novel PAT tool to improve process understanding in fluid bed granulation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 78, Issue 3, 2011, Pages 513-521

  Loureno, Vera ^a,b   Herdling, Thorsten ^b   Reich, Gabriele ^c   Menezes, José C ^a   Lochmann, Dirk ^b  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b Merck Serono GmbH   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Batch monitoring; Fluid bed granulation; Microwave resonance technology; Multivariate data analysis; PAT; QbD

Indexed keywords

ARTICLE; ATMOSPHERIC MOISTURE; CONTROLLED STUDY; DENSITY; DRUG GRANULATION; DRUG GRANULE; GRANULE CELL; MICROWAVE RADIATION; MICROWAVE RESONANCE TECHNOLOGY; MULTIVARIATE ANALYSIS; NONHUMAN; PARTICLE SIZE; PROCESS DESIGN; PROCESS TECHNOLOGY; SENSOR; TEMPERATURE;

DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HUMIDITY; LEAST-SQUARES ANALYSIS; MICROWAVES; MULTIVARIATE ANALYSIS; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; PRINCIPAL COMPONENT ANALYSIS; PROCESS ASSESSMENT (HEALTH CARE); QUALITY CONTROL; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 79960596983     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.02.008     Document Type: Article

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